succinate the substrate of succinate dehydrogenase and the product of fumarate reductase activity of complex ii prevents intra acinar hpv
Báo cáo y học: "Participation of the PI-3K/Akt-NF-κB signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 " pot
... factors that regulate the expression of Flk-1 in the lung and endothelium would provide general insights into the mechanisms of vascular development in health and diseases in the pulmonary circulation ... endothelial cells [2,24] An understanding of the mechanisms that underlie the transcriptional regulation of the Flk-1/KDR gene might provide important information about the molecular basis of ... point might be a result of HIMF degradation because we only administered the HIMF protein at the beginning of the experiment These effects parallel with the activation of IKK and increased PI-3K...
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Báo cáo sinh học: "Time-course of sFlt-1 and VEGF-A release in neutropenic patients with sepsis and septic shock: a prospective study" pptx
... complications in humans Therefore we explored the time-course and the significance of serum levels of sFlt-1 and VEGF-A in patients with FN and hematological malignancies The endothelial barrier-breaking ... in the regulation of angiogenesis, as the disassemble of an intact endothelial line is necessary for the incorporation of new endothelial cells during vessel sprout The clinical relevance of ... attenuate the severity of the inflammatory response and to antagonize the barrier-breaking properties of VEGF-A, thus suggesting a therapeutic role for this protein [8] The potential value of sFlt-1...
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báo cáo hóa học:" Time-course of sFlt-1 and VEGF-A release in neutropenic patients with sepsis and septic shock: a prospective study" pdf
... complications in humans Therefore we explored the time-course and the significance of serum levels of sFlt-1 and VEGF-A in patients with FN and hematological malignancies The endothelial barrier-breaking ... in the regulation of angiogenesis, as the disassemble of an intact endothelial line is necessary for the incorporation of new endothelial cells during vessel sprout The clinical relevance of ... attenuate the severity of the inflammatory response and to antagonize the barrier-breaking properties of VEGF-A, thus suggesting a therapeutic role for this protein [8] The potential value of sFlt-1...
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Báo cáo y học: "Characterization of N200 and P300: Selected Studies of the Event-Related Potential Salil H. Patel 1 and Pierre N. Azzam 2"
... interspersed by a stimulus which deviated from the standard in the intensity of the first component and the glide direction of the second constituent The number of distinct MMN components elicited by ... et al The relationship of age, gender, handedness, and sidedness to the size of the corpus callosum Academic Radiology 1994; 1:243-248 69 Driesen NR, Raz N The influence of sex, age, and handedness ... notable that the detection of a frontal N2 is associated only with instances of a NOGO response Thus, the P300 appears to be inhibited by the appearance of the N2b in tasks of motor activity suppression...
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Agile Web Application Development with Yii 1.1 and PHP5
... invoked to handle the request The controller interacts with the model The controller invokes the view The view renders the data (often as HTML) and returns it to the browser for display Yii's MVC ... covered: The importance and utility of application development frameworks What Yii is and the characteristics of Yii that make it incredibly powerful and useful The MVC application architecture and the ... framework Table of Contents Preface Chapter 1: Meet Yii Yii is easy Yii is efficient Yii is extensible MVC architecture The model The view The controller Stitching these together: Yii request routing...
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listen and speaking 1 and 2
... care of the garden earn money take care of the children The speaker needs to rake the lawn set the table the yard work Together, the family has to sit on the sofa and watch TV take care of the ... Listen and check off what you hear The mother has to cook the dinner pay the bills empty the dishwasher The father must wash the dishes cook the dinner empty the dishwasher the shopping They both ... needs to rake the lawn X set the table the yard work X Together, the family has to sit on the sofa and watch TV take care of the house X take care of each other X Part C My husband and I met in...
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Tài liệu ADC’s HDSL Interface Panel combines HDSL termination, DSX-1 and DSX-3 into a single shelf doc
... Specifications published here are current as of the date of publication of this document Because we are continuously improving our products, ADC reserves the right to change specifications without ... America, Call Toll Free: 1-800-366-3891 • Outside of North America: +1-952-938-8080 Fax: +1-952-917-3237 For a listing of ADC’s global sales office locations, please refer to our web site ADC ... you may verify product specifications by contacting our headquarters office in Minneapolis ADC Telecommunications, Inc views its patent portfolio as an important corporate asset and vigorously...
