nsaids and cyclooxygenase 2 cox 2 inhibitors
Báo cáo y học: "Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease" pptx
... study Int J Epidemiol 1999, 28 :717- 722 Woessner KM, Simon RA, Stevenson DD: The safety of celecoxib in patients with aspirin-sensitive asthma Arthritis Rheum 20 02, 46 :22 01 -22 06 Cowburn AS, Sladek ... different laboratories have now concluded that the specific COX -2 inhibitors rofecoxib and celecoxib not cross-react with aspirin and NSAIDs to cause exacerbation of asthma or naso-ocular symptoms ... specific COX -2 inhibitor in aspirininduced asthma Clin Exp Allergy 20 00, 31 :21 9 -22 5 Available online http://arthritis-research.com/content/5/1 /25 Dahlen B, Szczeklik A, Murray JJ: Celecoxib in...
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Báo cáo khoa học: Cytosolic phospholipase A2-a and cyclooxygenase-2 localize to intracellular membranes of EA.hy.926 endothelial cells that are distinct from the endoplasmic reticulum and the Golgi apparatus pdf
... Cyclooxygenase (COX) enzymes function downstream of cPLA2-a and convert arachidonic acid into prostaglandin H2 [8,9] To date, two distinct COX isoforms, COX- 1 and COX -2, have been identified and ... however, cPLA2-a was found to be coupled to both COX- 1 and COX -2 to produce prostaglandin E2 [51] The physical colocalization of COX and cPLA2-a in these systems, however, has not been studied, and this ... to cPLA2-a [35] and several reports have demonstrated that annexin V FEBS Journal 27 2 (20 05) 127 8– 129 0 ª 20 05 FEBS cPLA2-a localization in endothelial cells S Grewal et al A B Fig GFP–cPLA2-a transfected...
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Báo cáo y học: "Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathways" pot
... 20 07, 27 :25 24 -25 31 12 Mollace V, Muscoli C, Masini E, Cuzzocrea S, Salvemini D: Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors Pharmacol Rev 20 05, 57 :21 7 -25 2 ... with COX -2 to cause enzymatic activity Recent studies indicated that NO S-nitrosylates COX -2 in macrophages [9] and cytosolic phospholipase A 2a (cPLA2a) in human epithelial cells [ 32] and thus ... promoters for mouse iNOS and COX -2 Treating RAW264.7 macrophages with LPS (1 μg/mL) for 24 h led to an approximately 7 .2- or 3.8fold increase in iNOS (Figure 3C) and COX -2 (Figure 3D) promoter...
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Báo cáo y học: "Cost-effectiveness analysis for joint pain treatment in patients with osteoarthritis treated at the Instituto Mexicano del Seguro Social (IMSS): Comparison of nonsteroidal anti-inflammatory drugs (NSAIDs) vs. cyclooxygenase-2 selective inh
... 5,016.6 315.0 3,653.1 125 .0 10,795.3 4 52. 0 6, 528 .2 ± 6,199.9 28 9.0 5,300.0 26 5.0 2, 340.7 84.0 14,497.9 396.0 6,994.3 ± 46,583.7 27 5.0 5, 721 .5 25 9.0 2, 2 92. 7 74.0 15,994.9 351.0 *Standard deviation Costs ... tolerability of the selective cyclooxygenase2 (COX -2) inhibitor rofecoxib compared with nonselective COX- 1 and COX -2 inhibitors in osteoarthritis Arch Intern Med 20 00, 160 :29 98-3003 Bombardier C, Laine ... Med 20 04, 351:1707-1709 Marcus AJ, Brockman MJ, Pinsky DJ: COX inhibitors and thromboregulation N Engl J Med 20 02, 347:1 025 -26 Wright JM: The double-edged sword of COX -2 selective NSAIDs CMAJ 20 02, ...
