the rainfall of 2003
Population Genetics for Animal Conservation potx
... from the Ministry of Research and Innovation of the Autonomous Province of Trento, the Edmund Mach Foundation, the Centro di Ecologia Alpina, the Department of Biology and Evolution of the University ... representing the fact that the values of the population allele frequencies are unknown The type of the allele is denoted by Yi,1 for the first gene copy of the ith sampled fish, and Yi,2 for the second ... of the K tributaries that were at the fishery site when the sample was taken We might also want to infer the population of origin of each of the sampled fish Figure 2.2(a) shows the DAG for the...
- 415
- 566
- 0
Tài liệu Báo cáo khoa học: Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain ppt
... deletion of the promoter [12] In these mice, we could clearly demonstrate absence of Adh4 mRNA in the stomach epithelia – the tissue with the best characterized Adh4 expression Taken together, our ... retinol to retinal, providing the first step on the way to retinoic acid [31] The brain must thus rely on the activity of other enzymes, for example ADH3 or other members of the medium-chain dehydrogenase/reductase ... granular layer of human cerebellum Table compiles our findings in adult brain tissue of all three species Discussion The distribution of ADHs in the brain is of particular interest because of their implications...
- 11
- 603
- 0
Báo cáo khoa học: Characterization of the serotoninergic system in the C57BL/6 mouse skin potx
... products, apart from the NAS substrate The pattern of expression of these products changed during progression of the hair cycle (Fig 9) RP-HPLC separation of the reaction products of the HIOMT assay ... isoform of 252 bp was detected in the brain, pituitary, spleen and M3 subline of S91 melanoma, but not in the C57BL/6 mouse skin or the MelA melanocytes (Fig 3B, Table 1) This isoform had the ... facilities of the Albany Medical College, Albany, NY LC/MS assays, performed in Belarus, also used C57BL/6 mice (males 18 weeks old) obtained from the Vivarium of the Department of Biotestings of the...
- 10
- 409
- 0
báo cáo hóa học: " Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord" potx
... extent of initial demyelination is reduced in the NG2 null mouse, repair of this lesion nevertheless proceeds more slowly than repair of the larger lesion found in the wild type mouse The impact of ... the ablation of NG2 As a result of changes in multiple cell types, Page 11 of 13 the respective processes of myelin damage and myelin repair are both altered in NG2 null mice The complexity of ... quantify the extent of myelin damage (data not shown) Thus, despite the initially larger extent of inflammation and loss of myelin in wild type mice, myelin repair is superior in these mice to the...
- 13
- 480
- 0
báo cáo hóa học:" Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study" pptx
... is the first report of differences in the levels of ovarian gene expression in an obese mouse model The most important finding of this study is that modified gene expression in the ovaries of ... synthetic enzymes in the face of high leptin levels is consistent with a state of leptin resistance in the ovaries of obese LY mice Page of (page number not for citation purposes) Journal of ... associated with the LY mutation are shown in bold N = animals per group The Ay mutation is a large deletion that encompasses the promoter region of the agouti gene as well as a large portion of the coding...
- 9
- 346
- 0
Báo cáo y học: "Hepatocyte growth factor ameliorates dermal sclerosis in the tight-skin mouse model of scleroderma" doc
... accordance with the guidelines of the National Institutes of Health (Bethesda, MD, USA), as specified by the animal care policy of Hyogo College of Medicine Expression vector and preparation of liposomes ... acknowledges the support of a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (No 15591071) References LeRoy EC: A brief overview of the pathogenesis of ... of HGF-HVJ liposomes into TSK/+ mice Treatment consisted of once-weekly injection of either HGF-HVJ liposomes or control mock vector for a period of weeks Treatment was initiated at the age of...
- 7
- 399
- 0
Báo cáo y học: "Analysis of C4 and the C4 binding protein in the MRL/lpr mouse" pptx
... preventing the formation of the C3 convertase by binding to C4b; accelerating the natural decay of the classical pathway C3 convertase; and as a cofactor for the serine proteinase factor I in the proteolytic ... that the reduced levels of C4 in the MRL strain limit the intrinsic capacity of the classical pathway to generate C3b, there are data to suggest that amplification of C3b generation via the alternative ... MRL mouse is independent of Fc receptors [51], our studies showing the functional deficiency of C4 in these mice, and that the loss of the major negative regulator of the classical complement...
