neuroprotection in traumatic brain injury
báo cáo hóa học: " Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice" pot
... JW, Stover JF, McIntosh TK: Pharmacology of traumatic brain injury Curr Opin Pharmacol 2003, 3(1):27-32 Doppenberg EM, Choi SC, Bullock R: Clinical trials in traumatic brain injury: lessons for ... receptor type 1-related protein y, IgG1-linked murine recombinant fusion protein; MBP, mannose-binding protein; rVCP, recombinant Vaccinia virus complement control protein; sCR1, soluble complement ... (in 0.1% milk in PBS containing 0.05% TWEEN) and murine recombinant mouse C5a at defined concentrations for establishing the standard curve After incubation and subsequent washing steps, biotinylated...
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Báo cáo y học: "rogesterone in traumatic brain injury: time to move on to phase III trials" doc
... Schouten JW: Neuroprotection in traumatic brain injury: a complex struggle against the nature of biology Curr Opin Crit Care 2007, 13:134-142 Wang KK, Larner SF, Robinson G, Hayes RL: Neuroprotection ... Traumatic Brain Injury Clinical Trials Network JDK is a Principal Investigator in the Resuscitation Outcomes Consortium References Xiao G, Wei J, Yan W, Wang W, Lu Z: Improved outcomes from the administration ... clinical reality are vital to those of us seeking to expand our armamentarium of therapeutic options in the treatment of these injuries [6-8] Competing interests SMM is an investigator in the Traumatic...
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Báo cáo y học: " Intensive glycemic control in traumatic brain injury: what is the ideal glucose range" pps
... and brain tissue pH after traumatic brain injury Neurosurgery 2004, 55:877-881 12 Bilotta F, Spinelli A, Giovannini F, Doronzio A, Delfini R, Rosa G: The effect of intensive insulin therapy on infection ... days after brain injury in the intensive glycemic control group This unexpected worsening of mortality is cause for great concern among those who advocate intensive glycemic control in brain trauma ... to mmol/l) in patients with severe traumatic brain injury Crit Care 2008, 12:R98 Lam AM, Winn HR, Cullen BF, Sundling N: Hyperglycemia and neurological outcome in patients with head injury J Neurosurg...
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Báo cáo y học: "Standardisation of data collection in traumatic brain injury: key to the future" pot
... integrated in the US into a much larger interagency initiative towards ‘an integrated approach to research in psychological health and traumatic brain injury This initiative included working groups ... towards ‘an integrated approach to research in Psychological Health and Traumatic Brain Injury References Maas AIR, Stocchetti N, Bullock R: Moderate and severe traumatic brain injury in adults ... Steyerberg EW: Prognosis and clinical trial design in traumatic brain injury: the IMPACT study J Neurotrauma 2007, 24:232-238 Brain Trauma Foundation [http://www.braintrauma.org/site/ PageServer]...
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Báo cáo y học: "Bench-to-bedside review: Hypothermia in traumatic brain injury" pot
... trial in patients with raised intracranial pressure after traumatic brain injury Published: 15 February 2010 References European Brain Injury Society homepage [http://www.ebissociety.org/ head -injury. html] ... HQ, Jenkins LW, Marion DW, Dixon CE: Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumatic brain injury in rats Brain Res ... global ischemia Brain Res Mol Brain Res 2001, 86:34-47 33 Lyeth BG, Jiang JY, Robinson SE, Guo H, Jenkins LW: Hypothermia blunts acetylcholine increase in CSF of traumatically brain injured rats...
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Báo cáo y học: "The added value of ordinal analysis in clinical trials: an example in traumatic brain injury" potx
... simulation study evaluating approaches to the analysis of ordinal outcome data in randomized controlled trials in traumatic brain injury: results from the IMPACT Project Clin Trials 2010, 7:44-57 ... JM, Whitehead J: Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial GAIN International Investigators Lancet 2000, ... in stroke trials Stroke 2007, 38:1911-1915 doi:10.1186/cc10240 Cite this article as: Roozenbeek et al.: The added value of ordinal analysis in clinical trials: an example in traumatic brain injury...
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Cognitive rehabilitation of attention deficits in traumatic brain injury using action video games: A controlled trial
... McLaughlin, K A., Pavese, A., Heidrich, A., & Posner, M I (2000) Evaluation of attention process training and brain injury education in persons with acquired brain injury Journal of Clinical and ... demographics The following demographic information was taken: age at injury (in years), age at first assessment (in years), time since injury (in months), days of post -traumatic amnesia (PTA) ... The remainder of the time was dedicated to a psycho-education programme addressing common consequences of brain injury and introducing compensatory strategies 2.3 Statistical analysis Baseline comparisons...