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Báo cáo y học: "Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain" ppsx
... http://genomebiology.com /20 07/8/1/R14 R14.10 Genome Biology 20 07, 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 Volume 8, Issue 1, Article R14 Toscano et al Resting and arecoline-stimulated ... of COX- 1-/- and COX -2- /- mice [5,6], was not detected in cortex (COX- 1: z ratio = 0. 72, P = 0.03; COX -2: z ratio = 0.04, P = 0.9) and hippocampus (COX- 1: z ratio = - 0.89, P = 0.0 02; COX -2: z ... cortex: COX- 1-/= 12% and COX -2- /- = 7%; hippocampus: COX- 1-/- = 11% and COX -2- /- = 12% ) COX -2- /- mice exhibited significant changes in expression of genes belonging to the transmembrane (6%) and...
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Báo cáo y học: "Prescription channeling of COX-2 inhibitors and traditional nonselective nonsteroidal anti-inflammatory drugs: a population-based case–control study" pot
... nonselective NSAIDs (n = 12, 418) Celecoxib (n = 42, 422 ) Rofecoxib (n = 25 ,674) 18–34 18.6 3.7 6.7 35–44 15.8 6.5 9.7 45–54 13 .2 9.9 12. 1 55–64 13.5 15.9 16.4 65–74 18.8 30.5 27 .1 75–84 15.1 27 .1 22 .7 ... selective cyclooxygenase- 2 (COX -2) inhibitor rofecoxib compared with nonselective COX- 1 and COX -2 inhibitors in osteoarthritis Arch Intern Med 20 00, 160 :29 98-3003 Health Canada: Celecoxib: one ... (1.34–1.49) Low dose ASA 0.85 (0.81–0.89) 0.56 (0. 52 0.59) 10+ 2. 88 (2. 65–3.14) 1 .26 (1.13–1.41) 5–9 2. 21 (2. 10 2. 32) 1 .28 (1 .20 –1.37) 1–4 1.88 (1.80–1.97) 1 .26 (1.19–1.33) Reference Reference 0.99 (0.94–1.04)...
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báo cáo hóa học: " Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat" potx
... treatment and clinical outcome Stroke 1999, 30:5 02- 507 http://www.jneuroinflammation.com/content /2/ 1/3 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 Fisher M: Stroke Therapy 2nd edition ... 11 12 13 14 15 16 17 18 19 20 21 22 23 24 of the inducible nitric oxide synthase gene J Cereb Blood Flow Metab 1999, 19: 121 3- 121 9 Nogawa S, Zhang F, Ross ME, Iadecola C: Cyclo-oxygenase -2 gene ... similarly wide [10 ,22 ,51] These results have been also obtained with other COX -2 inhibitors (e.g., NS-398, SC58 125 and rofecoxib) in models of transient ischemic stroke [4, 52] and global cerebral...
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báo cáo hóa học: " Activation of α7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures" pdf
... virus coat protein gp 120 inhibits the beta- Page of 10 (page number not for citation purposes) Journal of Neuroinflammation 20 05, 2: 4 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 ... citation purposes) Journal of Neuroinflammation 20 05, 2: 4 http://www.jneuroinflammation.com/content /2/ 1/4 A B COX -2 β-actin 25 ** 25 COX -2/ β-actin 20 20 15 15 ** * 10 10 * 0 fc s lp s M M M M 1u ... Prostaglandins as modulators of immunity Trends Immunol 20 02, 23 :144-150 Minghetti L: Cyclooxygenase- 2 (COX -2) in inflammatory and degenerative brain diseases J Neuropathol Exp Neurol 20 04, 63:901-910...
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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx
... review and meta-analysis of observational studies Bmj 20 03, 327 : 128 Page 15 of 16 (page number not for citation purposes) Journal of Neuroinflammation 20 06, 3:6 19 20 21 22 23 24 25 26 27 28 29 30 ... transgenic mice J Neurosci 20 02, 22 :22 46 -22 54 West MJ: New stereological methods for counting neurons Neurobiol Aging 1993, 14 :27 5 -28 5 Rozas G, Lopez-Martin E, Guerra MJ, Labandeira-Garcia JL: The ... Chem 1991, 26 6: 128 66- 128 72 Needleman P, Isakson PC: The discovery and function of COX2 J Rheumatol 1997, 24 Suppl 49:6-8 Nikolic D, van Breemen RB: DNA oxidation induced by cyclooxygenase- 2 Chem...
