targets for cancer therapy pdf
Báo cáo y học: "Differential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cells" pdf
... g for 15 min, snap frozen and stored in liquid nitrogen for subsequent virus titration Immunofluoresence PBECs were rinsed x with 500 μL PBS Paraformaldehyde (4% v/v) was added/well (500 μL) for ... monitored microscopically for cytopathic effects (CPE) (NIKON ECLIPSE TE-2000 U), while others were fixed for immunofluorescence Medium (250 μL) was collected at hpi and every 24 hpi for cytokine/chemokine ... surgery Non-bronchoscopic bronchial brushings were performed as previously described [9] Before inclusion, all samples were confirmed negative for a panel of 12 respiratory viruses using a multiplex...
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Clinical significance of cancer stem cell markers and other related proteins in colorectal carcinomas biological and methodological considerations
... of human cancer subtypes (Frattini et al., 2004) However, it is becoming increasingly difficult for researchers to reconcile with the opinion that the sole targets for most cancer transformations ... Archival Formalin-Fixed Paraffin-Embedded Tissues 2.1.2 Samples for Studying Prognostic and Predictive Significance of Cancer Stem-Cell Markers 2.1.3 Samples for Studying the Implications of Cancer ... treatment of cancers, as different cancers have varied response to anti -cancer therapies Prognostic markers, on the other hand provide information on survival outcome independent of chemotherapy administered...
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Báo cáo y học: "yrosine kinase – Role and significance in Cancer"
... 2344-2352 38 Levitzki, A Tyrosine kinases as targets for cancer therapy Eur J Cancer 2002 38: S11-S18 39 Druker, BJ STI571 (GleevecTM ) as a paradigm for cancer therapy Trends Mol Med., 2002 8: S14-S18 ... kinases as targets for anticancer agents The role of tyrosine kinases in cancer molecular pathogenesis is immense and recently kinases have come in vogue as potential anticancer drug targets, as ... human cancers including non small cell lung cancer [22], bladder cancer, breast cancer and glioblastoma multiforme Increased expression of EGFR is reported in 40-80% of non small cell lung cancer...
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Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance doc
... become popular for screening for lung cancer, and we believe that it may also be used for follow-up study in pulmonary TB patients In conclusion, we suggest that lung cancer is one of the most important ... other medical therapy When 144 chest radiographs appear to indicate the concurrence of lung cancer and TB, it is strongly recommended that CT should be performed, and followed by biopsy for pathologic ... therefore recommend that in patients in whom chest radiographs and CT scans suggest the possible presence of a new tumorous lesion, biopsy is performed Low-dose CT has recently become popular for...
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Báo cáo hóa học: " Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer" potx
... methylation of cancerrelated genes may be essential for the diagnosis, prognosis and/or detection of metastatic potential of tumors, including lung cancer As the number of genes methylated in cancer ... lung cancer patients were based on the histopathologic information, covering from early to advanced stages It was also required to have tissue material available for obtaining high-quality DNA for ... selected could be of clinical relevance for the clinicopathologic staging of human lung tumors MS-MLPA profiles for clinical outcome prognosis for lung cancer patients In the next step, we tested...
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Báo cáo hóa học: " Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance" pptx
... during cancer invasion Traditionally, extracellular proteolysis and BM breaching are two absolute requirements for cancer invasion, while type IV collagen forms physical barrier against cancer ... biomarker for pancreas cancer British Journal of Cancer 2009, 101:91-97 24 Ono M: Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets ... deterring cancer invasion Moreover, tumor angiogenesis was also evaluated because provides potential routes for tumor dissemination as a result of the co-evolution of cancer microencironment and cancer...
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Báo cáo y học: "Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance" ppt
... Patients Page of (page number not for citation purposes) AIDS Research and Therapy 2008, 5:23 http://www.aidsrestherapy.com/content/5/1/23 with a lower BMI at initiation of therapy were more likely to ... patients that were tested for Hepatitis B surface antigen sero-status Page of (page number not for citation purposes) AIDS Research and Therapy 2008, 5:23 http://www.aidsrestherapy.com/content/5/1/23 ... citation purposes) AIDS Research and Therapy 2008, 5:23 http://www.aidsrestherapy.com/content/5/1/23 Kaplan-Meier cur ve for AIDS-r elated clinical events for patients with and without suboptimal...
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Báo cáo y học: "Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer" pot
... chemotherapy was performed for patients with stage III disease if the patients could tolerate such treatment after surgery, or unless the patients refused additional chemotherapy The chemotherapy ... of the patients was 51.0% for single lymph node positive, 58.9% for lymph nodes positive, 34.2% for lymph nodes positive, 30.0% for lymph nodes positive, and 20.4% for more than lymph nodes positive ... E: Cancer statistics, 2010 CA Cancer J Clin 2010, 60:277-300 Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Int J Cancer...
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báo cáo khoa học: "Expression and prognostic significance of cancer-testis antigens (CTA) in intrahepatic cholagiocarcinoma" ppt
... with breast cancer: characterization and antigen-specific activation Cancer Res 1996, 56:16-20 Caballero OL, Chen YT: Cancer/ testis (CT) antigens: potential targets for immunotherapy Cancer Sci ... previous studies); therefore, further validation will be required before these antigens can be tested for targeted immunotherapy Conclusion In conclusion, our data suggest that the cancer- testis antigens ... biliary tract cancer: a population-based study in China Br J Cancer 2007, 97:1577-1582 Suri A: Cancer testis antigens–their importance in immunotherapy and in the early detection of cancer Expert...
