primary epithelial ovarian neoplasms new concepts concerning origin pathogenesis and classification based on morphology immunomarkers molecular features and gene expression studies
Báo cáo khoa học: "Can primary optimal cytoreduction be predicted in advanced epithelial ovarian cancer preoperatively?" pdf
... advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google ... not demonstrated sufficient accuracy to achieve widespread applicability [13,21-24] The most common criteria cited as justification for abandoning an up-front attempt at surgical cytoreduction are ... manuscript, and acted as corresponding author and did the revisions MMG: carried out operations, she was head of the department FG: carried out operations NB: carried out operations SA: participated...
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Báo cáo y học: "A Randomized Study of Epithelial Ovarian Cancer: Is Chemotherapy Useful after Complete Remission"
... chemotherapy, and consolidation of response by whole-abdominal radiotherapy Cancer 1988;62:40-47 27 Gershenson DM, Mitchell MF, Atkinson N, et al The effect of prolonged cisplatin -based chemotherapy on ... Pordenone, Italy His past positions include full-time associate at the Division of Radiotherapy and Medical Oncology, Ospedale Civile in Pordenone, for years and at the Division of Medical Oncology, ... the consolidation therapy population and the nihil arm was 55 (range: 38-76 and 16-73, respectively) The stage distribution was 15 pts stage I C, 30 pts stage II B and II C, 71 pts stage III, and...
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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx
... Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis Nat Med 5, 793–802 23 Ilan N, Elkin M & Vlodavsky I (2006) Regulation, function and clinical significance ... intimately engaged in the regulation of gene transcription and acts as a master regulator of protease expression, mediating gene induction or repression, depending on the biological setting FEBS ... evidence for cooperation between heparanase and MMPs in regulating HSPGs on the cell surface and likely in the ECM, and are supported by the recent generation and characterization of heparanase knockout...
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Báo cáo khoa học: Sequences and structural organization of phospholipase A2 genes from Vipera aspis aspis, V. aspis zinnikeri and Vipera berus berus venom Identification of the origin of a new viper population based on ammodytin I1 heterogeneity docx
... introns (Table 3) Exons 3, and the 5¢ part of exon encode the mature protein; exon encodes the 5¢-UTR, and exon and part of exon encode the signal peptide The 110 nucleotides at the 3¢ end of exon ... polymorphisms in introns than in exons This was particularly true for intron C, which contained several short deletions and insertions (Fig 1) Two microsatellite regions of tandem CA and TCCC repeats ... snakes because no neurotoxic envenomation has ever been reported in the Clermont-Ferrand region (Gabriel Montpied Hospital, personal communication) The expression of these neurotoxin subunits in...
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Epithelial ovarian cancer: A national clinical guideline pdf
... structured emotional support, relaxation techniques, the use of audiocassette recordings of consultations, orientation programmes and general psychological and/ or emotional support The interventions reduced ... peritoneal washings, or ascites 29 EPITHELIAL OVARIAN CANCER Annex Classification of ovarian cancer Ovarian neoplasms are a heterogeneous group of tumours classified according to morphological and ... counselling, support and information before and after surgery EPITHELIAL OVARIAN CANCER Diagnosis 3.1 PRIMARY CARE 3.1.1 SIGNS AND SYMPTOMS Retrospective studies show that women with ovarian cancer...
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RHEOLOGY - NEW CONCEPTS, APPLICATIONS AND METHODS potx
... currents continue to be applied, polarized particles migrate and further combine, and conduction by particle-to particle contact overwhelms percolation and becomes the domi nant conduction phenomenon ... (G) At low er volume fraction = 0.2 and = 0.4, the addition of silver particles did not affect the 31 Rheology - New Concepts, Applications and Methods Newtonian continuous phase of the epoxy ... prenatal ontogenesis of not only the persons surveyed but also of their parents was marked It is shown the existence of geneti cally and epigenetically transferred from generation to generation relay-race...
