photodynamic therapy for the treatment of verrucae condylomata acuminata and molluscum contagiosum lesions
Báo cáo khoa học: Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action docx
... for the expression of the other viral genes, for the synthesis of full-length genomic RNA and, ultimately, for the production of progeny virions (reviewed in [40]) Rev channels the unspliced and ... multimerization of hnRNP A1 towards the A3 3¢ss leads to the occlusion of the PPT and to site A3 inhibition [36] Enzymatic and chemical probing revealed the occurrence of several SC35 and SRp40 binding ... limited contribution to the activation of site A3 (25% of the overall activation) Therefore, the most important parameter of site A3 activation is expected to be the displacement of protein hnRNP A1...
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Báo cáo khoa học: Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation potx
... showed a prevalence of one isoform over the other For instance in the spleen, the short isoform is the predominant AK species, whereas in the testis and kidney, the long isoform is more abundant ... is also present in the TH lanes The other is likely too close to the more prominent TH band to be visible likely to represent the long and short isoforms of the enzyme Many of the tissues included ... regions, with the exception of the cerebellum, express detectable levels of only the short isoform In the cerebellum, both isoforms are present at nearly equal levels metry of 0.99, 0.31, 0.61 and 0.97...
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INHIBITION OF APE1’S DNA REPAIR ACTIVITY AS A TARGET IN CANCER: IDENTIFICATION OF NOVEL SMALL MOLECULES THAT HAVE TRANSLATIONAL POTENTIAL FOR MOLECULARLY TARGETED CANCER THERAPY
... lesions and can reduce the effectiveness of chemotherapeutic agents Therefore, keeping in mind the importance of the BER pathway in the repair of such damage induced by chemotherapy, exploiting the ... enhance the cytotoxicity of MMS, and treatment with these inhibitors resulted in an increase of AP sites formed These compounds are known to target other molecules and are therefore, not specific for ... levels of other DNA repair pathway proteins leading to efficient repair of DNA damage and reducing the efficacy of cancer therapy Cancer cells deficient in the proteins of the HR pathway for instance...
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Flavor enhancement as a tool for increasing pleasantness and intakeof a snack product among the elderly
... initially recruited, but seven of the former and four of the latter group missed one of the three test sessions and were therefore excluded from the data analysis The independently living elderly ... 87–96 89 The tasting sessions for the young subjects were conducted in the sensory laboratory at the University of Helsinki, and for the elderly in the dining rooms or clubrooms of the service ... different information on the samples for the home-use One group in both age cohorts was informed about the organic quality of the sample and another group received information about the sample’s...
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Knowledge Management as a Catalyst for Innovation within Organizations: A Qualitative Study
... participating in the workshops were interested and involved in the area of knowledge management and agreed to participate further The main purpose of the research was to inductively build theory using ... knowledge and innovation within the culture of the organization from a wide range of new sources Furthermore, these sources of innovation can come from without the organization (boundary spanning) The ... construction and enable the process of innovation to be further incorporated within the organization Knowledge dissemination and innovation Innovation includes not only the construction and embodiment of...
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Module 7: Microsoft Proxy Server 2.0 as a Solution for Internet Connectivity
... section (either the Regional Reservations Center or one of the types of airports) of the lab exercise Present the lab, and make sure students understand the instructions and the purpose of the lab Direct ... infringements The central office for the firm is in Montreal, where the firm has a T1 connection to the Internet With the exception of the Vancouver branch office, all other branch offices are ... configured with software to forward traffic to the proxy server if the final destination is the Internet The following table lists the software options for private network computers and the reason...
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Module 8: Routing as a Solution for Private Network Connectivity
... field offices over the VPN connection To authenticate the routers and encrypt the data between the central office and the field offices To force all traffic between the central office and field ... entry that forwards e-mail messages to the field offices over the VPN connection To authenticate the routers and encrypt the data between the central office and the field offices To force all ... chart, or other presentation medium Review the scenario, the design requirements, and the diagram for the assigned location Follow the instructions to complete the exercise At the end of the exercise,...
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Module 10: RADIUS as a Solution for Remote Access
... allow the use of the Internet for accessing the private network The connection to the Internet supports the traffic created by the remote access clients The remote access strategy for the organization ... authentication and accounting for RADIUS clients, and interact with the authentication servers As a result, the authentication and accounting performance is determined by the RADIUS server performance ... vehicle The management of the consortium is a board of directors consisting of employees from each of the companies and is located in Bonn The members of the consortium have research and development...
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Social factors as a basis for treatment
... building up the public orientation of the business and forming links with treatment services The growth of the socialfirm movement is aided by an advantageous legal framework for the businesses, ... of the economic life of a group of people with serious mental illness in Colorado in 1992 found that their total consumption – the combination of their cash expenses and the non-cash income of ... planned All office-cleaning and streetcleaning contracts for the municipality of Trieste are currently awarded to social firms Other enterprises include shopping for the homebound, landscaping and 168...
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Tài liệu Module 2: TCP/IP as a Solution for Networking pdf
... students Present the lab and make sure students understand the instructions and the purpose of the lab Explain that the Design Worksheet is to be used to develop the design of their solution Remind ... Kbps, and Full T1 of 1.544 Mbps The links between locations are either T1 or Fractional T1 and support the full Ethernet MTU of 1,500 bytes Therefore, you not need to consider the possibility of ... TCP/IP protocol suite in detail The students are expected to know this information Use the slide to remind them of the extent of the TCP/IP suite and that the layer one and two network infrastructure...
