physiological properties and role in cardiovascular regulation

... mitochondrial-targeting domains on cofilin 100 5.6 Mitochondrial-targeting of cofilin induces apoptosis 101 5.7 A functional actin-binding domain is required for cofilin-induced apoptosis but ... and survivin (Salvesen and Duckett, 2002) The former three IAPs contain three BIR domains and the RING finger while NAIP and survivin possess only BIR domains XIAP, unlike the other members in ... the actin-binding property Although, we had shown domains required for cofilin translocation and apoptosis induction, the direct mechanism of cell death induction is not clear As actin-binding ability...

Ngày tải lên: 17/09/2015, 17:19

... Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... Osmosensing and signaling in mammalian cell function F Schliess et al [7] On the other hand, hyperosmotic shrinkage prevents insulin-induced hepatocyte swelling and proteolysis inhibition, indicating ... [12–14] Integrin-inhibitory peptides exhibiting an arginine-glycine-aspartic acid (RGD) motif abolish hypoosmotic osmosignaling towards Src-type kinases, mitogen-activated protein kinases (MAPKs) and...

Ngày tải lên: 18/02/2014, 16:20

... the cis-acting element and investigate the protein factors involved in regulation of the hGnRH II gene in TE61 and JEG-3 cells These cell lines, which endogenously co-express GnRH I and GnRH II, ... aprotinin and 1.5 lgÆmL)1 pepstatin A) and eluted in the elution buffer (1% SDS and 0.1 m NaHCO3) The mixture was incubated at 65 °C for h to reverse the formaldehyde cross-linking Protein was ... response element binding proteinbinding protein (CBP ⁄ p300) [26–28] This may explain the up -regulation (alleviation of the repressing effect of GII-Sil) of the hGnRH II promoter by the ligand-activated...

Ngày tải lên: 16/03/2014, 10:20

... trademarks, and are used only for identification and explanation without intent to infringe Library of Congress Cataloging -in- Publication Data The Fungal community : its organization and role in the ... level? The in uence of scale and heterogeneity in the ecosystem is a confounding factor in our attempts to understand ecology and community functioning However, these factors are inherent in ecosystems, ... focus is twofold in that an understanding of spatial and temporal scales is essential both for describing the distribution of organisms and for understanding the roles of organisms in ecosystem function...

Ngày tải lên: 23/03/2014, 01:20

... an intra-laminar progressive failure analysis An alternative way has to be found to decrease this high computation time while maintaining the combined modelling of intra-laminar and inter-laminar ... achieved and exceed a critical value Obtaining a metastable equilibrium 28 Nanocomposites with Unique Properties and Applications in Medicine and Industry Gc  R (6) Assuming that c and Cc are ... new damages (A and B) 18 Nanocomposites with Unique Properties and Applications in Medicine and Industry The ultimate stress obtained in the case of «Damage A» is 46% higher than in the case of...

Ngày tải lên: 29/06/2014, 13:20

... alpha-inducible protein (IFI6) Hs00242571_m1 Interferon, gamma-inducible protein 16 (IFI16) Hs00194261_m1 Interferon, alpha-inducible protein 27 (IFI27) Hs00271467_m1 Interferon, gamma-inducible protein 30 ... Guanylate binding protein (GBP1) Hs00266717_m1 Guanylate binding protein (GBP2) Hs00269759_m1 IL8RA Hs00174146_m1 C-type lectin domain family 4, member E (CLEC4E) Hs00372017_m1 TNF-induced protein (TNFAIP6) ... were included in the first network, including p38 mitogen-activated protein kinase (MAPK) complex and NFB complex depicted at the center of Figure 1a p38 MAPK is phosphorylated in response to inflammatory...

Ngày tải lên: 09/08/2014, 01:22

... alpha-inducible protein (IFI6) Hs00242571_m1 Interferon, gamma-inducible protein 16 (IFI16) Hs00194261_m1 Interferon, alpha-inducible protein 27 (IFI27) Hs00271467_m1 Interferon, gamma-inducible protein 30 ... Guanylate binding protein (GBP1) Hs00266717_m1 Guanylate binding protein (GBP2) Hs00269759_m1 IL8RA Hs00174146_m1 C-type lectin domain family 4, member E (CLEC4E) Hs00372017_m1 TNF-induced protein (TNFAIP6) ... were included in the first network, including p38 mitogen-activated protein kinase (MAPK) complex and NFB complex depicted at the center of Figure 1a p38 MAPK is phosphorylated in response to inflammatory...

