... analyses and Kaplan-Meier curves to assess the impact of suPAR serum concentrations on ICU- and overall survival among all critically ill patientsandthe subgroups of sepsis and non-sepsis patients ... suPAR serum concentrations upon admissiontotheICU are elevated in critically ill patients as compared with healthy controls and are higher in sepsis than in nonsepsis patientsTo examine the ... higher suPAR levels at admission as well as on days and (Figure 4a, Table 4) Low suPAR levels upon admissiontothe ICU, on Day and Day were a strong prognostic predictor for ICU- survival (admission...
... al Table Univariate analysis of categorical factors associatedwith death at year among sARF patients Factor Fatality rate with factor Fatality rate without factor Relative risk (95% CI) p value ... hospital admissionand (0 to 3) day afterICUadmission Among the 240 patientswith sARF, 203 (85%) had intra-renal, 36 (15%) preR702 Critical Care Vol No Bagshaw et al Table Risk of sARF associated ... help with database management and data entry, and Reza Shahpori for providing data from theICU Tracer database This study was funded by a grant from the Canadian Intensive Care Foundation SMB was...
... ICUpatientswith MDR VAP are very much warranted Only a few case reports in the literature deal withthe intrathecal administration of colistin for the treatment of ventriculitis and shunt infections ... pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration in critically-ill patientswith infections caused by gram-negative bacteria Antimicrob Agents ... postneurosurgical ventriculitis due to MDR A baumannii or P aeruginosa strains treated successfully and safely with CMS administered by the intrathecal or intraventricular route The dosage of colistin (base)...
... The study was undertaken in patients who died and underwent postmortem examinations afteradmissiontoa 13 bed general medical/surgical ICU in a university affiliated hospital The hospital offers ... investigators anda consensus on the cause of death was agreed after discussion Both the clinically diagnosed cause of death and other significant clinical diagnoses were recorded R130 The clinical ... examination and were classified as Goldman class III/IV discrepancies In patientswith class I discrepancies the most frequently missed diagnosis was myocardial infarction There was no relationship...
... that gastrointestinal bleeding, intracranial haemorrhage and septic shock are significant prognostic factors in SLE patients admitted totheICU In contrast, the causes ofICUadmissionand APACHE ... the ICU, including five patientswith two admissions and two with three admissions The causes ofICUadmission are summarized in Table The most common cause ofadmissiontotheICU was pneumonia ... Nevertheless, the actual frequency ofand factors contributing to intracranial haemorrhage in SLE patients remain undefined In theICU it is often difficult to make a diagnosis of cerebrovascular accident...
... transfusion data were unavailable were excluded Baseline characteristics at ICUadmissionand clinical outcomes for the remaining 155 patients are summarized in Tables andThepatients Page of (page number ... was approved by the hospital's institutional review board anda waiver of consent was granted Statistical analysis Continuous variables are summarized as mean ± standard deviation or median (interquartile ... of units of PRBC transfused as the dependent variable, anda similar backward selection technique to eliminate nonsignificant variables, was carried out as a secondary analysis All statistical...
... than that ofa pool of healthy historical controls, suggestive of some mitochondrial alteration Of note, the historical control pool is presented for general rather than statistical comparison ... collected as part of this study However, for the sake of comparison, the mtDNA/nDNA ratio ofa DNA pool containing buffycoat DNA from 24 healthy males (average age 39 years old) and used as internal ... a point of no return The aim of this study was to describe blood cell mtDNA levels in critically ill patientsand evaluate their association with intensive care unit (ICU) survival and admission...
... (25/39) ofthe patients, witha mean GEC of 2.8 ± 0.1 The demographic data and characteristics ofpatients who had normal and delayed GE are summarised in Table There was no relationship between the ... hypotheses: (a) slow GE isassociatedwith elevated plasma concentrations of CCK and PYY, and (b) GE isa determinant of postprandial concentrations of CCK and PYY in the critically ill Materials ... bIncluding Data are mean ± standard error ofthe mean patient may have one or more admission diagnoses sub-arachnoid haemorrhage and massive cerebral ischemic event APACHE II, Acute Physiology and Chronic...
... extended daily dialysis Table Demographic and clinical characteristics ofpatients Characteristic Value Number ofpatients (EDD), andthe need for antibiotic treatment The approach was chosen to study ... performed to compare Ang-1 and Ang-2 concentrations in patients with/ without atherosclerotic cardiovascular disease (n = 11), andwith malignant disease (n = 6) respectively The Ang-1 and Ang-2 concentrations ... concentration range The second decisive result is that both assays show adequate intra-assay and inter-assay imprecision across the range of values measured in apparently healthy individuals and...
