relevance of endogenous 1 25 oh 2 d synthesis for growth control of normal and neoplastic colon epithelial cells
Báo cáo y học: "Effect of interleukin-1β on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function" pot
... Acknowledgements 17 18 19 This study was supported by grants 10 50099 and 10 7 011 5 from Fondecyt 20 References 10 11 12 13 Alamanos Y, Voulgari PV, Drosos AA: Incidence and prevalence of rheumatoid arthritis, ... Bull 19 92, 29 :2 21 - 22 3 Diem R, Hobom M, Grotsch P, Kramer B, Bahr M: Interleukin1beta protects neurons via the interleukin -1 (IL -1) receptormediated Akt pathway and by IL -1 receptor-independent decrease ... required for threshold activation of Cfiber evoked reflex responses in normal and monoarthritic rats treated with propentofylline (10 μg /10 μl daily) or saline (10 μl daily) during 10 days Saline...
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Báo cáo y học: " A suboptimal 5'''' splice site downstream of HIV-1 splice site A1 is required for unspliced viral mRNA accumulation and efficient virus replication" pptx
... µg of HP plasmid and µg of pCMVβgal 110 as previously described [ 12 ,15 ] To measure viral mRNA turnover, 29 3T cells were plated at a density of × 10 6 cells per 25 mL in a 15 cm dish 48 hours prior ... spliced viral mRNA, increased levels of env/vpu mRNA containing exon (1. 2. 5I, 1. 2. 3.5I, & 1. 2. 4I) and vif mRNA (1. 2I) were observed in NLD2UPtransfected cells compared to NL4-3-transfected cells ... and tat mRNA species containing exon (1. 2. 5.7, 1. 2. 3.5.7, 1. 2. 3.4b/a.7, & 1. 2. 4.7) was observed in NLD2UP-transfected cells when compared to NL4-3-transfected cells (Fig 1C, compare lanes and...
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Tài liệu Báo cáo khoa học: Comparison of membrane fraction proteomic profiles of normal and cancerous human colorectal tissues with gel-assisted digestion and iTRAQ labeling mass spectrometry pptx
... A -1 A -2 C -1 C -2 N T N T N T N T 11 4 11 5 11 6 11 7 11 4 11 5 11 6 11 7 B -1 N B -2 T N D -1 T N T D -2 N T 11 4 11 5 11 6 11 7 11 4 11 5 11 6 11 7 LC-MS/MS analysis iTRAQ Quantitation by Multi-Q 90 52 Dataset D 27 ... COL1A1 COL1A2 BGN OGN ACTA2 MYH 11 SURF4 PRG2 SEC11C GPSN2 STT3A S100A8 ITGB2 TSPAN8 VDAC1 HLA-DRA TRAM1 LBR TMEM109 ANXA4 SLC25A4 HLA-A1 SLC25A6 SLC25A5 ATP5H COX7C ATP5F1 MT-ND4 MT-CO2 MT-ND2 COX5B ... N D 374 T N D 403 T N T CLDN3 ACTIN B 2 51 N TAPBP ACTIN B 24 8 T B 2 51 B 13 2 T N B 24 6 N T N B 24 6 T HLA-A1 ACTIN N N B 24 7 T N B 24 8 T N B 24 7 N T N C 25 2 T B 13 2 T B 24 8 T N N C 24 5 T C 23 2...
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Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
... + H2O2 HSP70 -2 + H2O2 # # 0.5mM H2O2 Q2 Q1 Q2 Q1 Q2 Q4 Q3 Q4 Q3 Q4 10 2 10 3 10 4 10 0 10 1 45 40 35 30 25 20 15 10 10 2 10 3 Annexin V-FITC 10 4 10 0 10 1 10 2 10 3 10 4 * # O H + 2 O 70 SP H 70 SP H -2 + ... bp 10 1 Q2 Q1 Q2 Q1 Q4 Q3 Q4 Q3 10 0 bp Q2 Q3 10 2 Q1 Q4 HSP70 -1 + H2O2 HSP70 -2 + H2O2 10 4 pcDNA3 .1 + H2O2 10 3 PI HSP70 HSP70 MpcDNA3 .1 pcDNA3 .1 pcDNA3 .1 HSP70 -1 HSP70 -2 pcDNA3 .1 + H2O2 HSP70 -1 + ... HSP70ΔPBD + H2O2 0.5 Caspase-9 Caspase-3 pcDNA3 .1 B pcDNA3 .1 + H2O2 a b HSP70ΔATP-BD + H2O2 HSP70 + H2O2 c HSP70ΔPBD + H2O2 d e % Apoptotic cells 70 60 * 50 40 pcDNA3 .1 pcDNA3 .1 + H2O2 HSP70 + H2O2...