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báo cáo khoa học: " The function and mechanism of COX-2 in angiogenesis of gastric cancer cells" pdf
... therapeutic avenues Pharmacotherapy 20 10, 30 (2) :169-76 Na rdone G, Rocco A: Chemoprevention of gastric cancer: role of COX -2 inhibitors and other agents Dig Dis 20 04, 22 (4): 320 -6 doi:10.1186/1756-9966-30-13 ... Matrigelcoated 24 -well plates, and incubated for 16 h with control SGC7901 medium (A) and COX -2- siRNA medium (B) Figure Expression of VEGF, Flt-1, Flk-1/KDR, angiopoietin-1, angiopoietin -2, tie -2, MMP2 and ... angiogenesis-related molecules in COX- 2mediated angiogenesis The results of RT-PCR and western blot showed that down-regulation of COX -2 might inhibit VEGF, Flt-1, KDR, angiopoietin-1, tie -2, MMP2 and OPN Conclusions...
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Báo cáo y học: "Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells" pot
... 19 20 21 22 23 24 25 26 27 28 29 30 31 Swierkosz TA, Mitchell JA, Warner TD, Botting RM, Vane JR: Coinduction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and ... prostaglandin E2 Effect of2 Effect of PIN1 knockdown on prostaglandin E2 COX2 -dependent prostaglandin E2 (PGE2) production was measured in cells treated with LPS, IFN, 20 μM arachidonic acid and ... cells increased the induction of COX -2, and COX -2- dependent production of prostaglandin E2 by LPS/IFN (figures and 2) Despite a nearly 5-fold greater induction of COX -2 protein in KD compared with...
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Báo cáo y học: "Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens, and impact of exogenous prostaglandin E" pot
... Inflammation 20 09, 6:30 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 lung responses are increased in prostaglandin H synthasedeficient mice J Clin Invest 1999, 104: 721 -7 32 Torres R, Herrerias ... exogenous PGE2 and sulprostone on airway COX -2 activity was measured by evaluating COX -2 mRNA expression in parallel to the BAL COX -2 products PGE2, PGI2, and PGD2 Baseline levels of lung COX -2 mRNA ... endogenous and exogenous prostaglandin E (2) on interleukin-1 beta-induced cyclooxygenase- 2 expression in human airway smooth-muscle cells Am J Respir Crit Care Med 20 00, 1 62( 6) :22 72- 227 7 Hinz B,...
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Báo cáo y học: "An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice" ppsx
... Int Arch Allergy Immunol 20 08 in press Page 10 of 12 (page number not for citation purposes) Respiratory Research 20 08, 9: 72 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Jaffar Z, Wan KS, ... unaltered [23 ] or increases to varying degrees in response to pharmacological inhibition [24 -28 ] or genetic disruption of COX -2 [23 ,27 ] Only Peebles and co-workers and our group [24 -26 ,28 ] have ... Research 20 08, 9: 72 http://respiratory-research.com/content/9/1/ 72 Background Materials and methods The synthesis of prostaglandins (PG) is catalyzed by either cyclooxygenase (COX) -1 or COX -2, and COX- 2...
