... Characterization of the bronchodilatory dose response to indacaterol inpatientswithchronicobstructive pulmonary disease using model-based approaches Respiratory Research 2011 12:54 ... from 7476 patients enrolled in 11 placebo-controlled studies in which indacaterol was administered topatientswith COPD at doses of 18.75 to 600 μg once daily (Table 1) The analysis involved ... study, for both indacaterol (lefthand panel) and comparators (right-hand panel) Visual inspection of the indacaterol data points indicated that with increasing dose the response asymptotically approached...
... the HADS total score Discussion This analysis showed that the minimal important difference of the HADS is approximately 1.5 points in COPD patients Investigators and those interpreting clinical ... specifying the patient-important difference that investigators want to detect To find a difference of 1.5 points at a significance level of 0.05 and with a power of 80% and assuming a SD of points ... range commonly encountered inpatientswithchronic disease.[26,27] A change of 1.5 points corresponds approximately to a 20% change from these baseline scores Inpatientswith substantially lower...
... will increase during the next decade In addition to the social strain, COPD also influences the patients' symptoms, function, and subjective health status [3] An important issue in understanding ... Sokolov I: Accuracy of nine commercially available pulse oximeters in monitoring patientswithchronic respiratory insufficiency Monaldi Arch Chest Dis 1994, 49:348-353 Bausewein C, Farquhar M, Booth ... variables were entered into the model, the adjusted R2 increased to 1% for physical health and 2% for mental health When symptoms were added, the explained variance increased to 36% for physical...
... polymorphism and chronic inflammatory lung diseases, including bronchial asthma and COPD, suggesting that IL-17F may be critically involved in the pathogenesis of chronic inflammatory lung diseases ... expression of the cytokines IL-17A and IL-17F is increased in COPD compared to control In the case of IL-17F, this increased expression extends to the epithelium and is not simply restricted to the submucosa ... increased expression of these cytokines in both CD4+ and CD8+ cells, suggesting that the inflammatory process in COPD may resemble that in other disorders where Tc17 cells are active These findings...
... status (4-point or more decrease from baseline in the total score for the SGRQ; 10-point or greater increasein total score for the CRDQ) [20-23] In addition, the change from baseline has been ... percentage of the clinically relevant difference for each measure (4 point decrease for SGRQ and 10 point increasein CRDQ) at and 12 months is shown in Figure indicating not only that increased numbers ... treated with salmeterol than with placebo/usual therapy A clinically meaningful change with the SGRQ (change in total score of units) corresponds to patients, for example, 'no longer having to walk...
... represented in the study, which was due to an inauspicious baseline imbalance Third, the data were collected in a clinical setting due to the requirement for video monitoring equipment However, patients ... and inpatientswithchronicobstructive pulmonary disease American Review of Respiratory Disease 1984, 130:584-587 Tobin MJ, Guenther SM, Perez W, Mador MJ: Accuracy of the respiratory inductive ... patientswith COPD who were videotaped in a quasi-controlled environment for 24 continuous hours while wearing the ambulatory system Methods Subjects Eight subjects withchronicobstructive pulmonary...
... were included in the questionnaire with the aim of comparing their performance in evaluating pain exacerbations in terms of reproducibility and of discriminatory capability to distinguish pain ... example: corresponding to "None", 1-4 to "Mild pain", 5-6 to "Moderate pain", and 7-10 to severe pain1 [14,27-29]), should be interpreted cautiously in clinical practice due to relevant individual discrepancies ... defined as "consistent" if background pain intensity was lower than peak intensity, otherwise it was defined as "inconsistent" (background pain intensity higher than or equal to peak pain intensity)...
... behind the increased levels of inflammatory mediators Thus different levels of molecules of the TLR intracellular signalling pathway might also account for the increased secretion of mediators ... that occurs in COPD patients [5] Interestingly, Riordan et al [27] have reported similar findings inpatientswith liver cirrhosis, a disease that, like COPD, is associated with systemic inflammation ... endogenous signalling repressor of cytokine signals [44,46] In vitro studies are currently going on in our laboratory to test the feasibility of these approachesin COPD Conclusion In summary, our...
... were self-administered at baseline, and again after months under the supervision of the investigators, in the same order, in booklet form An investigator (T.O.) reviewed the surveys to ensure that ... measuring health-related quality of life inpatientswithchronicobstructive pulmonary disease American journal of respiratory and critical care medicine 1998, 157(3 Pt 1):785-790 Jaeschke R, Singer ... those without exacerbations Despite no significant changes in the physiological indices, including the FEV1, an increased frequency of acute exacerbations was associated with a deterioration in...
... were self-administered at baseline, and again after months under the supervision of the investigators, in the same order, in booklet form An investigator (T.O.) reviewed the surveys to ensure that ... measuring health-related quality of life inpatientswithchronicobstructive pulmonary disease American journal of respiratory and critical care medicine 1998, 157(3 Pt 1):785-790 Jaeschke R, Singer ... those without exacerbations Despite no significant changes in the physiological indices, including the FEV1, an increased frequency of acute exacerbations was associated with a deterioration in...
