quantitative mr imaging of cartilage morphology in osteoarthritis
Báo cáo y học: "Quantitative ultrasonic assessment for detecting microscopic cartilage damage in osteoarthritis" pptx
... (Fig 4b) Histological findings Representative sections of collagenase-digested cartilage stained with Safranin-O are shown in Fig In control cartilage, the Safranin-O staining of the extracellular ... of degeneration time, Safranin-O staining became less intense in the deeper layers In vivo study Macroscopic and histological findings Figure shows the macroscopic and histological findings of ... for clinical use, but the rod of the instrument (5 mm in diameter) is too thick to evaluate the cartilage in all regions of knee joints or the cartilage in ankle and wrist joints [21] In contrast,...
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Báo cáo y học: "Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow" doc
... and include activating or increasing the level of factors able to inhibit proinflammatory cytokines or other catabolic factors Interleukin-1β For specific inhibition of the production/activity of ... efficacy of long-term intra-articular steroid injections in OA of the knee in a randomized, double-blind, placebo-controlled setting The patients received intra-articular injections of triamcinolone ... in cartilage These findings are in accordance with a study conducted in the dog ACL model in which Licofelone, a dual inhibitor of 5-lipoxygenase and COX activity, inhibited the development of...
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Báo cáo y học: "Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study" docx
... dysfunction in RA-related destruction of cartilage The induction of numerous cytokines/chemokines fits into the scenario of molecular changes occurring in RA cartilage Although mature articular cartilage ... producers of IL-6 and CXCL8 Expression of IL-6 in synovial fluid correlates with markers of inflammation, and blockade of IL-6 signaling is effective in prevention and treatment in models of inflammatory ... role in the development of osteoarthritis [59] In addition, testican 1, an inhibitor of MMP activation that has been described as having an important role in matrix turnover in osteoarthritis cartilage, ...
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báo cáo khoa học: " Computed tomography imaging of subpleural lipoma in two men: two case reports" potx
... the editing of the manuscript OFD was responsible for creating the figure files SL contributed to the editing and writing of the manuscript All authors read and approved the final version of the ... entities since the only key finding might be the mitosis rate of the tumor cells [2] However, CT is able to depict potential invasion of adjacent structures such as the ribs or the soft tissue of the ... attacks of bronchitis Discussion Before the implementation of computed tomography in diagnostic medical imaging, most subpleural lipomas were detected during autopsies or incidentally during thoracic...
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báo cáo khoa học:" Evaluation of health outcomes in osteoarthritis patients after total knee replacement: a two-year follow-up" ppsx
... National University of Singapore, Singapore 6Department of Community, Occupation, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore Authors’ ... functional outcome of 100 [26] Statistical analyses In order to determine the difference in demographic characteristics of the patients participating in baseline interviews compared to those in post-surgery ... stair-climbing and makes deductions for use of a walking aid, with 100 representing unlimited walking distance and normal stair-climbing without use of an aid Page of The OKS, a procedure- and joint-specific...
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Báo cáo thú y: "Survey radiography and computerized tomography imaging of the thorax in female dogs with mammary tumors" pot
... lymphatic drainage in the other mammary chain Four female dogs (Cases 1, 3, and 21) had already been spayed Before the imaging examinations in all female dogs, fine-needle aspiration cytology of the ... The dogs were maintained in spontaneous breathing during CT examination due to the type of anesthesia used However, the images obtained during the apneic period and at the inspiration peak are ... TW 2007, 729-735 24 25 26 Sorenmo KU, Shofer FS, Goldschmidt MH: Effect of spaying and timing of spaying on survival of dogs with mammary carcinoma J Vet Intern Med 2000, 14:266-270 Chang SC, Chang...