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Tài liệu Module 3: DHCP as a Solution for IP Configuration pptx
... This information provides the basis for defining the subnets and the options for the DHCP Client • Emphasize the message-driven protocol of requests and responses between the DHCP Server and the ... Read the scenario to the students and review the questions as a group Give the students time to consider their answers, and then lead a discussion of their responses To enhance the availability of ... protocol of requests and responses between the DHCP Client and the DHCP Server Refer students to the relevant RFCs, the online Windows 2000 Help files, and the Windows 2000 Resource Kit, for further...
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Tài liệu Module 4: DNS as a Solution for Name Resolution docx
... as the DNS root server for the organization • Ensure that students understand the scenario description and directions for the Discussion Direct them to read through the scenario and answer the ... Design for Performance Explain the methods of improving the performance of a DNS design Reducing the query resolution time, and reducing the impact of replication on network traffic, can maximize the ... students Present the lab and make sure students understand the instructions and the purpose of the lab Explain that the planning worksheet is to be used to develop the design of their solution...
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Tài liệu Learning Networks as a Means for Work Organization Development pptx
... components: the ease of information exchange and the novelty of information exchanged The ease of information exchange decreases with the increase of difference in the knowledge base of the network ... importance of democracy in the values and principles which guide processes of change, on the one hand, and the work and HRM practices which emerge as a result of these processes, on the other One way of ... Lapland between the Sodankylä Health Care Centre, the Lapland Central Hospital and Oulu University Hospital The project started in the form of cooperation between the Lapland Hospital District, the...
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Tài liệu Module 5: WINS as a Solution for NetBIOS Name Resolution doc
... to the instructions and the details of the scenario Divide the class into teams of two or more students Present the lab and make sure students understand the instructions and the purpose of the ... support the solution, and the location of these servers within the network Select the number of WINS Proxy Agents needed to support the solution, and designate their location within the network ... possibility for the performance problems is that the networking group installed two WINS servers, but placed them both on the same side of the T1 connection The WINS clients on the opposite side of the...
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Tài liệu Module 6: NAT as a Solution for Internet Connectivity docx
... connectivity design You make these decisions by: Determining the placement of the NAT server and the IP address, type of persistence, and data rate of the NAT server interface Selecting the appropriate automatic ... each home office Describe options for improving the performance of the NAT services Describe options for enhancing the availability of the NAT services 27 28 Module 6: NAT as a Solution for Internet ... office over the Internet At the end of each day, the manager of the retail stores exports sales data out of an SQL database into a Microsoft Excel worksheet The manager then sends the Excel worksheet...
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Tài liệu Songs as a Medium for Embedded Reproductive Messages doc
... in the other 50 percent of the genes being carried by their children, and because of their need for protection and provisioning, these themes have high reproductive relevance for females Cox and ... assess the fidelity of a mate Seeking information to ascertain the commitment of a mate and prevent abandonment/cuckoldry “I’m gonna love you forever/Forever and ever Amen” from ‘Forever and Ever ... set within the context of a larger composition called an opera Though arias are often performed independent of the full opera, they derive much of their meaning from the framework of the surrounding...
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Tài liệu Báo cáo khoa học: Phage-display as a tool for quantifying protein stability determinants pptx
... investigating the effect of mutations on the stability of the B1 domain of Streptococcal protein G (GB1) One aspect of GB1 stability that we have addressed is the tolerance for mutations in the core of the ... consequence of the irreversibility of thermal denaturation and the reversibility of chemical denaturation for scFV [8] In the case of GB1, with known hyperstable variants, we intend to compare the results ... expressed and purified for biophysical characterization; one of these differed only at boundary residues and was based on the consensus sequence from the third round of sorting, while two represented the...
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Tài liệu Báo cáo khoa học: Infrared spectroscopy as a tool for discrimination between sensitive and multiresistant K562 cells doc
... contained in fatty acids of the cell The band at 2963 cm)1 can be assigned to the asymmetric stretching of CH3, and the band at 2873 cm)1 to its symmetric mode The bands at 2926 and 2853 cm)1 can be ... spectra, circles) of the training (full) and test set (empty) The percentage of variance represented by each component is indicated on the axes Table Results of LDA for spectra of the test set when ... for the variables containing the greatest interclass variance and the smallest intraclass variance, and constructs a linear combination of the variables to discriminate between the classes The...
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Smoking and reproduction: The oviduct as a target of cigarette smoke ppt
... between the cumulus cell matrix and the tips of the cilia is necessary to move the complex over the surface of the infundibulum [45,72] The cumulus matrix attaches the complex to the infundibulum, and ... development, and transport of the preimplantation embryos to the uterus The movement of the embryo through the oviduct to the uterus is carefully timed by ovarian hormones and signals from the embryos ... complexes and Schematic diagram showing the three anatomical regions of the oviduct (infundibulum, ampulla, and isthmus) and the regions of the oviduct where oocyte cumulus complexes and preimplantation...
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Báo cáo khoa học: Staphylococcus aureus elongation factor G – structure and analysis of a target for fusidic acid pdf
... helices AV and BV at the surface of domain V Gly621 and Gly617 are in the area of contact with the 1095 and 2473 regions of 23S RNA The two helices are facing the ribosome, and the four-stranded b-sheet ... structures in the PDB The structures were superimposed on the basis of domains I and II Looking from the direction of the arrow in (A) and (B), the coordinates of His572 at the tip of domain IV ... new conformation is significant, as it demonstrates the size of the conformational space of EF-G when not bound to the ribosome The active conformation of EF-G is the one that occurs on the ribosome...
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