targeted therapy and multidisciplinary care
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P43 pdf
... complications, 114 postoperative mortality, 114 M.D Anderson Cancer Center, criteria for resection, 110t patient selection/preparation, 110 preoperative therapy chemotherapy, 118–120 PVE, perioperative outcomes/survival ... chemotherapy, 161–162 bevacizumab, administration of, 162 hepatic hypertrophy, impact on, 162 hepatic injuries, 162 408 PVE, indications and contraindications (cont.) preoperative chemotherapy, ... complications, 173 FLR volume measurement and functions, 157–159 indications and contraindications general contraindications, 162 general indications, 159–160 high-dose chemotherapy, 161–162 normal underlying...
- 10
- 449
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P1 doc
... Carcinoma Kelly M McMasters Jean-Nicolas Vauthey Editors Hepatocellular Carcinoma Targeted Therapy and Multidisciplinary Care 13 Editors Kelly M McMasters, MD, PhD Department of Surgery University ... poor Understanding of the etiology, epidemiology, pathophysiology, molecular biology, and clinical features of HCC is important in providing optimal patient care In addition, understanding of the ... liver is a massive and complex organ requiring an excellent knowledge of its anatomy and physiology, with an exquisite comprehension of its impact on cardiovascular, pulmonary, and renal function...
- 10
- 350
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P2 potx
... Pritesh Mutha, and Sanjay Gupta 319 21 Cytotoxic Chemotherapy and Endocrine Therapy for Hepatocellular Carcinoma Daniel Palmer and Philip J Johnson 337 22 Targeted Therapies ... Albany, and Ghassan K Abou-Alfa 355 23 The Future: Combination Systemic Therapy for Hepatocellular Carcinoma Ahmed O Kaseb and Melanie B Thomas 369 24 Follow-Up and Salvage Therapy ... India, and Africa Genotypes B and C are common in China, Japan, and Southeast Asia Genotype D is common in Mediterranean areas and in the Middle East [16] Genotypes E–G are common in Central and...
- 10
- 408
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P3 pot
... Arachidonic acid Prostaglandin COX-2 Fig 1.2 Steps in hepatocarcinogenesis, modified from Xu et al [90] and Bensinger and Tontonoz [91] On the other hand, the association between obesity and HCC is hammered ... (mycotoxins) produced by Aspergillus flavus and A parasiticus There are four AF compounds: B1 , B2 , G1 , and G2 [55] The most common and most toxic AF is AFB1 , and the most important target organ is ... by Reddy and colleagues [97] from Mayo Clinic who assessed the association between hypothyroidism and HCC among 54 HCC patients of unknown etiology and 116 HCC patients related to HCV and alcohol...
- 10
- 354
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P4 potx
... including DNA level, RNA level and protein level, with regard to chromosomal imbalance and genetic instability, epigenetic alteration, gene expression and gene regulation and translation [1] Whatever ... proteins, genes and miRNAs in biological pathways Furthermore, significant and complex cross talks among the different pathways exist and are involved in different aspects of HCC development and progression ... overexpression, ligand-independent signalling through structural alteration of receptors and alterations in components of the downstream cytoplasmic circuitry that receives and processes the signals...
- 10
- 477
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P5 ppsx
... clinicopathological factors such as proliferation, vascular invasion and tumour multiplicity and was reported to associate with not only invasion and metastasis of HCC but also postoperative recurrence [29] ... telomere shortening influences stem cell function, aging and carcinogenesis These mice exhibit an impaired maintenance and function of adult stem cells and reduced regenerative reserve in response to ... regeneration and sometimes in neoplastic transformation [59, 60] This relationship to fat metabolism appears to be important both in NAFLD-related cancer and in HCV, where steatosis, steatohepatitis and...
