questions 2 and 3

Considering mechanistic data to assess mode of action or human relevance

... Margin of Exposure 49 Figure 3: Implications for Dose-Response Analysis 450 Key Event N7-HPG (fmol/ug DNA) 400 DNA Adducts 35 0 30 0 25 0 20 0 150 100 Rat Mouse 50 0 100 20 0 30 0 400 500 Fold Increase ... Response 35 Evaluation of Human Relevancy (Questions and 3. ) • Are the same key events operative in humans? • Are there similarities or differences [qualitative (Q .2) /quantitative (Q .3) ] in the ... of Ottawa 31 Dose – Response and Temporality Temporal Dose (mg/kg bw/day) 0 .2 (2 ppm) (10 ppm) (40 ppm) Dose-Response Key event Key event Key event + + weeks 52 weeks ++ ++ + weeks 52 weeks 107...

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Báo cáo y học: " Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using modelbased approaches" ppt

Danh mục: Báo cáo khoa học

... Parallel-group, 12- week 32 3 1 63 Parallel-group, 12- week 31 8 159 Parallel-group, 12- week 5 52 92 91 94 92 7476 92 91 546 135 8 66 66 420 65 20 5 33 5 33 4 160 159 91 136 9 551 22 49 92 558 5 63 420 All studies ... and B 235 6) Design Indacaterol dose, μg Patients 18.75 37 .5 75 150 Pbo 30 0 Cross-over, 14-day 96 144‡ Parallel-group, 52- week 17 32 437 428 418 1 23 130 420 For Sal Tio 600 72 72 4 32 435 425 1 23 Parallel-group ... parameters Emax (mL) 177 13 1 52 176 20 6 ED50 (μg) 28 10 12 26 52 110 41 46 105 20 7 Derived parameters ED90 (μg) Effect as percentage of maximum effect 18.75 μg 42 27 42 62 37 .5 μg 59 42 59 76 75 μg 74...

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Báo cáo sinh học: " In vivo dose-response of insects to Hz-2V infection" pptx

Danh mục: Điện - Điện tử

... virus, Hz-2V, infecting agonadal female corn earworms, Helicoverpa zea J Invertebr Pathol 20 02, 81 :33 -44 Rallis CP, Burand JP: Pathology and ultrastructure of the insect virus, Hz-2V, infecting ... second set of primers (P4 -3, 5'-GCTGTGCTGTACAAGTGC -3' ; and P4-4, 5'-CCCTTGACGATCCCTTTTG3') was designed to amplify a 35 0 bp region directly interior to that of the P4-1 and P4 -2 amplified sequence ... High Prime DNA Labeling and Detection Kit, with 1X concentrations of Taq Polymerase buffer (100 mM Tris-HCl pH 8.0, 500 mM KCL pH 8 .3, and 25 mM MgCL2), 100 pM of both P4 -3 and P4-4 primers, a hexanucleotide...

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báo cáo hóa học:" In vivo dose-response of insects to Hz-2V infection" pdf

Danh mục: Hóa học - Dầu khí

... virus, Hz-2V, infecting agonadal female corn earworms, Helicoverpa zea J Invertebr Pathol 20 02, 81 :33 -44 Rallis CP, Burand JP: Pathology and ultrastructure of the insect virus, Hz-2V, infecting ... second set of primers (P4 -3, 5'-GCTGTGCTGTACAAGTGC -3' ; and P4-4, 5'-CCCTTGACGATCCCTTTTG3') was designed to amplify a 35 0 bp region directly interior to that of the P4-1 and P4 -2 amplified sequence ... High Prime DNA Labeling and Detection Kit, with 1X concentrations of Taq Polymerase buffer (100 mM Tris-HCl pH 8.0, 500 mM KCL pH 8 .3, and 25 mM MgCL2), 100 pM of both P4 -3 and P4-4 primers, a hexanucleotide...

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Báo cáo y học: "Extent of exposure to environmental tobacco smoke (ETS) and its dose-response relation to respiratory health among adults" doc

Danh mục: Báo cáo khoa học

... (20 .9) 1 131 (55.5) 4 82 ( 23 .7) 25 7 ( 23 .0) 578 (51.7) 28 3 (25 .3) mean ± SD mean ± SD 6.5 ± 3. 3 6.7 ± 3 .2 3. 3 ± 1.8 3 .2 ± 2. 5 3. 5 ± 1.9 3 .2 ± 2. 5 Household density (household/rooms) 2. 2 ± 1 .3 2. 2 ... Dose-response 1 .3 (0.8–1.9) 1.6 (1.1 2. 3) 1.8 (1 .2 2. 7) 3. 0 (1 .3 6.8) 1.9 (1 .2 2. 9) 1.7 (1.1 2. 6) 2. 0 (1 .3 3 .2) 2. 6 (1.1–6 .3) 0.004 0.001