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báo cáo hóa học: " Muscle-driven forward dynamic simulations for the study of normal and pathological gait" potx
... National Science Foundation (BES- 013 4 21 7 ) http://www.jneuroengrehab.com/content/3 /1/ 5 References 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 Yamaguchi GT: Dynamic Modeling of Musculoskeletal ... Biomech 20 05, 38: 21 8 1- 21 8 9 Thelen DG: Adjustment of muscle mechanics model parameters to simulate dynamic contractions in older adults J Biomech Eng 20 03, 12 5:70-77 Lloyd DG, Besier TF: An EMG-driven ... optimization of human walking J Biomech Eng 20 01, 12 3:3 81- 390 Davy DT, Audu ML: A dynamic optimization technique for predicting muscle forces in the swing phase of gait J Biomechanics 19 87, 20 :18 7 -2 01 Yamaguchi...
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Báo cáo khoa học: "Infrared spectroscopy characterization of normal and lung cancer cells originated from epithelium" pdf
... 1, 029 , 1, 056, 1, 118 , and 1, 155 cm 1 These bands could be correlated as carbohydrates or glycoconjugates In addition, the νas(PO2 ) band at 1, 23 5 cm 1 can be decomposed to the two bands at 1, 2 21 ... (NCI-H358) Cancer cells (NCI-H460) 1. 00 0. 814 0 . 12 4 0 .16 8 0 .16 8 0 .27 4 0.0 318 1. 00 0. 815 0 .16 8 0 .17 1 0 .23 4 0.556 0 .14 0 1. 00 0.8 81 0 .15 2 0 .19 1 0 .2 31 0. 426 0.0686 Assignment* Amide I Amide II Methyl ... (NCI-H358) Cancer cells (NCI-H460) 1, 649 1, 548 1, 456 1, 400 1, 23 5 1, 084 9 72 1, 648 1, 549 1, 456 1, 399 1, 23 6 1, 086 970 1, 645 1, 548 1, 456 1, 400 1, 23 9 1, 085 9 71 Assignment ‡ Amide I Amide II Methyl groups...
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Báo cáo y học: "Heterogeneity of CD4+ and CD8+ memory T cells in localized and generalized Wegener’s granulomatosis." potx
... CD62L Upregulated CCR5 and CCR3 expression on CD4+CD45RO+ and CD8+CD45RO+ and also on CD4+CD45RA+ and CD8+CD45RA+ T cells indicates activation and the potential to respond to chemotactic gradients ... regarded as significant Results CD45RA+ and CD45RO+ T cells express CCR3, CCR5 and CXCR3 The median CD4+/CD8+ T cell ratio was 2. 5 (range 1. 1–4.4) in localized WG, and 1. 1 (0.6 2. 6) in generalized ... [22 ] demonstrated that cytomegalovirus-specific T cells, that is, antigen-experienced T cells, are found within the fractions of CD27+CD28– and CD27–CD28– T cells These cells either express CD45RA...
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Báo cáo y học: "Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells" pps
... immunization By day 5, 20 out of the 25 mice developed signs of arthritis and were randomly allocated to two groups of 10 mice each: an experimental group and a control group From days to 18 , 10 0 µg DHMEQ ... expressed as the mean ± standard deviation of the total scores of 10 mice in each group, determined by five independent observers added and 14 hours later the cells were washed with PBS, detached by ... 0 10 µg/ml DHMEQ was added followed 20 minutes later by addition of ng/ml TNF-α and µCi/ml [3H]thymidine The cells were further cultured for 48 hours and incorporation of 3H during the last 24 ...
