... Aviation Administration and placed under the control ofthe U.S Department of Transportation (DOT) Beginning inthe 1970s, the inefficiency ofthe government regulated airline industry became of paramount ... that the inherent instability ofthe airline industry can be traced to the structure ofthe industry and its economics, including the highly cyclical demand for air travel, high fixed costs, and ... … by diluting and distorting managers’ incentives and thereby hurting corporate performance” (p 72) The authors argue that the inability ofthe optimal contracting approach in explaining executive...
... Comparison of fastness ofthe convergence Now, the interest of this paper is to compare the fastness ofthe convergence to the fixed point among the Krasnoselskij, Mann, and Ishikawa iterations for the ... both the Mann and Ishikawa iterations to the fixed point of T ∈ LS(K) Numerical examples The following examples show the fastness ofthe movement ofthe first 10 iterates towards the fixed point ... to the fixed point of T ∈ LS(K) Now, the following question arises: for a member T of LS(K) which one ofthe following, namely, Krasnoselskij, Mann, and Ishikawa iterations converges faster to the...
... BURNS, 1981) and ultimately the phenotype and fitness of individuals The study of metabolically related enzymes has likely potential in detecting and understanding epistasis andthe forces which ... higher density of this species (an estimated 2,000 inthe vicinity ofthe vineyard buildings) These numbers are more similar to those found in an equivalent area ofthe orchard In general, Drosophila ... of Gpdh-F frequency with maximum rainfall in Asia that was not apparent in Europe or North America Inthe Wandin North population, Gpdh-F frequency was independent of rainfall Factors affecting...
... was contained in lesser amounts inthe roots and rhizomes than inthe leaves and stems The content of 18:2n6c, 18:3n3 and LCFAs inthe leaves and stems was compared with that inthe roots and rhizomes ... structure inthe leaves and stems differ from those ofthe roots and rhizomes because the content ofthe fatty acid 18:3n3 inthe leaves and stems differ from that ofthe roots and rhizomes Therefore, ... leaves and stems, and -11.6 ± 1.5‰ inthe roots and rhizomes Meanwhile, Z marina inthe leaves and stems has -9.7 ± 1.0‰, andinthe roots and rhizomes has -9.6 ± 1.0‰ Fig shows that the leaves and...
... reflection to transcend the reciprocal determinations ofthe series (thinking the thinking of thinking, and so on ad in nitum) Nicholas Saul except in intellectual intuition, the philosopher concludes ... philosophical theories of cognition in our epoch In its wake came another variant ofthe demand for extending the legislation ofthe aesthetic into the cognitive domain: aesthetic natural science Goethe, ... (Platonic) cave he bathes inthe wellsprings of creation, the menstruum universale ofthe cosmic imagination Here, mere thinking is creation of self and other This phase ofthe dream, then, is a literary...
... they not their best, other thing which should be mentioned is the wrong schedule ofthe bus routes (which doesn’t take a proper account ofthe interests ofthe passengers); and finally, its the ... contract and then discuss its terms and conditions with the drivers, so we’ll determine exactly the duties and responsabilities of both parties Into our opinion they will be the following: a) the ... passing capacity ofthe roads that doesn’t cope with the growing number of cars and other carriers, build new roads and rearrange the traffic within the city in general); another highly probable...
... fueled renewed interest inthe origin of life andthe obvious extension: the synthesis of life inthe laboratory Concluding remarks As other chapters in this volume indicate, “Fitness” and “Order” ... questions: the origin ofthe universe, the origin of matter, the origin of life, the origin of sentience We, scientists and non-scientists alike, have troubles with such “origins” – we were not there ... for the creative thinking process used in developing the content of this book The chapters in this volume were developed following the symposium and take advantage ofthe rich technical and interdisciplinary...
... The kinase-deficient mutant, OXI1K45R, in which the lysine residue ofthe ATP binding domain is mutated to arginine, still interacted with PTI1-4 These data indicate that the kinase activity of ... ofthe input was loaded on to the gel and represents the amount of HIS-tagged proteins used for the assay Thein vitro binding assays were repeated twice using recombinant proteins prepared independently ... kinase-inactive GST-lofMPK3 and GST-lofMPK6 were mixed with HIS-OXI1 in kinase buffer and [c-32P]-ATP (B) Recombinant kinase-active GST-MPK3 and GST-MPK6 or recombinant kinase-inactive GST-lofMPK3...
... on the heart One ofthe original aims ofthe P-1 study was to determine whether tamoxifen reduced the risk of fractures ofthe hip, radius (Colles’), and spine The current findings indicating ... design ofthe study included formal interim monitoring for early stopping based on the primary end point ofthe trial, i.e., the incidence of invasive breast cancer The stopping rule of Fleming ... use of mammography has resulted inthe more frequent detection of DCIS In view ofthe cost involved andthe effort required to diagnose these tumors andin light ofthe debate about both the initial...
... concept of cross-cutting themes used inthe planning document should be reintroduced and moved toward the beginning ofthe plan as a way to reinforce the importance of these elements in creating the ... themes and disciplines, expanding the context to include international efforts, emphasizing the impacts of climate change andthe role of humans in inducing climate change, and increasing focus ... become the principal operating agency of both the National Academy of Sciences andthe National Academy of Engineering in providing services to the government, the public, andthe scientific and...
