safety and efficacy of a unique undenatured type ii collagen in the treatment of arthritis
Báo cáo y học: " Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial"
... attack (15) The present clinical trial evaluated the safety and efficacy of UC -II in the treatment of the knee in OA patients Materials and Methods Study Design This clinical trial (Human Clinical ... in this study were standard for OA and are widely used and recognized as reliable, accurate, and relevant WOMAC scores were determined, at screening, and baseline, as well as at days 30, 60 and ... Peal A, Alvey M, Simms C, Curtsinger A, Gupta RC, Canerdy TD, Goad J, Bagchi M, Bagchi D Therapeutic efficacy and safety of undenatured type II collagen singly or in combination with glucosamine...
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Báo cáo khoa học: "The Safety and efficacy of a new self-expandable intratracheal nitinol stent for the tracheal collapse in dogs" ppt
... cervical to thoracic tracheal area Coughing and dyspnea disappeared and the dogs resumed normal activity Stent implantation is a minimally invasive, effective, easy and brief procedure that can ... (b) intratracheal placement of self expandable nitinol stent with flare ends in a dog with tracheal collapse Collapsed trachea is extended and sustained (white arrow) Intratracheal nitinol stent ... treatment of tracheal collapse in a dog J Am Vet Med Assoc 2004, 225, 1217-1221 10 Moritz A, Schneider M, Bauer N Management of advanced tracheal collapse in dogs using intraluminal self-expanding...
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Báo cáo y học: " Safety and efficacy of a generic fixed-dose combination of stavudine, lamivudine and nevirapine antiretroviral therapy between HIV-infected patients with baseline CD4 " pot
... Techasathit W, Sonjai A, Suwanagool S: Safety and efficacy of a simplified fixed-dose combination of stavudine, lamivudine and nevirapine (GPO-VIR) for the treatment of advanced HIV-infected patients: ... combinations, Nevirapine, EFV: Efavirenz, d4T: Stavudine, 3TC: Lamivudine, ART: Antiretroviral therapy, OIs: Opportunistic infections, AST: Aspartate aminotransferase, ALT: Alanine aminotransferase ... study SL participated in the design of the study SS participated in the design of the study and statistical analysis Acknowledgements The authors would like to thank all the attending staffs and physicians...
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Báo cáo khoa học: " Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308]" pps
... first Pain was assessed with a six-point Pain Intensity (PI) scale, in which was no pain, was mild pain, was moderate pain, was severe pain, was very severe pain, and was worst possible pain If the ... study involved bradycardia, cerebral infarction, oedema, hypotension and intracranial haemorrhage in the remifentanil group, raised ICP in the fentanyl group, and bradycardia and raised ICP in the ... Karabinis et al and sedation beyond day 3, propofol was discontinued and replaced with midazolam in accordance with local transitioning protocols The infusion rates of fentanyl and morphine and...
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Báo cáo y học: "The short-term safety and efficacy of fluoxetine in depressed adolescents with alcohol and cannabis use disorders: a pilot randomized placebo-controlled trial" potx
... all of these laboratories and the electrocardiogram were repeated at the end of study participation All females had a urine pregnancy test performed at screening and at week or at termination of ... than the standard ANOVA method [44] The baseline and each post-baseline visit were included in the model as the dependent variables In addition, a CDRS-R "response" rate was prospectively defined ... amphetamines, opiates, cannabinoids, cocaine, and phencyclidine Also, at the study physician's discretion, a blood ethanol screen was also able to be obtained at additional study visits if there was...
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Báo cáo khoa học: "The safety and efficacy of gamma knife surgery in management of glomus jugulare tumor" pptx
... (hearing loss alone in three, facial numbness and hearing loss in one, vocal cord paralysis and hearing loss in one, and temporary imbalance and/ or vertigo in one) In 26 patients in whom hearing ... RFAH conceived and prepared the manuscript MSM and OMF participated in the design of the study All authors read and approved the final manuscript Competing interests The authors declare that they ... otorrhea, hemorrhage, bruit, and the presence of a middle ear mass Significant ear pain is uncommon Involvement of the inner ear produces vertigo and sensorineural hearing loss [11] Cranial nerve involvement...
