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Tài liệu PROTEOMIC APPLICATIONS FOR THE EARLY DETECTION OF CANCER doc

Tài liệu PROTEOMIC APPLICATIONS FOR THE EARLY DETECTION OF CANCER doc

Sức khỏe giới tính

... identification of biomarkers, not a direct means of early detection in itself Detection and identification of potential biomarkers Diagnostic pattern analysis in body fluids and tissues; potential ... in the identification of potential new biomarkers for early detection of disease Differential in-gel electrophoresis (DIGE) provides a methodology that improves the reproducibility, sensitivity ... consisting of three mass spectral ions was found to distinguish stage 0 I, as well as stage II III, breast cancer patients from normal controls with significantly greater sensitivity and specificity...
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Mammography and Beyond: Developing Technologies for the Early Detection of Breast Cancer pptx

Mammography and Beyond: Developing Technologies for the Early Detection of Breast Cancer pptx

Sức khỏe giới tính

... Partnership Initiative will investigate possibilities for early breast cancer detection Life Sciences Division supports research in the molecular basis of breast cancer, as well as technologies for detection ... epithelial cells Health Resources and Services Administration IBC IDE IGF1 IMDS IOM IRB invasive breast cancer investigational device exemption insulin-like growth factor type Imaging Diagnostic ... Medical screening I Nass, Sharyl J II Henderson, I Craig III Lashof, Joyce C IV Institute of Medicine (U.S.) Committee on the Early Detection of Breast Cancer V National Cancer Policy Board (U.S.)...
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Serum Biomarkers for Early Detection of Gynecologic Cancers ppt

Serum Biomarkers for Early Detection of Gynecologic Cancers ppt

Sức khỏe phụ nữ

... a sensitivity of 94% and a specificity of 94% for serous ovarian carcinoma in its early stage, and a sensitivity of 98% and a specificity of 98% for endometrioid ovarian carcinoma in its early ... This model provided a sensitivity of 89% and a specificity of 97% for the detection of early stage ovarian cancer Furthermore, the sensitivity and the specificity of this panel in distinguishing ... their limitations The principles of proteomic technology require stringent guidelines for the collection of clinical material, the application of analytical techniques, and for our interpretation...
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Near infrared autofluorescence imaging and spectroscopy for early detection of precancer and cancer in the colon

Near infrared autofluorescence imaging and spectroscopy for early detection of precancer and cancer in the colon

Cao đẳng - Đại học

... a thick turbid biologic tissue [38] It enables the optical sectioning capability for in vivo imaging of tissue with depth selectivity and realizes real-time microscopic visualization of tissue ... targets in a single experiment With the unique optical properties, QDs have been explored for in vivo fluorescence imaging to provide direct visual guidance for minimizing incision and dissection inaccuracies ... best diagnostic accuracy of 95.8% among the NIR AF and NIR DR imaging modalities, affirming the potential of the integrated NIR AF/DR imaging with polarization for improving the early detection...
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Near infrared raman spectroscopy for early detection of cervical precancer

Near infrared raman spectroscopy for early detection of cervical precancer

Cao đẳng - Đại học

... by peptide bond (-CONH-) Peptide bond gives rise to many different types of vibrational modes such as amide A and B bands, amide I, II, III, IV, and VII bands Among these, amide I and III bands ... sensitivity of 94% and specificity of 96% in discriminating cancer tissues from normal, fibrocystic and fibroadenoma tissues by performing logistic regression analysis on the fitting coefficients ... method (i. e., intensity ratio) for distinguishing stomach dysplasia [71] The combination of I8 75 /I1 450 and I1 208 /I1 655 proved optimal for the diagnosis of dysplasia with a sensitivity of 90.5%...
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Báo cáo hóa học:

Báo cáo hóa học: "Early detection of urothelial premalignant lesions using hexaminolevulinate fluorescence cystoscopy in high risk patients" potx

Hóa học - Dầu khí

... participated in its design and draft BEL has carried out the histological analysis LN has participated in its revision MG has conceived the study and participated in its design and coordination ... et al: A phase III, multicenter comparison of hexaminolevulinate fluorescence cystoscopy and white light cystoscopy for the detection of superficial papillary lesions in patients with bladder cancer ... resections of high risk patients and if the improvement in the rate of detection of flat lesions in the follow-up may improve the use of additional treatment and the prognosis of these patients...
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Chapter 078. Prevention and Early Detection of Cancer (Part 1) pps

