molecular factors opposing the expression and action of pro inflammatory cytokines in the brain
Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt
... deal of interest has been devoted to dissecting the role of the endocannabinoid system in physiology as well as in pathological processes The system incorporates the endocannabinoids, their synthetic ... to the many other classes of anti-excitotoxic drugs tested thus far in clinical trials and certainly may provide the basis for other failures in the future [6] Therefore, a better design of protective ... endothelial isoform of this enzyme are beneficial by, among other mechanisms, sustaining blood flow in the periphery of the ischemic brain On the other hand, under normal circumstances, stimulation of NMDA...
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Báo cáo khóa học: Collectins Players of the innate immune system docx
... ligands [74,75,80] Furthermore, the mode of galactose-binding was similar to the mode of ligand binding of the galactoserecognizing CRD from the asialoglycoprotein receptor [78] The molecular basis ... collectins depend on the density of carbohydrate ligands on the microbial surface [83] on the one hand, and on the degree of oligomerization of the collectin [66], on the other Clustering of glycoproteins ... of the binding of a single C-type CRD with a monosaccharide ligand is in the order of 10)3 M, whereas the Kd of binding of collectin trimers and higherorder multimers to polyvalent ligands is in...
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Paradoxical roles of the immune system during cancer development docx
... preventing apoptosis of cells with malignant potential, and second, by stimulating production of pro- inflammatory cytokines by cells of myeloid origin in tumours These pro- inflammatory cytokines then ... characterized by chronic infiltration of innate immune cells in the stromal tissue25,26 (FIG 2) Interestingly, the profile of infiltrating inflammatory cells in skin is distinct from that in cervix — pre-malignant ... T-helper-1 cytokines and anti -inflammatory T-helper-2 cytokines7 4; therefore, the nature and balance of surrounding stimuli might determine which type of NK-T-cell-induced T-helper response dominates and...
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Cancer of the Brain and Other Central Nervous System doc
... Tumors of the spine were the most common site with other CNS cancers, although malignant meningiomas of the brain had worse survival than those with malignant tumors in the spine Brain and other ... 80 Brain cancer occurring in the frontal lobes (25.8% of total), temporal lobe (20.1% of total), parietal lobe (14.6% of total) and overlapping lesions of the brain (19.8% of total) were the ... Cancer of the Brain and Nervous System Histologic Type of Tumor Classification NOS, C716 - Cerebellum, NOS, C717 - Brain Stem, C718 - Overlapping lesion of brain and C719 - Brain, NOS; SPINE: C701...
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Báo cáo khoa học: Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17b-estradiol pdf
... poorly investigated In the present study, we aimed to evaluate the effect of MCAo-induced brain insult on AEA regional level, metabolism, and receptor binding and expression The putative neuroprotective ... are known to protect the brain against focal ischemia [35] In order to investigate the role of the endocannabinoid system in the neuroprotection afforded by estrogen, the effect of acute treatment ... receptor binding in cortices and striata did not change following h of MCAo, either in the absence or in the presence of h of reperfusion (data not shown) Fig Endogenous levels of AEA (A) and activity...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... capable of binding to the cytoplasmic domain of the siglec-10 protein The binding of SHP-1, however, was missing from the Y667F mutant indicating this to be the preferred tyrosine for interaction ... binding of any of the adherent cell types Binding assays with siglec-expressing COS7 cells Results for COS7 binding experiments are shown in Fig 5C There was a significant increase in binding of ... binding, however, was only diminished by < 50% in the Y667F mutant, indicating that SHP-2 may be binding both to the tyrosine at position 667 and to other tyrosines in the cytoplasmic tail of...
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brain facts a primer on the brain and nervous system - the society for neuroscience
... form the hindbrain, midbrain and forebrain The first signs of the eyes and then the hemispheres of the brain appear later How does all this happen? Although many of the mechanisms of human brain ... enter the blood and travel to the brain and other organs In the brain, they alter the production of gene products that participate in synaptic neurotransmission as well as the structure of brain ... cells, the neuron is the basic working unit of the brain The brain is what it is because of the structural and functional properties of neurons The brain contains between one billion and one...