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Báo cáo y học: " Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy" ppsx

Danh mục: Báo cáo khoa học

... 0.09 3. 0E-5 0.480 2. 9E-5 nc 3. 2E0 Liver 0 .22 3. 4E -3 0. 32 3 0 .29 2. 6E-5 0 .24 3 3.4E-5 0.798 4.5E -2 Cervix 1.9 5.4E-4 nc 6.2E-1 nc 6.2E-1 Bladder Skin nc 0 .21 9 0.06 1.9E-5 1.1 2. 5E -3 nc 5.8E-1 0 .21 3 ... Biophys 20 04, 43 :22 5 - 23 1 Page 20 of 21 Schneider et al Theoretical Biology and Medical Modelling 20 11, 8 :27 http://www.tbiomed.com/content/8/1 /27 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 ... 0.46 (0.04 1. 43) 0.70 (0 . 23 1 .31 ) -0.61 -0. 024 ‡ 4 .36 2. 38 ‡ Thyroid 1 .2 (0.5 2. 2) 0.40 (0 .2 0.8) -0.046 0.6 Salivary Gland◇ 0.56 (0 .2 1 .2) 0. 73 (0 .26 1.6) -0. 024 ‡ 2. 38 ‡ - - -0.0 13 -0.56‡ ‡ -0.56‡...

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Approaches to Establish a Modeling WWTP with a Case Study in Qinghe WWTP

Danh mục: Môi trường

... Heijnen J.J (20 01) Metabolic modelling of full-scale biological nitrogen and phosphorus removing WWTP’s Wat Res 20 01 35 (11): 27 11 -27 23 (ix) Schutze M., Butler D., and Beck M B (20 02) Modelling, ... Activated sludge model No.2d, ASM2d Wat Sci Tech 1999 39 (1): 165-1 82 IAWQ (v) Henze M., Gujer W., Mino T and van Loosdrecht M (20 00) Activated sludge models ASM1, ASM2, ASM2D and ASM3 IWA Publishing, ... Science, 20 01 21 (4): 35 9 -36 1 (vii) Liu Y.Z (20 02) How to raise fund for urban sewage treatment in China Acta Universitatis Nankaiensis 20 02 35 (1):111-116 (viii) Meijer S.C.F., Van loosdrecht M.C.M and...

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Slide an investigation into some approaches to vocabulary teaching and learning and the application of games in teaching and learning vocabulary at pre – intermediate level at foreign language center – haiphong university

Danh mục: Khoa học xã hội

... d 76.6% 5.5% 14.4% 3. 3% 45.5% 17.8% 21 .1% 15.5% 42. 2% 41.4% 12. 2% 4.4% 25 .2% 13. 3% 34 .4% 26 .6% Options Questions Table 7: Learners’ reaction, their progress and expectation 1.What you think of ... Teachers and teaching methods 2. 3 Material and material assessments Part two: Development Chapter three: Data collection, findings and disscusion, some suggestions 3. 1 Data collection 3 .2 Findings and ... use 1.1.5 Form of words 1 .2 Vocabulary in language teaching and learning 1 .2. 1 A neglect aspect of foreign language methodology 1 .2. 2 Ineffective vocabulary learning 1 .2. 3 The status of vocabulary...

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Tài liệu Community Approaches to Child Health in Malawi: Applying the Community Integrated Management of Childhood Illness (C-IMCI) Framework docx

Danh mục: Sức khỏe trẻ em

... health facility within 24 hours 28 % 64% 21 % 31 % Modern family planning usage 23 % 61% Baer, Frank, Final Evaluation of the Tiweko Tose Child Survival Project, July 26 – August 5, 20 04, World Relief ... Multi-Country Evaluation of IMCI: Effectiveness, Cost and Impact Progress Report May 20 02 April 20 03 Department of Child and Adolescent Health and Development — World Health Organization Community ... Walker L., Pearcy K (20 02) An implementation framework for household and , community integrated management of childhood illness Health Policy and Planning, 17 (4): 34 5 35 3 Community Approaches...

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Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modiﬁcations ppt

Danh mục: Báo cáo khoa học

... FEBS Journal 27 5 (20 08) 1949–1959 ª 20 08 The Authors Journal compilation ª 20 08 FEBS D P Gamblin et al 20 21 22 23 24 25 26 27 28 29 30 31 B, Mitchell T et al (20 04) Engineering of an artiﬁcial ... structures such as the biantennary structure GlcNAc2Man5GlcNAc2 [20 ] and its extended variants Gal2GlcNAc2Man3GlcNAc2 [19] and Sia2Gal2GlcNAc2Man3GlcNAc3 [21 ] An alternative approach exploits ‘misacylated’ ... 100, 126 30 – 126 35 61 Sinensky M (20 00) Functional aspects of polyisoprenoid protein substituents: roles in protein–protein interaction and trafﬁcking Biochim Biophys Acta 1 529 , 20 3 20 9 62 Gomes...