Chapter 078. Prevention and Early Detection of Cancer (Part 1) pps

Sức khỏe giới tính

... every office visit, record the answer with the vital signs, and ask smokers if they would like assistance in quitting Current approaches to smoking cessation recognize that smoking is an addiction ... smoking did so on their own without participation in an organized cessation program, but cessation programs are helpful for some smokers The Community Intervention Trial for Smoking Cessation ... Counseling of adolescents and young adults is critical to prevent smoking A physician's simple advice to not start smoking or to quit smoking can be of benefit Physicians should query patients...
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Chapter 078. Prevention and Early Detection of Cancer (Part 2) ppt

Chapter 078. Prevention and Early Detection of Cancer (Part 2) ppt

Sức khỏe giới tính

... hypothesis for the association is that adipose tissue serves as a depot for aromatase that facilitates estrogen production Adiposity is also associated with poorer survival and increased risk of recurrence ... National Institutes of Health Women's Health Initiative, launched in 1994, is a long-term clinical trial enrolling >100,000 women aged 45–69 It placed women in 22 intervention groups Participants ... have differentiating properties Fiber does not increase bowel transit times High-fiber diets could lower the risk of breast and prostate cancer by absorbing and inactivating dietary estrogenic and...
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Chapter 078. Prevention and Early Detection of Cancer (Part 3) doc

Chapter 078. Prevention and Early Detection of Cancer (Part 3) doc

Sức khỏe giới tính

... promotion, or progression Compounds of interest in chemoprevention often have antimutagenic, antioxidant, anti-inflammatory, antiproliferative, or pro-apoptotic activity (or a combination) Table ... Cancer of the endometrium, liver, breast Ethyl alcohol Cancer of the liver, esophagus, head and neck Helicobacter pylori Gastric cancer, gastric MALT lymphoma Hepatitis B or C virus Liver cancer ... lymphotropic Adult T cell leukemia/lymphoma virus type I (HTLV -I) Immunosuppressive (azathioprine, glucocorticoids) agents cyclosporine, Non-Hodgkin's lymphoma Nitrogen mustard gas Cancer of the...
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Chapter 078. Prevention and Early Detection of Cancer (Part 4) pdf

Chapter 078. Prevention and Early Detection of Cancer (Part 4) pdf

Sức khỏe giới tính

... disease Epidemiologic studies suggest that diets high in calcium lower colon cancer risk Calcium binds bile and fatty acids, which cause proliferation of colonic epithelium It is hypothesized that ... placebo-controlled trials Response was associated with upregulation of retinoic acid receptor-β (RAR-β) Therapy with high, relatively toxic doses of isoretinoin (13-cis-retinoic acid) causes regression of oral ... occurrence is unknown Trials for prevention of sporadic colorectal cancers with COX-2 inhibitors were initiated but have been complicated by the association of these drugs with cardiovascular disease...
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Chapter 078. Prevention and Early Detection of Cancer (Part 5) pdf

Chapter 078. Prevention and Early Detection of Cancer (Part 5) pdf

Sức khỏe giới tính

... hepatitis and hepatomas due to chronic hepatitis B infection Public health officials are encouraging widespread administration of the hepatitis B vaccine, especially in Asia, where the disease is ... cancer prevention However, no data are available on this point Chemoprevention of Prostate Cancer Finasteride is a 5-α-reductase inhibitor It inhibits conversion of testosterone to dihydrotestosterone ... with familial polyposis or ulcerative colitis Prophylactic bilateral mastectomy is chosen for breast cancer prevention among women with genetic predisposition to breast cancer In a prospective...
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Chapter 078. Prevention and Early Detection of Cancer (Part 6) ppsx

Chapter 078. Prevention and Early Detection of Cancer (Part 6) ppsx

Sức khỏe giới tính

... clinically prudent, it is not known if it saves lives in these populations The Accuracy of Screening A screening test's accuracy or ability to discriminate disease is described by four indices: ... indices: sensitivity, specificity, positive predictive value, and negative predictive value (Table 78-2) Sensitivity, also called the true positive rate, is the proportion of persons with the disease ... the disease Similarly, negative predictive value is the proportion testing negative who not have the disease The sensitivity and specificity of a test are relatively independent of the underlying...
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Chapter 078. Prevention and Early Detection of Cancer (Part 7) pps

Chapter 078. Prevention and Early Detection of Cancer (Part 7) pps

Sức khỏe giới tính

... birth date, date of clinic visit); the findings of cohort or casecontrol analytic observational studies; the results of multiple time series study with or without the intervention; the opinions ... Potential Drawbacks of Screening Risks associated with screening include harm caused by the screening intervention itself, harm due to the further investigation of persons with positive tests ... Assessment of Screening Tests Good clinical trial design can offset some biases of screening and demonstrate the relative risks and benefits of a screening test A randomized, controlled screening trial...
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Chapter 078. Prevention and Early Detection of Cancer (Part 8) potx