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Tài liệu Chapter 4: Configuring Layer 1 and Layer 2 Features docx
... wander and jitter The router recovers the clock from the SyncE interface, converts it to the format required for the BITS interface, and sends to a SSU through the BITS port The SSU performs the ... in the DHCP snooping database includes the MAC address of the host, the leased IP address, the lease time, the binding type, and the VLAN number and interface information associated with the ... (up) the backup interface is in standby mode If the primary interface goes down, the backup interface transitions to the up state and the router begins using it in place of the primary When the...
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Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx
... of the catalytic domain and by the presence of an amino acid insertion of variable size between subdomains VII and VIII [8,9] Such as OXI, other AGC kinases of the AGC VIII subgroup have been shown ... of OXI1 with the 5¢UTR and 3¢UTR was amplified by PCR and cloned in the pCambia 3300 The HA tag was cloned at the SalI site found at the ATG site of OXI1 Plant material and growth conditions The ... GST-MPKs showed autophosphorylation activity, loss -of- function (kinase-inactive) forms of the MAPKs were produced as GST-lofMPK3 and GSTlofMPK6 However, when lofMPK3 and lofMPK6 proteins were tested...
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Tài liệu Báo cáo khoa học: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor pdf
... dependence of the inhibitory activity of soluble forms of HAI-1 and HAI-2 against the protease activity of TMPRSS13 (A) Schematic representation of the structure of the full-length HAI-1 (1) and soluble ... of the structure of the full-length HAI-2 (1) and a soluble form of HAI-2 tagged at the C-terminals with myc-His (2) (C) Dose dependence of the inhibitory activity of soluble forms of HAI-1 and ... Formation of complexes of TMPRSS13 and HAI-1–NK1 To confirm the inhibitory effect of HAI-1–NK1 on TMPRSS13, we examined the formation of complexes by the protease–inhibitor pair HAI-1–NK1 and HAI1–NK1LK2...
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Tài liệu Báo cáo khoa học: The two Caenorhabditis elegans metallothioneins (CeMT-1 and CeMT-2) discriminate between essential zinc and toxic cadmium docx
... ratio of 33 : [21 nm Cd (II) and 0.7 lm Zn (II) ] and 0.1 lm of CeMT-1 and CeMT-2 each, and the stability constants given in Table 2, it can be calculated that 98.6% of Cd (II) is bound to CeMT-2, and ... and (D) result from expression in the presence of the respective metal ion; sample (B) was obtained by expression in presence of Zn (II) and reconstitution of the apoprotein with Cd (II) )Met and ... Zn (II) is more evenly distributed (45 : 55%) between CeMT-1 and CeMT-2 When equimolar amounts of Zn (II) and Cd (II) are used (0.65 lm each), 93% of Zn (II) is bound to CeMT-1, and 85% of Cd (II) ...
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Tài liệu Báo cáo khoa học: Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4b-phorbol 12-myristate 13-acetate pptx
... this was not the case in the absence of PMA (Fig 3) Furthermore, the ratio between the ERK-PP concentration after stimulation with EGF and PMA together on the one hand, and the sum of the ERK-PP ... experiments, the error bars represent the standard error of the mean NRK cells with EGF, also in the presence of the PKC inhibitor bisindolylmaleimide I, and determined the ERKPP concentration after and ... tyrosine kinase activity of the receptor and causes the decrease of EGF binding affinity [30–32] It also results in diversion of the internalized EGFR from the regular degradative pathway to the recycling...
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Tài liệu Báo cáo khoa học: Characterization of promoter 3 of the human thromboxane A2 receptor gene A functional AP-1 and octamer motif are required for basal promoter activity docx
... and D; lane 1) and HEK293 (C and D; lane 2) cells The positions of the molecular size markers (kDa) are indicated to the left and right of the (C) and (D), respectively, whilst the position of ... death and stress but may also play a critical role in the assembly of the preinitiation complex within TATA-less promoters [47] The AP-1 complex is comprised of a group of proteins encoded by the ... Characterization of the 5¢ untranslated region of alpha and beta isoforms of the human thromboxane A2 receptor (TP) Differential promoter utilization by the TP isoforms Eur J Biochem 269, 4058–4073 26 Quandt...
