structure based drug design on membrane protein targets human integral membrane protein 5 lipoxygenase activating protein
Báo cáo y học: "The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein" doc
... levels in human osteoarthritic subchondral bone osteoblasts Bone 2006, 38:333-341 44 Bennett CF, Chiang MY, Monia BP, Crooke ST: Regulation of 5lipoxygenase and 5- lipoxygenase- activating protein ... induction of LTB4 production in response to NSAIDs or NS-398 in OA osteoblasts involved no major modification of 5- LO expression, in contrast to the situation observed in OA chondrocytes [56 ] In ... posttranscriptional regulation of 5- lipoxygenase mRNA expressionin the human monocytic cell line Mono Mac by transforming growth factor-β and 1, 25- dihydroxyvitamin D3 Adv Exp Med Biol 1999, 469:1 05- 111...
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Báo cáo khoa học: B1–Proteases as Molecular Targets of Drug Development B1-001 DPP-IV structure and inhibitor design ppt
... of Hong Kong, Hong Kong, PR China, 2Department of Biology, The Chinese University of Hong Kong, Hong Kong, PR China, Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong, ... MM and precipitation zone heights or squares consist 0 .56 0.73 (P < 0. 05) , between aXa activities and precipitation zone heights or squares consist 0.370 .54 (P < 0. 05) Conclusion: LMWH-SK was obtained ... protein damage was assessed as tryptophan oxidation, carbonyl, quenone and advanced oxidation protein products (AOPP) generation The increase of protein oxidation products was in concentration...
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Tài liệu Báo cáo khoa học: Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-D-glyceric acid Selective inhibition by structure-based design docx
... T225A (Pi site) 16 ± 85 ± 15 95 ± 100 ± 10 100 ± 13 2 35 ± 22 800 ± 90 70 ± 160 ± 90 2.6 ± 0.2 250 ± 20 10.7 ± 0.3 150 ± 20 50 ± 0 .5 2 35 ± 18 4.4 ± 0.3 51 5 ± 24 0.2 ± 0. 05 Enzymatic inactivation ... showing torsion angles in the favourable regions of the Ramachandran diagram [ 45] Only Val 255 from all monomers are in unfavourable regions Val 255 is located in a loop between two consecutive b ... to convert 3-PGA into 1,3BPGA The inhibition kinetics studies were performed with four different concentrations of ATP ( 250 , 350 , 50 0 and 600 lM), which correspond to 1,3-BPGA concentrations...
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Báo cáo khoa học: "Development of synthetic peptide ELISA based on nonstructural protein 2C of foot and mouth disease virus" doc
... 89/12 01/2 7/0 4/0 11/1 15/ 9 51 /4 ‡ ASILE bA †D3 VDMF 89/32 89/06 89 latoT 01/4 01 /5 01 dreH 7/2 7/3 dreH 4/0 4/2 4 dreH 11/2 11/11 11 dreH 15/ 01 15/ 82 15 dreH 51 /5 , *51 /11 51 dreH ‡ ‡ tik CBA3-DMF ... fo oN/ sevitisop fo oN ]4[ noitceted ydobitna D3 rof SQRVN yb depoleved dohtem ASILE ehT 0002 ,aeroK fo skaerbtuo DMF ni elttac morf selpmas ares dleiF* ‡ † 89/22 01/3 7/2 4/0 11/1 15/ 11 51 /5 ‡ ... nietorp larutcurts-non fo yticinegonummI F onirboS ,CJ ziaS ,J ozapoD ,A zeugirdoR 21 52 3 408-997 ,481 ,1991 ygoloriV snoitcefni tnetsisrep etal fo noitceted ni snegitna larutcurtsnon dereenigneoib...