... that many acute respiratory distress syndrome survivors have persistent functional impairment with decreased exercise tolerance, muscle weakness and muscle wasting up to years afterICU discharge ... via activation of caspase 3, oxidative stress, and decreased protein synthesis [9] These data indicate that hyperglycemia activates pathways involved in muscle atrophy In addition, studies evaluating ... Chonkar A, Hopkin R, Adeghate E, Singh J: Contraction and cation contents of skeletal soleus and EDL muscles in agematched control and diabetic rats Ann N Y Acad Sci 2006, 1084:442-451 Paulus...
... incorporating multiple demographic, clinical and laboratory variables at start of RRT (Table 4) All variables found to be statistically significant at a 10% level in the univariate analysis (sepsis, ... critically ill patientswith established AKI at initiation of RRT Elevated serum NGAL is independently related tothe severity of AKI (cystatin C and renal SOFA), but also tothe presence of sepsis ... characteristics at various cut-off values at initiation of RRT To assess the utility of NGAL measurements at varying cut-off values to predict mortality, a conventional ROC curve was generated andthe area...
... with standards ofthe National Association of Testing Authorities [17] andthe Royal College of Pathologists of Australasia [18] Statistical Analysis We used theICUadmission (LacADM) and maximal ... Interval (CI)) ofa multivariate analysis assessing the association between admission blood lactate (LacADM) within the normal range and hospital mortality (All ORs in the multivariate analysis ... used by the ANZICS-CORE - Adult Patient Database [16] All patients had initial arterial lactate and blood gas measured by blood gas analyser (Rapilab, Bayer Australia, Sydney, NSW, Australia, upper...
... For each patient, data from institutional ICUand follow-up databases (FileMaker Pro; FileMaker, Inc., Santa Clara, CA, USA) and from the Italian Group for the Evaluation of Interventions in Intensive ... timing and characteristics of psychological intervention [12] To improve the psychological outcomeofICUpatients by helping the patients, their relatives and healthcare personnel elaborate theICU ... perception of quality of life was estimated using the visual analogue scale (VAS), which isa 20-cm vertical visual analogue scale withthe end points labeled best imaginable health at the top and worst...
... Efficacy and safety ofa paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled ... expected to wake up with or without sedation (coma hepaticum or neurological coma) A total of 140 patients were randomized in two groups: 70 patients in the awake intervention group and 70 patients ... period and drawn separately for each group (intervention group with no sedation and control group with sedation) A mean value for each patient up toa period of 14 days was calculated and presented...
... resistin levels at admittance andICU survival or the overall survival of all patients, as well as severity of disease, as measured by APACHE II score for the subgroup of sepsis patients Remarkably, ... follow-up among all critical care patientsandthe subgroups of sepsis and non-sepsis patients Regarding all ICU patients, no association between survival and resistin serum levels could be revealed ... sepsis and non-sepsis patients Among the 170 critically ill patients enrolled in this study, 122 patients conformed tothe criteria of bacterial sepsis (Table 1) In the majority of sepsis patients...
... monitoring (in particular ofthe patient’s hydration status) and treatment (more rapid and adequate resuscitation of severe sepsis and shock and avoidance of concomitant administration of potentially ... Plachouras D, Karvanen M, Friberg LE, Papadomichelakis E, Antoniadou A, Tsangaris I, Karaiskos I, Poulakou G, Kontopidou F, Armaganidis A, Cars O, Giamarellou H: Population pharmacokinetic analysis of ... Colistin and rifampicin combination in the treatment of ventilator -associated pneumonia caused by carbapenem-resistant Acinetobacter baumannii Int J Antimicrob Agents 2008, 32:281-283 Falagas...
... chain aminoacids) vs Vivonex (standard enteral formulae) [30] In another study of trauma patients, Immun-Aid was associatedwitha trend toward a lower pneumonia rate than patients fed with Promote ... sucralfate; H2RA; over from jejunal to reviewed blinded persistent patients according to H2RA and antacids; gastric group andto group infiltrate and computer sucralfate andpatients crossed assignment ... of these comparisons precluded blinding ofpatientsand caregivers Patients were unlikely to be aware ofthe details of their care and were not participating in assessment ofthe presence of...
... PE, andto understand national interest in a VTE research program in theICU Instrument administration Analysis We report means and standard deviations, and proportions as appropriate Chi square ... approach to VTE diagnosis (laboratory and imaging studies), and recommendations for further research on the prevention and diagnosis of VTE in critically ill patients Respondents were asked to ... abstracts The high risk of DVT and PE in critically ill patients, its potential morbidity and mortality, andthe need for accurate diagnosis To select individuals with managerial responsibility and...
... carefully andto implement preventive measures It is necessary to analyze all types of catheter used andto report the data in a standardized and comparable manner, such as percentage of catheters accidentally ... 13 It is necessary to analyze all types of catheter used andto report the data in a standardized and comparable manner, such as percentage of catheters accidentally removed and number of ACRs/100 ... thoracic, abdominal, intraventricular brain and cardiac surgical drains We considered ACR to be the unplanned removal ofa catheter either by the patient or by the staff The patient can cause ACR either...