- 10
- 457
- 0
báo cáo khoa học: " Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor d from Peroxisome proliferatoractivated receptor g in the ob/ob mouse" ppt
... activated The exact balance between the concentrations of these pathways presumably arises from the balance between increased βoxidation and the actual activity of the synthetic pathway across the ... weighting each of the variables by the square root of that variable’s variance, minimizing the impact of noise and increasing the importance of low-concentration metabolites in the subsequent ... Multivariate analysis of some of the key metabolic changes induced by PPARd stimulation (a) PLS-DA scores plot showing the clustering of the GC-MS chromatograms from the organic fraction of liver tissue...
- 12
- 266
- 0
Báo cáo y học: "Quantifying the major mechanisms of recent gene duplications in the human and mouse genomes: a novel strategy to estimate gene duplication rates" docx
... retroposition The rates are the slopes of the linear functions (red lines) fitted to the curves of the cumulative distributions of retrogenes All of the linear functions are fitted to the part of the curves ... as the cut-off and fitted linear models to each part of the curves The results are shown in Table The slopes of the linear functions are therefore the estimates of gene duplication rates for the ... crossover The rates are the slopes of the linear functions (colored lines) fitted to the curves of the cumulative distributions of tandemly arrayed genes (TAGs) Parameter estimates of the linear...
- 11
- 357
- 0
Báo cáo y học: " Gene expression regulation in the context of mouse interspecific mosaic genomes" pdf
... MMU15) In the rest of the study, we will consider the combination of the 11 segments of M spretus origin present in the three IRCSs as a whole Overall, the proportion of dysregulated genes in the M ... summary of the modes of regulation encountered in the IRCSs and their parent strains A summary of the modes of regulation encountered in the IRCSs and their parent strains Blue marks the B6 chromosome ... observation, together with the fact that during the process of strain establishment 55% of the strains did not survive, indicates that there was strong selection acting against the maintenance of the M...
- 18
- 460
- 0
Role of SPHK2S1P signalling in regulating mitochondrial function in the MPTP induced mouse model of parkinsons disease and in the MPP treated MN9D cells
... down the progression of the disease 1.6 Pathological hallmarks of PD The archetypal pathological characteristic of PD involves the loss of the dopaminergic (DA) neurons The DA neurons of the substantia ... unaffected in the MPP+ treated groups in the presence of exogenous S1P Furthermore, the cell death was minimal in the MPP+-treated groups in the presence of exogenous S1P These results vouch for the protective ... in the development of PD (Gorell et al., 1998) Nevertheless, the results were not consistent The major drive for the environmental factors to be the major cause of PD came from the discovery of...
- 178
- 359
- 0
Tài liệu Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model doc
... disease, the primary pathology is in the kidney [1], the major site of Gb3 synthesis in man [11], and in the heart, possibly due to the association of Gb3 synthesis with the microvasculature GSL synthesis ... determined the effect of CsA on Gb3 synthesis in the Fabry mouse model Our studies have further delineated the abnormal Gb3 synthesis in this model and have shown that the inhibition of MDR1 is ... considered that the increased renal Gb3 of the Fabry mouse might extend to the glomerulus to provide a model of the human disease In the cortex of wild-type kidney, subpopulations of renal tubules...
- 12
- 432
- 0
Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
... CCAAT box at 324 bp upstream of the major transcription start site The presence of a CCAAT box and the absence of a TATA box seem to be one of the characteristics of the mouse integrin a3 gene ... previously reported the structures of the mouse a3 integrin subunit gene including the exon/intron organization and the alternative exon usage for the generation of variants of the a3 subunits (a3A ... and the sets of primers listed in Table After the PCR products were digested with KpnI and SacI, the fragments were inserted into the KpnI/SacI site of Fig Structures of the 5¢-flanking region of...
- 9
- 562
- 0
Báo cáo khoa học: Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3) docx
... cleavage of the c-phosphate does occur in the NBD with the mutation at the IC [36,38,39] Moreover, these and other studies suggest that the IC residues are involved in the formation of the NBD ... activates the attacking water molecule that cleaves the terminal phosphate of bound ATP In the latter model, the IC is part of a catalytic dyad, along with the histidine residue of the H-loop, ... sequence contacts the c-phosphate of the bound nucleotide across the dimer [15] and the aromatic residue of the A-loop Abcb1a catalytic mechanism stacks against the adenine moiety of bound nucleotide...