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Design of a near infrared spectrophotometry brain imaging system
... mspgcc-4.4.3, and then programed to the device using the TinyOS software 4.2 The Sensor The sensor was first designed by selecting the components The main problem was sourcing the LEDs with the desired ... (NIRS) system for the measurement of brain activity in localized areas in the brain A prototype of the design will be built and wirelessly interfaced with a computer The time-varying haemodynamic ... spending the time to find the required infrared LEDs and allowing for the purchase of them in low quantity The developers behind the mspgcc project deserve a large thank you for porting the GCC...
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scientific american - 1993 09 - special issue - life, death, and the immune system
... disease All these Þndings intensiÞed interest in one of the most central and baÝling SIR GUSTAV J V NOSSAL is director of the Walter and Eliza Hall Institute of Medical Research and professor of medical ... residence mainly in the lining of the reproductive organs in females and in the epithelium of the tongue in both sexes These cells carry a TCR called gamma Subsequent waves emigrate for the most ... diÝerentiate They give rise to successive kinds of T cells that populate the lining (epithelium) of the skin, various oriÞces (such as the mouth and vagina) and the organs that connect with them (the...
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báo cáo hóa học:" Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target" docx
... [1,2] Angiostatin and related forms consisting of the first 1–5 kingles in plasminogen (here termed collectively AST) is generated by the action of diverse proteases, including metalloproteases (MMP2, ... by a single stimulus to levels at times reaching that of the potent combination of IFNγ and LPS was quite remarkable Interestingly, the combination of AST and IFNγ/LPS was additive only in the ... values with standard errors were obtained using Qgene software and normalized to the expression of the house-keeping gene β-actin Data were obtained from independent experiments done in triplicate...
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Báo cáo sinh học: " Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" docx
... RD, Thein P: The effectiveness of the paramunity inducer Baypamun (PIND-ORF) for the prevention and metaphylaxis of an experimental infection with the infectious bovine rhinotracheitis virus in ... vaccine In Proceedings of the tenth Conference 5–7 November 1996 Faculty of Veterinary Medicine, Assiut Univrsity, Egypt; 1996:111-118 Trinchieri G: Interleukin-12 and the regulation of innate ... antagonize the effects of host cytokines mediating the antiviral process [16,26] In addition, inducing apoptosis in a significant number of antigen-presenting cells [20] as well as inducing IL-10...
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Báo cáo hóa học: " Effectiveness of a Wii balance board-based system (eBaViR) for balance rehabilitation: a pilot randomized clinical trial in patients with acquired brain injury" ppt
... RL and MA contributed to the design of the study, the software development and the interpretation of the results CC contributed to the design of the study, to the assessment of patients, to the ... transferences in sitting and standing position, which is an essential process in standing balance rehabilitation [24,25] The system calibrates the maximum excursion of the patients and adapts the range of ... required to maintain their soles on the WBB In sitting position, the patients sit directly on the WBB In the study presented in this paper, the patients play with the system in standing position...
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Báo cáo hóa học: " Brain-Computer Interface Controlled Functional Electrical Stimulation System for Ankle Movement" doc
... K, Yoshinobu T: Development of Brain- Computer Interface (BCI) System for Bridging Brain and Computer In 13th International Conference on Biomedical Engineering, Volume 23 of IFMBE Proceedings Edited ... ) > T2, the BCI-FES system transitions to idling state (pink block) during the training procedures revealed that the EEG power in the μ, b and low-g bands were responsible for encoding the differences ... representation area (located in the interhemispheric fissure of the brain) and/ or supplementary motor area This was further confirmed by examining the feature extraction maps of the prediction models...