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Báo cáo y học: " A controlled trial of value-based insurance design – The MHealthy: Focus on Diabetes (FOD) trial" docx
... Median Household Income† $55 ,086 $54 , 758 1.43 (0. 65) 1.46 (0.69) 53 .9% 43.4% 44.7% 21.7% 53 .6% 48.7%* 44 .5% 18.9%* Number of respondents enrolled Mean age in years (SD) Charlson Comorbidity Score‡(SD) ... benefit -based copay for prescription drugs: patient contribution based on total benefits, not drug acquisition cost Am J Manag Care 2001, 7:861-867 Chernew ME, Rosen AB, Fendrick AM: Value -Based ... impact of the value -based co-payment reductions Procedures Figure Identification of intervention and control groups Identification of intervention and control groups The large circle on the left (labeled...
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báo cáo khoa học: " A controlled trial of value-based insurance design – The MHealthy: Focus on Diabetes (FOD) trial" pps
... Median Household Income† $55 ,086 $54 , 758 1.43 (0. 65) 1.46 (0.69) 53 .9% 43.4% 44.7% 21.7% 53 .6% 48.7%* 44 .5% 18.9%* Number of respondents enrolled Mean age in years (SD) Charlson Comorbidity Score‡(SD) ... benefit -based copay for prescription drugs: patient contribution based on total benefits, not drug acquisition cost Am J Manag Care 2001, 7:861-867 Chernew ME, Rosen AB, Fendrick AM: Value -Based ... impact of the value -based co-payment reductions Procedures Figure Identification of intervention and control groups Identification of intervention and control groups The large circle on the left (labeled...
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Hollow fiber membrane design for membrane distillation (MD) and MD based hybrid processes
... distillation desalination process, Desalination, 56 (1983) 3 45- 354 [14] K Schneider, T.J Van Gassel, Membrane Distillation, Chemical Engineering & Technology, 56 (19 85) 51 4 -52 1 [ 15] M Gryta, Water membrane ... different operational parameters 149 6.4 Conclusions 150 6 .5 References 152 CHAPTER 7: A conceptual Demonstration of Freeze Desalination – Membrane Distillation Hybrid ... configuration is better as compared with the DCMD configuration Investigations are carried on the various effects of VMD operational conditions on the VMD performance of the fabricated MBF membrane, ...
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Computational study of therapeutic targets and ADME associated proteins and application in drug design
... entries/records 44 ,57 5,7 45, 176 49,127,9 25 5,7 85, 962 28,9 05 134,886 52 ,888 238 249,219 18,883,9 45 180,770 352 ,2 75 1,310,899 98,680 11,288,2 75 38,137 897,246 15, 382,6 75 341,602 16 ,52 1 Obviously, it ... development of rule -based prediction system 154 - VIII - Computational study of therapeutic targets and ADME-associated proteins and application in drug design Acronyms ACRONYMS ABC ADME ADME-AP ... ADME-associated proteins 1 45 6.2.3 ADME-associated proteins linked to reported drug response variations 149 6.2.4 Development of rule -based prediction system . 153 6.3 Conclusion ...
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A study to indicate the importance of consumer based-brand equity on consumer perception of brand (a case study of fast food restaurants).pdf
... customer -based brand equity on consumer’s perceptions of a brand This is based on the assumption that all these dimensions of customer based- brand equity will have influence on consumer’s perceptions ... 52 4.4 INCOMPLETE QUESTIONNAIRES .54 4.4.1 CHARACTERISTICS OF RESPONDENTS 54 4.4.2 CUSTOMER BASED BRAND EQUITY RATING 55 4.4.2.1 Brand awareness 55 4.4.2.2 ... of consumers Also, the economic situation, occupation, self-concept and consumers personality • Psychological factors include perception, motivation, learning, attitude and belief of the consumers...