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Tài liệu A Comparison of Approaches to Large-Scale Data Analysis pdf

Danh mục: Cơ sở dữ liệu

... 1400 6000 seconds seconds 120 0 1000 800 10 Nodes Vertica 25 Nodes DBMS−X ← 85.0 ← 36 .1 ← 29 .4 ← 31 .3 ← 29 .2 ← 28 .0 ← 28 .2 ← 21 .5 ← 15.7 Nodes ← 31 .9 20 00 400 4000 30 00 600 20 0 5000 50 Nodes 100 Nodes ... ﬁle, and redistributes that tuple to a dif- Nodes 10 Nodes Vertica 25 Nodes 50 Nodes ← 4 520 .8 ← 4486 .2 ← 4445 .3 ← 436 9.8 10000 5000 ← 22 62. 2 ← 75.5 ← 67.7 ← 76.7 ← 75.5 10000 ← 17.6 40000 20 000 ... Machine In VLDB ’86, pages 20 9 21 9, 1986 S Ghemawat, H Gobioff, and S.-T Leung The Google File System SIGOPS Oper Syst Rev., 37 (5) :29 – 43, 20 03 M Isard, M Budiu, Y Yu, A Birrell, and D Fetterly Dryad:...

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Tài liệu Báo cáo khoa học: Combinatorial approaches to protein stability and structure pdf

Danh mục: Báo cáo khoa học

... Biochem 27 1, 1 6 23 –1 629 61b Watters, A.L & Baker, D (20 04) Searching for folded proteins in vitro and in silico Eur J Biochem 27 1, 1615–1 622 62 Distefano, M.D., Zhong, A & Cochran, A.G (20 02) Quantifying ... USA 94, 4 937 –49 42 37 Roberts, R.W & Szostak, J.W (1997) RNA-peptide fusions for the in vitro selection of peptides and proteins Proc Natl Acad Sci USA 94, 122 97– 1 23 02 38 Stevens, R.C (20 00) High-throughput ... folding reporter Methods Mol Biol 23 0, 34 3 35 9 48 Waldo, G.S (20 03) Genetic screens and directed evolution for protein solubility Curr Opin Chem Biol 7, 33 38 49 Maxwell, K.L., Mittermaier, A.K.,...

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Tài liệu Báo cáo khoa học: Computational approaches to understand a-conotoxin interactions at neuronal nicotinic receptors doc

Danh mục: Báo cáo khoa học

... complex [15], a4b2 nAChR neuronal subtype of human [26 ], rat [ 23 ], and a3b2 and a4b4 nAChR neuronal subtype of human [26 ] 23 30 S Dutertre and R J Lewis (Eur J Biochem 27 1) Ó FEBS 20 04 Fig Sequence ... Ca2+-binding sites Proc Natl Acad Sci USA 99, 32 1 0– 32 1 5 Ó FEBS 20 04 23 34 S Dutertre and R J Lewis (Eur J Biochem 27 1) 24 Samson, A., Scherf, T., Eisenstein, M., Chill, J & Anglister, J (20 02) ... Neurobiol 53, 431 –446 Sine, S.M., Wang, H.L & Bren, N (20 02) Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain J Biol Chem 27 7, 29 210 29 2 23 Wang,...

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Asset based approaches to poverty reduction moser 2

Danh mục: Quản trị kinh doanh

... needs, human security and social integration ISBN: 0-979 037 6-0 -3 The Brookings Institution 1775 Massachusetts Ave, NW Washington, DC 20 036 Phone: (20 2) 797-6000 Fax: (20 2)797-6004 www.brookings.edu/global ... Globalized Context 27 th – 28 th June 20 06 Washington DC Tuesday 27 th June 9.00–9 .30 Welcome and workshop objectives Lael Brainard, Vice President and Director, Global Economy and Development Center, ... negative changes (Carter and Barrett 20 05; Barrett and Carter 20 05) This section draws on Moser (1998) See also Davies (19 93) , Devereux (19 93) , Maxwell and Smith (19 92) Vulnerability is deﬁned...

