parkinson s disease diagnosis and treatment tan eng king and john thomas
Báo cáo khoa học: LRRK2 in Parkinson’s disease: genetic and clinical studies from patients ppt
... Kawarai T, Sato C, SalehiRad S, Fisman GK, Al-Khairallah T, St George-Hyslop P, Singleton A & Rogaeva E (2005) LRRK2 gene in Parkinson disease: mutation analysis and case control association study ... Duke-NUS Graduate Medical School and SingHealth Services References Gandhi PN, Chen SG & Wilson-Delfosse AL (2009) Leucine-rich repeat kinase (LRRK2): a key player in the pathogenesis of Parkinson s ... Nuytemans K, Ross OA, Gibson JM, Tan EK, Gaig C, Tolosa E, Goldwurm S et al (2008) Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease Neurology 70, 1456–1460 27 Gorostidi A,...
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MECHANISMS IN PARKINSON’S DISEASE – MODELS AND TREATMENTS pot
... Impotence Sildenafil, tadalafil, and vardenafil Pain Adjust Parkinsons disease drugs and muscle relaxants Restless legs Dopamine agonists Orthostatic hypotension Adjust Parkinsons disease drugs; increase ... motor disorders, such as Parkinsons disease Thus, in PD, the loss of dopamine neurons causes the subsequent loss of striatal dopamine, and the presentation of motor symptoms, such as bradykinesia, ... continuously forming and disappearing in the diseased substantia nigra (Greffard et al, 2010) The brain-stem shape is a spherical Mechanisms in Parkinsons Disease Models and Treatments structure measuring...
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Báo cáo y học: "Phenomenology and management of cognitive and behavioral disorders in Parkinson''''s disease. Rise and logic of dementia in Parkinson''''s disease" pptx
... "has not yet obtained a place in the classification of nosologists Some have regarded its characteristic symptoms as distinct and different diseases, and others have given its name to diseases ... J, Tolosa E Baltimore: Williams and Wilkins; 1998:837-858 Bodis-Wollner I: Neuropsychological and perceptual deficits in Parkinson' s disease Parkinsonism and Related Disorders 2003, 9 :S8 3 -S8 9 Lezak ... in the individual subject rests on the use of criteria derived from unsatisfactory definitions and procedures Assessments such as the WAIS bring a degree of objectivity to assessment of cognitive...
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PARKINSON''''S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN potx
... PARKINSON' S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN CURRENT CLINICAL PRACTICE Parkinson s Disease and Movement Disorders: Diagnosis and ... LIEBERMAN AND JOHN A ANDERSON, 1997 Osteoporosis: Diagnostic and Therapeutic Principles, edited by CLIFFORD J ROSEN, 1996 PARKINSON' S DISEASE AND MOVEMENT DISORDERS DIAGNOSIS AND TREATMENT GUIDELINES ... disorders On the island of Guam, amyotrophic lateral sclerosis, parkinsonism, and dementia occur in various combinations, perhaps as manifestations of the same disease process Outside Guam, the association...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
... 11.3 Parkinson s Disease Parkinson s disease (also known as Parkinson disease or PD) is a degenerative disorder of the central nervous system that often impairs the sufferer s motor skills and speech ... functions, neurotransmitter levels, emotional stress, and progression of neurodegenerative conditions such as Parkinson s and Alzheimer s diseases (Rahman et al., 2008) 11.4 Heart Disease 11.4.1 Case ... flesh, including essential fatty acids from seeds and seed oils, and fibers, such as microcrystalline cellulose, pectins, lignins, cutin-like polymers, and condensed tannins, have been suggested...
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Surgical Treatment of Parkinson’s Disease and Other Movement Disorders pot
... disorders These diseases are conventionally categorized into either hypokinetic disorders, such as Parkinson s disease, or hyperkinetic disorders such as hemiballism or drug-induced dyskinesias ... disorders such as Huntington s disease (HD) or dystonia, which seem to cross the boundary between these diseases Another common misconception is that movement disorders are basal ganglia diseases ... in Parkinson s Disease: Costs and Benefits 129 Simon Parkin, Carole Joint, Richard Scott, and Tipu Z Aziz Subthalamotomy for Parkinson s Disease 145 Steven S Gill, Nikunj K Patel, and...
