o acetylated sialic acids and their role in immune defense
Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... depending on the disease As a case in point, formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and small inclusion bodies of ... in b-pleated sheet, and some contain neurofilament proteins as in desmin-related myopathy inclusions and Parkinson’s associated Lewy bodies Protein deposits observed in neurological diseases may ... sclerosis (MS), a chronic autoimmune neurological condition involving brain and spinal cord in ammation T cells from MS patients express a dominant response to aB-crystallin, a major autoantigen affiliated...
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Aggregate bankruptcy probabilities and their role in explaining banks’ loan losses doc
... Substitution of average p is calculated for the following neighbouring counties39: For For For For For For For For For For For county county county county county county county county county county county ... comments and discussions 1 Introduction One of the most important roles of banks as financial intermediaries is allocation of credit, screening and monitoring of borrowers’ creditworthiness, and ... test how they can explain banks’ loan losses controlling for macroeconomic and various bank specific factors We incorporate in the econometric model some major economic factors to measure influence...
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Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx
... Nematodes and vertebrates also have a tll homolog TLL is primarily involved in the development of forebrain, and its role in segmentation was probably acquired during the evolution of holometabolous ... DNA binding The two ‘zinc fingers’ span about 60–70 amino acids, and a few receptors also contain a carboxy-terminal extension containing T-box and A-box motifs [124] In each zinc finger, four invariant ... Monophagous or oligophagous species feeding on PEnegative host plants were either deterred from feeding or showed marked abnormalities in growth and development after incorporation of 20E in their...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... Characterizing the role of RAGE in vivo and in vitro can be broadly applied to a variety of pathological conditions and incorporated into a wide array of treatment regimens for these conditions Competing ... numerous sites of phosphorylation, acetylation and/ or methylation Possibly SUMOylated and ADPribosylated Nucleus but has role in shuttling HIPK2 (homeodomaininteracting protein kinase 2) to the ... Expression, purification and fluorine-18 radiolabeling of recombinant S100 proteins–potential probes for molecular imaging of receptor for advanced glycation endproducts (RAGE) in vivo Protein Expr...
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báo cáo khoa học: "A Review of Metallothionein Isoforms and their Role in Pathophysiology" ppsx
... zinc inhibition of protein tyrosine phosphatase 1B, the major phosphatase controlling the phosphorylation state of the insulin receptor, is responsible for these insulinomimetic effects of zinc ... groups of investigators found direct casual relationships between MT and pathophysiology but more pronounced reasons among those was endogenous and exogenous stimuli including glucocorticoids, interferon, ... Ito Yoshihisa, Suzuki Takashi: Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis Toxicology...
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báo cáo khoa học: " Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis" pps
... Liu from Harbin Medical University, China, for kindly providing fist antibody of Ets-1 and histomorphology center for providing the facility Authors’ contributions ZJL and YL conceived, coordinated ... expression in left ovarian serous papillary cystadenocarcinoma; D: Ang-2 expression in ovarian borderline mucinous cystadenoma; E: Maspin expression in mucinous cystadenocarcinoma; F: Maspin expression ... Ang-2 and Maspin in ovarian tumor tissues A: Ets-1 expression in ovarian moderately and poorly differentiated serous adenocarcinoma; B: Ets-1 expression in ovarian borderline mucinous cystadenoma;...
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Báo cáo y học: " T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology" doc
... advantageous to cyanomyoviruses infecting Prochlorococcus which not contain standard phycobilisome complexes Alteration of host photosynthetic machinery appears to be of prime importance to cyanomyoviruses ... cyanomyoviruses infecting Synechococcus The role of PTOX in cyanobacteria, let alone cyanomyoviruses, is not completely understood, but it is thought to play a role in photo-protection In Synechococcus it ... of their 13 Synechococcus strains, whereas one would infect only the strain used for isolation One myovirus isolated on a phycocyanin-rich Synechococcus strain, would also infect phycoerythrin-rich...