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Báo cáo hóa học: " Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer" ppt
... survival (RFS) and overall survival (OS) according to RBM3 expression Cox regression proportional hazards models were used to estimate the impact of RBM3 expression on RFS and OS in both uni- and multivariate ... antibody tested in A2780 ovarian cancer cells and immunohistochemical RBM3 expression in primary ovarian tumors RBM3 protein expression was significantly decreased after transfection with siRNA against ... at both the gene expression and protein levels in two relatively large independent cohorts RBM3 protein expression was assessed using a monoclonal antibody which displayed a single band of the...
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báo cáo hóa học:" The detection, treatment, and biology of epithelial ovarian cancer" pdf
... Testa JR, Handel LM, Liu Z, Vanderveer LA, Tracey PA, Hamilton TC: Spontaneous transformation of rat ovarian surface epithelial cells: association with cytogenetic changes and implications of Gubbels ... Berchuck A, Schmandt R, Whitaker R, Gershenson DM, Mills GB, Bast RC Jr: Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis ... Obstetrics and Gynecology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53792, USA Authors’ contributions JAAG, JPC, and MSP did the majority of the writing of this manuscript NC and...
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báo cáo hóa học:" Development of a syngeneic mouse model of epithelial ovarian cancer" ppt
... likely additional genetic, epigenetic and/ or gene expression alterations that contribute to ovarian tumor progression, and identification of these alterations may contribute to our understanding of ... Ellenson LH, Connolly DC: Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53 PLoS One 2009, 4:e8404 35 Aunoble B, Sanches R, Didier E, Bignon YJ: Major oncogenes ... Liu Z, Vanderveer LA, Tracey PA, Hamilton TC: Spontaneous transformation of rat ovarian surface epithelial cells: association with cytogenetic changes and implications of repeated ovulation in...
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Báo cáo khoa học: "Lymph node metastasis in grossly apparent clinical stage Ia epithelial ovarian cancer: Hacettepe experience and review of literature" doc
... collecting the data and making statistical evaluations, AA and KY primarily responsible for the management of patients surgically and worked in critical revision and edition of manuscript, AU, ... 8(2):103-8 Maggioni A, Benedetti Panici P, Dell’ Anna T, Landoni F, Lissoni A, et al: Randomised study of systematic lymphadenectomy in patients with epithelial ovarian cancer macroscopically confined ... one had squamous cell (grade 3) and one had mixed serous and mucinous carcinoma (grade 2) The patient with omental metastasis had mucinous carcinoma (grade 3) One patient with contralateral ovarian...
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New Concepts in Diabetes and Its Treatment - part 1 ppt
... F, Mogensen CE (eds): New Concepts in Diabetes and Its Treatment Basel, Karger, 2000, pp 1–2 Introduction Diabetes mellitus and its complications are clinical conditions of growing importance ... source of information concerning the New Concepts in Diabetes and Its Treatment Francesco Belfiore Carl Erik Mogensen Suggested Reading Alberti KGMM, Zimmet P, DeFronzo RA: International Textbook of ... secretion and different levels of insulin resistance In the patients with long-standing diabetes, late complications develop consisting of alterations and failure of various organs (especially the noninsulin-sensitive...
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New Concepts in Diabetes and Its Treatment - part 2 docx
... stimulation of insulin secretion and more pronounced extrapancreatic effects It is effective at lower dosage, has a more rapid onset of action than glibenclamide and a long duration of action There ... as -blockers and alcohol) can alter sulfonylureas activity in opposite directions Sulfonylureas of ‘second generation’ may have less interactions than those of the ‘first generation’ Some data ... As consequence of the stimulation of secretion, sulfonylureas can induce morphological alterations of the -cells such as degranulation, loss of zinc and aspects of emiocytosis Chronic Effects on...
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New Concepts in Diabetes and Its Treatment - part 3 docx
... NPH and a duration of action very long (about 24 h), especially appropriate for type diabetics Insulin Concentration The insulin preparation available on the market today is a concentration of ... proline and lysine at position B28 and B29 of human insulin produces an analogue Belfiore/Iannello 74 Table Types of insulin Type Preparation Onset of action h Peak action h Duration of action h ... dose depends on the patterns of food intake and physical activity, on diurnal variations in insulin requirement, on experience of hypoglycemia, on the state of injection sites and on the type...