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Tài liệu Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis docx
... inhibit the LBS function of either K1 [34] or K4 [35] and have used them to analyse, in functional isolation, the role of these LBS on plasmin(ogen) binding and activation The effect of these mAbs ... effects of intact mAbs, including the reproduction of 3390 similar results with their Fab fragments and the absence of effect on plasminogen binding and activation in the presence of the unrelated ... determine the effect of the mAbs 34D3 and A10.2 on plasminogen activation, the fibrin plates and the cells were incubated with different concentrations of these mAbs in the presence of fixed concentrations...
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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf
... 5¢-ATGTTTGAGACCTTCAACAC-3¢, and reverse primer, 5¢-CACGTCACACTTCATGAT GGA-3¢ then excised from PCR2.1 by digestion with HindIII and SalI and transferred into the pGL2-Basic utilizing the HindIII and XhoI sites ... the KpnI and XhoI sites in the vector and KpnI and SalI sites in the PCR2.1 clones of the promoter fragments All promoter constructs were sequenced to confirm their orientation and to verify their ... fgl2 mRNA The left side of the figure is the sequence ladder using the same primer and the pM166 clone as template Arrow indicates the nucleotide that is matched to the band present in the primer...
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Tài liệu Báo cáo Y học: Binding of gelsolin domain 2 to actin An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin pptx
... cross-linked by EEDQ They involved the electrophoretic and immunological analysis of the cross-linked products formed either on proteolysis of the complex by V8 protease or on cross-linking of the 159–193 ... sequences (and homologue S2 equivalents) within residues 197–226 (including the long helix of the domain) and within residues 161 – 172 (including the A strand and the AB loop in S2) in the interaction ... cross-linked product corresponds to the actin–peptide complex Fig Structure of the synthetic gelsolin peptide 159–193 Second derivative of the IR Fourier transform spectrum Amide I region of the IR...
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Báo cáo khoa học: The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors pdf
... expressed as the fold activation of luciferase activity of the deletion mutant of interest compared with the activity of the empty pGL3 basic vector (white bar) The standard deviation represents the means ... found in cells of the gland ducts and mucous glands [9] In the adult lung, the expression of MUC5B follows a restricted pattern, with a positive gradient from the surface to the glands and a decrease ... cells (Fig 2C) The influence of the 5¢-UTR on promoter activity was studied using the constructs )478 ⁄ +47 and )717 ⁄ +47 When the 5¢-UTR region +1 ⁄ +47 was included, the activity of the promoter...
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Báo cáo khoa học: Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans pot
... isolated from the rat liver mitochondrial matrix and classified as a class theta GST [1] The determination of the three-dimensional structure of the class kappa enzyme from rat (rGSTK1-1), complexed ... determine the spatial and temporal expression patterns of gstk-1 and gstk-2 genes in C elegans, we constructed gfp::gstk-1 and gstk-2::gfp fusions under the control of approximately kb of the 5¢ ... further insight into the potential function(s) of GSTK-1 and GSTK-2, RNAi was used to knock down the expression of the two corresponding genes, either separately or simultaneously Knockdown of...
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Báo cáo khoa học: Complexes of Thermoactinomyces vulgaris R-47 a-amylase 1 and pullulan model oligossacharides provide new insight into the mechanism for recognizing substrates with a-(1,6) glycosidic linkages docx
... on the structure of the substrate to form favorable interactions with the substrate In the binding of G6, Phe313 mainly interacts with the six membered ring of Glc–3, while in the binding of ... Thus, the roles of these substrate binding sites are still unclear Our results show the substrate recognition mechanism of TVAI behind the hydrolysis of both starch and pullulan, the complete substrate ... pullulan model ligand A Abe et al Fig Stereoview of the catalytic site of D356N ⁄ E396Q ⁄ P5 The binding of P2 and P5 is shown in orange and blue, respectively The binding of ACA and Trp398 in TVAI...
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Handbook of Residue Analytical Methods for Agrochemicals VOLUME 1 and VOLUME 2 doc
... Execution of the field portion of the worker exposure/re-entry study Observations of the volunteers during the conduct of the field study Data collection and the use of field forms Storage and shipping of ... determine the potential impact of the agrochemicals and their degradation products/metabolites on the environment and sensitive ecosystems The quality of the residue data, including the reliability and ... guidelines between the various regulatory authorities and the lack of standardization in test method specifications further complicate the interpretation and broad application of the exposure data...
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