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Báo cáo y học: "Propofol: neuroprotection in an in vitro model of traumatic brain injury" pot
... tissue injury was maintained in all slices prior to inclusion in the study groups This initial injury could be observed in all slices and is attributable to minimal cell death originating from ... cell injury in the slices The normalised integral was defined as the trauma intensity This analysis was performed for each slice in every group Two types of tissue injury were defined: 'Total injury' ... before final fluorescence imaging Microscopy and staining PI is a nucleic acid intercalating agent that is membrane-impermeable in vital cells with intact cell membranes In damaged cells gaps in the...
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Báo cáo y học: "Argon: Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury" pdf
... injury were first incubated for 30 minutes at 37°C, 95% air and 5% CO2 in EM containing 4.5 μM PI Following baseline fluorescence imaging the traumatic brain injury was generated using an apparatus ... McIntosh TK: Apoptosis after traumatic brain injury J Neurotrauma 2000, 17:927-938 Faden AI: Neuroprotection and traumatic brain injury: theoretical option or realistic proposition Curr Opin ... flushed using a premixed argon gas mixture (5% CO2, 21% O2, x% Argon, [74-x]% N2; Air Liquide Santé International, Paris, France) Traumatic brain injury All slices subject to traumatic brain injury...
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Báo cáo y học: "Technical Considerations in Decompressive Craniectomy in the Treatment of Traumatic Brain Injury"
... Surgeons The Joint Section on Neurotrauma and Critical Care Management and prognosis of severe traumatic brain injury, part 1: Guidelines for the management of severe traumatic brain injury J Neurotrauma ... of interest exists References 10 11 12 13 14 15 16 17 18 Timofeev I., Hutchinson PJ Outcome after surgical decompression of severe traumatic brain injury Injury 2006;37:1125-1132 Coplin WM Intracranial ... hemicraniectomy in normal brain An experimental PET-study in cats Brain Res 2003;982:31-37 37 Sakamoto S, Eguchi K, Kiura Y, et al CT perfusion imaging in the syndrome of the sinking skin flap before...
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báo cáo hóa học: " Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury" pptx
... Post -Injury (hours) E * D Brain IL-2 (pg/mg protein) Brain TNF (pg/mg protein) B Time Post -Injury (hours) C Brain IL-4 (pg/mg protein) * Brain IL-1 (pg/mg protein) Brain IL-6 (pg/mg protein) A Page of 16 ... severe traumatic brain injury in adults Lancet Neurol 2008, 7:728-741 Gaetz M: The neurophysiology of brain injury Clin Neurophysiol 2004, 115:4-18 Masel BE, DeWitt DS: Traumatic brain injury: ... Post -Injury (hours) Figure Increase in brain edema does not differ in traumatic axonal injury rats with or without hypoxia Brain water content was determined at 2, 24, 48, 72 and 96 h post -injury, ...
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Traumatic brain injury and the effects of diazepam, diltiazem, and MK-801 on GABA-A receptor subunit expression in rat hippocampus ppt
... in an incomplete understanding of their contribution to injury- induced pathology, but have indicated that the receptor is affected by injury Sihver et al [12] found a decrease in GABAAR binding ... the injuryinduced decrease in expression (M = 74.93) [F(3,9) = 14.907, p < 01], indicating DZ decreased α3 expression, regardless of injury condition DZ normalized γ2 injuryinduced decreases in ... ME, McIntosh TK: Workshop of animal models of traumatic brain injury J Neurotrauma 1994, 11:723-732 30 Hamm RJ, O'Dell DM, Pike BR, Lyeth BG: Cognitive impairment following traumatic brain injury: ...
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Báo cáo y học: " Communication patterns in a psychotherapy following traumatic brain injury: A quantitative case study based on symbolic dynamics" pptx
... of mind after traumatic brain injury Neuropsychologia 2005, 43:99-114 Havet-Thomassin V, Allain P, Etcharry-Bouyx F, Le Gall D: What about theory of mind after severe brain injury? Brain Injury ... factors in brain injury- associated personality change Brain Injury 1994, 8(3):265-276 Turkstra LS, Dixon TM, Baker KK: Theory of Mind and social beliefs in adolescents with traumatic brain injury ... traumatic brain injury Brain Injury 1996, 10:319-327 Ashman TA, Spielman SA, Hibbard MR, Silver JM, Chandna T, Gordon WA: Psychiatric challenges in the first years after traumatic brain injury: ...
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Báo cáo khoa học: "SOFA is superior to MOD score for the determination of non-neurologic organ dysfunction in patients with severe traumatic brain injury: a cohort study" doc
... mediator production following traumatic brain injury In Shock, Sepsis, and Organ Failure -Brain Damage Secondary to Hemorrhagic -Traumatic Shock, Sepsis, and Traumatic Brain Injury: Fifth Wiggers Bernard ... in severe traumatic brain injury Crit Care Med 2005, 33:654-660 Zygun DA, Doig CJ: Measuring organ dysfunction In Yearbook of Intensive Care and Emergency Medicine Edited by: Vincent JL Berlin, ... mmHg Dopamine ≤5a, dobutamine (any dose) Dopamine >5a or epinephrine ≤0.1a or norepinephrine ≤0.1a Dopamine >15a or epinephrine >0.1a or norepinephrine >0.1a Hematologic: platelet count >150 ≤150...