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Báo cáo y học: " Oxygen-regulated transcription factors and their role in pulmonary disease" pptx
... factor expression are induced in the lung and marked vascular deposition of fibrin is observed, whereas none of these responses occur in knockout mice lacking expression of the gene encoding protein ... production of tissue factor by monocytes leads to hypoxia-induced fibrin deposition in the pulmonary vasculature [8] In the lungs of mice subjected to hypoxia, EGR-1 and tissue factor are coinduced ... Although the pathophysiology of pulmonary hypertension is complex [18], a major component of this process is the elaboration of peptides, such as endothelin-1 (ET-1) and angiotensin II, that induce...
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Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
... protein with an aminoterminal domain that has significant homology to Toll and the cytoplasmic domain of the IL-1R1 Introduction of the N gene into tobacco mosaic virus-sensitive strains of tobacco ... feature of being involved in host responses to injury and infection [8] Most notably, in humans these include not only the receptor and accessory protein for IL-1, but also the IL-18 receptor and ... Drosophila homolog of TRAF6 with the Drosophila homolog to evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) Transfection of dECSIT in insect cells leads to production of...
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Báo cáo y học: "Psychosocial factors and their role in chronic pain: A brief review of development and current stat" ppsx
... surprising that the on-going evolution of the understanding of the non-physical aspects of pain has been applied to the areas of screening for, intervening in and predicting those at risk of developing ... Questionairre and the role of Fear Avoidance beliefs in chronic low back pain and disability Pain 1993, 52:157-168 Asmundson GJ, Norton PJ, Norton GR: Beyond pain, the role of fear and avoidance in ... displaced onto the body where it is more bearable For example, conscious or unconscious guilt with pain serving as a form of atonement, or the development of pain to replace feelings of loss Critics...
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Bees and their role in forest livelihoods A guide to the services provided by bees and the sustainable harvesting, processing and marketing of their products
... perhaps play a minor role as pollinators in the rain forest compared to their role in temperate forests, monsoon forests and savannah woodland In tropical rain forests, many trees are pollinated by ... levels and combinations of assets, and are probably the major influence on people’s choice of Livelihood Strategy For example, in a household that depends on farming for most of its food and income, ... clothing and containers for harvesting, storing, processing and marketing honey 35 Bees and their role in forest livelihoods Main advantages of movable comb hives over fixed comb hives x The combs...
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HCV functional genomic protein interactions with NS3 and their role in viral replication
... however, the protein shift to a dimer form and no higher oligomer was observed (Figure 3-7) The proportion of dimer versus monomer increased as the molar ratio of oligonucleotide to protein increased ... our understanding of HCV replication and propagation 1.3 HCV protein-protein interaction Viral proteins are known to interact with one another in the formation of the viral replication complex The ... Characterization of NS3-NS3 interaction 3.1.1 Delineating the region of self-interaction in NS3 Protein-protein interactions among all HCV proteins were tested and NS3 was found to interact strongly...
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Effect of muscarinic agents on sclera fibroblast and their role in myopia 1
... effect of atropine and pirenzepine on BrdU incorporation was compared with non-treated controls and found to inhibit DNA synthesis of SF from non-myopic control and myopic eyes 42 Atropine caused ... The response of SF to growth factors The changes in growth factors and matrix metalloproteinases in response to atropine The changes in matrix metalloproteinases in response to growth factors 25 ... 37°C/5%CO2 2.2.8 Determination of protein concentration Total protein concentration was determined using Coomassie plus protein assay reagent (Pierce) Briefly, when Coomassie binds to protein in an...
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Effect of muscarinic agents on sclera fibroblast and their role in myopia
... to undergo apotosis produced dark brown stain in apoptic nuclei) B Atropine 0.1 µM C Atropine µM D Atropine 10 µM E Atropine 100 µM Fig10A Immumocytochemistry of mAchR subtypes in human SF in ... Effect of atropine inhibiting SF cell proliferation in culture Chick SF were incubated with atropine Phase contrast photomicrographs were taken after 24 hrs (magnification x100) A Control culture ... was observed (negative control) m1 m4 m2 negative control Fig10B Protein corresponding to mAchR subtypes m1,m2,m4, and m5 identified in mouse sclera by immunoblotting Subtype selective antibodies...
