multiple sclerosis variable spectrum and disease progression
MULTIPLE SCLEROSIS CURRENT STATUS AND STRATEGIES FOR THE FUTURE ppt
... slow clinical worsening Disease activity and progression have both clinical and subclinical components Clinical disease activity and progression are judged by observation and neurologic examination ... of the disease, causes, course, and treatments (Chapters 2, 5, and 6); (2) adaptation and management (combination of medical, technological, and psychosocial aspects) (Chapters and 4); and finally, ... developed and validated to increase the reliability and power of clinical trials and to improve individual patient care 10 MULTIPLE SCLEROSIS BOX Recommendations on Disease Adaptation and Management...
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báo cáo hóa học:" Decreased levels of serum glutathione peroxidase 3 are associated with papillary serous ovarian cancer and disease progression" pot
... conceptualized and designed the experiments, collected, assembled, analyzed and interpreted data, and drafted the manuscript OC conceptualized and designed the experiments, and collected, assembled and ... designed and implemented experiments SS recruited, collected and annotated specimens, and interpreted data KO recruited, collected and annotated specimens, and interpreted data SC collected and annotated ... specimens, and analyzed and interpreted data PD conceptualized and designed the experiments, analyzed and interpreted data, and helped with the drafting of manuscript JM conceptualized and designed...
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báo cáo hóa học: " Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis" ppt
... study; NV, JFEP, PM, APZ and JG performed it; NV and JFEP analyzed the data; and NV, JFEP and MP wrote the manuscript MJR and NM participated in the design of the study and helped draft the manuscript ... (Sulzfeld, Germany) and maintained on a 12:12 h light:dark cycle, with standard chow and water freely available Animals were handled according to European legislation (86/609/EEC) and all manipulations ... 23:8568-8577 Gold R, Linington C, Lassmann H: Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis...
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Tài liệu Complementary and Alternative Medicine and Multiple Sclerosis Second Edition pdf
... Complementary and Alternative Medicine and Multiple Sclerosis Second Edition This page intentionally left blank Complementary and Alternative Medicine and Multiple Sclerosis Second Edition ... title Alternative Medicine and Multiple Sclerosis Library of Congress Cataloging-in-Publication Data Bowling, Allen C Complementary and alternative medicine and multiple sclerosis Allen C Bowling—2nd ... Alternative medicine and multiple sclerosis c2001 Includes bibliographical references and index ISBN-13: 978-1-932603-54-5 (pbk : alk paper) ISBN-10: 1-932603-54-9 (pbk : alk paper) Multiple sclerosis Alternative...
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Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt
... Syndecans-1 and -3 core proteins are larger than those of syndecan-2 and -4, and can bear both heparan and chondroitin sulfate chains The GAG chains are substituted on core protein serine residues and ... syndecan-specific variable (V) region syndecan-3 can mostly be found in neuronal tissues and some musculoskeletal tissue Here, our understanding of syndecan shedding and its function in wound healing and tumour ... processes and are key to normal matrix turnover, but also have essential roles in development and reproduction, and in pathological tissue remodelling during inflammatory disease, cancer invasion and...
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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx
... metastasis and higher microvessel density [23–25] We choose to highlight the role of heparanase in human cancer by focusing on head and neck carcinoma and multiple myeloma as examples of solid and hematological ... tumor progression, combining enzymatic activity-dependent and -independent activities of heparanase and affecting two systems critical for tumor progression, namely tumor vascularization and EGFR ... signaling function, and elucidation of heparanase route and function in the cell nucleus, will advance the field of heparanase research and reveal its significance in health and disease Resolving...
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Assessment and Management of the Elderly Patient with Multiple Sclerosis pot
... intensity and catastrophizing in individuals with multiple sclerosis and chronic pain Int J Clin Exp Hypn Jan 2011; 59(1):45–63 Krupp LB Fatigue in multiple sclerosis: Definition, pathophysiology and ... mood and affect in multiple sclerosis Multiple sclerosis therapeutics New York: Martin Dunitz; 2003:651–89 Sadovnick AD, Eisen K, Ebers GC, Paty DW Cause of death in patients attending multiple sclerosis ... clinical course of multiple sclerosis: Results of an international survey National multiple sclerosis society (USA) advisory committee on clinical trials of new agents in multiple sclerosis Neurology...