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Tài liệu Next Generation Enterprise MPLS VPN-Based WAN Design and Implementation Guide doc
... 1 25. 0.0.0 0. 255 . 255 . 255 area maximum-paths ! router bgp no synchronization bgp log-neighbor-changes network 1 35. 10.1.1 mask 255 . 255 . 255 . 255 network 1 35. 10.1.2 mask 255 . 255 . 255 . 255 neighbor 1 25. 1.1 25. 15 ... 1 25. 1.1 25. 6 255 . 255 . 255 . 255 ! interface Loopback1 Next Generation Enterprise MPLS VPN -Based WAN Design and Implementation Guide 5- 5 Chapter Building Redundancy ip address 1 35. 10.1.1 255 . 255 . 255 . 255 ... 255 . 255 . 255 .0 ! interface GigabitEthernet0/1.2 encapsulation dot1Q 242 ip vrf forwarding red-voice ip address 1 25. 1.18.1 255 . 255 . 255 .0 ! interface FastEthernet1/1 ip address 1 35. 0.6.2 255 . 255 . 255 . 252 ...
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Tài liệu Next Generation Enterprise MPLS VPN-Based MAN Design and Implementation Guide doc
... Restrictions 6 -55 Configuration and Monitoring 6 -56 PXF -Based Cisco 7600 Configuration 6 -56 Cisco 12K Configuration 6 -56 Cisco 7200 Configuration 6 -56 Cisco 3 750 Metro Configuration 6 -57 Cisco PXF -Based ... forwarding red-data ip address 1 25. 1.1. 65 255 . 255 . 255 .224 ! interface GigabitEthernet5/7.2 encapsulation dot1Q 50 6 ip vrf forwarding red-voice ip address 1 25. 1.10.9 255 . 255 . 255 . 252 ! c Redistribute VPN ... GigabitEthernet5/7.2 encapsulation dot1Q 50 6 ip vrf forwarding red-voice ip address 1 25. 1.10.9 255 . 255 . 255 . 252 ! Egress interfaces connecting to PE: ! interface GigabitEthernet5/7.1 encapsulation dot1Q 50 5...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt
... analyses of a Phe ⁄ Tyr switch 1842 53 54 55 56 57 58 59 60 61 controlling product specificity of histone lysine methyltransferases J Biol Chem 280, 55 63 55 70 Qian C, Wang X, Manzur K, Sachchidanand, ... observed conformation of the isolated MLL1 SET domain in the crystal structure represents the range of possible conformations that may exist in solution 1836 Consistent with the conformational change ... of WDR5 bound to Mixed Lineage Leukemia Protein- 1 peptide J Biol Chem 283, 32 158 –32161 25 Song JJ & Kingston RE (2008) WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding...
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Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf
... solubilization Digitonin 1 25 Triton X-100 100 75 50 25 0 10 Temperature (°C) 25 Fig Stability of the 50 0 kDa bc1 sub-complex in different conditions of solubilization (A) Mitochondrial membranes ... (DIC): translocation across the mitochondrial outer membrane and 1914 48 49 50 51 52 53 54 subsequent release from the TOM channel are membrane potential-independent J Mol Biol 310, 9 65 971 Laemmli ... maturation of the bc1 complex in the inner mitochondrial membrane Δ Δ QCR9/ΔQCR10 WT A Δ ISP/ΔQCR10 Δ V Zara et al ~1000 kDa ~ 850 kDa 670 kDa ~50 0 kDa ~ 35 kDa ~230 kDa ~50 0 kDa ~230 kDa ~50 0 kDa ~35...
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Tài liệu Báo cáo khoa học: "BASED TEXT SEGMENTATION ON SIMILARITY BETWEEN WORDS" pdf
... Candance L (1986) "Attention, intentions, and the structure of discourse." Computational Linguistics, 12, 1 75- 204 Halliday, Michael A K., Hasan, Ruqaiya (1976) Chesion in English Longman Hearst, Marti, ... 0.6 tations 12 : lO 0 .5 '4 0.4 • ' izi 0.3 100 J 300 200 i 400 i 50 0 I 600 , 700 i (words) F i g u r e Correlation between LCP and segment boundaries VERIFICATION OF LCP • Analyzing text structure: ... activation on an English dictionary." to appear in Proceedings o] EA CL-93 Morris, Jane, and Hirst, Graeme (1991) "Lexical cohesion computed by thesaural relations as an indicator of the structure...
