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Báo cáo khoa học: Deadenylation of interferon-b mRNA is mediated by both the AU-rich element in the 3¢-untranslated region and an instability sequence in the coding region pot
... synthesis isinduced by stimulating agents. The fact that the 65-kDaprotein binds ARE and CRID in UV-crosslinking experi-ments, performed with cytosolic extracts from both non-infected and infected ... [13], further supports the involvement of this protein in the deadenylation processof IFN-b mRNA. Interestingly, IFN-b ARE does notrecruit other ARE- binding factors (data not shown),thereby ... the in uence of the ARE and the CRID on the poly(A) status of the human IFN-b mRNA in naturalconditions of IFN-b synthesis.Materials and methodsReagentsAll the reagents and enzymes used in...
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Tài liệu Báo cáo khoa học: The role in the substrate specificity and catalysis of residues forming the substrate aglycone-binding site of a b-glycosidase docx
... site.This hypothesis was further investigated by deter-mining the in uence on the glycone binding of the Sfbgly interactions with the aglycone. Thus, the effectof the alteration of the glycone ... Furthermore, these data may be of particular importance in understanding the physiological role of b-glycosidases and in designinginhibitors. In addition, another important issue in understand-ing the ... about the role of different resi-dues of the aglycone-binding site in the stabilizationof ESà and the interdependence between the binding ofaglycone and the positioning of glycone in subsite...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... members of the actin-bindingLIM protein (ABLIM) family, ABLIM-2 and -3, asSTARS-interacting proteins. These novel proteins con-tain four LIM domains and a C-terminal villin head-piece domain, which ... occurring C-terminal 100 kDa fragment offilamin, interacting with the motor protein dynein,may exert its inhibitory effect by interfering with inter-actions between the N- and C-terminal domains, ... chro-matin remodeling and regulation of the AR N-terminaldomain, and the LBD interaction (N ⁄ C interaction)[78–82]. All available data suggest that no singleAR-binding protein completely defines the...
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Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
... unique characteristics in RA patho-genesis [1]. FLSs play a key role in the development ofsustained in ammation and angiogenesis in arthriticjoints [2–4]. Several cytokines and RA factors existing in ... inter-leukin-1b, TNF-a and interleukin-6. However, thesefactors are not sufficient to cover the active prolifera-tion capacity of RA FLSs, thus indicating that otherfactors must be involved in this ... MG-132showed an additional increment in the protein level ofGM-CSF-induced MLN51 (Fig. 2E). These data indi-cate that GM-CSF not only induces the expression ofMLN51, but also blocks the proteasome-mediateddegradation...
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Báo cáo khoa học: Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake potx
... in the brainstem and hypo-thalamus, and induce neuroendocrine and behavioralresponses. Food intake also activates the brainstem and hypothalamus, resulting in the termination ofmeals and the ... RFRP-immunoreactive fibers are widely distributed within the brain [44]. Expression of the main receptor for RFRP, GPR147, is broadly dis-tributed within the brain, including the septal areas,amygdala, ... mRNA in the hypothalamus are increased [49]. RFRP fibers are observed in the hypothalamic paraventricular nucleus and appear to project directly to cells containing CRHor oxytocin [46] in the...
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CONFLICTS OF INTEREST IN THE HOLLYWOOD FILM INDUSTRY: COMING TO AMERICA - TALES FROM THE CASTING COUCH, GROSS AND NET, IN A RISKY BUSINESS pdf
... class="bi x0 y0 w1 h1" alt="" Claremont Colleges working papers in economicsClaremont Graduate University ã Claremont Institute for Economic Policy Studies ã Claremont McKenna College • Drucker ... Claremont McKenna College • Drucker Graduate School of Management • Harvey Mudd College • Lowe Institute • Pitzer College • Pomona College • Scripps College
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the mit ress vision and mind selected readings in the philosophy of perception sep 2002
... elucidate the notion of seeing in terms of the notion of perceivingthings to have such -and- such features, smelling in terms of perceiving things to havesuch -and- such other features, and so on. In ... now incapable of bring-ing any precise testimony, and leaving the object as incomplete and open as it isindeed, in perceptual experience. Through this opening, indeed, the substantialityof the ... arriving in this place after the removal do not get hurt. Smells, on the other hand, do linger in places, and so are “detachable” from the material objects which are their source.Though pains...