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PARKINSON’S DISEASE: National clinical guideline for diagnosis and management in primary and secondary care ppt
... Throughout disease Diagnosis and early disease Disease progression Parkinson s disease algorithm Figure 3.1 Parkinson s disease algorithm: interventions for people with PD 3.3 Key messages 19 Communication ... condition Diagnosis is particularly highlighted This can be difficult, and while swift assessment by someone with appropriate expertise is important when suspicion of Parkinson s disease first arises, ... or organisations: all healthcare professionals people with the disease and carers of these people patient support groups commissioning organisations service providers Parkinson s disease 2.4 Involvement...
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Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx
... THERAPEUTICS of PARKINSON S DISEASE and OTHER MOVEMENT DISORDERS Therapeutics of Parkinson s Disease and Other Movement Disorders Edited by Mark Hallett and Werner Poewe © 2008 John Wiley & Sons, Ltd ISBN: ... degradation and PARKINSON S DISEASE AND PARKINSONISM PARKINSON S DISESASE Sporadic Autosomal Dominant SYN LRRK2 UCH-L1 GENES TOXIN Autosomal Recessive AGING PARKIN DJ-1 Protein O abnormal autophagy UPS ... McNaught, K .S and Jenner, P (2001) Proteasomal function is impaired in substantia nigra in Parkinson s disease Neuroscience Letters, 297 (3), 191 194 20 PARKINSON S DISEASE AND PARKINSONISM McNaught,...
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Tài liệu Parkinson’s Disease and Related Disorders docx
... L.: Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview Arnulf, I.: Sleep and wakefulness disturbances in Parkinson s disease ... outstanding scientists and clinicians, Toshiharu Nagatsu, Yoshikuni Mizuno, Japan (Award of the WFN Research Group on Parkinsonism and Related Disorders), Saskia Biskup, Germany and Andrew B Singleton, ... Disease and Parkinsonism seen at the Columbia-Presbyterian Medical Center from 1949 to 1964 Nearly 85% had classic Parkinson s Disease and 13% had post-encephalitic associated Parkinsonism This...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... biology and oxidative stress in Parkinson disease pathogenesis Nat Clin Pract Neurol 4, 600–609 Lesage S & Brice A (2009) Parkinson s disease: from monogenic forms to genetic susceptibility factors ... a statistically significant interaction network, as well as statistically significant functional association with GO classifications [16] Western blotting Expression of a-synuclein and HSP70 was ... MF (2007) Parkinson s disease Hum Mol Genet 16 Spec No 2, R183–R194 Devine MJ & Lewis PA (2008) Emerging pathways in genetic Parkinson s disease: tangles, Lewy bodies and LRRK2 FEBS J 275, 5748–5757...
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An Atlas of PARKINSON’S DISEASE AND RELATED DISORDERS pdf
... index ISBN 1-85070-943-2 Extrapyramidal disorders Atlases Parkinsonism Atlases Movement disorders Atlases I Title II Series [DNLM: Parkinson Disease atlases Basal Ganglia Diseases atlases Movement ... Parkinson s disease ©2004 CRC Press LLC Figure 11 Posture in later-stage Parkinson s disease Figure 12 Parkinson s disease: Impaired fist clenching Figure 13 Parkinson s disease: Tremor illustrated ... characteristics of Parkinson' s disease must take into account the inaccuracies of clinical diagnosis In a successive series of 100 patients with a clinical diagnosis of Parkinson' s disease, only...
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An Illustrated Pocketbook of Parkinson''''s Disease and Related Disorders pot
... PARKINSON S DISEASE Figure 16 Parkinson s disease: dystonic posturing of the big toe secondary to dopa therapy 15 16 AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 17 Parkinson s disease: ... Posture in later-stage Parkinson s disease AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 12 Parkinson s disease: impaired fist clenching 11 12 AN ILLUSTRATED POCKETBOOK OF PARKINSON S ... RD, Bakay RA Neurosurgical horizons in Parkinson s disease Neurology 1993;43:l–7 Parkinson' s disease Any discussion of the clinical characteristics of Parkinson s disease must take into account...