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Tài liệu Báo cáo khoa học: Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites pdf
... order reaction condition for peptide using a substrate concentration range (0.02–0. 15 mM) in which the activity was a linear function of the substrate concentration Ó FEBS 2002 Studies on mutant ... (1.0) 0 .5 (0.6) 0.3 (0.4) 7.6 (9 .5) b Wild-type 0.6 (1.0) 2.6 (4.3) 0. 05 (0.08) 0.3 (0 .5) 0 .5 (0.8) 0.4 (0.7) 0. 05 (0.1) 8.7 (14 .5) 1.2 (1.0) 0.9 (0.8) 0.03 (0.03) 0.06 (0. 05) 0.7 (0.6) 0.6 (0 .5) ... signal transduction: analysis of protein- protein contacts and active sites in several glycolytic enzymes Front Biosci 4, D 557 – D570 ´ Tozser, J., Gustchina, A., Weber, I.T., Blaha, I., Wondrak, E.M...
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Tài liệu Báo cáo khoa học: "An Alignment Algorithm using Belief Propagation and a Structure-Based Distortion Model" pdf
... 2002 Conference S Kurohashi and M Nagao 1994 A syntactic analysis method of long japanese sentences based on the detection of conjunctive structures Computational Linguistics, 20(4) :50 7 53 4 I ... V-Node can take for Pconcept (ei , fj ) (i,j)∈a (1) This model only take into consideration oneto-one alignments Therefore, from now on, we will call this model “monolink” Considering 168 case ... should also be a kind of structure conservation”, with most structures on one side having an equivalent on the other Before going further, we should precise the idea of structure we are going...
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Diversified Funding streams for University-based research: Impact of external project- based research funding on financial management in Universities docx
... recommendations of appropriate action at European and national levels Based on the terms of reference the Expert Group concentrated its reflections on three aspects: The Experts Group’s focus on the ... should consider drawing up good practice guidelines for external funding Terms and conditions in consultation with universities Role and responsibility at national level Recommendations for strategic ... by the organisations involved The Group was also interested in seeing what consistency there might be at national level between sponsors and what impact sponsor conditions had on universities...
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Báo cáo Y học: Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein–protein interactions pdf
... infection independent of the action of interferon or p53 FASEB J 15, 50 1 51 5 35 Nakaya, T., Sato, M., Hata, N., Asagiri, M., Suemori, H., Noguchi, S., Tanaka, N & Taniguchi, T (2001) Gene induction ... concentration was decreased by dilution, and the diluted proteins were incubated with the indicated GST fusions immobilized on glutathione sepharose Proteins retained on the GST fusions were eluted ... activation of interferon regulatory factor by lipopolysaccharide J Biol Chem 274, 355 35 355 38 Au, W.C., Moore, P.A., LaFleur, D.W., Tombal, B & Pitha, P.M (1998) Characterization of the interferon...
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Báo cáo khoa học: Emerging tools for real-time label-free detection of interactions on functional protein microarrays ppt
... Biophys Biomol Struct 25, 55 –78 FEBS Journal 272 (20 05) 54 12 54 25 ª 20 05 FEBS Label-free detection for protein microarrays 56 Karlsson R (2004) SPR for molecular interaction analysis: a review ... concentrations from 0.3 to 50 0 pm, they FEBS Journal 272 (20 05) 54 12 54 25 ª 20 05 FEBS N Ramachandran et al A B Label-free detection for protein microarrays cules tested, eliminating most nonprotein ... plasmon resonance Technology Resolution (RIU) Multiplexing Conventional SPR [57 59 ,81] · 10)7 (angular interrogation) · 10 )5 (wavelength interrogation) · 10)6 (8 kDa minimum size) 3.4 · 10 )5 (308...
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