... determine the RD of the PRIMUS and U-FIS The aim of the present study was twofold First, to provide further evidence of the validity of the PRIMUS and U-FIS in a RRMS sample Secondly, to investigate the ... with each other The EDSS showed low to moderate correlations with the PRIMUS scales and with the U-FIS The PRIMUS QoL scale andthe U-FIS showed weak associations with the MSFC scales and composite ... than expected However, associations between the MSFC, EDSS and EQ-5D were also weaker than expected suggesting that further investigation of the relation between the MSFC and other clinical outcome...
... people and their families The Forum’s starting point for identifying theoutcomesand indicators that matter most for children and young people was the existing NHS and Public Health Outcomes ... that these health outcomes are achieved Questions the Forum addressed The current NHS and Public Health Outcomes Frameworks include a number of outcomesand indicators specific to children and ... REPORT OF THE CHILDREN AND YOUNG PEOPLE’S HEALTH OUTCOMES FORUM Table – Outcomes for children and young people in the Public Health Outcomes Framework Domain Indicator /Outcome Children and young...
... statistical relationship between the latent construct andthe measured items, andthe ε1 represents the random measurement error in the ith measured item The Convenience scale of the Treatment Satisfaction ... Health and Quality of Life Outcomes 2006, 4:65 by the Scientific Advisory Committee (SAC) of the Medical Outcomes Trust [4] In this guidance the SAC states that PROs should be evaluated on the following ... with MEI and SEI models, the direction of the arrows is reversed andthe model lacks error term for each of the observed indicators A disturbance term (ς1) on the latent construct indicates the proportion...
... forwards to assess the utility of these questionnaires in another practice setting Therefore the aim of this observational study was to assess the utility of the MYMOP2 and W-BQ12 health outcomes measures ... Profile P Equals the mean of the scores recorded mental) of a specific problem they need assistance with and consider the severity of these symptoms over the last week The third item asks the patient ... treatment for their complaint during the course of the study; inability to complete or understand the required informed consent or outcome measures and inability to comply with the treatment...
... ablation of the thyroid gland 4.2.1.4 Chemotherapy and hormone therapy Sections 4.1.3 and 4.1.4 describe thepalliative role of chemotherapy and hormone therapy This section draws attention to their ... of the neuro-mechanisms of pain, although these can only give insight into part of the overall complexity Nevertheless, they allow the development and trial of novel therapies Unfortunately, there ... ascending pathways are the spinothalamic and parabrachial neurones • The spinothalamic neurones connect the dorsal horn via the thalamus to the cortex These give intensity andthe topographic location...
... volume fracturing of some tight gas and conventional reservoirs in the southern part of the North Sea and in onshore Germany, the Netherlands, Denmark andthe UK Preliminary indications are that ... this area include Poland, Germany, the Netherlands, the UK, Spain, Romania, Lithuania, Denmark, Sweden and Hungary The North American context Technological advancements andthe integration of horizontal ... extracted The challenge of ensuring the integrity of wells and other equipment throughout the development, operational and post-abandonment lifetime of the plant (well pad) so as to avoid the risk...
... Universities of Cape Town, KwaZulu Natal and Witwatersrand, the Ugandan National Council for Science and Technology, Hospice Africa Uganda andtheHospicePalliative Care Association of South Africa Assessing ... of the MVQoLI in Uganda [13], andthe complexity and length of the tool suggest it may be inappropriate for use in many settings in Africa In the Ugandan study the average time to complete the ... participating sites, managed the research nurseand reviewed the paper TM collected data for the study and reviewed the paper KM collected data for the study and reviewed the paper TM served as Principal...
... secondary to the negative correlation between ficolin-3 on the one hand andthe severity of ischemic stroke andthe infarct size on the other hand, as discussed above It is well known that both the high ... when the admission samples were analyzed Next, in order to assess the strength of association between the low ficolin-3 and high CRP levels on the one hand andthe unfavorable outcome of the disease ... good expectedoutcomeand those with NIH scale of >16 with poor expected outcome, andthe ficolin-3 levels were compared accordingly There were significantly (p=0.017) lower ficolin3 levels in the...
... recorded together with the degree of overhang of the prosthesis in millimeters andthe presence or absence of posterior osteophyte Each prosthesis was then scored radiographically by summing the degree ... correlation, between the varus/valgus positioning of the femoral component andthe Oxford score (0.38) Examples of good and poorly positioned prosthesis can be seen in Figures and Edmondson et ... study, of the 48 Oxford unicompartmental knee replacements had been revised within the 4.5 year follow up period and our outcomes in the surviving knees were disappointing compared with other studies...
