the immune system in health and disease
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
Ngày tải lên :
14/02/2014, 18:20
... involved in ligand binding, presumably abolishing the interaction with signaling partners The remaining mutations alter amino acids located outside the ligand-binding pocket and reduce protein ... lymphoproliferative disease Arginine 335 is found in the ‘BG loop’ not involved in phosphotyrosine binding and mutation to tryptophan most probably causes instability of the SH2 domain Thus, these patients ... the linker B kinase region of SYK The PH domain of TFKs usually binds to phosphatidylinositol-3,4,5-trisphosphate, thereby bringing them in close proximity to other membrane-tethered signaling...
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The Neuronal Environment: Brain Homeostasis in Health and Disease pot
Ngày tải lên :
15/03/2014, 19:20
... interactions The special status of the brain in having its own insulated circulation system — the cerebrospinal fluid contained in the ventricles and ducts — is also underlined The brain is the only ... challenges Most diseases originating in the brain start in these accessory systems of the neuronal microenvironment and affect neurons only second hand Therefore, understanding the elements of the neuronal ... participate in the process of the control of the composition of the extracellular space in the brain: the cellular elements constituting intraparenchymal vessels, the endothelial cells lining the intraluminal...
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Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt
Ngày tải lên :
15/03/2014, 23:20
... between the EGFR and the androgen receptor in prostate carcinoma cells [50] The interplay between decorin and the EGFR is further underscored by osteosarcoma cells which escape the decorin-suppressing ... strategies In addition to being a strong trigger of proinflammatory signaling within the innate immune system, biglycan can also affect bone morphogenetic protein (BMP) signaling, thereby in uencing the ... signaling activity [30,31] Subsequent studies using the yeast two-hybrid system revealed that decorin binds to a narrow region within ligand-binding domain L2 of the EGFR, overlapping with the...
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Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt
Ngày tải lên :
15/03/2014, 23:20
... occludens-domain-containing proteins such as syntenin, Ga-interacting protein (GAIP)-interacting C-terminus ⁄ synectin and calcium ⁄ calmodulin-associated serine kinase, since the C2 region contains a ... catalytic domain with a zinc-binding site (Zn, HEXXHXXGXXH) and a conserved methionine (Met-turn) supporting the catalytic zinc Interaction between cysteine–zinc maintains proMMPs in an inactive state ... syndecans, and are endopeptidases belonging to the family of metzincins (zinc endopeptidases) which contain three major multigene families: seralysins, astacins and a disintegrin and metalloproteinase...
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The Maternal Management of Children, in Health and Disease ppt
Ngày tải lên :
23/03/2014, 02:20
... impaired SYMPTOMS. The earliest symptom is a dragging sensation in the back when the child is in the act of sucking, and an exhausted feeling of sinking and emptiness at the pit of the stomach afterwards ... would stint the growth of such a child, and induce a state of body deficient in vigour, and unfit for maintaining full health: scrofula and other diseases would be induced At the same time let the ... against, that of covering up the infant in its cot with too much clothing throwing over its face the muslin handkerchief and, last of all, drawing the drapery of the bed closely together The...
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Báo cáo y học: "The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease" docx
Ngày tải lên :
14/08/2014, 14:21
... region encoding the carboxy-terminal propeptide domain; H, encodes the heparin-binding domain; N, encodes the NRP1/heparin-binding domain; NP, encodes the amino-terminal propeptide domain; SP, signal ... mediated by two distinct domains In VEGF-A, these correspond to the basic heparin-binding domain encoded by exon and the NRP1/heparin-binding domain encoded by exons and [10] The nuclear magnetic ... within the cystine-knot superfamily, notably the glycoprotein hormone and mucin-like protein families and, more distantly, the transforming growth factor- (TGF) family The absence of any of these...
