oxidative stress and the immune system
scientific american - 1993 09 - special issue - life, death, and the immune system
... interlopers and guide the bodyÕs defenses This process is crucial to the function of the immune system and its failure 80 How the Immune System Recognizes the Body Philippa Marrack and John W Kappler The ... American, Inc Life, Death and the Immune System By defining and defending the self, the immune system makes life possible; malfunction causes illness and death Study of the system provides a unifying ... chemicals that boost the activity of other cells in the immune system the junctions between the V and D or D and J segments when they interlink, which further increases the number of possible...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... digesting the fragment with HindIII and Bgl II and the plasmid with HindIII and Bam HI The fragment was ligated into the plasmid and the integrity of the insertion was validated by digesting the plasmid ... purified (< 820 bp) The insert was then ligated into the pSPORT vector and the resulting full-length siglec-10 clone was designated 995-2 and the sequence was verified against the other siglec-10 clones ... peripheral blood cells The anti-(siglec-10) Ig recognized a single band approximately at the expected Mr of between 90 and 120 kDa There were no other visible bands, implying that the antibody is specific...
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
... ANT1 effect is mediated by oxidative stress A possible explanation for the ANT1-silencing effect on oxidative stress and cell survival could reside in the loss of the basal proton conductance ... h after the transfection with pcDNA-ANT1, pcDNA-ANT2 or pcDNA; the 39 kDa band corresponds to recombinant FLAG-ANT1 or ANT2 protein, the 42 kDa band corresponds to ERK2, the 44 kDa band, where ... protein in Scrambleand ANT1 and ANT2 siRNA-transfected cells; the 33 kDa band corresponds to ANT proteins, the 43 kDa band corresponds to actin (E) Western blot analysis of FLAGANT1 and FLAG-ANT2...
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Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx
... the phenomenon In the zooxanthella, heat stress has been demonstrated to reduce the photosynthetic rate by decreasing the efficiency of the photosystem II [4–6] and ⁄ or by causing damage to the ... studies and supports the occurrence of an oxidative stress period in heat stressed A viridis [24] We suggest that apoptosis induction could be the consequence of the previous oxidative stress ... gastrodermal detachment [7,52,57] Nevertheless, independently of the resulting effect of the thermal stress, all mechanisms point to the involvement of oxidative stress in the early stages of symbiosis...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
... (Institute for Work and Health) for their help in the metal/creatinine analysis, and comments on the manuscript The medical team of the Institute for Work and Health (Prof Marcel-André Boillat, Dr ... participated in the study design and planning, was responsible for the field campaign, performed the PM measurements and characterization, evaluated and interpreted the data and participated in the writing ... measurements and contributed to the writing of the manuscript FS: participated in the field campaign, performed the 1-OHP analysis and contributed to the writing of the manuscript SD: participated in the...
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Báo cáo sinh học: "Parasite immunomodulation and polymorphisms of the immune system" ppsx
... exceptionally susceptible to either infection or pathology, and a deeper understanding of the intimate co-evolution of pathogens and the immune system 10 11 12 13 14 Acknowledgements The author’s research ... [8] and animal models [9] The best-understood of these suppressive systems is the regulatory T cell (Treg), a cellular safety catch on the immune response that normally blocks autoimmunity and ... less well recognized for the regulation of immune responses The effect of parasites, for example, has been to dampen, rather than fully ablate, immune responsiveness, and the degree of immunosuppression...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... impossible to prove whether the TR cells isolated from peripheral blood originate in the thymus, and are expanded in the periphery, or whether they have been generated in the periphery The possibility ... inducing the local induction of Th3 or Tr1 cells [74], extends this paradigm The fate of the TR cells induced at the site is not known — whether these cells exist only transiently then die, whether they ... treat autoimmune disease A better understanding of how these forces work together will allow us to understand immunologic settings where either the immune response is inadequate, such as the response...
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Báo cáo y học: " Mimicking microbial ‘education’ of the immune system: a strategy to revert the epidemic trend of atopy and allergic asthma?" ppt
... through natural soil dust and contaminated food Rook and Stanford [11] proposed that mycobacteria might therefore have influenced the evolution of the immune system because they have been ubiquitous ... (dendritic cells) may be the target of a microbial bystander effect, that may dictate the pattern of accessory molecules and cytokines, and modulate the outcome (Th1- or Th2-like) of the allergen-specific ... allergen for allergen-specific immunotherapy, and from trials with Homeostasis of the immune system is so complex and microbial exposure is so diversified that, at the present state of our knowledge,...
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Báo cáo y học: " Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system" pps
... have been observed in the functional structure of some key components of the innate immune response, such as the human TLRs system, and of the adaptive immune system, such as the TCR Even if microbial ... DR and GCC conceived of the study, AZ and MM participated in its development, PT, AG and CF drafted the manuscript All authors contributed to write the manuscript, and then read and approved the ... upon the system s dynamics and functionality Indeed, the architectural characteristics of a system and the features of individual components together play indispensable roles in forming the symbiotic...
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Báo cáo y học: "Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b" ppt
... 11 Candesartan docked into the VDR ligand binding pocket Candesartan docked into the VDR ligand binding pocket Note: The core structure of the hydrogen-bonded residues is expanded to a 'ball -and- stick' ... ligand binding pocket The VDR agonist TX522 in the VDR ligand binding pocket Note: The core structure of the hydrogen-bonded residues is expanded to a 'ball -and- stick' format, so as to show the ... ARG274 and the hydroxyl of SER237, and another pair from the ligand's O3 oxygen to SER278 and TYR143 Figure shows that the VDR agonist TX522 [42] also forms a double hydrogen bond between the oxygen...