- 13
- 458
- 0
Báo cáo khoa học: Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase pdf
... energies of the original resiDG i;j due i in the native protein with the rest of the residues, self DDG k mutị are the changes of the self energies of the residues k that change either their ionization ... Electron-density map of the dCMP-binding region for the R188M CMP kinase variant The Fo ) Fc omit map calculated for the dCMPR188M CMP kinase complex in the absence of the dCMP model is green The contour ... Moreover, the kcat value with UMP increased by one order of magnitude with respect to the wild-type enzyme, at the expense of the Km value The overall effect of this structural change is a twofold...
- 11
- 437
- 0
Báo cáo khoa học: Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain pdf
... of a total of 290 lL of 80–200 lm of the gp130 peptide The heat of dilution of the gp130 peptide into buffer was determined in control experiments and subtracted from the raw data of the binding ... Other members of the SOCS family contain putative PEST sequences, but these are all located in the N-terminal region, upstream of the SH2 domain The conservation of the PEST motif of SOCS3 in mammals ... unstructured and part of the PEST region We examined the sequence of the 19 structured residues immediately downstream of the PEST region and found a high likelihood that they constitute the BG loop and...
- 11
- 525
- 0
Báo cáo khoa học: New members of the brachyurins family in lobster include a trypsin-like enzyme with amino acid substitutions in the substrate-binding pocket potx
... from the 3¢ UTR region of PaTry2 However, the 3¢ UTR sequence of PaTry4 differed to those of the other trypsins in more than 36% of its nucleotides All ORFs started at the first ATG codon of the ... comparative modelling The aim of the present work was to study the diversity of trypsins in the digestive gland of P argus, with focus on: (a) the position of lobster trypsins within the brachyurins ... the wall of the binding pocket and allow the access of bulky residues, like Arg and Lys, whereas the basic side chain of these residues is stabilized by Asp189 (chymotrypsin numbering) near the...
- 13
- 474
- 0
Báo cáo khoa học: The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells pdf
... to nearly half the initial amount On the other hand, the amount of glycoprotein in the medium did not differ substantially from the beginning to the end of the experiment, because the medium was ... other sources We then determined the variation of amount of glycoprotein in cells As shown in Fig 5E, although the total amount of protein in cells decreased to 87% after 48 h of incubation, the ... [19] The arrow indicates the location of non-glycosylated DNase I, and ‘]’ shows the migration of the singly glycosylated DNase I The percentage of glycosylated molecules is indicated under the...
- 11
- 428
- 0
Báo cáo khoa học: Identification of an antibacterial protein as L-amino acid oxidase in the skin mucus of rockfish Sebastes schlegeli pot
... the antibacterial activity of SSAP was examined The addition of catalase almost completely abolished the antibacterial activity of SSAP, indicating that H2O2 is the mediator of the activity of ... consisting of 75-kDa subunits by SDS ⁄ PAGE, partly because of the scarcity of the protein of interest In this study therefore we isolated the antibacterial protein, SSAP, from the skin mucus of S ... consistent with those of the FAD standard Figure 5B shows the mass spectrum of the chromophore from SSAP ESI-TOF-MS in the positive mode gave the main peak at m ⁄ z 786.32 and the ion peaks at m...
- 12
- 470
- 0
Báo cáo khoa học: Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F-11 and biochemical analysis of VRL-1 after heterologous expression pptx
... result in one band The slower migrating of the two F-11 PCR bands always corresponded to the rat brain control, the faster migrating band to the N18TG2 control In case of C the PCR product from ... alignment of the open reading frames of rat VRL-1 (Acc No AF129113) and mouse VRL-1 (Acc No NM_011706) Rat and mouse VRL-1 cDNA share a homology of 92% The ORF length of rat VRL-1 is 2286 bp whereas the ... visible in the agarose gel for each PCR product, sequence analysis of different cloning experiments yielded either the rat or sometimes the mouse VRL-1 sequence To prove the possible expression of mouse...
- 8
- 439
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25