nhung van de ky thuat cua ade 775x
Báo cáo y học: "Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis" potx
... Steenvoorden MM, van der Helm -van Mil AH, Stoeken G, Bank RA, Devries RR, Huizinga TW, Degroot J, Toes RE: The RAGE G82S polymorphism is not associated with rheumatoid arthritis independently of ... creatinine clearance from serum creatinine Nephron 1976, 16:31-41 van der Heijde D: How to read radiographs according to the Sharp /van der Heijde method J Rheumatol 2000, 27:261-263 Page of (page number ... after onset has been independently associated with the risk of CV death [9,10] Thus, the progress of CV disease might depend on the burden of inflammation The receptor for advanced glycation end...
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Báo cáo y học: "levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control" docx
... expression by adenosine: role of A3 adenosine receptors J Immunol 1996, 156:3435-3442 Tanaka N, Yonekura H, Yamagishi S, Fujimori H, Yamamoto Y, Yamamoto H: The receptor for advanced glycation ... receptor for S100/ calgranulin polypeptides Cell 1999, 97:889-901 Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, Tanji N, Lu Y, Lalla E, Fu C, et al.: Blockade of RAGE-amphoterin signalling ... functioning as a 'decoy' abrogating cellular activation, since the cell surface receptor remains unoccupied Indeed, it has been demonstrated in a number of experimental animal models that treatment...
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Báo cáo y học: "erum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis" doc
... 69:986-994 26 Hammer HB, Odegard S, Fagerhol MK, Landewe R, Heijde D van der, Uhlig T, Mowinckel P, Kvien TK: Calprotectin (a major leucocyte protein) is strongly and independently correlated with ... the multiple linear regression model because these covariates did not independently correlate with the dependent variable R2 of the multiple linear regression model = 0.24 Adjusted R2 = 0.1 aLogarithmic ... in first-degree relatives was determined by questionnaire History was not included if a stroke was deemed hemorrhagic Body mass index (BMI) was calculated as weight in kilograms divided by the...
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Báo cáo y học: ":The expression of the receptor for advanced glycation end-products (RAGE) in RA-FLS is induced by IL-17 via Act-1" ppsx
... and fixed in 4% paraformaldehyde solution overnight at 4°C, dehydrated with alcohol, washed, embedded in paraffin, and sectioned into 7-μmthick slices The sections were depleted of endogenous peroxidase ... joint destruction In our experiment, IL-17 induced RAGE production as well as RAGE mRNA expression in RA-FLS in a dose-dependent manner The engagement of RAGE stimulates diverse signaling cascades ... were added and the membranes were incubated for 30 minutes at room temperature The hybridized bands were detected using the ECL detection kit and Hyperfilm-ECL reagents (Amersham Pharmacia) Determination...
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Báo cáo khoa học: Analysis and biological relevance of advanced glycation end-products of DNA in eukaryotic cells ppt
... S & Severin T (1994) Reaction of 2¢-deoxyguanosine with glyceraldehyde Liebigs Ann Chem 851–853 Seidel W & Pischetsrieder M (1998) DNA-glycation leads to depurination by the loss of N2-carboxyethylguanine ... Pischetsrieder M (2005) Identification of DNA adducts of methylglyoxal Chem Res Toxicol 18, 1586–1592 13 Schneider M, Thoss G, Hubner-Parajsz C, Kientsch¨ Engel R, Stahl P & Pischetsrieder M (2004) Determination ... separated by 1% agarose gel electrophoresis Maillard LC (1912) Action des acides amines sur les ` ´ sucres; formation de melanoides par voie methodique C R Acad Sci 154, 66–68 Koening R, Blobstein...
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Báo cáo y học: " Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study" potx
... scatter plot of the PG of emphysema by the two independent raters was tested for departure from perfect agreement by fitting a simple linear regression model and testing the null hypothesis that the ... emphysema We included chronic cor pulmonale in a secondary analysis Sex and age were matching variables by design, and their effect could not be assessed The potential dependence of the observations ... Definitions of abbreviations: BMI = body mass index; FEV1 = forced expiratory volume in one second; DLCO = diffusing capacity of the lung for carbon monoxide; PE = pulmonary embolism; DVT = deep...
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Báo cáo y học: "Mechanical ventilation during experimental sepsis increases deposition of advanced glycation end products and myocardial inflammation" pdf
... Rhodes A: What role does the right side of the heart play in circulation? Crit Care 2006, 10(Suppl 3):S5 Begieneman MP, Goot FR van de, van dBI, Noordegraaf AV, Spreeuwenberg MD, Paulus WJ, van ... were fixed in 4% formaldehyde, imbedded in paraffin, and μm sections were mounted on SuperFrost Plus glass slides (Menzel-Gläser, Baunschweig, Germany) The slides were deparaffinised, hydrated, ... intraabdominal sepsis: a clinically relevant model Can J Microbiol 1988, 34:323-326 23 Chaudry IH, Wichterman KA, Baue AE: Effect of sepsis on tissue adenine nucleotide levels Surgery 1979, 85:205-211...