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Báo cáo sinh học : "The genomic ‘inner fish’ and a regulatory enigma in the vertebrates." docx
... ontogeny and ultimately adult anatomy [2].DNA sequencing and the understanding that changes in sequence can also be used to deduce the relatedness ofspecies marks another important landmark in the ... Conservative and non-conservative changes tocodons have been a boon in understanding the influence ofselection and chance on evolution. The form and functionof vertebrate tissues and organ systems are ... regions are significant.Since Cuvier, careful cataloging of anatomy in the context ofphylogeny and development has had a major impact on ourunderstanding of how living organisms evolve. While thereare...
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Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
... and erythema from the ankle to the tarsal bone,3 = moderate edema and erythema from the ankle to the tarsalbone, and 4 = edema and erythema from the ankle to the entireleg. The sum of the values ... be interesting toinvestigate IDO expression in different subsets of DCs fromtolerized mice and to characterize their role in the induction and maintenance of immune tolerance.Figure 5Indoleamine ... induction of T-cell tolerance and immune inhibition in the induction of oral tolerance in the murine CIA model. We examined the change in the expressionof IDO in CD11c+ DCs of Peyer's...
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Báo cáo hóa học: "Prognostic impact of clinical course-specific mRNA expression profiles in the serum of perioperative patients with esophageal cancer in the ICU: a case control study" potx
... damage to endothelial megakaryocytesexpressing VWF. In the signaling pathway, VWF inter-acts with integrins in the extracellular matrix (ECM) and has functions in t he complement and coagulationcascades, ... expres-sion (GE) in the serum and synchronizing GE changeswith the clinical course of events.Processing of the blood and serum samples w as per-formed after blood sampling during the operation and at ... coagulationcascades, linking downstream to the inflammatory pro-cess or to B cell receptor signaling.NAMPT is another indicator for prognosis. It is the rate-limiting component in the mammalian nicotina-mide...
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Báo cáo Y học: The unorthodox histidine kinases BvgS and EvgS are responsive to the oxidation status of a quinone electron carrier ppt
... parts of the senor proteins interact with the quinones,although this interaction must involve the cytoplasmicdomains present in the truncated proteins used for thesestudies. The PAS domains, which ... afteraddition of the oxidized ubiquinone to the histidine kinasesmay either be the consequence of a decrease in the histidinekinase activity, or, alternatively, of an increase in an intrinsicautophosphatase ... of quinones on the activity of BvgS and EvgS In the genus Bordetella, ubiquinone-8 (Q-8) is the predom-inant quinone [27], whereas the major quinones synthesizedby E.coliare Q-8, menaquinone-8...
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Báo cáo khoa học: The starch-binding capacity of the noncatalytic SBD2 region and the interaction between the N- and C-terminal domains are involved in the modulation of the activity of starch synthase III fromArabidopsis thaliana pdf
... not the individual starch-binding domains, are involved in the interaction with the catalytic domain. We also determined that the resi-dues W366 and Y394 in the D2 domain are important in starch ... in the D2 domain and D(495–535) in the D3 domain, are involved in the interaction with CD, and that thisinteraction enhances the catalytic activity of the enzyme. Our results show that the interaction ... confirmed the results obtained in the pull-down assays, showing that there is a physicalinteraction between the N- and C-terminal domains ofSSIII in vitro.Mapping of the CD-binding region in the N-terminal...
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báo cáo hóa học: " Indoors illumination and seasonal changes in mood and behavior are associated with the health-related quality of life" pdf
... challenge these time-keeping mechanisms ofaction as, for instance, the evening-active cells yield the dominance to the morning-active cells within the princi-pal circadian clock following the shortening ... 2000 and July 2001. The two-stage stratified cluster sampling designwas planned by Statistics Finland. The sampling framecomprised adults aged 30 years and over living in main-land Finland. ... signing, and a questionnairecontaining self-reports such as the SPAQ, the 15D, the GHQ-12 and the Beck Depression Inventory (BDI) thatinterviewees were asked to fill in and bring along to the health...
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Tìm thêm: khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25