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Báo cáo y học: "Tumor microenvironments, the immune system and cancer survival" ppt
... different cell types of the immune system (indicated by round cells) may lead to elimination of the cancerous cells (b) If elimination is unsuccessful, the immune system and the cancer can reach ... cells their component cells, and their microenvironment Among the important advances that have derived from these technologies is the molecular classification of tumors on the basis of only their ... reinvigorated approach These studies highlight the importance of studying the genetics and phenotypes not only of cancer cells but also of the surrounding microenvironment The immune system has long...
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Báo cáo y học: "Gene regulation and signal transduction in the immune system" pptx
... Cell-fate determination in the immune system A few talks focused on the role of asymmetric division in cell-fate determination, and provided compelling evidence suggesting that the cell fate determinant ... in the immune system Tannishtha Reya (Duke University Medical Center, Durham, USA) used a reporter system that marks Notch expression to study stem-cell commitment, and showed that all of the ... Numb and the transcription factor T-bet, become localized to the immunological synapse (proximal) side of the cell, whereas protein kinase C-ζ becomes partitioned to the distal side of the cell...
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Basic immunology functions and disorders of the immune system
... infections is called the immune system, and the coordinated reaction of these cells and molecules to infectious microbes is the immune response Immunology is the study of the immune system and its responses ... for their ligands on the endothelium Concurrently, TNF and IL-1 act on the endothelium to stimulate expression of ligands for integrins The firm binding of integrins to their ligands arrests the ... for immunotherapy of cancer FIGURE 1-1 The importance of the immune system in health and disease This table summarizes some of the physiologic functions of the immune system Note that immune responses...
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Money, banking and the financial system (1st edition) r glenn hubbard, anthony patrick o''''brien prentice hall (2011)
... 11.4 Systemic Risk and the Shadow Banking System 335 Systemic Risk and the Shadow Banking System Regulation and the Shadow Banking System The Fragility of the Shadow Banking System ... to other investment banks The Deepening Crisis and the Response of the Fed and Treasury Some economists and policymakers criticized the decision by the Fed and the Treasury to help arrange the ... introduction and overview of the Fed in Chapter 1, “Introducing Money and the Financial System, ” and in each subsequent chapter, we expand on the Fed’s role in the financial system So, by the time...
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Tài liệu OXIDATIVE STRESS AND DISEASES pptx
... in antioxidant defence system 4 Oxidative Stress and Diseases Evidences for connection of oxidative stress with the stresses induced by other factors are promptly gained The potency of transition ... polyunsaturated fatty acids and vitamins, and other vitamins with the focus on the micro-algal sources of these compounds The Chlorophyceae class is rich in these nutraceuticals and genus Chlorella, ... general aspects of oxidative stress theory, shows the potential cellular targets for ROS attacks, and via understanding of key aspects along with the details of ROS roles in biological systems, describes...
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Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... access to food and water and with a standard light ⁄ dark cycle (lights on at 07:00 h) The experiments were performed according to the Guide for the Care and Use of Laboratory Animals of the US Department ... radicals and ⁄ or a deficiency of antioxidant systems, as evidenced by the augmented nitrite content, the unaltered superoxide dismutase activity, and the GSH consumption, all of which characterize oxidative ... compared with the control group On the other hand, a 55% decrease in GSH concentration [T(10) ¼ 27.452; P < 0.0001] compared with the control group was detected (Fig 1) Superoxide dismutase and catalase...
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Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ppt
... hyperlipidemia and atherosclerosis, and has been used extensively in understanding the mechanisms of lipoprotein metabolism and atherosclerosis The ApoE-/- mice are generated on a C57BL/6 background, and ... (Figures 2A and 2B) and iBAT (Figures 2C and 2D), respectively, and the analyses of mitochondria number (Figure 2E) and area (Figure 2F) In the PM2.5-exposed group, the mitochondrial number and area ... cycle They were fed ad libitum on standard laboratory mouse chow and had free access to water The investigation conforms to the Guide for the Care and Use of Laboratory Animals published by the...
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Paradoxical roles of the immune system during cancer development docx
... increased when there is a previous history of alcohol and tobacco use66,67 On the other hand, the RR for the most common non-viral-associated solid tumours of epithelial origin is decreased in immune- suppressed ... cancer, either because they are maintaining low-level chronic inflammation as a consequence of defects in their natural immune defence mechanisms, and/ or because they fail to normalize their immune ... orchestrate the elimination of invading organisms and initiate local tissue repair DCs, on the other hand, take up foreign antigens and migrate to lymphoid organs where they present their antigens...
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Báo cáo khoa học: Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice pdf
... transgenic mice The present study provides the first evidence indicating that the overexpression of CYP2E1 causes cardiac oxidative stress, myocyte apoptosis and the DCM phenotype Materials and methods ... enzyme, and can generate ROS and promote oxidative stress in cells during its catalytic cycle [9,23] The formation of ROS can occur even in the absence of added exogenous substrates in the CYP2E1-expressing ... hypothesis that oxidative stress and myocyte apoptosis play an important role in the pathogenesis of cardiovascular diseases such as ischemic heart disease, atherosclerosis, cardiomyopathy and...
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American Public Service: Radical Reform and the Merit System pot
... Abert The States and the Metropolis, Patricia S Florestano and Vincent L Marando 11 Changing Bureaucracies: Understanding the Organization before Selecting the Approach, William A Medina 12 Handbook ... essential topic Their readiness to revise and resubmit their initial manuscripts attests to their respect for the subject matter and their skill in mastering it The task was facilitated by the thorough, ... in the national government James R Thompson outlines the design of the new personnel systems for the Departments of Homeland Security and Defense, which together comprise a large portion of the...
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