t¹i cng ty ph¬ng ph¸p kõ to¸n ®îc ¸p dông lµ ph¬ng ph¸p kª khai thêng xuyªn
Báo cáo khoa học: Alpha-fetoprotein antagonizes X-linked inhibitor of apoptosis protein anticaspase activity and disrupts XIAP–caspase interaction ppt
... inhibition of caspase activity in activated cell-free extracts Addition of AFP in the cytosolic extract induced significant enhancement of the DEVD-ase activity The same caspase activity was detected upon ... isolated from human cord serum using ion-exchange, affinity and gel-filtration chromatography as described previously [27] The purity and homogeneity of the protein were assessed by SDS ⁄ PAGE and western ... peptide derivatives [24–28,38, 39,42] The growth-suppressive activity of AFP can be realized by inducing apoptosis in many types of tumor or activated immune cells [24–28,41] AFP can trigger...
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Báo cáo y học: " Mild autonomic dysfunction in primary Sjögren''''s syndrome: a controlled study" pptx
... activity levels were measured using the short telephone form of the International Physical Activity Questionnaire [14] Participants were classified as HEPA (health enhancing physical activity) ... (MET)-minutes/week; or or more days of any combination of walking, or activity of moderate intensity or vigorous intensity achieving a minimum of at least 3,000 MET-minutes/week All study participants ... current smokers (Health Enhancing Physical Activity) active is the highest physical activity level, as measured using the International Physical Activity Questionnaire cSicca was defined as an unstimulated...
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Báo cáo y học: " A three-year-old boy with X-linked adrenoleukodystrophy and congenital pulmonary adenomatoid malformation: a case report" doc
... of gestation Three histopathological types were originally described by Stocker while two more subtypes were added by other authors [4,13] CPAM, especially type II, is associated with other congenital ... lung cysts [4] CPAM can be safely removed with excellent prognosis and virtually no morbidity or mortality occurs especially in centers with adequate experience in lung resection [4] The association ... long chain fatty acids; X-ALD: X-linked adrenoleukodystrophy 10 11 14 Mahmood A, Dubey P, Moser HW, Moser A: X-linked adrenoleukodystrophy: therapeutic approaches to distinct phenotypes Pediatr...
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Báo cáo y học: "Recurrent pneumonia with mild hypogammaglobulinemia diagnosed as X-linked agammaglobulinemia in adults" pot
... revealed no abnormal findings He was negative for both HIV and HTLV-1 Blood type testing showed that, although his blood type was O, he had neither anti-A nor anti-B antibodies Although we did not ... clearly illustrates the utility of flow cytometric analysis for the diagnosis of XLA, and also raises questions regarding the factors that determine the onset of the XLA phenotype This study presents ... Miyawaki T, Kiyosawa K: The oldest case with X-linked agammaglobulinemia in Japan lacking Bruton-type tyrosine kinase protein detected by flow cytometry Rinsho Ketsueki 1998, 39:44–47 11 Kornfeld...
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Báo cáo y học: "X-linked agammaglobulinemia diagnosed late in life: case report and review of the literature." pps
... humoral immunity These patients are highly susceptible to recurrent bacterial infections, bacteremia, and sepsis resulting in high mortality rates Among these disorders there is heterogeneity of clinical ... age from encephalitis [13] This case demonstrates the clinical variability of a XLA within a family in which typical and atypical variants exist and the need for maternal screening and early treatment ... produce low levels of wild-type BTK transcripts Journal of Clinical Immunology 2002, 22:306-18 Morwood K, Bourne H, Philpot R, Gold M, Gillis D, Benson EM: Phenotypic variability: Clinical presentation...
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Báo cáo y học: "Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals" pps
... density of essential genes in the chromosomal vicinity, independent of protein abundance Domains with a high density of essential genes with low levels of transcriptional noise harbor more phenotypically ... linked with X chromosome abnormalities and, more importantly, to expression heterogeneity and phenotypic variability among females [26] Genes escaping X-inactivation have similar expression levels ... be a crucial concern Moreover, diversity in the phenotypic states at the single-cell level might maximize the population's biological function and ability to cope with changing environmental...
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Báo cáo y học: " Autonomic Dysfunction Presenting as Postural Orthostatic Tachycardia Syndrome in Patients with Multiple Sclerosis"
... the morbidity and disability these patients are already suffering from As seen in our patient population recognition and management of POTS in patients of MS may result in improved quality of life ... has been no correlation between fatigue and the overall severity of disease (24-26) All of our patients had orthostatic intolerance Fifty percent patients of POTS have been reported to have orthostatic ... episodes now have a prodrome and have decreased in severity and frequency Patients who have abrupt onset syncope with convulsive activity might have prolonged episodes of bradycardia or an asystole...