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Báo cáo khoa học: "Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study" docx
... villi of the small intestine Orthogonal polarization imaging of a repeating vascular structure; the villi of the small intestine Objective 5×, on screen 325× method has yet been validated in terms ... part of treatment of an abdominal sepsis OPS imaging was performed both in the sublingual region and in a stoma during the intensive care unit stay on days 1, and after the surgical procedure In ... versatile incident illuminator for intravital microscopy Int J Microcirc Clin Exp 1987, 6:391-397 Mathura KR, Alić L, Ince C: Initial clinical experience with OPS imaging for observation of the...
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Báo cáo sinh học: "A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma" ppsx
... (during and after GCV therapy) of tumor volumes and integrated light intensity units within a region of interest (ROI) including all tumors were plotted against each other (Figure 5) Within the ... and nuclear noninvasive imaging Eur J Nucl Med Mol Imaging 2004 in press Ray P, De A, Min JJ, Tsien RY, Gambhir SS: Imaging tri-fusion multimodality reporter gene expression in living subjects ... fluorescence imaging, where autofluorescence may interfere with the signal of interest [13], background luminescence is negligible This study aimed at generating a sensitive tool for noninvasive in vivo...
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Báo cáo y học: "Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study" pot
... resonance imaging score (WORMS) of the knee in osteoarthritis Osteoarthritis Cartilage 2004, 12:177-190 25 Resnick D, Kang HS: The knee In Internal Derangements of Joints: Emphasis on MR Imaging Edited ... between cartilage volume loss and the severity of symptoms, including worsening of pain at 24 months Competing interests JFB, GAC, and JMM declare that they have financial competing interests ... Whitehead J: Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee LINK Study Group Longitudinal Investigation of Nonsteroidal Antiinflammatory Drugs in Knee Osteoarthritis...
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Báo cáo y học: " Relationship of compartment-specific structural knee status at baseline with change in cartilage morphology: a prospective observational study using data from the osteoarthritis initiative" pps
... change (in mm) in all knees to the mean baseline values of all knees The following baseline features of quantitative MRI of cartilage morphology were examined in the context of predicting change: ... evaluating the effect of glucosamine sulfate Osteoarthritis Cartilage 2003, 11:1-5 43 Wluka AE, Stuckey S, Snaddon J, Cicuttini FM: The determinants of change in tibial cartilage volume in osteoarthritic ... promising surrogate endpoint Also, the current analysis relied on central radiographic readings of the OA Initiative imaging data, which was adjudicated in case of discrepancy between two independent...
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Báo cáo y học: "Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction" potx
... appearance, corresponding to grade of the Larsen grading system, is defined by the presence of grade joint space narrowing combined with osteophytes, or of grade or joint space narrowing Control synovial ... expression of hyaluronidase-2 in the synovium of OA and RA was approximately four times that in the control synovium This finding suggests that in OA and RA, the protein expression of hyaluronidase-2 in ... β-actin gene in the same sample tube when the intensity of the reporter fluorescent signal reached 10 times the standard deviation of the baseline of fluorescent signal intensity The CT value of...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... GAG in cartilage were analyzed by determining the GAG content remaining in cartilage tissue relative to the total amount of GAG in the culture (GAG released into the culture media plus GAG in ... to the articular cartilage matrix, we examined the amount of GAG remaining in cartilage tissue and that was released into the culture medium in organ culture in the presence of an antioxidative ... antioxidative agent in tissue culture abolic change in articular cartilage matrix was analyzed by determining the GAG content remaining in the cartilage extract relative to the total amount of GAG in the...
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Báo cáo y học: "Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic change" pps
... Whitehead J: Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee LINK Study Group Longitudinal investigation of nonsteroidal antiinflammatory drugs in knee osteoarthritis ... S: Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings Radiology 2003, 226:373-381 Biswal S, Hastie T, Andriacchi TP, Bergman GA, Dillingham ... Knee In MRI of the Musculoskeletal System Philadelphia, PA: JB Lippincott Company; 1990:7.29-7.5 Resnick D, Kang HS: Chapter 16, The knee In Internal Derangements of Joints: Emphasis on MR imaging...