... (pharmacological and non-pharmacological treatments) and relevant efficacy (analgesic and other patient-reported outcomes (PRO) outcomes such satisfaction, quality of life measures) and safety outcomes ... according to the usual practice (standard of care) and followed over time using standardized methods and forms to make possible a valid and reliable description of case-mix, pattern of care andoutcomes ... purposes) Health and Quality of Life Outcomes 2006, 4:7 http://www.hqlo.com/content/4/1/7 variance to analyze and separate the effects of treatments and time and test the interaction between the two,...
... identify the genes controlling this disease the group has made crosses between susceptible and resistant rat strains Several loci that control the onset of arthritis, the severity and chronicity of the ... be involved in the regulation of Th cell polarization andthe shaping of the immune response Dr Harald Illges (Biotechnology Institute Thurgau, Switzerland) described studies on the K/BxN murine ... death, CD4/CD8 ratio, ATP/ADP ratio andthe production of reactive oxygen species Professor Rikard Holmdahl (Lund University, Sweden) described theidentification of the Ncf1 genetic polymorphism controlling...
... changes at the time the information is provided [40,41,43] In other words, "the right information andthe right process – at the right time." The stages are: Precontemplation (uninformed about the need ... measurement of the impact of interventions on these health outcomes is fundamental to advancing clinical practice and research The current use of patient-oriented outcome measures in research and practice ... will insure they have a comprehensive understanding of the interpretation of responses during the chart-stimulated recall Their orientation will consist of training on the theory and methods...
... zygomatic arch andthe inferior border of the mandible (Fig 1) Accelerometers were fastened on the forehead as a reference and on the middle point of the chin concavity of the mandible with vinyl ... EMG and ACC KT participated in collecting the data from the sleep laboratory together with HY and helped to construct research design SS participated in the design of the study and coordinated the ... unintentionally and they were not bruxer The experimental design, procedures and tasks were carefully explained to the volunteers prior to starting the experiment Each volunteer slept for the entire...
... UL26 and UL26.5 in the DEV Clone-03 strain The location of the R and M cleavage sites are indicated by the arrows andthe dashed lines indicate the cleavage sites The results were based on the ... [6] The B-capsids of HSV-1 contain a large amount of the scaffolding protein (the product of the UL26.5 gene), and smaller amounts of VP24 and VP21, the products of the UL26 gene The UL26 and ... cleavage by the products of the UL26 gene Figure shows the proteins that are predicted to originate from the products of the DEV UL26 and UL26.5 by the alignment of the homologous in HSV-1 The DEV...
... DH and BW performed the sequencing of the c0t-1 clones, provided the BAC end sequence database and helped to draft the manuscript TS participated in the design and coordination of the project and ... contributions FZ and TW wrote the paper, participated in the bioinformatic analyses of the c0t-1 library, carried out the alignments of the tandemly repeated c0t-1 sequences and performed the molecular ... demonstrate the potential of the c t-1 DNA library for the detection of novel repeat classes we focused on theidentification of tandemly repeated sequences, particularly on the identification...
... analysis of the NSs and NSm genes from SI+ and I+ mosquitoes The multiple functions of the NSs (S segment) and NSm (M segment) proteins in the viral life cycle make these proteins strong candidates ... collected from the same site in consecutive years are very similar to one another The other three SI+ isolates are paraphyletic and therefore not phylogenetically distinct from the previously ... from each of the four SI+ collection sites (Figure 1) ML trees were created for the entire S, M and L segments (Figures 3, 4, and 5, respectively) and for the NSm gene (Figure 6) The S segment...
... Rotterdam, The Netherlands Authors’ contributions FG and RD had full access to all of the data in the study and take responsibility for the integrity of the data andthe accuracy of the data analysis ... Christianne de Groot from the Department of Obstetrics and Gynaecology of the Medical Center Haaglanden, The Hague, The Netherlands, for advice This research was financed by the Dutch Arthritis Association ... tryptic glycopeptides, and mass spectra of IgG1 and IgG2 were processed using FlexAnalysis software (Bruker Daltonics, Wormer, The Netherlands) The characteristics of the patients and controls are...
... considered The indications for this drug should be guided by the type of infection andexpected associated outcome, andthe presence of comorbidities, which may influence the natural history of the ... alfa (activated) as adjunctive therapy for severe sepsis In the PROWESS study, the time window between the development of the first organ dysfunction andthe start of the infusion could reach 36 ... thromboplastin time (APTT) and PT are further prolonged by a few seconds by the drug, but the clinician will not be able to differentiate the influence of Surgery and procedures In the PROWESS study,...
... preoperatively, they were able to assess the level, length and diameter of tracheal stenosis This potentially life-threatening complication differs between the two groups in the above parameters, and therefore ... preferable that they stay in the admitting non-neurosurgical centre, given the demand on the all too few neurosurgical intensive care beds in the UK Subsequent monitoring, and therefore management, ... affects the treatment options available to the patient The results showed that, compared with ST, PT caused tracheal stenosis closer to the vocal cords (1.6 cm versus 3.4 cm; P = 0.04) andthe onset...