- 10
- 389
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P6 ppsx
... subtypes, frequently found simultaneously, are trabecular, pseudoglandular (acinar), compact, and scirrhous The trabecular and acinar patterns are commonly observed in well to moderately differentiated ... of all cases) These tumors occur at a young age and are not associated with common risk factors such as chronic hepatitis and cirrhosis [35–38] and thus are frequently amenable to surgical resection ... inclusions, and fibrinogen containing pale bodies, presenting as pale ground-glass cytoplasmic inclusions [24, 36, 41] Combined Hepatocellular Carcinoma and Cholangiocarcinoma Combined HCC and cholangiocarcinomas...
- 10
- 347
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P7 pdf
... demonstrated in up to 96% of HCC [65] Polyclonal CEA and CD10 Both polyclonal CEA and CD10 (neprilysin) antibodies have cross-reactivity with glycoprotein I and exhibit a canalicular distribution pattern ... be negative, and occasional metastatic adenocarcinomas have been reported to be immunoreactive [76] Cytokeratin Low molecular weight keratins, including CAM 5.2 and cytokeratins and 18, usually ... adenomatous hyperplasia, and HCC [62, 77, 78] Diffuse CD34 sinusoidal reactivity would support a diagnosis of HCC [79] and can help differentiate dysplastic nodules and early HCCs from macroregenerative...
- 10
- 369
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P8 pptx
... and patients with chronic HCV infection who have cirrhosis stand a very high risk of developing HCC [19] In Japan, HCV infection spread throughout the country mainly in the 1950s and 1960s, and ... their design and in the characteristics of the targeted patients in terms of, for example, disease etiology and severity of background liver diseases Moreover, the reported specificity and sensitivity ... noninvasive Although both the ribs and the air in the lungs and gastrointestinal tract surround the liver and potentially hinder imaging, newer ultrasound devices and techniques have improved hepatic...
- 10
- 374
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P9 pps
... systems may serve to guide choice of therapy, aid in patient counseling, allow comparisons of the end results of therapy, and facilitate patient selection and randomization for research protocols ... patients, a minority (10%) of whom underwent surgical resection and a majority (58%) of whom received only supportive care and no locoregional therapy [6] This staging system builds on the AJCC 5th edition ... P, Albertini A, Decarli A et al (2002) Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women Am J Epidemiol 155:323–331 24 Kuper H,...
- 10
- 456
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P10 potx
... system (and related JIS score) may, however, have particular advantages in patients with early HCC As the therapeutic modalities available for HCC and the indications for aggressive therapy expand, ... carcinoma undergoing non-surgical therapy: comparison of Okuda, CLIP, and BCLC staging systems in a single Italian centre Gut 54:411–418 Chapter Multidisciplinary Care of the Hepatocellular Carcinoma ... Carcinoma Patient Carlo M Contreras, Jean-Nicolas Vauthey, and Kelly M McMasters Keywords HCC care · Hepatocellular carcinoma · Multidisciplinary care · HCC treatment Introduction Hepatocellular carcinoma...
- 10
- 369
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P11 doc
... including liver resection and liver transplantation, percutaneous ablation therapy as represented by radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI), and transcatheter arterial ... the results of liver resection and PEI when the degree of liver damage was B and the tumor was solitary and no more than cm in diameter, percutaneous ablation therapy is also recommended Although ... Study Group of Japan, and replies were 94 K Hasegawa and N Kokudo obtained from 843 (37%) of them Of those who replied, 55.4% were hepatologists and 38% were liver surgeons, and more than 70% of...
- 10
- 358
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P12 pot
... and above a certain level and reflects it, and it is useful for explaining the complex decision-making process to patients in a way that is easy to comprehend, and for obtaining their understanding ... 96 K Hasegawa and N Kokudo Conclusion Because many effective methods are available to treat HCC and the balance between tumor status and liver function status must be taken ... hepatologists, liver surgeons, and primary care physicians Gut 56:1020–1021 14 Lencioni RA, Allgaier HP, Cioni D et al (2003) Small hepatocellular carcinoma in cirrhosis: randomized comparison of radio-frequency...