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Báo cáo y học: "α The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis" pot
... survival During hypoxic and normoxic conditions, functional inactivation of HIF-1α in the presence of interleukin-1β resulted in a significantly increased number of apoptotic chondrocytes These in vitro ... overload of bovine cartilage discs leads to an increased expression of VEGF-A via HIF-1 In conclusion, the α-subunit of HIF-1 is stabilized and HIF-1 activity is significantly increased in chondrocytes ... T, Nishioka K: Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1a in articular chondrocytes: involvement of HIF1a in the pathogenesis of osteoarthritis Arthritis Res Ther...
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Báo cáo y học: "Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblast" potx
... metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation Matrix Biol 2002, 21:271-288 Burrage PS, Mix KS, Brinckerhoff ... There is increasing evidence that SFs are key players in the pathogenesis of RA by invading and eroding hyaline cartilage SFs, activated locally, produce a variety of cytokines, chemokines and ... resulted from enzyme release by cells (including infiltrating inflammatory cells) within the joints Competing interests The authors declare that they have no competing interests Authors' contributions...
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Báo cáo khoa học: "Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series" docx
... brought into an operating room and placed in a supine position She was then sedated with propofol mg intravenously (push) and a 20 mg/hour rate of continuous infusion After cleaning her abdominal ... following cases concern four different individuals Of the four, the first two cases involve bone regeneration in osteonecrosis of hips, the latter two cases regeneration of cartilage in osteoarthritis ... PRP-activating agent [11] This series of case reports demonstrates successful clinical results of regenerating bones in osteonecrosis and cartilage in patients with osteoarthritis, using percutaneously...
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Báo cáo y học: "The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study" pptx
... radiologic features of tibiofemoral OA were graded in each compartment, on a 4-point scale (0 to 3) for individual features of osteophytes and joint space narrowing [19] In the case of disagreement ... grade of the tibiofemoral joint Arthritis Rheum 2003, 48:682-688 21 Peterfy CG, Gold G, Eckstein F, Cicuttini F, Dardzinski B, Stevens R: MRI protocols for whole-organ assessment of the knee in osteoarthritis ... change in cartilage volume was calculated by cartilage change (follow-up cartilage volume subtracted from initial cartilage volume) divided by initial cartilage volume and time between MRIs Outcome...
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Báo cáo y học: "Texture analysis of cartilage T2 maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T2 compared to normal controls - data from the osteoarthritis initiative" pptx
... Detection of changes in cartilage water content using MRI T2-mapping in vivo Osteoarthritis Cartilage 2002, 10:907-913 42 Xia Y: Magic-angle effect in magnetic resonance imaging of articular cartilage: ... SMC-3:610-618 11 Link TM, Steinbach LS, Ghosh S, Ries M, Lu Y, Lane N, Majumdar S: Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings Radiology ... disease The Osteoarthritis Initiative is a multi-center, longitudinal study aimed at assessing biomarkers in osteoarthritis (OA) including those derived from magnetic resonance (MR) imaging The OAI...
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Tài liệu Detection of Pulmonary tuberculosis: comparing MR imaging with HRCT pptx
... interpretation All MR images were independently analyzed by two board-certified radiologists (VS, EBR, both with 10 years of experience in clinical MR imaging and 25 years of experience in chest imaging) The ... CT and MR images, each parenchymal finding was scored on a scoring sheet using the following sliding scale of relative certainty: = definitely negative; = probably negative; = indeterminate; ... results of our study even suggest that MRI could replace CT in assessing lung tuberculosis in some subsets of patients such as children, women, during pregnancy (MR imaging should be avoided during...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an embryonic cartilaginous limb) of the development of neural crest derivates, including ... the interaction of AP-2 and its binding partners in cartilage However, at least CBP ⁄ p300-interacting transactivator with ED-rich tail and protein poly(ADP-ribose) polymerase-1 are expressed in ... a suppressor of these two cartilage matrix genes during cartilage differentiation [64–66] (Fig 2) High expression levels of AP-2a in chondroprogenitor cells maintain these cells in an early differentiation...
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