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báo cáo hóa học: "The impact of regular physical activity on fatigue, depression and quality of life in persons with multiple sclerosis" pot
... and leisure IPAQ score and the BDI, and all subscales of MFIS and SF36 were performed Univariate analysis between disease severity, exercise status and the BDI and all subscales of the MFIS and ... characteristics including: sex, age, year of MS diagnosis and disease course The Disease Steps Scale (DSS) and Multiple Sclerosis Impact Scale (MSIS-29) assessed disease severity The DSS is an ordinal scale ... of persons with multiple sclerosis: the possible warning signs Mult Scler 2007, 13(8):1038-1045 Multiple Sclerosis Council for Clinical Practice Guidelines: Fatigue and multiple sclerosis: evidence-based...
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Báo cáo sinh học: " Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients" docx
... immunological marker of disease activity in multiple sclerosis Brain 1997, 120(Pt 1):1-13 Sorensen PS: Biological markers in body fluids for activity and progression in multiple sclerosis Mult Scler ... biological markers and clinical measures No significant correlation emerged between laboratory data and disease progression EDSS changes at any of the examined time points; Disease progression was ... correlation between biomarkers and clinical efficacy, we also investigated whether disease progression and the occurrence of clinical relapses influenced neopterin production and tryptophan degradation...
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báo cáo hóa học: " Effects of glatiramer acetate on fatigue and days of absence from work in first-time treated relapsing-remitting multiple sclerosis" doc
... with multiple sclerosis Multiple sclerosis (Houndmills, Basingstoke, England) 2005, 11(5):602-609 Comi G, Leocani L, Rossi P, Colombo B: Physiopathology and treatment of fatigue in multiple sclerosis ... in multiple sclerosis: an expanded disability status scale (EDSS) Neurology 1983, 33(11):1444-1452 Multiple Sclerosis Council for Clinical Practice Guidelines: Fatigue and multiple sclerosis: ... assessment of fatigue in MS? Multiple sclerosis (Houndmills, Basingstoke, England) 2005, 11(2):198-202 Jackson MF, Quaal C, Reeves MA: Effects of multiple sclerosis on occupational and career patterns...
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báo cáo hóa học: " Soluble HLA measurement in saliva and cerebrospinal fluid in Caucasian patients with multiple sclerosis: a preliminary study" pdf
... possible alteration of sHLA-I and/ or sHLA-II levels as a reflection of disease activity in multiple sclerosis (MS) Clinical and brain magnetic resonance imaging (MRI) disease activity in MS is associated ... of soluble HLA-I and soluble HAL-II Drs Minagar and Kelley have contributed to this manuscript by recruiting and examining multiple sclerosis patients, interpretation of data and preparing the ... assay included a standard curve derived from positive and negative controls Negative controls consisted of 2% BSA and human serum, free of sHLA-I and sHLA-II Positive control standards were prepared...
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báo cáo hóa học: " Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions" pptx
... expression and distinct regulation of pro- and secreted IL-16 in acute, subacute and chronic MS lesions, and in normal-appearing white matter, from brain and spinal cord of 39 patients with MS and 19 ... BD: Axonal degeneration and progressive neurology disability in multiple sclerosis Neurotox Res 2003, 5:157-64 Lassmann H, Bruck W, Lucchinetti C: Heterogeneity of multiple sclerosis pathogenesis: ... and Microglial Cells of the MS-Plaque Neurosci Res 1996, 44:606-611 Gveric D, Cuzner ML, Newcombe J: Insulin-like growth factors and binding proteins in multiple sclerosis plaques Neuropath and...
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báo cáo hóa học: " Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis" potx
... acid and lysophospholipids and therefore also control levels of inflammatory mediators and cytotoxic metabolites including prostaglandins, leukotrienes, and reactive oxygen species PLA2 enzymes and ... infiltration and activation during Wallerian degeneration and axonal regeneration J Neurosci 1998, 18(17):6713-6722 Kurtzke JF: Rating neurologic impairment in multiple sclerosis: an expanded disability ... manuscript and together with LC designed and implemented the EAE studies JG screened subjects for the human studies, conducted neurological exams and collected samples from patients and controls...
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báo cáo hóa học: " Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis" pptx
... methods and Table S1 Acknowledgements Support from the National Multiple Sclerosis Society (RG3743 and a Pediatric MS Center of Excellence Center Grant) and the Department of Defense Multiple Sclerosis ... IL-12p40 and IL-23 in multiple sclerosis patients treated with interferon-beta1b Mult Scler 2010, 16:801-809 29 Minagar A, Jy W, Jimenez JJ, Alexander JS: Multiple sclerosis as a vascular disease ... EDSS < 4.0 and ≥ 4.0 The baseline EDSS groups were analyzed using logistic regression with sex as a factor and disease duration and lipid profile variable of interest The CE-LV, T2-LV and T1-LV...