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Báo cáo y học: "Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathie" doc
... IP10 and Mig production by glomerular cells in human prolifera- Page 13 of 14 (page number not for citation purposes) Arthritis Research & Therapy 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 ... of 17 5 cm2) were induced by combined treatment with IFN-γ (20 ng/ml), LPS (5 µg/ml) and double-stranded RNA (10 µg/ml) for 96 hours to obtain maximal production of CXCL10 [11 ] The conditioned ... and their role in immunity Immunity 20 00, 12 : 12 1 - 12 7 Rot A, von Andrian UH: Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells Annu Rev Immunol 20 04, 22 :8 91- 928 ...
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Báo cáo y học: "Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reacti" potx
... -3. 31 1.00 10 0.5 COL9A3 26 .3 32. 7 -3 .22 1. 00 10 4.8 CSPG2 21 . 4 34.3 -3 .25 1. 00 10 3 .2 CTSB 19 .7 32. 6 -3 .24 1. 00 10 3.3 CTSD 24 .1 34 .2 -3 .29 1. 00 10 1.5 DCN 19 .0 31. 9 -3 .25 1. 00 10 3.0 GAPDH 22 .7 35 .2 ... 0.99 10 0 .2 AGC 18 .5 34.7 -3 .29 0.99 10 1.5 BGN 20 .8 34.8 -3.49 1. 00 93.3 COL1A2 17 .4 33.5 -3.30 1. 00 10 1.0 COL2A1 22 .7 32. 2 -3 .22 1. 00 10 4.6 COL3A1 16 .5 33.0 -3.33 1. 00 99.9 COL5A1 23 .2 33 .1 -3. 31 ... 0.9 91 CSPG2 27 0.079 0 .27 9 2. 530 0.0005 0.9 81 COL5A1 28 0. 615 2 .18 8 2. 555 0.0069 0.887 COL3A1 26 10 .573 37.867 2. 5 81 0.0 011 0.9 82 COL1A2 28 0.805 6.9 41 7.6 21 0.0043 0.737 MMP13 26 0. 014 0 .16 1 10 . 322 ...
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Báo cáo y học: "Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport" doc
... the immunofluorescence assays and drafted the manuscript; JLB and MS: conceived the envelope-derived tagged ligands while; JLB, HA, ML and JT: generated, optimized and produced these ligands; SB: ... labelled for GLUT1 The Purkinje cells were irregularly labelled for GLUT1 (Figure 1F), PiT1 and PiT2 (Figure 2D) Regional GLUT1, PiT1 and PiT2 distribution in the brain of MPTP-intoxicated mice ... peptide, the RBD and the proline-rich region, to the rFc tag, herein, referred to as GRBD HRBD, AmphoΔSU and GRBD tagged ligands, and control conditioned medium were produced by transfecting 29 3T...
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báo cáo khoa học: "Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251" pdf
... control: 19 9.46 ± 32 .11 and Ad-GFP: 19 6.99 ± 25 . 24 ; 48- 72 h: control: 2 61. 74 ± 21 . 47 and Ad-GFP: 25 8 .50 ± 14 . 21 ) (Figure 3A) In contrast, the IL-6 level in the Ad-bFGFsiRNA group, although increased ... Foundation of China (3067 21 5 8, 811 019 11) and the Tianjin Science and Technology Committee (11 JCYBJC1 21 0 0) Author details Graduate school, Tianjin Medical University (22 # Qixiangtai road Hexi District), ... molecules and the expression of downstream molecules of STAT3 in U2 51 cells (A) Ad-bFGF-siRNA (MOI = 10 0) reduces the phosphorylation/activation of ERK1 /2 and JAK2 in a time-dependent manner in U2 51 cells...