- 10
- 398
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P13 pps
... postoperative morbidity and mortality as well as optimal long-term survival – are contingent upon proper identification of appropriate candidates for safe, complete resection A systematic and careful assessment ... permission) alcohol injection in five, cryotherapy in two, and transarterial oily chemoembolization in two) with 63 patients who underwent nonsurgical therapy and showed that partial hepatectomy resulted ... survival of 3.4 years and 1-, 3-, and 5-year survival rates of 82, 42, and 42%, respectively Recurrent HCC Tumor recurrence represents the major drawback after curative liver resection and the most common...
- 10
- 383
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P14 potx
... (TLV) is defined as the standardized FLR (sFLR) and it provides the percent of TLV remaining after resection Preoperative Therapy Transarterial Chemoembolization (TACE) and Portal Vein Embolization ... Advances in anesthetic and surgical techniques, as well as a thorough understanding of the liver anatomy and tumor biology, have contributed dramatically to the safety and effectiveness of liver ... mechanism of intrahepatic recurrence, and later to extrahepatic organs such as the lungs, bone, and adrenal glands These two forms of spread, vascular invasion and intrahepatic metastasis, are among...
- 10
- 345
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P15 pot
... level of blood loss and donors complications when the two-surgeon technique was used In a randomized controlled trial, El Moghazy et al [68] demonstrated a lower blood loss and a faster parenchymal ... faster parenchymal transection time in the group randomized to ultrasonic dissector and saline-linked cautery compared to ultrasonic dissector and bipolar cautery in living donor hepatectomy This ... complications such as bile leak and hemorrhage that needed surgical or radiologic interventions Outcome After Resection Morbidity and Mortality Improvements in patient selection and surgical technique...
- 10
- 370
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P16 potx
... veins as landmarks to reduce the risk of major morbidity and mortality Definition of the tumor–vessels relationship is relevant for planning the type of resection, and based on that, specific and original ... volume, its stability, and the wideness of the ultrasonographic scanning window: the best probe should be small, thin in width, and short in transverse length, stable, and with a wide ultrasonographic ... the contact area between the probe and the liver and a scanning window which enlarges as it gets deeper It is also evident, how at IOUS, the portal vein (PV) and the hepatic vein (HV) have different...
- 10
- 353
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P17 pps
... method for the surgeon to understand the liver anatomy and the relations between tumors and intrahepatic vessels This information is crucial for planning the resection and in this sense IOUS probably ... the FLR before and after PVE, technical aspects of PVE, and potential surgical strategies are ongoing and in continual evolution This chapter reviews the current indications for and technical ... well visualized (arrows) at IOUS, and it runs towards the tumor (T) visualized by IOUS If the target site is correct, the portal branch is ligated and divided and segmentectomy is completed under...
- 10
- 322
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P18 ppsx
... patient’s age and comorbidities (e.g., diabetes) that may affect hypertrophy and perioperative outcome Thus, after all of these factors have been evaluated and the patient remains a candidate for ... failure and death If a marginal volume of liver remains, cirrhotic or not, the lack of reserve often leads to a cascade of complications, prolonged hospital and intensive care unit stays, and 160 ... reported by Farges and colleagues [71], showed that patients with chronic liver disease who did not have PVE before right hepatectomy had more complications and longer intensive care unit and hospital...
- 10
- 319
- 0
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P19 ppsx
... livers and HCC may limit the effects of PVE To this end, sequential chemoembolization and PVE were used to prevent tumor progression during the time between the PVE and planned hepatectomy and to ... spherical and non-spherical microparticles (e.g., PVA particles and tris-acryl gelatin microspheres), and absolute alcohol Choosing a particular embolic agent is at the operator s discretion, and the ... [101] Later, Madoff and colleagues [87, 88] showed that a combination of particles (e.g., polyvinyl alcohol particles (PVA) and tris-acryl gelatin microspheres) and coils is safe and effective for...
- 10
- 299
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25