Chapter 078. Prevention and Early Detection of Cancer (Part 8) potx

Sức khỏe giới tính

... evidence to cervix, include in examination beginning of sexually active years after first women intercourse by age Yearly or 21 for standard Pap; every years with liquid test Pelvic examination No F: ... years (fair evidence) Complete skin examination Insufficient evidence for or exam Periodic Poor evidence to include or exclude against a Summary of the screening procedures recommended for the ... recommendation recommendation recommendation Insufficient M: ≥50, Recommendation specific antigen evidence to every year against recommend Pap test F: 18–65, every 1–3 years F: uterine with Fair evidence...
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Chapter 078. Prevention and Early Detection of Cancer (Part 9) potx

Chapter 078. Prevention and Early Detection of Cancer (Part 9) potx

Sức khỏe giới tính

... proportion of this benefit is due to screening after these women turned 50 is not known In randomized screening studies of women aged 50–69, the mortality decline begins about years after initiation ... initiation of screening Nearly half of women aged 40–49 screened annually will have false-positive mammograms necessitating further evaluation, often including biopsy The risk of false-positive testing ... cancer mortality by a third The sensitivity for fecal occult blood is increased if specimens are re-hydrated before testing, but at the cost of lower specificity The false-positive rate for rehydrated...
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Chapter 078. Prevention and Early Detection of Cancer (Part 10) doc

Chapter 078. Prevention and Early Detection of Cancer (Part 10) doc

Sức khỏe giới tính

... recommended for routine screening of ovarian cancer The risks and costs associated with the high number of false-positive results is an impediment to routine use of these modalities for screening Most ... that routine screening for ovarian cancer is not indicated for standard-risk women or those with single affected family members, but might be worthwhile in families with genetic ovarian cancer ... palpation, transvaginal ultrasound, and serum CA-125 assay have been considered for ovarian cancer screening These tests alone and in combination not have sufficiently high sensitivity or specificity...
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Báo cáo y học:

Báo cáo y học: "Early Detection of cytokine protein expression in mouse lung homogenates using suspension bead array" ppt

Báo cáo khoa học

... saline (PBS, Sigma) ; Tissue Protein Extraction reagent (T-PER, Pierce, Rockford, IL, USA); Complete Mini Protease Inhibitor Cocktail tablets (Roche Diagnostics, Indianapolis, IN, USA); bicinchoninic ... investigate the feasibility of using suspension bead array for detection of LPS (i. p administration of 0.25 mg/ml)evoked changes in levels of cytokine protein expression (at 2- and 24-hours post ... correlated with qualitative protein expression profile data (i. e., as low as 10 pg/ml of IL-2) detected using antibody array In this study, antibody arrays findings suggested significantly increased...
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Báo cáo y học:

Báo cáo y học: " Early detection of Varicella-Zoster Virus (VZV)-specific T-cells before seroconversion in primary varicella infection: case report" potx

Báo cáo khoa học

... reactivation as indication for zoster vaccination Here we report that the detection of VZV-specific T-cells may (f) additionally support the rapid diagnosis of an early varicella infection before ... of this journal Additional file 1: Protocol for the detection of VZV-specific T-cells: This additional file provides a detailed protocol for the detection of VZVspecific T-cells from heparinized ... diagnosis of a pathogen involvement if serological parameters are impaired, (b) the differentiation between different stages of viral infections, (c) the monitoring of the immune status of immunosuppressed...
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Guidelines for the early detection and screening of breast cancer ppt

Guidelines for the early detection and screening of breast cancer ppt

Sức khỏe giới tính

... radiation Therefore, its indications are very limited Magnetic resonance imaging (MRI) The sensitivity of MRI is over 95% but its specificity is low, with a range of 53%–70% False positive diagnoses ... no distance metastasis 87% Invasive carcinoma < cm without nodal involvement but with movable axillary nodes and no distance metastasis 75% II III Invasive carcinoma < cm in size with nodal involvement ... Breast neoplasms – Epidemiology I Modjtabai Atord II Title III WHO Regional Office for the Eastern Mediterranean IV Series ISBN : 978-92-9021-406-9 ISSN : 1020-0428 (NLM Classification : WP 870) ©...
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Báo cáo khoa học:

Báo cáo khoa học: "Use of soft X-radiography for early non-destructive detection of floral differentiation in Douglas fir buds" pptx

Báo cáo khoa học

... drawbacks with the X- ray technique In particular, the inability to obtain pictures precise enough for the observation of the meristematic apex made it impossible to apply the height/width ratio of the ... stage of organs and tissues for sampling, especially for sparse material Studies on conifer bud initiation/differentiation and development provide excellent examples of the potential use of this ... Radiographs provide morphological information about organs or tissues which would otherwise be masked by others, while preserving plant specimens intact With this technique, it is possible: (i) ...
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