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Báo cáo y học: "Safety of rFVIIa in hemodynamically unstable polytrauma patients with traumatic brain injury: post hoc analysis of 30 patients from a prospective, randomized, placebo-controlled, double-blind clinical trial" pps
... Marwaha N, Singh D, Varma N, Mathuriya SN: Change in tissue thromboplastin content of brain following trauma Neurol India 2005, 53:178-182 Stein SC, Smith DH: Coagulopathy in traumatic brain injury ... drug was administered in addition to standard treatment for injuries and bleeding at the participating hospitals Traumatic brain injury post hoc subanalysis In accordance with protocol inclusion ... clotting system with rFVIIa in such injuries, due to the release of tissue factor (TF) in the brain and the prevalence of consumption coagulopathy or disseminated intravascular coagulation in brain...
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Báo cáo y học: " The costs of traumatic brain injury due to motorcycle accidents in Hanoi, Vietnam" doc
... year after traumatic brain injury: A multicenter analysis Arch Phys Med Rehabil 1997, 78:125-31 Ruffolo CF, Friedland JF, Dawson DR, Colantonio A, Lindsay PH: Mild traumatic brain injury from ... possible, households were strategic in minimizing the loss of household income by selecting Table 1: One-year costs associated with treatment by level of traumatic brain injury (Unit: USD, 1USD = 15,850 ... road traffic injuries, a rate of 734 per 100,000 population [2] According to the World Health Organization, traumatic brain injury (TBI) is the main cause of fatal and non-fatal injury for motorcycle...
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Báo cáo y học: "In vitro norepinephrine significantly activates isolated platelets from healthy volunteers and critically ill patients following severe traumatic brain injury" pptx
... less than 2% severe traumatic brain of surface P-selectin in with healthy controls Changes in expressioninjury patients comparedplatelets isolated from severe traumatic brain injury patients compared ... Figure Relative increases in norepinephrine-induced expression of P-selectin in arterial (blackhealthy controls (white bars) expressed as a percentage of severe traumatic brain injury (TBI) patients ... correlated with the rate of norepinephrine infusion during steady-state conditions of the norepinephrine infusion period The average norepinephrine dose infused in the presently investigated patients ranged...
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Báo cáo y học: " Differential temporal profile of lowered blood glucose levels (3.5 to 6.5 mmol/l versus 5 to 8 mmol/l) in patients with severe traumatic brain injury" docx
... moderate fluid-percussion brain injury in rats J Neurotrauma 2002, 19:681-692 30 Hui L, Pei DS, Zhang QG, Guan QH, Zhang GY: The neuroprotection of insulin on ischemic brain injury in rat hippocampus ... Changes in arterial blood glucose, insulin and norepinephrine dose, and ICP Shown are changes in arterial blood glucose, insulin and norepineICP phrine dose, and intracranial pressure (ICP) in surviving ... metabolic reduction in gray matter acutely following human traumatic brain injury J Neurotrauma 2004, 21:149-161 Bartnik BL, Hovda DA, Lee PW: Glucose metabolism after traumatic brain injury: estimation...
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Báo cáo y học: " Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial" ppsx
... Thoracic injury 0.13 Abdominal injury 0.34 Extremities injury 0.20 Diffuse injury without brain swelling 12 0.046 Diffuse bilateral brain swelling 12 Diffuse unilateral brain swelling with midline ... reactivity (n)a One reacting Both reactingb 12 14 Diffuse injury without brain swelling Diffuse bilateral brain swelling Diffuse injury unilateral brain swelling with midline shift Any mass lesion ... responsible for designing the study and reviewing CT findings JI was responsible for designing the study and reviewing CT findings JI revised the article critically and gave final approval to the...
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Báo cáo y học: "Optimizing cerebral glucose in severe traumatic brain injury: still some way to go" pdf
... Glenn T, Martin N, Hovda D: Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving lactate/pyruvate ratio after traumatic brain injury Crit ... 34:850-856 Hamlin GP, Cernak I, Wixey JA, Vink R: Increased expression of neuronal glucose transporter but not glial glucose transporter following severe diffuse traumatic brain injury in rats J Neurotrauma ... Holbein M, Béchir M, Ludwig S, Sommerfeld J, Cottini SR, Keel M, Stocker R, Stover JF: Differential influence of arterial blood glucose on cerebral metabolism following severe traumatic brain injury...
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