pahs induced oxidative stress
Particle Toxicology - Chapter 11 pot
... particle monolayer surface (Borm et al 2005) 11.2.3 ORGANIC COMPOUNDS AND OXIDATIVE STRESS Evidence for the involvement of oxidative stress in the effects of organic compounds came from the initial observation ... Xie, Y., Loo, J A., and Nel, A E., Use of a fluorescent phosphoprotein dye to characterize oxidative stress -induced signaling pathway components in macrophage and epithelial cultures exposed to diesel ... implicated in the IL-8 mRNA expression induced by DEP and their benzene organic extracts in BEAS-2B cell line (Kawasaki et al 2001) and in the release of IL-8 and RANTES induced by DEP extracts in peripheral...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
... 13-acetate (PMA) -induced Erk1/2 activation (Fig 7B) Inhibition of S1P -induced Erk1/2 phosphorylation by Pd98059 indicated the effectiveness of this drug while decreased S1P -induced Akt/PKB phosphorylation ... Cyr61/CCN1 gene expression In contrast, SB-203580, a specific inhibitor for the stress- activated protein kinase (SAPK) p38, induced a 38% decrease of Cyr61/CCN1 mRNA levels in cells treated with S1P ... RSK) which is activated by ERK1/2 and mitogen- and stress- activated protein kinase (MSK) which is activated by either ERK1/2 or p38 As S1P -induced Cyr61/CCN1 gene expression is not mediated through...
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Báo cáo khoa học: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells docx
... different stimuli For example, SUMO conjugation is increased in response to heat shock or oxidative stress [42,43] By contrast, a low concentration of hydrogen peroxide induces protein desumoylation ... confirmed by western blot analysis (Fig 7H) Taken together, these data show that cAMP signaling induced a significant change in expression of several sumoylation-related genes Discussion SUMO modification ... homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone -induced granulosa cell differentiation Endocrinology 145, 3821–3829 42 Saitoh H & Hinchey J (2000)...
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Erectile Dysfunction – Disease-Associated Mechanisms and Novel Insights into Therapy Edited by Kenia Pedrosa Nunes potx
... ED showed a higher expression of the active ERK 94 ERK can be triggered by cellular stresses such as oxidative stress and hyperglycemia, which play an important role in the development of diabetic ... of oxidative stress in the pathophysiological mechanism of erectile dysfunction J Androl 2006;27: 335-47 [114] Zalba G, Beaumont J, San Jose G, Fortuno A, Fortuno MA, Diez J Vascular oxidant stress: ... mediator of RAS, induces vascular injury through many mechanisms, including vasoconstriction, oxidative stress and inflammation Both peptides have been shown to increase TNF- levels and this pro-inflammatory...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... J.A & Stamenkovic, I (1992) CD22-mediated stimulation of T cells regulates T-cell receptor/CD3 -induced signaling Proc Natl Acad Sci USA 89, 10242–10246 Falco, M., Biassoni, R., Bottino, C., Vitale, ... 269 (16), 11783–11786 Hanasaki, K., Varki, A., Stamenkovic, I & Bevilacqua, M.P (1994) Cytokine -induced beta-galactoside alpha-2,6-sialyltransferase in human endothelial cells mediates alpha-2,6-sialylation...
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báo cáo hóa học:" Bioactivity-guided identification and cell signaling technology to delineate the immunomodulatory effects of Panax ginseng on human promonocytic U937 cells" potx
... IL-1β and TNF-α -induced protein (TNFIP3) The genechip results of CXCL-10 and IL-8 were validated by quantitative RT-PCR and ELISA Consistently, PGSE showed inhibition on TNF-α -induced CXCL-10 ... IL18R1 IL1B IL1B Chemokine (C-X-C motif) ligand 10 TNF-α -induced protein Chemokine (C-X-C motif) ligand NK-κB inhibitor, alpha TNF-α -induced protein Immediate early response G protein-coupled ... protein-coupled receptor 84 NF-κB inhibitor, zeta Phosphodiesterase 4B Interleukin TNF-α -induced protein TNF-α -induced protein Homo sapiens IL8 C-terminal variant Chemokine (C-C motif) ligand Chemokine...
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báo cáo hóa học: " Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury" potx
... neuroinflammation Inflammatory mediators are able to alter cellular metabolism by inducing oxidative stress and mitochondrial dysfunction [43], resulting in pathologic abnormalities [44] Abnormally ... function Increased Iba-1 immunoreactivity is a hallmark of burn -induced inflammation It has been proposed that microglial activation induced by sepsis is involved in the pathogenesis of delirium ... might be a consequence of multiple factors, including proinflammatory mediators, ischemia, and oxidative stress We further found that gelsolin treatment dramatically inhibits expression of phospho-ERK1/2...
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Báo cáo hóa học: " Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain" pptx
... Using a model of incision -induced allodynia in mice, we further demonstrate that local injection of resveratrol around the surgical wound strongly attenuates incision -induced allodynia Intraplantar ... (Figure 5) These findings indicate that resveratrol blocks IL6 -induced signaling in sensory neurons Figure Resveratrol blocks IL-6 induced signaling in sensory neurons TG neuron cultures were pre-treated ... resveratrol blocks IL-6 induced acute allodynia in a dose-related manner A) Intraplantar injection of IL-6 (0.1 ng) and co-treatment with resveratrol (0.1, and 10 µg) blocks IL-6 induced allodynia...