... expression ofthe pMetY-Cgate vector inthe presence of methionine is low The C-terminus is important for protein–protein interaction Discussion Using the split-ubiquitin system, we investigated the interaction ... and stability ofthe protein at the plasma membrane, whereas the addition of Mg2+ to the growing cells induces rapid degradation ofthe protein via the endocytotic pathway, ending inthe vacuole ... with two TM domains and both termini inthe cytoplasm andthe folding ofthe large N-terminal part into a large funnel-like structure with a potential binding site for Mg2+ As an independent approach...
... that inthe future further subfamilies will be identified, owing to the appearance of new members or by subdivision ofthe existing subfamilies Indeed, there are several GH-57 candidates inthe ... domain (SLD2), a threonine-rich region and a putative transmembrane domain [22] Interestingly, the 3D structure of a protein domain, which is clearly homologous to SLD1 and -2 of Q9Y8I8_THEHY, ... the C-terminus ofthe first b-strand ofthe catalytic (b/a)7-barrel [16] Interestingly, the three shortest GH-57 members, which include the P furiosus a-galactosidase (Q9HHB5_PYRFU), exhibit the...
... unusual in having two histidine residues (rather than the His-Asn pair seen in OYE, MR and some ofthe other member proteins; Fig 1B) inthe active site for ligand and substrate binding For those ... productive binding of steroid substrates: inthe first, a (small) sub population of enzyme binds directly the steroid inthe reactive conformation, with the remainder ofthe enzyme binding the unreactive ... 1A) and 2-cyclohexen-1-one indicate that these ligands bind above the si face ofthe FMN isoalloxazine ring and are held in position by hydrogen bond interactions with His181 and His184 [2] These...
... tagging, including co-reference linking, rhetorical structuring and syntactic structuring The use ofthe tool is rapidly spreading: inthe first 15 months of availability, the tool has been downloaded ... showing only the differences between coders, and also indicating total coder agreement The software can also produce a “consensus” version ofthe annotations, taking the most popular coding where ... images instead of text files In this context, one can swipe regions ofthe image to create a selection, and assign features to the selection Since stand-off annotation is used for both text and...
... those of monomers obtained at low pH [35] or under pressure [10] Arg148 is not the only buried arginine inthe structure of BLG The whole side chain of Arg40 (the other main point of trypsin action) ... distant I strand inthe C-terminus region that includes Cys160 and connects to the leftovers of strand D via a disulfide bridge to Cys66 [5] As stated inthe introduction, one ofthe goals of this ... feature, namely the presence ofthe disulfide bridge connecting Cys66 and Cys160 inthe native protein The position of these fragments inthe primary sequence of BLG is given in Fig A nonspecific...
... 5A,B) In contrast, the intensity ofthe shifted band that included GST–Sp1 gradually increased Conversely, the addition of GST–Sp3 resulted in a similar reduction inthe binding of Sp1 to the GA ... expression ofthe Dnmt1 gene from the minimum promoter insomatic cells remain to be determined In this report, we identified a ciselement inthe promoter ofthe Dnmt1 gene insomatic cells and showed ... similar and binding of these factors is independently regulated by different coactivators in a cell-cycle-dependent manner The distinct functions of Sp1 and Sp3 inthe regulation of expression of the...
... of this family including UspA itself (Fig 2), and one larger protein consisting of two UspA domains in tandem [17] The small members of this family are proteins of 142–144 amino-acids long; they ... between the amounts of UP12 andthe total amount of protein inthe extracts, a series of samples containing determined amounts ofthe purified UP12 were separated by SDS/PAGE along with the cell ... Department ofthe Weizmann Institute by a single injection of 150 lg ofthe purified protein, followed by two booster shots ofthe same amount of protein at 2-week intervals Serum was collected and used...
... 73.5 lM) The lower panels show the binding isotherm andthe best-fit curve according to the three sequential binding sites model BIAcore analysis ofthe GS–TnrA interaction The results ofthe immunoprecipitation ... concentrations on GlnK binding to TnrA GlnK–TnrA interaction inthe presence of mm ATP On the other hand, 2-oxoglutarate did not in uence the GlnK–TnrA interaction, either alone, inthe absence of divalent ... negatively affect the binding of ATP to GlnK [12] Therefore, we investigated the binding of TnrA to GlnK inthe presence of different mixtures of Mg2+ or Mn2+ with the effector molecules ATP and 2-oxoglutarate...
... from the councils ofthe National Academy of Sciences, the National Academy of Engineering, andthe Institute of Medicine The members ofthe panel responsible for the report were chosen for their ... Academy of Sciences to secure the services of eminent members of appropriate professions inthe examination of policy matters pertaining to the health ofthe public The Institute acts under the responsibility ... principal operating agency of both the National Academy of Sciences andthe National Academy of Engineering in providing services to the government, the public, andthe scientific and engineering communities...
... another Inthe “Chronic Insurgencies/Instability” trajectory, Ink Blot would be reserved for those insurgencies and areas of instability in which the insurgents are gaining ground andin uence The ... combined with our understanding ofthe components ofthe long war, provided the basis for a set of seven strategy options for the United States inthe long war xvi Unfolding the Future ofthe ... longer-term planning horizons, andthe enduring missions ofthe force In these terms, maintaining flexibility inthe force is critically important, both to prepare for the various ways in which the long...