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Bacteria of the sulphur cycle An overview of microbiology, biokinetics and their role in petroleum and mining industries
... biogenic production of H2 S in oil reservoirs (souring) and the associated corrosion which occurs during the production, transportation and processing of the crude oil and various petroleum products ... microbial population in treatment of acid mine drainage Control of biogenic production of sulphide in model laboratory systems and in oil reservoirs thorough the removal of sulphate from injection water, ... to water flooding (souring) is a serious concern for the oil industry Toxicity of H2 S, accelerated corrosion of pipeline, production and processing equipment, and decrease in efficiency of secondary...
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The ancient origin of NF kb ikb and thioredoxin and their roles in immune response
... with homologous proteins Phylogeny of CrNFκB and related NF-κB proteins Amino acid sequence alignment of CrIκB and homologous proteins Unrooted phylogenetic tree of IκB proteins Amino acid sequence ... Isolation of C rotundicauda NF-κB and IκB homologues 70 Cloning and characterization of NF-κB p65 homologue, CrNFκB 70 Cloning of Cactus and IκB homologue, CrIκB 74 Cloning of horseshoe ... sequence comparison of CrRelish with homologous proteins Phylogeny of CrRelish and related NF-κB proteins Binding of CrNFκB protein to horseshoe crab Factor C (CrFC) κB probe Binding ability of CrNFκB...
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PHYTOCHEMICALS – A GLOBAL PERSPECTIVE OF THEIR ROLE IN NUTRITION AND HEALTH potx
... such as chrysophanol, aloe-emodin, rhein, salinos poramide, luteolin (Fig 7) and emodin have in common a double hydroxylation at positions C-1 and C-8 To test for free anthraquinones, powdered plant ... alkaloids of plant origin include the addictive stimulants caffeine, nicotine, codeine, atropine, morphine, ergotamine, cocaine, nicotine and ephedrine (Fig 1) Amino acids act as precursors for biosynthesis ... glycosides The two major types of steroidal sapogenin are diosgenin and hecogenin Steroidal saponins are used in the commercial production of sex hormones for clinical use For example, progesterone is...
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Báo cáo y học: "Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease" ppsx
... Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis J Clin Invest 2005, 115:1571-1579 Hogan BL: Bone morphogenetic proteins in development ... model of osteoarthritis, confirming the in vitro pro-anabolic and anti-catabolic properties of BMP7 as proposed by Chubinskaya and colleagues [34] and Fan and colleagues [35] Overexpression of ... the final manuscript Authors' information MD is the recipient of a fellowship from the Institute for the Promotion of Innovation through Science and Technology in The authors thank Ann Hens for...
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báo cáo khoa học: " Functional analysis of B and C class floral organ genes in spinach demonstrates their role in sexual dimorphism" pdf
... suppression of recombination of the masculinizing and feminizing factors by chromosomal linkage and inversion The result is the establishment of sex determining superloci that allow for segregation of ... regulator of sex determination in spinach A Model for Sex Determination and Sexual Dimorphism in Spinach Charlesworth and Charlesworth [50] proposed a model for the evolution of dioecious species ... the spinach C class gene appears to be required for microsporogenesis These observations conform to reports in Arabidopsis that AGAMOUS controls microsporogenesis through activation of SPOROCYTELESS...
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The role of matrix metalloproteinases (MMP) and their inhibitor in influenza a virus induced host lung injury
... pro-domain (Pro), which contains a zinc ligating thiol (–SH) group, and catalytic domain, which contains a zinc ion (Zn2+) Hemopexin-like domains are essential in binding to tissue inhibitors of ... and thrombomodulin protein markers in the BALF and protein leakage into the airspaces We show here that oral administration of a low dose of doxycycline, a MMP inhibitor which inhibits gelatinases ... shown to process transforming growth factor β (TGF-β), tumor necrosis factor (TNF) and interleukin-1β (IL-1β) into their active form, both being involved in inflammatory processes In the modulation...
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