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Báo cáo y học: "Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes" pdf
... GNG 11 0.57 3 31. 31 29 8 .19 1. 65 -18 1.06 podocalyxinlike PODXL 0.50 29 7 .24 20 8.74 1. 14 -18 2. 62 proteoglycan PRG4 917 .06 27 .09 722 .28 3 .25 -22 2.06 Minogue et al Arthritis Research & Therapy 2 010 , 12 :R 22 ... 6053.50 29 86.89 27 86.96 -2 .17 -1. 07 -1. 78 matrix Gla protein MGP 8480. 52 77 42 .10 28 65.30 -2. 96 -2. 70 -3. 21 alpha-2macroglobulin A2M 9.49 26 . 62 11 .37 1. 20 -2. 34 -1. 77 annexin A4 ANXA4 12 23 . 21 2 318 .40 ... 2 318 .40 12 73 .29 1. 04 -1. 82 -1. 55 desmocollin DSC2 1. 88 14 0. 72 68 .18 36.30 -2. 06 -1. 22 keratin 18 KRT18 0. 01 0.04 94 .10 15 990.45 26 47.60 18 60.77 neural cell adhesion molecule NCAM1 0.76 0.94 12 .64 16 .55...
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Báo cáo y học: " Phenotypic characteristics of human type II alveolar epithelial cells suitable for antigen presentation to T lymphocytes" pptx
... Research 2 011 , 12 :15 http://respiratory-research.com/content / 12 /1/ 15 24 25 26 27 28 29 30 31 32 33 34 35 36 37 Page of induction of HLA class I by interferon-gamma Placenta 19 91, 12 (3): 21 7 -22 6 Creery ... Research 2 011 , 12 :15 http://respiratory-research.com/content / 12 /1/ 15 the A549 cell line and the freshly isolated AECII expressed CD54 and CD58 with a higher level of expression of CD54 and a lower ... critically read the manuscript and approved its submission Page of 9 10 11 12 13 14 15 16 17 18 19 20 Competing interests The authors declare that they have no competing interests 21 Received: 14 September...
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Báo cáo y học: " Anti-inflammatory effects of antibacterials on human bronchial epithelial cells" pdf
... mg/l 62. 5 mg/l 62. 5 mg/l + + + - n = 11 n = 17 n = 11 n = 11 n = 11 n = 17 n = 11 n = 11 n = 11 n = 11 n = 10 n = 10 AZM 0.5 mg/l 1. 0 mg/l 1. 5 mg/l 1. 5 mg/l + + + - n = 12 n = 12 n = 12 n = 11 n ... n = 10 n = 10 n = 10 n=8 n = 10 n = 11 n = 11 n = 11 LVX mg/l mg/l mg/l mg/l + + + - n = 12 n = 16 n = 11 n = 10 n = 11 n = 18 n = 11 n = 11 n = 11 n = 11 n = 11 n = 11 MXF mg/l mg/l mg/l 16 mg/l ... + + + - n = 24 n = 25 n = 23 n = 14 n = 11 n = 22 n = 23 n = 23 n = 14 n = 11 n = 14 n = 11 n = 14 n = 11 Page of (page number not for citation purposes) Respiratory Research 20 09, 10 :89 http://respiratory-research.com/content /10 /1/ 89...
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Báo cáo y học: " Computer simulation analysis of normal and abnormal development of the mammalian diaphragm" doc
... Acad Sci U S A 20 03 Jul 8 ;10 0 (14 ):8607] Proceedings of the National Academy of Sciences of the United States of America 20 03, 10 0(9):5 21 7 - 522 2 Crick F: Diffusion in embryogenesis Nature 19 70, 22 5( 52 31) : 420 - 422 ... not achieved Page 12 of 17 (page number not for citation purposes) Theoretical Biology and Medical Modelling 20 06, 3:9 E 11. 5 E 12 http://www.tbiomed.com/content/3 /1/ 9 E 12. 5 E13 Figure 13 Simulation ... and nitrofeninduced CDH Comparable embryonic stages are as follows: mouse (rat) – 11 .5 (13 ), 12 (13 .5), 12 .5 (14 ), 13 (14 .5), 13 .5 (15 ), 14 (15 .5) Footnote 3: Nudge++™ is used under license from...