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Tài liệu Rubber Planting in Laos: Local Approaches to New Challenges ppt

Danh mục: Lâm nghiệp

... (see Haberecht 20 09 :21 ff.; Lao People‟s Democratic Republic 20 03: 29 ; Neudorfer 20 07; UNDP 20 08, ) Since the end of the Cold War, the Laotian government has changed its course and has aspired ... such as deterioration of watersheds and deforestation Slash -and- burn farming, animal husbandry, hunting and gathering, wet-land and dry-land rice cultivation, and livestock cultivation not guarantee ... risks, the farmers‟ livelihoods are diverse: slash -and- burn farming, animal husbandry, hunting and gathering, wet-land and dry-land rice cultivation, and livestock breeding are important sources of...

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Tài liệu Status Report on The Application of Integrated Approaches to Water Resources Management ppt

Danh mục: Cao đẳng - Đại học

... 1990) InIn the years 20 12 – 20 13 UN-Water also publishes: the years 20 12 – 20 13 UN-Water also publishes: In the years 20 12 – 20 13 UN-Water also publishes: In the years 20 12 – 20 13 UN-Water also publishes: ... 133 6 Percentage Percentage responded responded within each of total category Number 69% 30 HDI Groupings Low HDI 32 71% 24 % Medium HDI 31 66% 23 % High HDI 36 75% 27 % 10 Very High HDI 34 72% ... INSTRUMENTS 19 20 23 24 26 26 29 4.1 Progress with management instruments 4 .2 Management instruments and the integrated approach 4 .3 Summary of progress on applying management instruments 35 39 DEVELOPING...

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A Review of Approaches to Mobility Telemonitoring of the Elderly in Their Living Environment potx

Danh mục: Sức khỏe người cao tuổi

... maintain and operate them TABLE Summary of wearable systems discussed Author Mathie and Celler5 ,22 , 23 ,25 Prado 43, 44 Wilson and Dadd 12, 59 Noury et al. 32 (VTAMN) Sarela46 CSIRO PERSiMON41 N´ Scanaill30 ... EMBS, vol 2, pp 13 72 137 5, 20 03 45 Sabatini, A M., V Genovese, and E S Maini Portable system for data acquisition and transmission based on handheld PC technology Electron Lett 38 :1 635 –7, 20 02 46 ... biomechanical and physiological data regardless of subject location Wearable sensors can be integrated into clothing10, 32 , 38 and jewelry,1,46 or worn as wearable devices in their own right.5 ,22 , 23 ,25 ,30 ,45...

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Continuing Challenges and Potential for Collaborative Approaches to Education Reform pot

Danh mục: Cao đẳng - Đại học

... Location 20 04 20 05 20 06 20 07 20 08 20 09 Total Austin 26 24 15 19 92 Chicago 22 16 12 17 74 Jackson 21 14 17 17 78 Puerto Rico 38 5 25 17 N/A 90 Washington, D.C 12 20 12 14 61 119 21 79 81 28 67 39 5 ... Santa Monica, CA 90407 -21 38 120 0 South Hayes Street, Arlington, VA 22 2 02- 5050 4570 Fifth Avenue, Suite 600, Pittsburgh, PA 1 521 3 -26 65 RAND URL: http://www.rand.org To order RAND documents or to ... 99 Tables 1.1 1 .2 2.1 3. 1 4.1 4 .2 4 .3 Collaboratives’ Original Descriptions, 20 03 20 05 Plans CERI Sites Started with Significant Variation...

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Đề tài " Classical and modular approaches to exponential Diophantine equations I. Fibonacci and Lucas perfect powers " pdf

Danh mục: Thạc sĩ - Cao học

... 100 and put K = mLa1 a2 a3 , with 10 < m < 50, and take R1 = c1 L2 /3 a2 a3 , S1 = c1 L2 /3 a1 a3 , T1 = c1 L2 /3 a1 a2 , with c1 = ( 32 . 001 m2 )1 /3 , and ﬁnally R2 = c2 La2 a3 , S2 = c2 La1 a3 , T2 ... 1) KK0 (K0 + 1)(K0 + 2) = + − 4K K0 + N 6N N2 2( 2K − 3) 2( K − 1)(2K − 1) = 1+ + − 4K 2K − KL 3K L2 N2 1+ + = − − − + 2 4K L 2K − 3L KL KL 3K L2 N2 4 ≥ − 1+ + − , 4K L 2K − 3L2 KL KL(N − |I|) + ... b with a2 + b2 = y and ±4i = (2 + i)(a + ib)p − (2 − i)(a − ib)p (27 ) Dividing by 2i, we get [p /2] 2 = k=0 [p /2] + k=0 p a2k (−1)(p−2k−1) /2 bp−2k 2k p a2k+1 (−1)(p−2k−1) /2 bp−2k−1 2k + We...

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Social determinants approaches to public health: from concept to practice docx

Danh mục: Sức khỏe trẻ em

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