... on the van der Waals surface of the protein modelThe analysis of cavities in the proteins was made using the program avp [69], using a probe of 0.5 A to assess the packing of the molecules The ... C-terminal region and that the C-terminal peptide of SsCU-NH is necessary for the integrity of the active site These results conrm the conclusions drawn fromthe analysis of the sequence alignment ... present in the templates, supporting the correctness of the nal alignment that was used to create the structure of the monomeric SsCU-NH (data not shown) Among the ten models obtained using the two...
... and D166 and the adjacent H138 are present in the active site Moreover, the construction of a reasonable model for the Rep245 prim–pol domain (as we designate it from now on) fromthe pRN1 prim–pol ... and the b9 strand to the b10 strand at the bottom of the Zn-stem loop in the pRN1 prim–pol structure However, because the Zn-stem loop is a fairly self-standing structure protruding fromthe ... interface between the DNA binding and the active site subdomains, we managed to modelthe entire domain without it Another significant finding concerns the nature of the acid residues within the active...
... protect the rights of the most vulnerable.”25 Sharma further highlights the difficulty the CIFs model has in offering genuinely legitimate representatives fromthe constituencies of the most ... by the Bretton Woods Project and other groups has shown, there are numerous issues and concerns around the operations of the CIFs These include, but are not limited to: the accountability of the ... reaching the most vulnerable, and used to analyse the institutional arrangements, operational modalities, and performance of the CIFs A faulty model? Background – The CIFs as a model for the GCF? The...
... referred to as the `base-line' and the `spatial' models In both models, we assumed that the vector of the estimated regression coecients obtained fromthe ®rst-stage analysis, conditional on the vector ... regression models with and without modelling of the possible spatial autocorrelation among the c s which we refer to as the base-line and spatial models respectively 4.1 Modelling approach The modelling ... between the posterior inferences under the two models and assesses the sensitivity of the results to the choice of lag structure and prior distributions Description of the databases The analysis...
... delays the career track of newer pilots 4 modeling their decisions, and estimating themodel to identify crucial factors in their decisionmaking In the following chapters, we summarize the data ... of the development of the specific mathematical form of our pilot attrition model Dependent Variable The dependent variable is the indicator of whether an individual stays or leaves during the ... chapter, the dependent variable in themodel is the indicator of the decision to stay or leave during the ADSO window Some of the independent variables included in themodel are • military and civilian...
... performance on the web data, the similarity of the HTML tag structures between the parallel web documents should be leveraged properly in the sentence alignment model In order to improve the quality ... STSG in the context of language generation, while we search for the best alignment on the condition that both trees are given To facilitate the presentation of the tree alignment model, the following ... to the corresponding DOM tree; N iD refers to the ith node of T D (here the index of the node is in the breadth-first order), and TiD refers to the sub-tree rooted at N iD , so N1D refers to the...
... Likewise, the secondary structure of the phorphorylation domain deduced fromthemodel built here using the Ca2+-ATPase as template and that determined directly fromthe amino acid sequence of the ... H+-ATPase The chemiosmotic model for PMA1_NEUCR In the P-type proton pumps, the origin of the transported proton as well as the proton entry pathway is still unknown The socalled Ôchemiosmotic model ... begin close to the phosphorylated aspartate (Asp378) The major steps of themodel are as follows: The first step is a covalent phosphoryl-transfer reaction fromthe MgATP molecule to the strictly...
... Security Models We want models that represent a range of sensitivities and that separate subjects fromthe objects they should not have access to The military has developed various models for ... authority – E.g the operating system enforces the control by checking information associated with both the subject and the object to determine whether the subject should access the object MAC ... Take-Grant Models, pg Since the graph only includes arcs corresponding to non-empty entries in the access control matrix, themodel provides a compact representation Question of Take-Grant Models:...
... by the theory of relations We review the essentials of therelational approach in this chapter Relational Model Concepts Themodel was first proposed by Dr E.F Codd of IBM in 1970 in the ... Model of Data is based on the concept of a Relation A Relation is a mathematical concept based on the ideas of sets The strength of therelational approach to data management comes fromthe ... Outline RelationalModel Concepts RelationalModel Constraints and Relational Database Schemas Update Operations and Dealing with Constraint Violations RelationalModel Concepts The relational...