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Báo cáo khoa học: New insights into Fragile X syndrome Relating genotype to phenotype at the molecular level docx
... Thus, the wild-type dFXRP activity exhibited when Fig Fly eye phenotypes associated with overexpression of dFXRP(wild-type) and dFXRP(I307N) (A) A normal fly eye (B) dFXRP(wild-type) overexpressed ... wildtype dFXRP results in a rough eye phenotype, which has been shown to be a consequence of the induction of apoptosis Overexpression of dFXRP(I307N), however, causes a much less severe phenotype, ... proteins 873 Genotype vs pheonotype in Fragile X syndrome Dreyfuss and colleagues introduced the I307N point mutation in dFXRP (the equivalent of I304N in human FMRP) [20] Wild-type dFXRP and dFXRP(I307N)...
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modeling fragile x syndrome
... allows them to tease out the genotypic effects of a particular phenotype from nongenetic, maternal-genotype-dependent ones They demonstrate that heterozygous wild-type offspring, i.e., Fmr1 heterozygous ... wild-type males are more active than wild type–wild type offspring Moreover, male Fmr1 knockout mice born to heterozygous or Fmr1 knockout mothers are even more active than the heterozygous wild-type ... hyperactivity in the Fmr1 knockouts is the result of the combination of the maternal and the offspring genotype effects On the other hand, hyperreactivity, audiogenic seizure susceptibility, and...
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Báo cáo vật lý: "ATTENUATION STUDIES ON DRY AND HYDRATED CROSS-LINKED HYDROPHILIC COPOLYMER MATERIALS AT 8.02 TO 28.43 keV USING X-RAY FLUORESCENT SOURCES" ppt
... 1: Typical arrangement of the XRF set-up at the City University 4500 4000 Kα 3500 Unattenuated Attenuated Counts 3000 2500 Kβ 2000 1500 1000 500 16 17 18 19 20 21 Energy (keV) Figure 2: A typical ... The radiation source at the City University, London was an industrial Xray machine It was water-cooled and could produce X-radiation continuously The tube assembly type was a Comet ceramic X-ray ... where x is the thickness of the samples, It is the intensity of the transmitted beam and I0 is the intensity of the incident beam The density of the samples was determined by weighing and measuring...
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Báo cáo y học: "Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome" pot
... 100 × (mean radioactivity of sample minus mean radioactivity of background)/(mean maximum radioactivity minus mean radioactivity of background) (JRA) NK cell cytolytic activity in patients with ... regions were set by using isotype-matched negative control samples, and the percentage positive for each gate was reported Figure NK cell cytotoxicity analysis NK activity was assessed after co-incubation ... in HLH, NK function is profoundly depressed in the vast majority of patients with MAS [17] suggesting that this immunologic abnormality might be relevant to the pathogenesis of the syndrome In...
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Báo cáo y học: "NPAS2 and PER2 are linked to risk factors of the metabolic syndrome" pps
... rs11549147 All samples were successfully genotyped, yielding the success rate of 100% for all SNPs, and about 5% of samples were re-genotyped to confirm the genotyping results The following three SNPs ... potential role in the function of the gene, which augments the possibility that the genotype seen here contributes to the phenotype although experimental analysis is needed for verification http://www.jcircadianrhythms.com/content/7/1/5 ... selected by systematic probability proportional to size sampling in each stratum, and their sample sizes (ranging from 50 to 100) were equal within each university hospital region, the total number...
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Báo cáo y học: " Triple X syndrome in a patient with partial lipodystrophy discovered using a high-density oligonucleotide microarray: a case report" doc
... metformin, enteric coated acetylsalicylic acid (ASA), rabeprazole, amitriptyline, meloxicam, K-lyte, and magnesium On physical examination, she had a typical Dunnigan-type lipodystrophic habitus, ... polymorphism intensity for 29 female lipodystrophy patients Green dots represent SNP intensity for 11 male lipodystrophy patients Blue dots represent single nucleotide polymorphism intensity for the female ... analysis, have uncovered mutations in genes responsible for two subtypes of congenital generalized lipodystrophy (AGPAT2, BSCL2), three subtypes of familial partial lipodystrophy (LMNA, PPARG, CAV1),...