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Tài liệu Aneuploidy in Health and Disease Edited by Zuzana Storchova doc
Ngày tải lên :
21/02/2014, 23:20
... spindle-assembly checkpoint in space and time Nat Rev Mol Cell Biol 8, 379-393 [17] Nilsson J, Yekezare M, Minshull J and Pines J (2008) The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 ... types The approach is remarkably general in that almost any type of data may be incorporated, and in the paper they include compelling examples of the integration of expression and protein sequence ... neurodegeneration and aging Recent discoveries that abnormal chromosome numbers impact on protein homeostasis has pointed out a possible link to neurodegenerative diseases and instigated the interest in the...
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Modern Nutrition in Health and Disease pot
Ngày tải lên :
06/03/2014, 05:21
... of the limiting amino acid is the protein's score Typically, the limiting amino acids in dietary proteins are lysine, the sulfur-containing amino acids, threonine, and/ or tryptophan The BCAAs and ... creatinine excretion returns to baseline, indicating that creatine in the diet per se affects creatinine production ( 38) Therefore, consumption of creatine and creatinine in meat-containing foods ... approaches Purine and Pyrimidine Biosynthesis The purines (adenine and guanine) and the pyrimidines (uracil and cytosine) are involved in many intracellular reactions when high-energy di- and triphosphates...
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Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf
Ngày tải lên :
15/03/2014, 00:20
... cleaved inside the cells by furin-like proteinases The two gelatinases (MMP-2 and -9) contain three FnII-like repeats in their catalytic domain, N-terminal to the catalytic Zinc-binding site ... One involves proteolytic processing of one or several nuclear proteins, whereas the other is independent of the processing capacity of the proteinase and involves the HPX domain A DNA-binding ... immunoglobulin-like (Ig) domain other MMPs by lacking the HPX domain, which is replaced by a C-terminal cystein array region and an immunoglobulin G-like domain, and, instead of the N-terminal signal...
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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx
Ngày tải lên :
15/03/2014, 23:20
... evidences indicate that HSPGs act to inhibit cellular invasion by promoting tight cell–cell and cell–ECM interactions, and by maintaining the structural integrity and self-assembly of the ECM [10,11] ... protein-coding genes contain introns that are removed in the nucleus by RNA splicing and are often alternatively spliced Alternative splicing increases the coding capacity of the genome, generating ... comprising this segment linked to the C-domain sequence (8-C) [73,78] This finding further supports the predicted 3D model, indicating that the C-domain is indeed a valid functional domain responsible...
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Lipoproteins – Role in Health and Diseases by Saša Frank and Gerhard Kostner doc
Ngày tải lên :
17/03/2014, 21:20
... located in the N-terminal and Cterminal domains are in close vicinity to each other on the opposite side of LDL [36] In addition, a prominent protrusion is visible in the images at the pointed ... though, one has to keep in mind that these domains are not static or confined in size and number and co-determine the intrinsic dynamics of LDL Based on these types of findings, it seems reasonable ... times, the target protein or particle has to be purified from the blood of human probands and the New Insights into the Assembly and Metabolism of ApoB-Containing Lipoproteins from in vivo Kinetic...
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BIOACTIVE FOOD PEPTIDES IN HEALTH AND DISEASE pot
Ngày tải lên :
23/03/2014, 04:20
... be due to the inhibition of serine proteases involved in the cleavage of neu-oncogen protein on the cell surface, preventing the release of the extracellular domain of the protein into the bloodstream ... present in all of the Solanaceae family, except L Chinensis, but not in any of the Phaseolus beans [28] These findings suggested the presence of lunasin or lunasin-like peptides in other grains and ... half-life of 10 h in rats and hamsters, and are excreted in urine and faeces [38] In humans, BBI are taken up rapidly and can be detected in the urine within 24-48 h [6] These findings suggest that...
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Immunosuppression – Role in Health and Diseases Edited by Suman Kapur and Maristela Barbosa Portela ppt
Ngày tải lên :
30/03/2014, 23:20
... produced by the immune system but recognise the proteins produced in the individual’s own body The antibodies that usually attack the proteins present in the nucleus of the cell are called antinuclear ... organized into two sections: one delineating the current opinions in “Immunosuppression and Regulation of Immune Response” and the other dedicated to strategies adopted in “Transplantation and other ... receptors in the CNS, causing the release of catecholamines and/ or steroids, which in turn further affect the immune cell functions They play a role in suppressing a variety of immunological end points...
