metabolism and genotoxicity of dihaloalkanes
Báo cáo hóa học: " Effects of rehydration nutrients on H2S metabolism and formation of volatile sulfur compounds by the wine yeast VL3" docx
... incorporation of solubilised sterol present in IDY (Soubeyrand et al 2005,) Additions of fermentable carbon source and magnesium salts were also shown to enhance both viability and vitality of dehydrated ... formation of H2S while the addition of DAP delayed it Page of 11 (Figure 1c) Nonetheless, these results support our previous hypothesis of distinct effects for each of the treatments and further ... Blateyron L, Sablayrolles JM (2001) Stuck and slow fermentations in enology: statistical study of causes and effectiveness of combined additions of oxygen and diammonium phosphate J Biosci Bioeng...
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Báo cáo y học: " Effect of 28 days of creatine ingestion on muscle metabolism and performance of a simulated cycling road race" docx
... phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest Methods and variance of values Scandinavian Journal of Clinical and Laboratory Investigation 1974, 33:109-120 ... as: Hickner et al., Effect of 28 days of creatine ingestion on muscle metabolism and performance of a simulated cycling road race Journal of the International Society of Sports Nutrition 2010, ... 90% of maximal power output In contrast, we detected an interaction of treatment (creatine and placebo) and time (pre and post supplementation) for submaximal oxygen consumption near the end of...
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Genotoxicity of 255 chemicals in the Salmonella microsome test (Ames test) and 8-hydroxyguanine (8-OH-Gua) assay for the detection of carcinogens
... Kasai, H., Sofuni, T and Nohmi, T (1997) Construction of mutants of Salmonella typhimurium deficient in 8-hydroxyguanine DNA glycosylase and their sensitivities to oxidative mutagens and nitro ... 233-246 Yamada, M., Sedgwick, B., Sofuni, T and Nohni T (1995) Construction and characterization of mutants of Salmonella typhimurium deficient in DNA repair of O6-methylguanine, J Bacteriology, ... 2-Nitrofluoranthene, 1-nitropyrene and 1,8-dinitropyrene are tested without S9mix, Glu-P-1 and Trp-P-2 are tested with S9mix using TA98 and YG1041 2-Nitronaphthalene, 2,4-dinitrotoluen and 4-nitroquinoline...
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Tài liệu Báo cáo khoa học: 1. Signal Transduction 1.1 Integration of Metabolism and Survival pdf
... Division of Cellular and Molecular Biology, Department of Biology, University of Oslo, Oslo, Norway Androgens have critical roles in the development and maintenance of the male reproductive system and ... REV-ERBalpha governs the circadian expression of several enzymes and regulators of lipid metabolism Our genetic Rev-Erbalpha loss -of- function and gain -of- function studies suggest that circadian ... months) and its period is compensated for temperature and nutrtional changes Extensive studies of metabolism and micromolecular synthesis indicate that an oscillatory alternation between oxidative and...
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Tài liệu Báo cáo khoa học: Oral Presentations Integration of Metabolism and Survival pdf
... Swiss Institute of Bioinformatics, CMU, Geneva, Switzerland,2Department of Structural Biology and Bioinformatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland E-mail: andre.stutz@isb-sib.ch ... inhibition of c6 glioma cells in monolayer and spheroid cultures by the combination of carvedilol and imatinib M Erguven1, A Bilir2, S Tuna2 and N Akev1 Department of Biochemistry, Faculty of Pharmacy, ... Additional knowledge of the role of genes in IS may improve our understanding of the cause of IS, provide new insights in prevention and factors that influence the outcome of IS, as new therapeutic...