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Báo cáo y học: "Chemical pneumonitis and subsequent reactive airways dysfunction syndrome after a single exposure to a household product: a case report" pptx
... hyperreactivity [7,8] Other hypotheses involve direct damage to the bronchial mucosa and the release of mediators altering smooth muscle responsiveness, both eventually causing bronchial hyper-reactivity ... Respiratory Problems U.S Consumer Product Safety Commission, 08/31/2005; Washington, DC.) 'Stand N' Seal "Spray-On" Grout Sealer' is composed of Dlimonene, n-butyl acetate (
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Báo cáo y học: "Rapidly progressive Bronchiolitis Obliterans Organising Pneumonia presenting with pneumothorax, persistent air leak, acute respiratory distress syndrome and multi-organ dysfunction: a case report" pdf
... pathology The second peculiarity of our case is the fulminant progression of BOOP into multi-organ failure after two weeks of apparent stability A rapidly progressive type with multi-organ failure ... sternotomy and cardiopulmonary bypass to enable removal of the thrombus, at which time the opportunity was taken to perform an open lung biopsy from the right middle lobe This showed changes showing ... bacterial, fungal or viral infection and the leukocyte count remained normal Serological testing for atypical pneumonia (Legionella, Mycoplasma, Chlamydia and Coxiella), viral infection (Hepatitis virus...
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Báo cáo y học: "Close relationship of tissue plasminogen activator–plasminogen activator inhibitor-1 complex with multiple organ dysfunction syndrome investigated by means of the artificial pancreas" doc
... III complex (TAT), protein C antigen and activity, protein S antigen and activity, plasminogen, antithrombin III (AT-III), PAI-1 antigen and activity, and tissue plasminogen activator (tPA)–PAI-1 ... 75–125 AT-III (%) 70–120 Protein C activity (%) 55–140 Protein C antigen (%) 70–150 Protein S activity (%) 60–150 Protein S antigen (%) 65–135 PAI-1 activity (U/ml) 12–15 PAI-1 antigen (ng/ml) ≤50 ... score TAT tPA–PAI-1 complex PLT Protein S activity Plasminogen Protein C activity D-Dimer FDP Protein C antigen Protein S antigen PAI-1 activity PT ratio AT-III PIC PAI-1 antigen Fibrinogen AT,...
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Báo cáo khoa học: "Cutaneous vascular reactivity and flow motion response to vasopressin in advanced vasodilatory shock and severe postoperative multiple organ dysfunction syndrome" pot
... 62.5%; P = 1), pre-existing morbidity (P = 0.784), multiple organ dysfunction syndrome score (12.3 ± 1.1 versus 12.2 ± 0.4; P = 0.84), and intensive care unit mortality (80 versus 87.5%; P = 1) Table ... blood flow that occurs after ischaemia In general, the ability of an organ to exhibit reactive hyperemia reflects the autoregulative capacity of its microcirculation [1] Representing the proportion ... chronic renal disease, non-insulin-dependent diabetes mellitus) and intensive care unit mortality were recorded in all patients A modified Goris multiple organ dysfunction syndrome score [13]...
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Báo cáo y học: "Argatroban therapy for heparin-induced thrombocytopenia in ICU patients with multiple organ dysfunction syndrome: a retrospective study" pps
... impairment is 0.5 μg/kg/ Despite the availability of these recommendations, limited and inconsistent data exist about dosing patterns, efficacy, and safety of argatroban therapy in intensive care ... assays as well as functional assays (platelet activation) are used, both showing a high sensitivity [7,9] According to consensus guidelines, when HIT, with or without thrombosis, is diagnosed or ... suspected or diagnosed HIT between March 2007 and March 2009 at the general ICU of a German university hospital (Klinikum rechts der Isar der Technischen Universität München, Munich, Germany) The...
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CONTRIBUTION OF K+ CHANNELS TO CORONARY DYSFUNCTION IN METABOLIC SYNDROME
... reduced current density relative to lean while single channel activity and channel protein expression remained similar (38) In arterial myocytes of diabetic fatty rat models of type II diabetes mellitus, ... cardiovascular morbidity and mortality in obese patients with the metabolic syndrome Metabolic syndrome and the coronary circulation Due to the limited anaerobic capacity of the myocardium, the ... baseline coronary blood flow) with obesity and metabolic syndrome (27; 33; 87; 92; 137), indicating that the capacity to vasodilate is greatly reduced in obesity For instance, Kiviniemi et al reported...
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