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báo cáo hóa học: " Application of a hybrid wavelet feature selection method in the design of a self-paced brain interface system" pptx
... epochs), the size of the NC training feature set was reduced to be the same as the size of the training IC feature sets This was done by randomly selecting epochs from the NC training set Results In ... 2, since the input and output can only take two values: IC and NC), P(xi) is the probability of occurrence of an input state xi, P(yj) is the probability of the output class yj when the input ... from Table 2) The blue line shows the fitness of the classifier as a function of the number of top features We began by training and testing the classifier using only the feature with the highest...
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báo cáo hóa học: " Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis" docx
... of complement anaphylatoxins C3a and C5a are dramatically increased in the CSF enhancing the influx of inflammatory cells into the ventricle and increasing complement biosynthesis and promoting ... epithelial cells of the choroid plexus and the ependyma of the ventricle which may be due to the local inflamed microenvironment The mechanisms controlling the expression of Cregs on brain epithelial ... responses to protect the brain against the rather proinflammatory/toxic response in severe bacterial meningitis The severity of the lesioned microenvironment may determine ependymal cell survival and...
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báo cáo hóa học: " Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice" doc
... MT-I/II expression is increased in the brain after brain injury which suggests that some of the protective effects of MT-I/II after brain injury are acting directly on the injured brain However, ... neurotoxic and can impede the resolution of brain injury [19-21] It is feasible that the number of immune cells entering the CNS can influence the progression of brain injury but the phenotype of the ... modulation of immune response after brain injury than MTI/II produced within the CNS Such an interaction Page 10 of 11 would increase the prospects for the use of MT-I/II as a therapeutic for brain injury...
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báo cáo hóa học:" Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" doc
... RD, Thein P: The effectiveness of the paramunity inducer Baypamun (PIND-ORF) for the prevention and metaphylaxis of an experimental infection with the infectious bovine rhinotracheitis virus in ... vaccine In Proceedings of the tenth Conference 5–7 November 1996 Faculty of Veterinary Medicine, Assiut Univrsity, Egypt; 1996:111-118 Trinchieri G: Interleukin-12 and the regulation of innate ... antagonize the effects of host cytokines mediating the antiviral process [16,26] In addition, inducing apoptosis in a significant number of antigen-presenting cells [20] as well as inducing IL-10...
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Báo cáo sinh học: "Parasite immunomodulation and polymorphisms of the immune system" ppsx
... also the need to balance effective pathogen elimination against the risk of self-destructive reactions This is well recognized for polymorphisms affecting the structural domains of proteins that ... showing greatest variability included some encoding cytokines controlling both innate immune responses (such as the IL-1 family) and adaptive Th2 responses (such as IL-4 and IL-4R) Strikingly (in ... that there is no certain genetic optimum and that, in an environment with diverse pathogens demanding conflicting response patterns, the fine-tuning effect of multiple allelic variants allows the...
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Báo cáo sinh học: "Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system" docx
... subsets, distinguished by the different cytokines they produce (indicated under each CD4 T cell type): the cytokines act on other immune cells, activating them in turn The four known subsets of CD4 ... importantly, in inducing them to secrete the cytokine interleukin (IL)-22 (a cytokine implicated in the defense of mucosal barriers) AhR-dependent induction of IL-22 is seen with several distinct ligands, ... test AhR ligands for their suppressive effect in this autoimmune model with a view to future application in treatment of the disease While the role of AhR in the induction of the cytokine IL-22...
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Báo cáo khoa học: "The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis)" pdf
... WC1-N4 isoforms The frequency of WC1+ γδ T cells was high in young animals and low in adults There were corresponding differences in the frequency of CD2+ αβ T cells in young and adult animals There ... times (800 × g/3 min) in PBS-HS, then incubated in the dark for 30 minutes at 4oC in 100 µl of a : 200 dilution of fluorescein (FITC)-conjugated goat anti-mouse immunoglobulin (IgG and IgM specific ... molecules should prove useful in study of the response to infectious agents and vaccines [8] ACT1 is expressed within 16 to 24 hrs of stimulation with A similar to the kinetics of appearance of CD25 ACT2...
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