... once the work ‘leaves the lab’ The proposed NIH percubator program pushes this concept one step further by eliminating the barrier altogether, but at the same time respecting and building upon the ... progresses through the early incubation phase it must then traverse the so-called valley of death - from promise to real delivery - from drug candidate to effective therapeutic - from prototype to ... support to go from start to finish, alone or in a later-stage, de-risked partnership with other companies - down into the valley of death, across the basin, and up the steep grade of the opposite...
... once the work ‘leaves the lab’ The proposed NIH percubator program pushes this concept one step further by eliminating the barrier altogether, but at the same time respecting and building upon the ... progresses through the early incubation phase it must then traverse the so-called valley of death - from promise to real delivery - from drug candidate to effective therapeutic - from prototype to ... support to go from start to finish, alone or in a later-stage, de-risked partnership with other companies - down into the valley of death, across the basin, and up the steep grade of the opposite...
... The results indicated that there is redundancy in pathogenic TNF sources (bone marrow cells in the TNF∆ARE model or stromal-radioresistant cells in the Tg197 hTNF+/– model) that suffice for the ... identify the genes controlling this disease the group has made crosses between susceptible and resistant rat strains Several loci that control the onset of arthritis, the severity and chronicity of the ... all cases examined, the indispensable receptor for the arthritic process is TNF-R1 in recipient mice The research within EUROME also focuses on the identification of possible therapeutic targets...
... P(i) be the ith sorted P value and i its rank Then, the FDR for each sorted P value was calculated by timing the P value with m/i, and monotonizing all of the FDRs fromthe largest to the smallest: ... murine autoimmune arthritis models [11,13-15] in order to appreciate better the gene expression in PBMCs in the rat CIA model We retrieved the reported DEGs from these published studies Comparisons ... members of the functional genomics group for helpful discussion, and the members of the Shou laboratory for critical reading of the manuscript We also acknowledge the support fromthe bioinformatics/IT...
... included, neither in the generation of the data nor in themodel fitted The negative value for this configuration indicates that, although the bias seems fairly independent of the size of the fixed ... for the values of the variance components obtained for the corresponding full model, ie model 1-5 Variability due to estimation of the variance components is ignored For each line in the table the ... effects below the line Referring to a chi-square distribution, in model seasonal effects seem to be unimportant and are excluded fromthe subsequently fitted models In model for the M-set, the following...
... which themodel could be fully externally validated Therefore, to gain a measure of the applicability of themodel to other European populations, themodel was tested against data fromthe Munich ... accuracy tested The results from this analysis were then compared to the results for themodel Results Development of the predictive modelThe 15 variables in the FLIP study are compared in the hospitalised ... excluded fromthe analysis The predictive function derived fromthe FLIP dataset was tested in two ways against data fromthe Munich RSV study Firstly, the predictive variables identified fromthe FLIP...
... patients with IIP [7] These data all together suggest a common pathway in the development of these two pathologies According to a current view, pulmonary emphysema originates from an imbalance between ... damage in this condition This hypothesis is based on a mixture of evidence from animal models, broncho-alveolar lavage fluid (BALF) data, in vitro experiments, and fromthe high incidence of emphysema ... Thus, these studies suggest a significant role for the antiprotease screen not only in the development of pulmonary emphysema but also in the modulation of fibrotic lesions This is further supported...
... study the early immunological responses to HIV infection Another limitation in HIV research is the lack of a tractable small animal model susceptible to HIV infection The most widely used model ... fortifying the immunological control of FV [57-59] On the other hand, CD4+ Tregs down-regulate the immune responses of CD4+ Th cells [32,58] and CD8+ CTLs [39,60-62] thus, prolonging the recovery from ... is determined by the nature of the infectious agent and the inflammatory milieu formed by the pathogen [103-105] Although T cell help may be dispensable in the priming phase of the CD8 + T cell...
... errors for the Insulin Sensitivity Indices fromthe Single Delay Model (KxgI) and fromthe Minimal Model (SI) For the KxgI the average values were computed both in the Full Sample and in the reduced ... reported the averages of each pair of Insulin Sensitivity Indices (one fromthe Single Delay Model KxgI and one fromthe Minimal Model SI) fromthe reduced Sub-Sample (obtained eliminating the 18 ... to be the case for the KxgI index as shown by the actual range of values, by the correlation with the 1/HOMA-IR and HOMA2 indices, by the correlation with the M index fromthe EHC, and by the very...