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Báo cáo y học: "Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice" docx
... unwinding collagen fibril inside the cell Sections through several planes of more than 50 cells were examined for each treatment CII, stained and imaged at the same gain and offset levels as the ... which the level of intracellular CII dropped, probably due to terminal lysosomal transport and degradation II collagen (CII) by macrophages The effect of inhibitors of uptake on the intracellular ... inhibitors of uptake Pretreatment of macrophages with cytochalasin D or amiloride reduced accumulation of CII in fractions and (Figure 4c) Monodansylcadaverine and filipin had no effect on CII internalization...
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Báo cáo y học: "Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen" pot
... arthritic DBA/1 and B6 mice revealed that, in early arthritis (up to weeks after onset), there was a similar degree of inflammatory cell infiltration in the two strains In contrast, in late arthritis ... stained with haematoxylin and eosin In the early stages of CIA, inflammatory infiltrates were found in both the DBA/1 (Figure 2a) and B6 (Figure 2b) joints However, at late stages of disease, ... (Margate, Kent, UK) The phenotype of arthritis was milder in B6 mice than in DBA/ mice, with less swelling and a more gradual increase in clinical score Histological assessment of the hind paws...
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Báo cáo y học: "A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis" ppsx
... efficacy of an oral tolerance approach for RA To evaluate the efficacy and safety of CCII in RA patients further, we treated two groups of RA patients with oral CCII or MTX in a randomized, doubleblind, ... of efficacy were made at baseline and repeated 12 and 24 weeks later Efficacy variables included [21,22] pain, and pain intensity was assessed by visual analogue scale (VAS) of (no pain) to 10 ... models, including arthritis CII is the most abundant structural protein of human cartilage The cartilage within the joint caused mainly damage of autoimmunity in patients with RA CII autoimmunity may...
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Báo cáo y học: "Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritis" pdf
... antibodies against bovine type II collagen (CII) and human CII Scatter plot of the levels of IgG antibodies against human CII and bovine CII in sera of patients with rheumatoid arthritis (RA; n = ... = of bovine type II collagen in patients with rheumatoid arthritis= 34) and 96), psoriatic serum of antibodies against CB10 (a) and (RA; (b) in normal human arthritis (PsA; n 33), collagen in ... Mechanisms of disruption of the articular cartilage surface in inflammation Neutrophil elastase increases availability of collagen type II epitopes for binding with antibody on the surface of articular...
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Báo cáo y học: "Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review" pdf
... Annals of General Psychiatry 2009, 8:16 the treatment of acute mania, the approval of quetiapine and the olanzapine-fluoxetine combination against acute bipolar depression and the approval of ... Sharma A, Kovalick LJ, Reeves RA: Pharmacokinetics and tolerability of intramuscular, oral and intravenous aripiprazole in healthy subjects and in patients with schizophrenia Clin Pharmacokinet ... efficacy of aripiprazole against acute mania and they report that the separation from placebo occurred as early as days to They also provide some support for its efficacy against mixed episodes and...
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Báo cáo y học: " Efficacy, safety and pharmacokinetic of once-daily boosted saquinavir (1500/100 mg) together with 2 nucleos(t)ide reverse transcriptase inhibitors in real life: a multicentre prospective study" ppt
... Infecciosas, Hospital Universitario Infanta Cristina, Badajoz, Spain Authors’ contributions Conception, design, analysis, interpretation of the data, drafting of the article and obtaining of funding: LFLC ... Community of Andalusia, and conducted according to the principles contained in the Declaration of Helsinki All patients gave an informed consent The patients’ inclusion was censored in May 2007 to allow ... maintenance therapy [23,24] We are aware that the open-label characteristics of the study, the heterogeneity of the analyzed population and the lack of available genotypic resistance tests in...
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Báo cáo y học: "Ablation of atrial fibrillation with the Epicor system: a prospective observational trial to evaluate safety and efficacy and predictors of success" pptx
... analysis Data were entered into a computerized database and analyzed with a statistical package (STATISTICA; StatSoft, Inc) The descriptive summary of data included mean ± standard deviation and 95% ... Postoperative protocol After surgery, all patients were treated with intravenous heparin and amiodarone With reconvalescence of the patient, anticoagulation (warfarin or coumadin) and antiarrhythmic ... therapy (amiodarone 200 mg/d) were switched to oral medication and maintained for months After months continuance of oral anticoagulation was determined on basis of the CHADS2 score In case of...