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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx
... nervous system neurons A recent study analyzed the enteric nervous system in PD and found that both Meissner s and Auerbach s plexuses were affected already in early stages of disease and terminal ... components Signal intensities were scored using a semiquantitative scale with five steps (–,+),+,++ and +++) Scores were based on several sections ⁄ animal and several animals ⁄ observation and confirmed ... excellent technical assistance This study was supported by the Swedish Research Council, the Swedish Brain ˚ Foundation and the Hallsten Foundation, the Swedish Parkinson Foundation, Swedish Brain Power,...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: function in cells and neurodegeneration doc
... a fellowship from the American Parkinson s Disease Association A.B.W is supported by the Michael J Fox Foundation for Parkinson s Disease Research, the American Parkinson s Disease Association, ... kinase associates with lipid rafts Hum Mol Genet 16, 678–690 15 West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL & Dawson TM (2005) Parkinson s disease- associated mutations ... morphogenesis, with the caveat that successful LRRK2 knockdown and even verification of endogenous expression is difficult to assess in most cell lines as a result of the presumed low levels of protein and...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
... kinase (LRRK2) ⁄ PARK8 possesses GTPase activity that is altered in familial Parkinson s disease R1441C ⁄ G mutants J Neurochem 103, 238–247 Guo L, Gandhi PN, Wang W, Petersen RB, WilsonDelfosse ... processes and will continue to impact our understanding of disease pathogenesis This minireview will examine the previous studies of genes for ROCO or LRRK2 homologs in slime mold Dictyostelium ... dopamine transmission) and likely pre-symptomatic (or early) events of the disease process They should also be useful in testing the ‘two-hit’ or ‘multiple-hit’ hypothesis proposing that LRRK2 and other...
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Psychiatric and Cognitive Disorders in Parkinson’s Disease pptx
... aspects of Parkinson s disease Parkinsonism and Parkinson s disease 34 Cognitive deficits in Parkinson s disease 55 Depression in Parkinson s disease 88 Anxiety, phobias, apathy, and premorbid personality ... guidelines, case studies and rating scales will meet the needs of all clinicians working with Parkinson s disease patients Sergio E Starkstein was Assistant Professor of Psychiatry at Johns Hopkins ... motor sequelae 3 Parkinsonism and Parkinson s disease The diagnosis of PD requires a thorough investigation of the main neurologic signs of the disease, as well as the search for signs that...
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báo cáo hóa học:" Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson''''s disease" doc
... Independent ttest followed by post hoc Bonferroni tests were used for the analysis of other data via the SPSS 10.0 soft packages (SPSS Inc., USA) The criterion for statistical significance was set at ... in vivo neurotrophic factors expression, 15 mg wet tissues with microcarriersRPE cells and tissues with microcarriers were lysed for ELISA assay The lysis buffer was prepared according to the ... tissues were dissected from embryonic brain and trypsinized into single-cell suspension using sterilized micropipette tips The cells were resuspended in DMEM and Ham 's F12 at 1:1 (D-F12), supplemented...
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Báo cáo hóa học: " Audio-Biofeedback training for posture and balance in Patients with Parkinson’s disease" doc
... perform sit-to-stand and stand-to-sit transfers Patients were instructed to stand up and sit down five times as fast as possible Page of starting in the sitting position and stopping after sitting ... minutes in each session Assessments Assessments included standardized tests of balance and, postural control as well as ADL s to evaluate the effects of training Balance tests that were used included: ... task was trained during the sessions and reflects a training specific change Patients scored less (better) on the GDS (p = 0.05) and PDQ-39 scales, which suggests less depressive symptoms and...
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báo cáo hóa học: " The effects of high frequency subthalamic stimulation on balance performance and fear of falling in patients with Parkinson''''s disease" docx
... the tests (eyes open, eyes closed) The same test order was maintained during the DBS OFF and ON measurements In every test situation, spontaneous sway was recorded for 30 seconds (quiet stance) ... improves certain aspects of postural control in Parkinson' s disease, whereas medication does not Mov Disord 2006, 21:1088-1097 Magnusson M, Johansson K, Johansson BB: Sensory stimulation promotes ... hypotension5 Prior surgery related to Parkinson' s disease6 Pain symptoms Assistive device (walking indoors) Assistive device (walking outdoors) Falls within the past months7 Median (range) 66...
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