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Báo cáo khoa học: Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine⁄chemokine production in endothelial cells via activation of both mitogen-activated protein kinases and nuclear factor-jB pdf
... resulted in a significantly increased production of IL-6, IL-8 and MCP-1 in both a time-dependent (Fig 1A) and dose-dependent (Fig 1B,C) fashion Notably, AGE-HSA and LPS induced a very similar pattern ... compared to blockade of either ERK1 ⁄ 2, JNK or NF-jB, indicating a predominant role of the p38 pathway in the AGE-HSA and LPS amplified inflammatory response Furthermore, blockade of both MAP kinases ... the underlying signal mechanisms involved, have not been fully understood In the present study, we found that both AGE-HSA and LPS, in a very similar patter, induced a time- and dose-dependent...
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Báo cáo y học: "Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells" doc
... -80°C The double stranded NFκB consensus oligonucleotide was end-labelled using T4 polynucleotide kinase and [γ-32P] ATP (5000 Ci/mmol) followed by purification over a G-25 Sephadex column (GE Healthcare, ... only marginally by AGEBSA in dermal fibroblasts GAPDH = glyceraldehyde 3-phosphate dehydrogenase The enhanced release of AGE-modified molecules during cartilage degradation into the synovium ... 2000, 350(Pt 2):381-387 28 DeGroot J, Verzijl N, Wenting -van Wijk MJ, Jacobs KM, Van El B, Van Roermund PM, Bank RA, Bijlsma JW, TeKoppele JM, Lafeber FP: Accumulation of advanced glycation end products...
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Báo cáo y học: " Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats" pot
... grade of lung fibrosis was scored on a scale of to using the following criteria: grade 0, normal lung; grade to 2, minimal fibrous thickening of alveolar or bronchiolar wall; grade to 4, moderate ... was determined according to the instruction of the commercial ELISA kit (Uscnlife, Missouri City, TX) Samples were measured photometrically by an automated plate reader (Microplate Reader Model ... thickening of walls without obvious damage to lung architecture; grade to 6, increased fibrosis with definite damage to lung structure; grade to 8; severe distortion of structure and large fibrous areas...
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báo cáo hóa học: " Imaging the effect of receptor for advanced glycation endproducts on angiogenic response to hindlimb ischemia in diabetes" docx
... acquisition of data DW provided the highresolution gamma imaging device AMS and SFY developed the RAGE-/animal model RH provided us the RGD peptide LJ has been involved in designing the experiments, ... [Arg-Ala-Asp-D-Phe-Lys (HYNIC)] (Peptides International, Louisville, KY, USA) was similarly radiolabeled and used as control peptide Radiochemical purity was >94% by Tec-control chromatography (Biodex, Shirley, NY, ... groups were made using the Student’s t test Correlation was assessed using the Pearson product-moment correlation coefficient All statistical tests were two-tailed, with P < 0.05 denoting significance...
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Báo cáo y học: "Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-α and matrix metalloproteinase-13 in human chondrocyte" ppsx
... with 70 mMfresh glycoaldehyde in PBS (pH 7.4) without calcium chloride and magnesium chloride for days at 37°C The reaction was terminated by removing nonreacted glycoaldehyde by dialyzing extensively ... particular AGE MMPs, a large family of structurally related calcium-dependent and zinc-dependent proteolytic enzymes, are involved in the degradation of many different components of the extracellular ... higher level of glycoaldehyde-mediated modifications (Figure 1b) AGE-specific absorbance was detected at 340 nm [21] and was found to be significantly high in glycoaldehyde-treated BSA as compared...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... Santamaria-kisiel L, Rintala-dempsey AC, Shaw GS: Calciumdependent and -independent interactions of the S100 protein family Biochem J 2006, 396:201-214 Ostendorp T, Leclerc E, Galichet A, Koch M, Demling N, Weigle ... epidermis, and dermal smooth muscle endothelial cells [126] Binding, signaling, and chemotaxis of S100A7 are dependent on Zn++ and RAGE in vitro, while S100A7A seems to signal through a RAGE-independent ... nonsense-mediated decay (NMD) pathway and thus are likely to be degraded before protein expression Several more lack the signal sequence on exon1 and thus the expressed protein could be subject to premature degradation...