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Associated Technologies And Milling Cutter by J Smith_2 doc
... on a brittle material The cutter’s exit can influence the type of stress induced into the workpiece surface – a compressive stress being preferred (more will be said on this topic later, in the...
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Molecular and Cellular Signaling docx
... Pheromones 6.15 Osmotic Stresses Activate Glycerol Response Pathway 6.16 Yeasts Have a General Stress Response 6.17 Target of Rapamycin ... Permeability 15.10 Mitochondria Release Cytochrome c in Response to Oxidative Stresses 15.11 Mitochondria Release Apoptosis-Promoting Agents ... several reasons It insulates the DNA against oxidative byproducts of normal cellular processes taking place in the cytoplasm and from mechanical forces and stresses generated by the cytoskeleton It...
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ERECTILE DYSFUNCTION – DISEASE-ASSOCIATED MECHANISMS AND NOVEL INSIGHTS INTO THERAPY pdf
... ED showed a higher expression of the active ERK 94 ERK can be triggered by cellular stresses such as oxidative stress and hyperglycemia, which play an important role in the development of diabetic ... of oxidative stress in the pathophysiological mechanism of erectile dysfunction J Androl 2006;27: 335-47 [114] Zalba G, Beaumont J, San Jose G, Fortuno A, Fortuno MA, Diez J Vascular oxidant stress: ... mediator of RAS, induces vascular injury through many mechanisms, including vasoconstriction, oxidative stress and inflammation Both peptides have been shown to increase TNF- levels and this pro-inflammatory...
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Báo cáo sinh học: "The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling" potx
... starvation on water, oxidative- stress challenge, bacterial infection, heat shock, and heavy-metal stress, the only condition for which hypersensitivity was observed is oxidative stress When placed ... that distinct stress -induced signaling pathways activate dFOXO under conditions of cellular stress, in addition to the negative input from the insulin cascade, as several stress -induced phosphorylation ... against oxidative stress is conserved across species Figure (see figure on the next page) Null dFOXO mutants are viable, have no overgrowth phenotype and are hypersensitive to oxidative stress...
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Báo cáo sinh học: "Dishevelled and Wnt signaling: is the nucleus the final frontier" potx
... Dishevelled to actin stress fibres and vesicular membranes Nature 2002, 419:726-729 24 Torres MA, Nelson WJ: Colocalization and redistribution of dishevelled and actin during Wnt -induced mesenchymal...
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Báo cáo y học: " Eph Receptors and Ephrin Signaling" pps
... pathways in both the receptor-expressing and the ligand-expressing cells [4] Forward signaling is induced in the Eph receptor-expressing cells, whereas the ephrin-Eph receptor interaction also induces ... and control cell shape and movement, by promoting the formation of lamellipodia, filopodia and stress fibers [9] This GTPase activation is mediated by exchange factors and adaptor proteins such ... points towards an inhibitory regulatory role Crosstalk In addition to the bi-directional signaling induced by Eph receptor and ephrin ligand interactions; both receptor and ligand are capable of...
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Báo cáo y học: "Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury" potx
... damage To this end we have used an ex vivo model to investigate the modulation of gene expression induced by mechanical injury to adult human articular cartilage explants We have detected upregulation ... terminated for gene expression analysis by quantitative real time PCR Culture in the presence of LiCl induced the upregulation of axin-2 (c) and c-JUN (d) mRNAs, thereby confirming that these two genes...
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Báo cáo y học: "Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study" pot
... than the PAR-2 activation IL-1β induced mean increases for MMP-1, MMP-13, and COX-2 of 29%, 20%, and 18% compared with means of 73%, 44%, and 40% for PAR2-AP PAR-2 -induced signalling pathways The ... number not for citation purposes) that regard, an important role for PAR-2 in the mouse adjuvantinduced arthritis model has been shown by using a PAR-2 gene knockout mouse in which the appearance ... levels compared with the control (p < 0.03) but to a lesser extent than at minutes PAR-2-AP also induced p38 phosphorylation (p-p38) rapidly, with a maximum stimulation at minutes (p < 0.03) (Figure...
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Báo cáo y học: "Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells" doc
... (AGE)-BSA after one day induced the upregulation of RAGE mRNA (*P < 0.001, n = 15) (b) RAGE protein expression as determined by western blots mg/ml AGE-BSA for 48 hours significantly induced RAGE protein ... Figure 14 Hypothetical relation between AGE -induced NFκB activation and cell cycle arrest in osteoarthritic FLS Reactive oxygen species (ROS), known to FLS be induced by receptor for AGEs (RAGE) activation, ... contributes to the activation of redox-sensitive transcription factors such as NFκB and subsequently induced expression of proinflammatory cytokines such as TNF-α and IL-6 [24] To investigate whether...
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báo cáo khoa học: "Different patterns of NF-B and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma" ppt
... Notch1 and NF-B signaling and tumor -induced lymphangiogenesis Taken together, our findings imply that Notch1 and NF-B signaling have counter-acting roles in tumor -induced lymphangiogenesis in ESCC, ... NF-B signaling have been reported to play an important role in carcinogenesis by promoting tumor -induced angiogenesis and neoplastic proliferation [14], the association of NF-B with lymphangiogenesis ... context [17] Given the uncertain contributions of differential NFB and Notch signaling to tumor -induced lymphangiogenesis of ESCC, we here assessed the expression of NF-B and Notch1 in ESCC tissues...
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