the central vasopressinergic system in experimental left ventricular hypertrophy and dysfunction
Báo cáo khoa học: Experimental and steady-state analysis of the GAL regulatory system in Kluyveromyces lactis docx
... nucleus and cytoplasm; (d) the nuclear confinement of KlGal80p; and (e) the fact that KlGAL4 is the only gene in the GAL system with one binding site, with the remaining genes having two binding sites ... designs of the GAL system It is of interest to ascertain the role of autoregulation in the synthesis of activator protein KlGal4p in K lactis as the synthesis of the corresponding activator in S cerevisiae ... galactose into the cytoplasm, which, in combination with ATP, activate the protein KlGal1p The protein KlGal1p, being bifunctional, has both inducer and galactokinase activity The activated KlGal1p then...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... 1, Fig 5A–C) During the clinical remission phase (day 18), inflammation and demyelination in the spinal cord were considerably diminished (Fig 3G, 3I) and the number of infiltrating macrophages ... 0.05) and CCR5 (P < 0.05) within the so called IADM (inactive and demyelinated) lesions areas characterized by complete demyelination and low inflammatory and demyelinating activity In these ... immunization) of EAE show extensive inflammation involving the white and grey matter (D), with marked demyelination in the inflammatory areas (F) The majority of the infiltrating inflammatory cells are macrophages,...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... treatment, there was a 2.5-fold increase in apoptosis in the subventricular zone (SVZ) and a 4-fold increase in the dentate gyrus of the hippocampus (DG) The increased cell death persisted in the SVZ and ... on the chemotherapeutic agents cisplatin, BCNU (carmustine) and cytarabine [79] To estimate clinically relevant concentrations, we used the following information: routinely used continuous intravenous ... density in the CC has decreased markedly (e,f) The expression of MBP seen in control animals (e) (the fiber-like green fluorescence staining in the CC and white-matter tracts in the peri-ventricular...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... nNOS and iNOS in neurons increased when bacterial encephalitis occurred This is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine ... brainstem and the staining pattern was similar to those of control brains with nonneurological diseases In the microabscesses, iNOS was recognized in inflammatory cells (mainly macrophages) in the ... staining for iNOS in caprine listeriosis compared with the previous bovine study [6] We prefer to postulate that the differences are due to the different detection system of immunostaining and...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... nanoparticles will interact with the proteins present in the biological system, i.e the material surrounding the nanoparticles are proteins present in the nervous system of the cockroach Discussion The results ... nAuNPs in the cockroach’s brain and to study the interactions between nAuNPs and the brain tissue: hyperspectral Page of imaging, XPS, confocal microscopy, and TEM imaging The Hyperspectral imaging ... identify the organs affected by the nAuNPs The XPS was used to verify the presence of nAuNPs embedded in the brain tissue The confocal microscope and TEM were used to gain insights into the interaction...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation ... enhancing the activity of gamma-glutamylcysteine synthetase and up-regulating cystine transport The upregulation in gammaglutamylcysteine synthetase activity facilitates the redistribution of GSH into ... transpired (Abe and Kimura, 1996) Since then its possible roles in all body systems were and are being investigated worldwide In mammalian central nervous system (CNS), its prominent effects include...
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Chemical drug assisted gene transfer a sensible approach to improve transgene expression in the central nervous system
... rate of injection was μl/min and the needle was allowed to remain in situ for mins before being slowly retracted at the end of each injection The intrathecal lumbar injection was done using a 10 ... remain at large in terms of choosing appropriate MW PEIs and biodegradable linkages as well as designing the degree of cross-linking, the particle size and the surface charge of the resulting ... HDAC inhibitors to enhance baculovirus-mediated gene therapy by increasing the expression of the transgene In addition, with their intrinsic anti-tumor activities, HDAC inhibitors also have the...
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INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY
... constituent instead of sphingomyelin (PE-cer has phosphoethanolamine as the head group, instead of the phosphocholine head group in SM) [32] Despite having shorter fatty acyl chains (the longest being ... contain the same head groups as mammalian cells (phosphoethanolamine, phosphocholine, phosphoserine and phosphoinositol) Drosophila’s sphingolipids also contain a shorter acyl chain on the sphingoid ... fluctuations contain information which can be extracted by analysing the rates and the amplitudes of the intensity fluctuations and subjecting them to an autocorrelation analysis The normalized...
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BIS Working Papers No 333 Banking crises and the international monetary system in the Great Depression and now ppt
... and Austria and Germany on the other obstructed the functioning of the international monetary system The data in table 3.2 suggest that the Netherlands and Switzerland, too, did not recycle the ... only in the U.K., Russia, Switzerland, Hong Kong and Singapore The widespread falls in bank deposits in 1931 were only the beginning of the story and they were followed in most countries by further ... 2008-09, in order to identify similarities and differences, both in the scale and nature of the crises and in the central banks’ policy response The timing of the banking crisis in relation to the...
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THE REFORM OF THE SAVINGS BANK SYSTEM IN FRANCE – A MODEL FOR OTHER COUNTRIES? docx
... may in turn draw from its regional savings bank The local savings companies thus act as the connecting link between the savings banks and the numerous (indirect) investors, and relieve the savings ... to represent the common interests of the savings banks, especially in dealing with the public sector, and to intensify the links between the savings bank group and other European savings bank organisations ... gained in France in conjunction with the reform of 1999 in the following key domains: – The legal and actual conversion of the savings banks into cooperatives, – The use of the revenues accruing...