Ngày tải lên: 09/08/2014, 13:22

... in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage or retrieval system, without prior permission in writing ... Acetophenone 2-Acetylaminofluorene Acrolein Acrylamide Acrylic acid Acrylonitrile Allyl chloride 4-Aminobiphenyl Aniline o-Anisidine Asbestos Benzene (including benzene from gasoline) Benzidine Benzotrichloride ... Title V air permitting and consulting services for government and industrial clients at ERM-Northeast in Albany, NY Prior to his more recent work in environmental consulting and corporate EHS...

Ngày tải lên: 11/08/2014, 09:21

... volatile organic and inorganic compounds (i.e., VVOC and VVINC), volatile compounds (VOC and VINC), semivolatile compounds (SVOC and SVINC), and nonvolatile compounds (NVOC and NVINC) The vapor ... compounds in particle phase Metals; plating Inorg NVINC Insoluble Cobalt compounds Inorganic compounds in particle phase Metals Inorg NVINC Insoluble Coke Oven Emissions Mixture of organic and ... chemicals Inorg Chlor-alkali; biogenic NVINC Insoluble Inorg 2.0 × 10–3 mm at 20˚C 356 6.0 × 10–5 7439-97-6 200.6 SVINC NVINC Insoluble Insoluble e.g., particle phase Fine mineral fibers (incl...

Ngày tải lên: 11/08/2014, 09:21

... physical and chemical properties presented in Chapter 2, and by the atmospheric lifetimes and reaction pathways reported in Chapter Those properties and reactivity determine the types of sampling and ... Determination of Polychlorinated, Polybrominated and Brominated/Chlorinated Dibenzo-p-Dioxins (TCDDs) and Dibenzofurans in Ambient Air, Second Edition 1/97 TO-10A Determination of Pesticides and ... Detector using sampling device consisting of cassettes each containing two sulfuric acid-treated glass fiber filters for Benzidine, 3,3’-Dichlorobenzidine, 2,4-Toluenediamine, and 2,6-Toluenediamine 7/89...

Ngày tải lên: 11/08/2014, 09:21

... 71 Includes 12,393 nondefects Includes 51 nondetects 11 Summer samples Spring samples Winter samples Spring samples Winter samples 11 1,2-Propyleneimine (2-methyl aziridine) 75-55-8 Quinoline ... polychlorinated dibenzo-p-dioxins and dibenzofurans in Ohio: sources and health risk assessment, Chemosphere, 18, 1713, 1989 18 Eitzer, B.D and Hites, R.A., Polychlorinated dibenzo-p-dioxins and dibenzofurans ... Leuenberger, C., Ligocki, M.P., and Pankow, J.F., Trace organic compounds in rain Identities, concentrations, and scavenging mechanisms for phenols in urban air and rain, Environ Sci Technol., 19(11):1053,...

Ngày tải lên: 11/08/2014, 09:21

... hydroxyl radical and dinitrogen pentoxide, Int J Chem Kinet., 21(9), 775, 1989 46 Atkinson, R et al., Kinetics and nitroproducts of the gas-phase hydroxyl and nitrogen oxide (NO3) radical-initiated ... 27, 1832, 1993 160 Atkinson, R., Aschmann, S.M and Arey, J., Formation of ring-retaining products from the OH radical-initiated reactions of o-, m- and p-xylene, Int J Chem Kinet., 23, 77, 1991 ... 94 Cotton, F.A and Wilkinson, G., Advanced Inorganic Chemistry, 2nd ed., Interscience Publishers, 1966, pp 489-518 95 Winer, A.M and Atkinson, R., Atmospheric reaction pathways and lifetimes for...

Ngày tải lên: 11/08/2014, 09:21

... http://www.biomedcentral.com/1471-2229/11/19 of coordination and crosstalk must exist between pathways involved in Pi and sulfate transport and homeostasis in plants, important players acting in this coordination remain to be clearly ... by phosphite, indicating that phosphite interferes specifically with early events involved in Pi sensing and signaling, including responses typically associated with local Pi sensing or long-distance ... events involved in Pi sensing and signaling, including responses typically associated with local Pi sensing or long-distance signaling [47-50] While addition of phosphite attenuated the induction...