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beer in health and disease prevention 2009 - preedy
Ngày tải lên :
12/06/2014, 11:26
... alive to dead grains and should be Ͼ95% in rapid tests; Ͼ96% after cleaning and sorting in storage Non-germinating grains retained as raw during malting may become infected by mildew and bacteria ... each system Hop is added during wort boiling Brewers this at the beginning or end of boiling or dose hop into the whirlpool Hop dosage at the beginning of wort boiling serves for bittering and ... provide insight into the possibilities of the role of beer in health maintenance as well as prevention of diseases Contributors are authors of international and national standing, leaders in the...
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IMMUNOSUPPRESSION – ROLE IN HEALTH AND DISEASES pdf
Ngày tải lên :
27/06/2014, 11:20
... produced by the immune system but recognise the proteins produced in the individual’s own body The antibodies that usually attack the proteins present in the nucleus of the cell are called antinuclear ... organized into two sections: one delineating the current opinions in “Immunosuppression and Regulation of Immune Response” and the other dedicated to strategies adopted in “Transplantation and other ... receptors in the CNS, causing the release of catecholamines and/ or steroids, which in turn further affect the immune cell functions They play a role in suppressing a variety of immunological end points...
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ANEUPLOIDY IN HEALTH AND DISEASE docx
Ngày tải lên :
28/06/2014, 14:20
... spindle-assembly checkpoint in space and time Nat Rev Mol Cell Biol 8, 379-393 [17] Nilsson J, Yekezare M, Minshull J and Pines J (2008) The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 ... types The approach is remarkably general in that almost any type of data may be incorporated, and in the paper they include compelling examples of the integration of expression and protein sequence ... neurodegeneration and aging Recent discoveries that abnormal chromosome numbers impact on protein homeostasis has pointed out a possible link to neurodegenerative diseases and instigated the interest in the...
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medical biochemistry human metabolism in health and disease
Ngày tải lên :
06/07/2014, 15:19
... (oxaloacetate in the TCA cycle and ornithine in the urea cycle) At the end of one cycle, the key intermediate is regenerated and available to participate in another turn of the cycle Although the TCA and ... polyunsaturated fatty acids (linoleic and a-linolenic) and the carbon skeletons of some of the amino acids They also include the vitamins (such as thiamine and niacin), most of which serve as components ... oxidative and involve transfer of reducing equivalents (hydrogen atoms) to nicotinamide-adenine dinucleotide (NADf) or flavineadenine dinucleotide (FAD) The reducing equivalents in the resulting NADH...
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Báo cáo y học: "Tibialis posterior in health and disease: a review of structure and function with specific reference to electromyographic studies" pot
Ngày tải lên :
10/08/2014, 21:23
... walking in health and disease Tibialis posterior EMG activity during walking in health and disease – schematic estimates for ensemble-averaged tracings adapted from the respective studies 0% and ... avoided The anterior insertion involves guiding the electrode through tibialis anterior and the interosseous membrane avoiding the deep anterior neurovascular bundle When choosing either the anterior ... Competing interests The authors declare that they have no competing interests 11 Authors' contributions 12 DET and JW conceived the idea for the review, RS and GSM drafted the manuscript and the...
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báo cáo khoa học: " Gut microbiome-host interactions in health and disease" pdf
Ngày tải lên :
11/08/2014, 12:21
... (Figure 1) The concept that intestinal microbial composition affects the health of the gut, and also influences centrally mediated systems involved in mood and mental health, is being increasingly ... taurine and betaine levels than other gut regions HBF mice showed lower taurine and myo-inositol levels in the colon, and all ex-germfree animals had higher taurine, choline and ethano amine ... microbiome in health, disease and in drug efficacy We review current methods for the modulation of the gut microbiome for the improvement of human health and disease, and Kinross et al Genome Medicine...
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