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Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
... represent the coding region and the noncoding regions of the planarian PHM cDNA, respectively; whereas the two flanking broad lines outside indicate the k ZAP II vector The two gray boxes in the planarian ... numbered from the 5¢ to the 3¢ end, and the amino acid residues are numbered starting with the first ATG in the open reading frame The translation termination codon is indicated by an asterisk The sequence ... the time of the emergence of the Plathelminthes in the evolutionary history The eye of the planarian is one of the most ancestral and primitive types of visual systems in animals and is 950 A...
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Section III - Drugs Acting on the Central Nervous System docx
... plexus found within the intracerebral ventricular system) , and the meninges, which cover the surface of the brain and comprise the cerebrospinal fluid-containing envelope Macroglia are the most abundant ... Disorders) Norepinephrine There are relatively large amounts of norepinephrine within the hypothalamus and in certain zones of the limbic system, such as the central nucleus of the amygdala and the dentate ... supervisory integration of the autonomic nervous system, and they may integrate somatic and vegetative functions, including those of the cardiovascular and gastrointestinal systems Limbic System The...
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Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... with certain brain tumors, especially for the very young Because of the rapid myelinization that occurs in infants, the finding by Noble and colleagues [1] of the adverse effects of chemotherapy ... treated with high-dose intravenous methotrexate (5 g/m2) and also methotrexate injected into the brain cavities (intraventricular injection), together with other chemotherapy, but no radiation ... eliminating radiation in certain ‘good risk’ children by using a regimen of prolonged postoperative combination chemotherapy (CDDP, cyclophosphamide, vincristine and etoposide) [9] Current and...
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Báo cáo sinh học: "How chemotherapy damages the central nervous system Christina A Meyers" ppsx
... hippocampus and the corpus callosum), primarily in progenitor cells and oligodendrocytes To determine whether these findings resulted in functional impairment, they investigated the auditory brainstem ... response in the mice at various times following treatment Loss of myelin is known to increase the latency between specific peaks in the auditory brainstem response, reflecting slowing of the impulse ... also found that the agents caused increased cell death and decreased cell division in the subventricular zone, the dentate gyrus of the hippocampus and the corpus callosum in mice These effects...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... image (a) showing a mass with mixed signal intensity and a surrounding edema area On the T1-weighted image after the administration of contrast material (b and c), the mass has an inhomogeneous ... 45 mg/dl) and myelin basic protein (MBP) (2.23 nmol/ l; normal < 0.55 nmol/l) The immunoglobulin (Ig) G in CSF index was remarkably increased (20.5 mg/dl; normal < mg/dl) Oligoclonal bands (OB) ... were negative No marked increase in antiviral titers in the serum or CSF was observed With great interests, we carefully rechecked all the paraffin sections of the mass, and a big surprise for...
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Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis" pdf
... both the FcR and complement system, as part of the innate immune system, are involved in early immune defense and subsequently activate and instruct the adaptive immune system; at the same time they ... at the same time and, for B cells, on the very same cell Both FcRs and complement receptors are involved in the binding of ICs and phagocytosis; they deliver signals leading to the activation and ... [20] The complement receptor CR1 binds the C3b, iC3b and C4b fragments, CR2 binds the C3d and iC3b fragments, and CR3 binds the iC3b fragments These interactions have been implicated in the immune...
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Báo cáo y học: "Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis" pdf
... and RNA and the endocannabinoids AEA and 2-AG are present in the synovia of patients with end-stage OA and RA The presence of increased levels of AEA and 2-AG in the synovial fluid of OA and RA ... and histology scoring, and contributed to the writing of the manuscript AJR contributed to the writing of the manuscript VC designed research and significantly contributed to the writing of the ... (Figure 6) To further investigate the role of the cannabinoid receptors in mediating the effects of HU210 on phosphorylation of ERK1, ERK2, and p38 MAPK, the potential ability of the CB1 and CB2 receptor...
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Báo cáo y học: "Cardiac CT and MRI guide surgery in impending left ventricular rupture after acute myocardial infarction'''' ppt
... myocardium in the lateral left ventricular wall was evident The epicardium was intact and the area correlated with the preoperative imaging Since the region was very close to the base of the heart ... imaging findings most likely saved the patient's life Additional file Cine short axis MRI Akinesia at the inferior wall and moderate hypokinesia at the inferior septum and lateral wall with the ... narrow neck in the lateral left ventricular wall (arrow) Figure of infarcted myocardial pass perfusion compatible with demonstrate aleft ventricular rupture thin rim 3and and inferoseptal lefttissue...
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Báo cáo y học: "Insulin alleviates degradation of skeletal muscle protein by inhibiting the ubiquitin-proteasome system in septic rats" pps
... correlation between insulin, cytokines and the Ub system remains to be further investigated Another possibility is that insulin may inhibit the proteasome through an associated protein, IDE The catalytic ... insulin infusion; however, when the insulin infusion was 4.8 mU.kg-1.min-1, the concentration of E2-14KDa protein decreased compared to the LPS and low-dose insulin groups (Figure 4B) After insulin ... concentration of tyrosine and other mRNA and protein levels of the Ub system changed only slightly When the infusion dose of insulin was increased to 4.8 mU.kg-1.min-1, the Ub mRNA level was further reduced...
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Báo cáo y học: " Angiotensin-converting enzyme 2 autoantibodies: further evidence for a role of the renin– angiotensin system in inflammation" potx
... expression potentially contributing to the protective mechanisms of these therapies There is increasing evidence for the interplay of the renin–angiotensin system and in ammatory events [5] Pre-eclampsia ... activity in a patient population The current findings are of potential importance in our understanding of the role of circulating and tissue sources of ACE2, particularly in various disease states Increased ... nephropathy [8] and liver fibrosis [9] or in the genetic expression of ACE2 in pulmonary hypertension [10] Page of Although the ongoing study of the renin–angiotensin system has now surpassed the century...
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