Ngày tải lên: 11/08/2014, 11:21

... flowering and sex-determination is very scarce, yet essential to accelerate breeding and aid our understanding of flowering control in kiwifruit and woody perennial species in general Molecular and ... genes in a range of angiosperms has been instrumental in the development and testing of these models [reviewed in 58] and further broad comparative studies, including normal and aberrant flowers in ... resulting in an entry clone All entry clones were verified using sequence analysis before cloning in the yeast two-hybrid GAL4 binding domain vector pDEST32 (bait) and GAL4 activating domain vector...

Ngày tải lên: 11/08/2014, 11:22

... DSCR1/RCAN1 endogenously inhibits the binding of calcineurin to NFAT, preventing its calcineurin from dephosphorylating NFAT and allowing its nuclear translocation (FUENTES et al 2000); and DYRK1A primes ... also seen in Treacher Collins syndrome of cranial NCC origin in which individuals develop hypoplasia of facial bones including the maxilla and mandible, and alterations of the external and inner ... Harmine Ameliorate Proliferation and Migration Deficits in Ts65Dn PA1 and NT Tissues In Vitro 60 5.4 EGCG and Harmine Ater Proliferation and Migration in Ts1Rhr PA1 and NT Tissues In Vitro...

Ngày tải lên: 24/08/2014, 11:47

... angiopoietin family is composed of four ligands (Angiopoietin1, Angiopoietin2 and Angiopoietin3/4) and two corresponding tyrosine kinase receptors (Tie1 and Tie2) Ang3 and Ang4 are orthologs found in ... many basement membrane proteins produces many antiangiogenetic fragments including angiostatin, endostatin, kininostatin, endorepellin ,restin, tumstatin and vastatin (Chen et al 2006, Jimenez ... Ang1, Ang2 and Tie2 Hypoxia induces VEGF expression in ECs and pervascular cells and regulates EC functions via autocrine and paracrine VEGF signaling It is very interesting to note that intracellular...

Ngày tải lên: 24/08/2014, 11:59

... Jugovic; and my cousins Erin Dunivan and Kristin and Scott Petherick Your love and support throughout my life and education has been and continues to be incredible My brother Robbie Collins for ... challenging me and supporting me in ways only a sibling could I am grateful that you are both my brother and my friend My parents Bob and Mary Ann Collins for always loving me, supporting me and inspiring ... carboxylesterases include angiotensin-converting enzyme inhibitors, salicylates, haloperidol, cocaine, heroin, and the chemotherapeutics irinotecan and capecitabine (Satoh and Hosokawa, 1998)...

Ngày tải lên: 24/08/2014, 12:18

... cytoplasmic tail interacts with PDZ domaincontaining scaffolding proteins including ZO-1, while the D1 domain interacts with the D1 domain of an opposing JAM-A molecule to form physiologically ... FAK and Fyn/Shc pathways represent two main signaling pathways activated by integrins Apart from these main signaling pathways, integrins can also initiate several other signaling pathways leading ... continuously subjected to mechanical strain with each heart beat, epithelial cells lining the alveoli in the lungs are stretched during inspiration, and epithelial cells lining the gastrointestinal...

Ngày tải lên: 11/09/2015, 09:04

... Tyr694 in Stat4 and Stat5a, Tyr699 in Stat5b and Tyr641 in Stat6 Such tyrosine phosphorylation of STATs is catalyzed by ligand-activated receptors with intrinsic tyrosine kinase following ligand-binding, ... identified independently by a few research groups using different strategies, and named as SOCS/JAK-binding protein (JAB)/STAT-induced STAT inhibitor (SSI)/cytokine-inducible SH2-containing proteins ... Pin1 knockout MEFs 113 4.5 Pin1 increases Stat3 and p300 binding 118 4.6 Effects of Pin1 on Stat3 ubiquitination 121 4.7 Role of Ser727 in Stat3 ubiquitination and protein degradation 122 vi 4.8...

Ngày tải lên: 15/09/2015, 17:10

... sufficient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinase potentiates insulin action in muscle of insulin-resistant rats [39], and that prolonged GSK3 inhibition ... for GS in the absence and presence of insulin in control cells were 0.029 ± 0.01 (basal), 0.67 ± 0.01 (insulin), and in GSK3S9A expressing cells were 0.06 ± 0.03 (basal), 0.05 ± 0.01 (insulin)] ... and the kinase has been implicated in down-regulating insulin signalling via its ability to serine phosphorylate IRS1 [40], it is possible that inhibition of GSK3 potentiates insulin signalling...

Ngày tải lên: 08/03/2014, 08:20