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Epigenetic regulation of normal and malignant hematopoiesis
... AF10 and AF4, MLL-AF10, MLL-AF4 (associated with T-ALL and AML) NSD1 NSD2/MMSET SUV 420 H1 SUV 420 H2 H4K20 (À) me1/me2 t(5 ;11 ) associated with AML t(4 ;14 ) associated with multiple myeloma me1/me2 ... basis of sequence and domain similarity, and include Class I HDACs (HDAC1–3 and HDAC8), which possess homology to yeast Rpd3 and are localized to the nucleus; Class II HDACs (HDAC4–7, HDAC9 and 10 ), ... role mediated by RIZ1 The NSD family of SET domains includes NSD1, MMSET (NSD2) and NSD3 (Stec et al., 19 98) NSD1, which methylates H3K36 and H4K20 residues, is implicated in AML as a result of the...
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Quantification of epidermal growth factor receptor dynamics and interactions in living cells by fluorescent correlation and cross correlation spectroscopy
... "Phosphatidylserine dynamics in cellular membranes.", Mol Biol Cell 2 0 12 Jun ;23 (11 ): 21 9 8- 21 2 Epub 2 0 12 Apr 11 Ma X, Ahmed S, Wohland T "EGFR activation monitored by SW-FCCS in live cells" , Front ... 10 1. 1.5 EGFR in the nucleus 13 1. 1.6 Dimerization of EGFR 14 1. 1.7 EGFR and lipid raft 16 1. 1.8 EGFR and the cytoskeleton 22 1. 2 Other members of ... al 19 95) Among them, domain L1 and L2 consist of β-helix folds, and shares 37% amino acid identity CR1 and CR2, as indicated by the names, are rich in cysteine CR1 domain forms disulfide bonds...
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A study into the different mechanisms of anti cancer effect of docosahexanoic acid in colon cancer cells
... Effect of JNK mutants on DHA-induced cell death 52 4 .2. 2 Role of ROS in DHA induced cell death 53 4 .2. 2 .1 Generation of ROS by DHA 53 4 .2. 2 .2 Effect of antioxidants and H2 02 on DHA-induced MAPK ... 1. 6 .2 PPARγ and colon cancer 22 1. 6.3 PUFAs and PPARs 23 1. 7 Objectives of the Study 24 CHAPTER II: MATERIALS AND METHODS 25 2 .1 Cell lines and chemicals 26 2. 2 Cell culture and fatty acid supplementation ... 19 88; Reddy and Maruyama, 19 86a; Reddy and Sugie, 19 88) whereas saturated fats and n-6 PUFA rich diets enhance tumor production (Reddy and Maeura, 19 84; Reddy and Maruyama, 19 86b) In addition,...
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Báo cáo y học: "Effect of 1,25-dihydroxy-vitamin D3 in experimental sepss"
... a LPS +1, 25 vit -D 20 8 ± 21 4 a 12 ,0 ± 0 ,2 12 ,2 ± 0,7 11 ,4 ± 0,4 a 12 ,0 ± 0,4 53 ± 53 ± 12 4 ± 16 7 94 ± 24 a 0,68 ± 0 ,29 0, 62 ± 0 ,27 1, 77 ± 1, 10 2 , 12 ± 0,53 a 41 ± 46 ± 19 44 ± 57 ± 11 8 ,2 ± 0,5 ... 6 31 ± 48 Shamoperation + 1, 25 vit -D 5 51 ± 53 CLP +vehicle CLP + 1, 25 vit -D 647 ± 95 Control + 1, 25 vit -D 606 ± 13 9 418 ± 49 b 515 ± 53 c 12 ,0 ± 0 ,2 12 ,2 ± 0,7 11 ,4 ± 0,6 11 ,0 ± 0,8 12 ,5 ± 1, 2 12 ,7 ... 10 56 ± 19 6 Control + 1, 25 vit -D 980 ± 26 0 LPS + vehicle 10 480 ± 80 a LPS + 1, 25 vit -D 10 415 ± 63 a 21 , 4 ± 3,5 17 ,9 ± 2, 0 29 ,8 ± 6 ,1 26 ,6 ± 3,6 a 53 ± 18 78 ± 30 66 ± 93 ± 33 Int J Med Sci 20 07,...
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