... reduced in nine of our patients, including six with a normal BMI This suggests preferential skeletal muscle mass loss in 20% of our patients, which is in keeping with levels reported inpatientswith ... patients had a lower total 25OH Vitamin D level than controls confirming previous findings [36] Insufficient total 25-OH Vitamin D levels were seen in 80% of patientswith around a third having ... low levels reported in aging populations Indeed, 60% of the control subjects had insufficient 25-OH Vitamin D levels In four patientswith insufficient 25-OH Vitamin D and increased PTH there...
... training The training was intensive starting at 80% of the patients maximum walk speed on treadmill, and included also intensive step training The patients were encouraged and supervised during ... to influence your ability to cope with COPD in everyday life Yes/Unchanged toincrease your physical performance Yes/ Unchanged to influence your ability to cope with activities of daily living ... for COPD patients As such tools for monitoring, relevant databases are to be developed in the near future For such monitoring to be effective, it is necessary, to define new success indicators relevant...
... disease to heart failure still need further investigation The identification of the cytokines associated withchronic heart failure is not only important to get deeper insights into the inflammatory ... patientswith ICM as well as in NIDCM with respect to controls (p < 0.05) Further, the IL-6 cytokine (panel F) was significantly increased in ICM patients vs healthy controls (p < 0.05) The cytokines ... response monitoring [17] The aim of this study was to investigate the inflammatory pathways associated with CHF, and to assess whether disease etiology affects cytokine cascades To this end,...
... disease to heart failure still need further investigation The identification of the cytokines associated withchronic heart failure is not only important to get deeper insights into the inflammatory ... patientswith ICM as well as in NIDCM with respect to controls (p < 0.05) Further, the IL-6 cytokine (panel F) was significantly increased in ICM patients vs healthy controls (p < 0.05) The cytokines ... response monitoring [17] The aim of this study was to investigate the inflammatory pathways associated with CHF, and to assess whether disease etiology affects cytokine cascades To this end,...
... J: Single photon emission computerized tomography and reverse gantry computerized tomography findings inpatientswith back pain investigated for spondylolysis Clinical Journal of Sport Medicine ... on planar bone scintigraphy (B) [Red arrows point to the scintigraphic abnormality] A B C Figure CT findings in a patient with pars interarticularis fracture: Normal facet joint below fracture ... [19] In a longterm follow-up study, Bellah et al reviewed findings on planar and SPECT bone scintigraphy in 162 patients aged 6-32 years with symptoms of low back pain potentially related to stress...
... second interesting finding from Vander Cruyssen and colleagues’ study, which was not highlighted in the article, is that more than 50% of the patientsin which the infliximab dose was not increased ... physician opinion on whether or not toincrease the infliximab dose However, the results of Vander Cruyssen and colleagues can best be understood when looking at Figure in their article [1], depicting ... reflects best the physician’s clinical judgement of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score inpatients under infliximab treatment Arthritis...
... calcineurin inhibitor plus mycophenolate mofetil (n = 2), or none (n = 3) The calcineurin inhibitor included cyclosporine administered to 33 patients and tacrolimus to six patients End points ... conditioning, 14 patients received cytoreductive chemotherapy in the three weeks before conditioning Prophylaxis for acute GVHD was a calcineurin inhibitor alone (n = 5), calcineurin inhibitor plus short-term ... chemotherapy 14 (33.3) GVHD prophylaxis None (7.1) Calcineurin inhibitor alone Calcineurin inhibitor + sMTX (11.9) 32 (76.2) Calcineurin inhibitor + MMF (4.8) Donor (HLA-A, B and DRB1 antigens) Matched...
... PPS in GAD patientswith or without MDD [8] Briefly, the study was carried out in a primary care setting covering 87 sites in Spain during April-June, 2007 The study had stages in its design, including ... of GAD in primary care patients was around 8% In order to obtain a final sample size of 249 patientsin the comorbid group (GAD+MDD+), screening of 8650 patients was performed in order to adjust ... contributes to the understanding of the specific role of such pain symptoms in worsening the functioning inpatientswith GAD The presence of PPS is associated with a statistically and clinically...
... that there was no increased preponderance of fungal infection inpatientsin the treatment arms compared to placebo, this finding is not necessarily at odds with evidence of increased prevalence ... for routine antifungal prophylaxis inpatientswith severe acute pancreatitis even if these patients are receiving antibiotic therapy The subset of patientswith on-going disease requiring prolonged ... et al 20 Paphitou NI, Ostrosky-Zeichner L, Rex JH: Rules for identifying patients at increased risk for candidal infections in the surgical intensive care unit: approach to developing practical...