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Báo cáo y học: "Dose-associated changes in safety and efficacy parameters observed in a 24-week maintenance trial of olanzapine long-acting injection in patients with schizophrenia" pdf
... reports the results of post hoc analyses of a 24-week maintenance study of olanzapine LAI [2] examining the potential association between olanzapine LAI dose and several safety and efficacy parameters ... Statistical Analyses The primary objective of these post hoc analyses was to examine the potential relationship between different olanzapine LAI doses and changes in safety and efficacy parameters ... treated with oral olanzapine have found an association between olanzapine plasma concentrations and changes in some metabolic parameters [3,4], as well as differences in changes in efficacy and...
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Báo cáo y học: "Efficacy and safety of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema – a systematic review and meta-analysis" docx
... Poulton and colleagues [65] more than 60 years ago, and seven years ago the first meta-analysis appeared, showing the efficacy of CPAP in the treatment of ACPE [10] Since then, several RCTs comparing ... using any device) and medical therapy compared with standard medical therapy alone; use of NPPV (with any device) and medical therapy compared with standard medical therapy alone; or use of CPAP ... NPPV and SMT versus SMT alone; and NPPV and SMT versus CPAP and SMT Secondary aims were to analyze the impact of patients' baseline hypercapnia on the efficacy of CPAP and NPPV and to test a common...
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Báo cáo y học: " A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults" pdf
... from sites in North America, Thailand and Australia, between 2002 and 2005 Study material or placebo was administered in a 100 mL bag of normal saline Addition of IV ibuprofen to the bag for dilution ... and MA made substantial contributions to the conception and design of the study, acquisition of data and the interpretation of data PM and PW drafted the manuscript and PM, JP, KG, PW and MA revised ... Page of 13 Figure Mean ibuprofen concentrations (hour to 4), by treatment group and randomization stratum In a secondary analysis of efficacy, the efficacy of IV ibuprofen was analyzed by assessing...
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International consensus recommendations on the aesthetic usage of botulinum toxin type A (Speywood Unit) – part II: wrinkles on the middle and lower face, neck and chest pdf
... is at the medial side of the orbit, and is the smallest and the innermost part of the orbicularis oculi The palpebral portion raises the eyelid and controls the involuntary action of blinking The ... lines and drooping nasal tip Bunny lines refer to the wrinkles on the lateral part of the nose In some patients, the wrinkles also exist on the dorsal part of the the procerus, the nasalis and ... injection.31 Anatomy The masseter is the largest and strongest muscle functioning in mastication Its superficial portion originates from the zygomatic arch and inserts into the ramus of the mandible and the...
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Báo cáo sinh học: " Attenuation and efficacy of human parainfluenza virus type 1 (HPIV1) vaccine candidates containing stabilized mutations in the P/C and L genes" potx
... shut-off temperature is ≤40°C Evaluation of replication of viruses in AGMs and efficacy against challenge AGMs in groups of two to four animals at a time were inoculated intranasally (i.n.) and intratracheally ... increase the overall stability of the virus by increasing the total number of attenuating mutations present in the vaccine candidate To generate the two live attenuated HPIV1 vaccine candidates, ... laboratory is developing a live attenuated virus vaccine for HPIV1 for intranasal administration to infants and young children The intranasal route of administration is needle-free and has the...
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báo cáo hóa học: " Type D personality in the general population: a systematic review of health status, mechanisms of disease, and work-related problems" docx
... immunological mechanisms that may advance our understanding of biological pathways in non-clinical populations The presence of Type D personality may also be associated with health-related problems in the ... reactivity [11] Type D was also associated with a differential activity of the amygdala in reaction to fearful versus neutral face and body expressions Emotion-evoked activation of the amygdala ... systolic and diastolic blood pressure Page of 10 reactivity [11], and dampened heart rate reactivity during experimental stress Type D was also associated with a decreased activity in the amygdala in...
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Báo cáo sinh học: "Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety" ppt
... excretion of albumin and protein was measured before (day 1), during (days and 14), and and 14 days after HGF administration Repeated doses of rh-HGF induced an increase in urinary albumin excretion in ... Proc Natl Acad Sci USA 1994, 91:4357-4361 Morishita R, Aoki M, Hashiya N, Makino H, Yamasaki K, Azuma J, Sawa Y, Matsuda H, Kaneda Y, Ogihara T: Safety evaluation of clinical gene therapy using ... miniature swine, six to seven months of age, and male Wistar rats, seven weeks of age, were obtained from Japan Farm (Kagoshima, Japan) and Charles River Laboratories Japan Inc (Yokohama, Page...
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