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Báo cáo y học: " Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases" pptx
... Roche, Basel, Switzerland), and/or the presence of specific IgE (RAST class >2) The RAST was performed for forty inhalation and food allergens (Sanofi Diagnostics Pasteur, Inc, Chaska, MN) All asthma ... performed according to the ATS guidelines [14] The clinical indication for BAL in pediatric asthmatic patients was the severity and chronicity of the asthmatic disease that prompted us to perform ... and BAL was performed prior to the surgical procedure for research purposes This study was approved by the institutional review board of the LMU Children’s hospital Written informed consent was...
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Báo cáo y học: "Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults" pot
... collected for both knees Additional available baseline data A standing anteroposterior semiflexed view of the right knee with 15° of fixed knee flexion was performed and scored individually for osteophytes ... results were quite different for each sub-group Over the course of the study period (five years), there were 12 knee replacements; therefore, we were only able to perform an exploratory analysis ... predicted knee replacement surgery after adjustment for potential confounders All statistical analyses were performed on Intercooled Stata 10.0 for windows (StataCorp, College Station, TX, USA)...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
... signatures are a more informative source for classification of tumor taxonomy than genomic profiling [16] Moreover, miRNAs can serve as unique targets for diagnostic imaging in vivo for taxonomic classification ... the mRNA target for translational repression or degradation Figure reproduced from a previous publication [9] miRNAs as mechanism-based therapeutic targets in cancer The case for miRNAs as tumor ... cancer, colon cancer and endocrine pancreatic tumors [8,17–22,26,45,52–54] Similarly, miRNA expression profiles provide a powerful source of molecular taxonomic information, with an accuracy for...
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NUTRITION AND METABOLISM Underlying Mechanisms and Clinical Consequences pdf
... association of obesity and cancer risk Poor dietary habits account for about 35% of incident cancers and smoking accounts for 30%; obesity accounts for 15% About 16–20% of cancer deaths in US women ... well-accepted guidelines for clinical practice are not currently available Two chapters review recommendations for diet and physical activity for healthy adults in one chapter and for the prevention ... Editor, for her thoughtful suggestions I certainly hope that the efforts of all of us will not only provide much needed information to our practicing colleagues but also serve as a stimulus for further...
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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot
... breast cancer or DCIS as stated below: RS lower than 18: The cancer or DCIS has a low risk of recurrence The benefit of chemotherapy for early-stage breast cancer or radiation therapy for ... Cancer Proteomics – 18 Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer clinicians with more information on the treatment outcomes of using chemotherapy, endocrine therapy ... between 18 and 31: The cancer or DCIS has an intermediate risk of recurrence It’s unclear whether the benefits of chemotherapy for early-stage breast cancer or radiation therapy for DCIS outweigh...
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cell cycle control mechanisms and protocols methods in molecular biology - tim humphrey, gavin brooks
... Although some of these are specific for the endosperm, for example, the SPATZLE gene is specifically required for cellularization, many functions are also required for embryo development (90) The ... in promoting irreversible cell cycle advance For proteolysis to occur, proteins must first be targeted for destruction by the proteasome The signal for this is ubiquitylation, which is carried ... in which securin binds and inhibits separase activity for most of the cell cycle However, at anaphase onset the APC targets the securin for 12 Humphrey and Pearce degradation, allowing the separase...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... RAGE in Cancer and Inflammation Inflammatory state, disease or cancer Effect of RAGE/HMGB1 Colon cancer Co-expression of RAGE and HMGB1 leads to enhanced migration and invasion by colon cancer ... binding induces a large conformational change which exposes a hydrophobic binding domain (except for S100A10 which is locked in this conformation) [47] This change in conformation allows an S100 ... vasculitic neuropathy CHRONIC STRESS RAGE CANCER • Increased in epithelial malignancies except lung and esophageal cancers with stage • Promotes chemotherapy resistance • Promotes autophagy PULMONARY...
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báo cáo hóa học: "Estimation of minimally important differences in EQ-5D utility and VAS scores in cancer" pot
... FACT-G based quintiles for the overall cancer cohort were 0.09 for UK Table 1: Patients characteristics, all cancers and lung cancer subgroup All cancers (n = 534) Lung cancer (n = 50) 59 (12) ... 0.74 (SD 0.16)] (Table 2) Mean VAS scores for the lung cancer subgroup [68 (SD 18)] were the same as for the overall cancer cohort [68 (SD 20)] For all cancer patients, mean difference scores anchored ... chemotherapy, or if chemotherapy was non-cyclical, had been receiving it for at least month Efforts were made to recruit 50 patients for each type of http://www.hqlo.com/content/5/1/70 cancer, ...
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Báo cáo hóa học: " Colistin: recent data on pharmacodynamics properties and clinical efficacy in critically ill patients" pot
... colistin-susceptible K pneumoniae strains These findings suggest that CMS monotherapy and extended-interval dosage regimens, as has been aforementioned for A baumannii isolates, may promote colistin resistance in ... humans in critically ill patients For this reason, the optimum target for colistin Cmax/MIC ratio is not yet known In addition, there is still a lack of PK/PD Page of information to optimize colistin ... might not provide the most effective therapy and therefore might justify administering larger colistin doses in longer intervals However, although the potential for a longer dosing interval may be...
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Báo cáo y học: "The Inventory of Personality Organisation: its psychometric properties among student and clinical populations in Japan" pptx
... therefore dropped from the final subscale construction Our dataset ultimately consisted of 11 items for Reality Testing, items for Identity Diffusion, and items for Primitive Defence We then performed ... 430) Usable data were available from 374 for paternal Care, 372 for paternal Overprotection, 288 for maternal Care, 283 for maternal Overprotection, and 369 for the CATS As expected, all IPO subscales ... partial correlations were performed for each of the IPO subscale scores with the group (students 1: outpatients 2) controlled for age and gender After controlling for age and gender, the IPO subscale...
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