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báo cáo hóa học:" Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients" pot
... immunological marker of disease activity in multiple sclerosis Brain 1997, 120(Pt 1):1-13 Sorensen PS: Biological markers in body fluids for activity and progression in multiple sclerosis Mult Scler ... biological markers and clinical measures No significant correlation emerged between laboratory data and disease progression EDSS changes at any of the examined time points; Disease progression was ... correlation between biomarkers and clinical efficacy, we also investigated whether disease progression and the occurrence of clinical relapses influenced neopterin production and tryptophan degradation...
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báo cáo hóa học:" Impact of HIV-1 viral subtype on disease progression and response to antiretroviral therapy" pot
... HIV-1 Env subtypes A and D and disease progression in a rural Ugandan cohort AIDS 2001, 15:293-299 17 Alaeus A, Litman K, Björkman A, Giesecke J, Albert J: Similar rate of disease progression among ... six, nine and 12 months was, respectively: 66%, 78% and 88% for subtype B; 77%, 81% and 88% for subtype A; 82%, 85%, 92% for subtype C; 78%, 88% and 88% for subtype D; and 65%, 65% and 74% for ... there is a similar rate of progression and response to HAART for subtype B and the non-B subtypes, A and C, but that subtype D is associated with a faster rate of disease progression Our study is...
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báo cáo hóa học:" Interpreting scores on multiple sclerosis-specific patient reported outcome measures (the PRIMUS and U-FIS)" doc
... Reliability and Validity The distributional properties of the PRIMUS and U-FIS were explored through descriptive statistics (mean, standard deviation, median and inter-quartile range [IQR]) and floor and ... depression in multiple sclerosis a population based perspective Neurology 2003, 61:1524-27 Montel SR, Bungener C: Coping and quality of life in one hundred and thirty five subjects with multiple sclerosis ... previous years), Expanded Disability Status Scale (EDSS) score of between and 5.5 and neurologically stable for at least 30 days prior to randomization Twiss et al Health and Quality of Life...
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báo cáo hóa học:" The impact of regular physical activity on fatigue, depression and quality of life in persons with multiple sclerosis" pdf
... and leisure IPAQ score and the BDI, and all subscales of MFIS and SF36 were performed Univariate analysis between disease severity, exercise status and the BDI and all subscales of the MFIS and ... characteristics including: sex, age, year of MS diagnosis and disease course The Disease Steps Scale (DSS) and Multiple Sclerosis Impact Scale (MSIS-29) assessed disease severity The DSS is an ordinal scale ... of persons with multiple sclerosis: the possible warning signs Mult Scler 2007, 13(8):1038-1045 Multiple Sclerosis Council for Clinical Practice Guidelines: Fatigue and multiple sclerosis: evidence-based...
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Báo cáo y học: "Increased plasma homocysteine levels in patients with multiple sclerosis and depression" ppsx
... homocysteine (Hcy) and vitamin B12 in multiple sclerosis (MS) patients and controls Box and1 Box and whisker plot of plasma homocysteine (Hcy) and vitamin B12 in multiple sclerosis (MS) patients and controls ... anxiety and depression in multiple sclerosis outpatients Acta Neurol Scand 2007, 115:67-72 Provinciali L, Ceravolo MG, Bartolini M, Logullo F, Danni M: A multidimensional assessment of multiple sclerosis: ... homocysteine levels in multiple sclerosis Arch Neurol 1994, 51:1181 Refsum H, Nurk E, Smith AD, Ueland PM, Gjesdal CG, Bjelland I, Tverdal A, Tell GS, Nygard O, Vollset SE: The Hordaland Homocysteine...
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Báo cáo y học: " Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune disease" pot
... clinical course and progression of multiple sclerosis J Neuroimmunol 2003, 140:188-193 87 Ligers A, Xu C, Saarinen S, Hillert J, Olerup O: The CTLA-4 gene is associated with multiple sclerosis J ... [81,82] For multiple sclerosis, most studies showed no indication for a contribution of CTLA-4 polymorphisms at positions –318 and +49 as a disease risk factor in Canadian, Polish, Finnish, and Dutch ... allele of the CTLA-4 gene at position +49 and the severity of multiple sclerosis in Swedish and German patients [87,88] A recent study in mice identified a disease- susceptibility polymorphism of...
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