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Báo cáo y học: "Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an antiinflammatory cyclooxygenase-2 (COX-2) pathway" doc
... Prod 1999, 62: 601-604 Ulivi et al Arthritis Research & Therapy 20 11, 13:R 92 http://arthritis-research.com/content/13/3/R 92 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Marcolongo ... Therapy 20 11, 13:R 92 http://arthritis-research.com/content/13/3/R 92 Page of 12 Figure 15ΔPGJ2 (15-deoxy-Δ 12, 14-prostaglandin J2,) represses mPGES (microsomal PGE synthase) expression and PGE2 (prostaglandin ... 15ΔPGJ2 the % value referred to the value in IL-1a induced cells (100%) is calculated Average ± standard deviation is shown 15ΔPGJ2, 15-deoxy-Δ 12, 14-prostaglandin J2,; COX -2, cyclooxygenase- 2; DGDG,...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 2
... 32. 0, 29 .8, 29 .6, 29 .4, 29 .2, 28 .9, 28 .7, 28 .0, 25 .8, 25 .4, 23 .2, 22 .7, 18.7, 14.0; HRMS calculated for C26H47O4N + Na: 460.3397, found 460.3406 Yield: 7% Table 2. 1 Compounds 2a1(compound1=CP1) 2b1 ... SPHK Inhibitors 3. 72 (m, 2H), 2. 18 (t, 2H), 1.43 (s, 9H), 1 .24 (m, 12H), 0.85 (t, 3H); 13C NMR (300 MHz, CDCl3) δ 156 .2, 87.9, 80.0, 64.3, 62. 6, 55.8, 31.7, 29 .1, 29 .0, 28 .8, 28 .4, 28 .2, 22 .5, ... 3.70 (m, 2H), 2. 19 (t, 2H), 1.44 (s, 9H), 1 .24 (m, 22 H), 0.86 (t, 3H); 13C NMR (300 MHz, CDCl3) δ 156 .2, 88.0, 80.0, 64.4, 63.6, 62. 6, 55.8, 31.8, 29 .6, 29 .3, 29 .0, 28 .8, 28 .5, 28 .3, 22 .6, 18.6,...
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Longman-Grammar and Vocabulary for Cambridge Advanced and Proficiency (2)
... Expressing knowledge and belief 23 0 23 8 Verb cornplernentation Entry test SECTION I SECTION SECTION 20 6 20 8 Exam practice 12 210 Unit thirteen 21 2 23 9 OVERVIEW Verbs followed by -ing and infinitive ... by as 24 0 24 2 24 4 Vocabulary SECTION SECTION Competition, opposition, disagreement Starting and ending: creating and destroying Exam practice 15 24 6 24 8 25 0 Reported speech Entry test 21 2 Progress ... Vocabulary SECTION SECTION Quoting, reporting and interpreting Communicating Exam practice 13 21 8 22 0 22 2 25 2 • Syllabus map Unit one page 16 Grarnrnar Probiem tmses Present Perfect Present Perfect...
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English for Tourism and Hospitality 2
... 0003 0078 22 78 3308 B: Would you mind saying that again please? C: 0003 0078 22 78 3308 A: 5 526 4671 98 02 88 92 B: I’m sorry, I didn’t hear you Was that double eight five two? A: No, 88 92 The Chant ... loud Could you repeat, Could you repeat, Could you repeat that please? Oh -2 double 6? Or Oh -2 double 3? Answers: 1) welcome 2) expiry 3) both 4) repeat 5) double 6) credit card ... EXERCISES Key vocabulary Look up the meaning and pronunciation of these words in your dictionary credit card both double expiry repeat welcome...
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English for Tourism and Hospitality 2
... two Leo: 4434 123 4 5678 99 02 Mona: That's right 123 4 5678 99 02 Quí bạn theo dõi Học Tiếng Anh Cho Ngành Du Lịch Đài Úc Châu thực Bài Học 2: Nhận Giữ Phòng Qua Điện Thoại Lesson 2: Taking a Reservation ... rooms for Ms White and Mr Webber (Tôi giữ hai phòng cho cô White ông Webber.) Leo: from Wednesday the 25 th to Saturday the 28 th of September (Từ thứ Tư ngày 25 đến thứ Bảy ngày 28 tháng Chín.) Mona: ... Leo: And when would you like the rooms? Mona: From the 25 th to the 28 th of September Leo: Arriving the 25 th of September and leaving on the 28 th? Three nights? Mona: That's right 7 Leo: Just a...
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Noughts and crosses 2
... Noughts and crosses X1 X2 X3 X4 X5 X6 X7 X8 X9 X X Xo o o X OO OX X X OO OX X O1 O2 O3 O4 O5 O6 O7 O8 O9 ...
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