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Báo cáo y học: "Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis." ppt
... specifically excluded Patients with well defined diffuse connective tissue diseases such as systemic lupus erythematosus and scleroderma were also excluded A tender joint count was determined by ... radiologist Patients were deemed to have an erosive arthropathy if one or more definite erosions were demonstrable in any peripheral joint radiograph No attempt was made to quantify the degree of erosive ... not considered to be an essential part of the definition Enthesitis was considered to be present if the insertion of the Achilles’ tendon or the plantar fascia was either swollen or tender on examination,...
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Báo cáo y học: "No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis" pdf
... Invest 2006, 116:485-494 Joosten LA, Koenders MI, Smeets RL, Heuvelmans-Jacobs M, Helsen MM, Takeda K, Akira S, Lubberts E, Loo FA van de, Berg WB van den: Toll-like receptor pathway drives streptococcal ... Genotyping was carried out essentially as described previously (PubMed Identifier: 17160404) Assay design was supported by Calcdalton software (PubMed Identifier: 16526404) For each SNP, both PCR-RFLP ... because chromosomal interactions occur between genes independently from enhancer sequences known to exist in the regulated gene Independent genes can therefore exert effects via intra-chromosomal...
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Báo cáo y học: "Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish wome" pdf
... grade = mild OA, grade = moderate OA, and grade = severe OA [22] Osteophytes were separately classified as absent (grade 0), minimal or questionable (grade 1), or distinct (grade 2) Reference images ... was graded separately, and was classified for the presence of OA using a modified Kellgren and Lawrence system [27] The classification criteria were: grade = no OA, grade = doubtful OA, grade = ... Available online http://arthritis-research.com/content/8/1/R20 52 van Saase JL, van Romunde LK, Cats A, Vandenbroucke JP, Valkenburg HA: Epidemiology of osteoarthritis: Zoetermeer survey Comparison of...
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Báo cáo y học: "No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis" ppt
... Invest 2006, 116:485-494 Joosten LA, Koenders MI, Smeets RL, Heuvelmans-Jacobs M, Helsen MM, Takeda K, Akira S, Lubberts E, Loo FA van de, Berg WB van den: Toll-like receptor pathway drives streptococcal ... Genotyping was carried out essentially as described previously (PubMed Identifier: 17160404) Assay design was supported by Calcdalton software (PubMed Identifier: 16526404) For each SNP, both PCR-RFLP ... because chromosomal interactions occur between genes independently from enhancer sequences known to exist in the regulated gene Independent genes can therefore exert effects via intra-chromosomal...
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Báo cáo y học: " Glucocorticoid receptor gene polymorphisms associated with progression of lung disease in young patients with cystic fibrosis" doc
... responses Steroids 2005, 70(5-7):407-417 van Rossum EF, Feelders RA, van den Beld AW, Uitterlinden AG, Janssen JA, Ester W, Brinkmann AO, Grobbee DE, de Jong FH, Pols HA, Koper JW, Lamberts SW: ... which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels Diabetes 2002, 51(10):3128-3134 van Rossum EF, Koper JW, van den Beld AW, Uitterlinden ... methods for P-value adjustment John Wiley & Sons, Inc, New York 1993 van Rossum EF, Voorhoeve PG, te Velde SJ, Koper JW, Delemarrevan de Waal HA, Kemper HC, Lamberts SW: The ER22/23EK polymorphism...
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Tài liệu Báo cáo khoa học: Complex transcriptional and translational regulation of iPLA2c resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization docx
... prepared as described in Experimental procedures Fractions (100 lg protein per lane) were loaded onto a 10% polyacrylamide gel, resolved by SDS/PAGE, transferred to a poly(vinylidene difluoride) membrane, ... analysis demonstrated the mitochondrial localization for this polypeptide (see above) To confirm the mitochondrial localization of the iPLA2c polypeptide experimentally by an independent, functional ... N-terminal mitochondrial leader sequence in this isoform Discussion After the initial discovery of a novel intracellular calciumindependent PLA2 activity in myocardium [6], subsequent detailed biochemical...
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Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts pot
... in controls Microbiological diagnosis was made in 142 (77.2%) TB patients; pathological diagnosis was made in 27 (14.7%), and clinical diagnosis was made in 15 (8.1%) Allele and genotype frequencies ... dominant model better than other models of inheritance, such as recessive and heterozygous advantage Continuous variables between the groups were analyzed by a Mann-Whitney U-test or independent T ... -174 del/del homozygote genotype might have a preventive effect on the development of systemic symptoms, including fever, anorexia, and weight loss An association between the -196 to -174 Del/Del...
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