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New Concepts in Diabetes and Its Treatment - part 4 ppsx
... motility and inhibition of gastric emptying Inhibition of postprandial glucagon secretion Suppression of postprandial hepatic glucose production Suppression of arginine-stimulated glucagon secretion ... activity), and shows a common conformation with the hypoglycemic sulfonylureas glibenclamide and glimepiride (see chapter II on Insulin Secretion and Its Pharmacological Stimulation) Belfiore/Iannello ... important in the generation of immune response Conditions of Altered Insulin Responses Conditions of altered insulin responses include: (a) insulin resistance linked to occult infections; (b) iatrogenic...
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New Concepts in Diabetes and Its Treatment - part 5 pdf
... of the relative gluconeogenic enzymes) All these hormones have a synergic action on the induction of hyperglycemia and on the prevention and correction of hypoglycemia Glucagon plays the most important ... apathy and lethargy Frequent yawning and perioral numbness Disturbed vision and diplopia Paresthesias and motor dysfunction Cognitive impairment, mental confusion and inebriation Personality ... impairment, mental confusion, inebriation, personality changes and psychotic behavior, disturbed vision and diplopia, perioral numbness, paresthesias, motor dysfunction, convulsions, occasionally transient...
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New Concepts in Diabetes and Its Treatment - part 6 pot
... retinal lesions cannot be documented in detail, that the retinal changes are difficult to quantify, and that the quality and conclusion of the examination depend on the experience and attitude ... long term); (3) qualified personnel is available to carry out the screening examinations and evaluations, and (4) patients are taught about the advantages of screening, and are given motivation ... in addition to the personal consequences, diabetic retinopathy also has great social and economic implications for the patients’ relatives and for the society as a whole Preserved vision may make...
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New Concepts in Diabetes and Its Treatment - part 7 pdf
... albuminuria Comparison of cases with onset of albuminuria after short or long duration APMIS 1998;106:361–370 Parving HH: Renoprotection in diabetes: Genetic and non-genetic risk factors and treatment ... decompensation In addition, qualitative alterations of lipoproteins (mainly LDL) occur in diabetic patients, including glycation, oxidation and peroxidation as well as composition abnormalities consisting ... defect exists, secondary to impaired remnant-receptor interaction and increased competition with VLDL remnants Concerning apoproteins, increased ApoB and ApoC-III concentration has been reported...
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New Concepts in Diabetes and Its Treatment - part 9 pdf
... in SHBG and/ or inappropriate gonadotropin secretion In addition, there also appears to be an alteration in gonadic response to tropine stimulation with a tendential rise in basal LH and a more ... animals’ sexual behaviour and a reduction in the weight of their secondary sex glands, in their production of androgens and in spermatogenesis as a result of altered gonadotropin pulsatility Diagnosis ... that erectile dysfunction in diabetes is often psychological in origin The main contributory factors are: awareness of suffering from a chronic condition, relationship problems and the fear of failure...
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báo cáo khoa học: "Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma" pptx
... volume contribution of APPs expression in negative control women and patients in different stages of Mean Mean percentage of volume contribution of APPs expression in negative control women and patients ... cancer, expression of the serum APPs did not conform to the altered progression changes The expression of HAPc and AATf did not demonstrate any correlation with all stages of EOCa (Fig 2, panels F and ... Albert JM, Gonzalez A, Massion PP, Chen H, Olson SJ, Shyr Y, Diaz R, Lambright ES, Sandler A, Carbone DP, Putnam JB Jr, Johnson DH, Lu B: Cytoplasmic clusterin expression is associated with longer...
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báo cáo khoa học: "Phase 2 study of canfosfamide in combination with pegylated liposomal doxorubicin in platinum and paclitaxel refractory or resistant epithelial ovarian cancer" docx
... the M.D Anderson Cancer Center, University of Texas institutional review board and reviewed annually The study was conducted in accordance with the International Conference on Harmonization Good ... upper limit of normal and adequate cardiac function [left ventricular ejection fraction (LVEF) of ≥ 50% of the institutional normal and New York Heart Association classification Class I or II] or ... et al: Expression of anionic glutathione- S-transferase and P-glycoprotein genes in human tissues and tumors Cancer Res 1989, 49(6):1422-8 13 Tew KD, Monks A, Barone L, et al: Glutathione-associated...
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