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Tài liệu Báo cáo khoa học: Abstract Integration of Metabolism and Survival PP-1 The metabolic switch in liver methionine metabolism pptx
... levels of Bcl-2 and Bax genes may be one of the mechanisms of acquired resistance in MCF-7 cells PP-16 Differential expression of isoforms of spleen tyrosine kinase in tissues: effects of the ... phosphorylation of JAK3, and STAT-3 and -5 The cells were stimulated with 10 U/ml of IL-2 and 100 lM of piceatannol for different periods of time IL-2 induced phosphorylation of JAK3, STAT3 and STAT5 in ... nitrite/nitrate and VEGF-A levels of lung cancer patients and control group were 93.7 ± 48.9 and 63.7 ± 32.2 lM (P = 0.018), and 620 ± 491 pg/ml and 255 ± 157 pg/ml (P = 0.001), respectively Cut-off value of...
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Báo cáo khoa học: Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii Implications for the disulfide metabolism of anaerobic hyperthermophiles doc
... Thermostability and thermoactivity of the CoADR phCoADR is stable for months at both )80 °C and )20 °C, and has half-lives of > 100 and 39 h at 85° and 95 °C, respectively Figure shows the dependence of the ... Addition of a second equivalent of NADPH to the EH2 form of phCoADR results in an increase in absorbance in the regions between 507 and 700 nm and 400 and 500 nm There is also an increase and FEBS ... above Thiols were quantified by comparison of peak areas to standard curves of those standards Coenzyme A was measured as the sum of the areas of the CoA and dephospho CoA peaks, as described previously...
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Báo cáo khoa học: Metabolism of N-methyl-amide by cytochrome P450s Formation and characterization of highly stable carbinol-amide intermediate pdf
... In order to gain insight into the P450 metabolism mechanism of N-Me-cyclo-peptides, the metabolism of a set of molecules composed of TTX (8a), iso-TTX (8b) and dihydrotentoxin (9) was studied in ... retention time and MS cleavage of Ala1-TTX; and (c) the relative amounts of M1 and M2 were different depending on the acidity of the HPLC eluent or on the time elapsed between incubation and analysis ... and characterization of stable carbinol-amide L Perrin et al Table Amounts of metabolites M1 and M2 recovered after 10 incubations of 100 lM tentoxin using lM of rat microsomal preparations and...
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Báo cáo khoa học: Increased glucose metabolism and ATP level in brain tissue of Huntington’s disease transgenic mice pdf
... values of all glycolytic enzymes, or of only HK, did not result in good fits for lactate and pyruvate An increase of the Vmax of GAPDH to that of the control sample without, or with, an increase of ... all metabolite levels related to GAPDH and aldolase and (b) the absence of the reduction of Km of GAP for GAPDH and aldolase should cause an elevation of all metabolite levels related to these ... HD In extracts of the posterior brain region of control and HD mice in the presence of excess ATP, NAD+, inorganic phosphate and glucose, we determined the total concentration of the triosephosphates...
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Báo cáo khoa học: Regulation of maize lysine metabolism and endosperm protein synthesis by opaque and floury mutations potx
... coordinator of the expression of storage protein, and nitrogen and carbon metabolism genes [30] Although there is now plenty of information available about o2, information related to lysine metabolism ... the percentage of lysine in true proteins by assuming the lysine content of nonzeins is independent of genotype and equal to g per 100 g of proteins, and based on the distribution of the endosperm ... between that of Oh43fl1, similar to that of the wild type, and that of Oh43o2 From these results it was possible to assess the importance of lysine-rich nonzeins with accuracy, because of the quantitation...
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Báo cáo lâm nghiệp: "Extraction and study of enzymes linked to malate metabolism in tree leaves" pdf
... separation of the two malic enzymes and to detect the presence of isoforms The purification study must continue to evaluate the elution buffer and the purification of samples from different periods of ... leaves of the first flush for oak leaves (May 1988) and on the needles of 1987 for spruce needles The enzymatic capacities increased markedly during the growing season (March) of spruce and during ... DEAE-Trisacryl column (25 x 1.6 cm) at a flow rate of ml/min Fifty fractions of ml were collected and tested for enzyme activities For oak leaves (Fig 2A) and spruce needles (Fig 2B), NADP-malic enzyme...
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Báo cáo y học: "Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureu" pot
... http://genomebiology.com/2011/12/3/R24 Page 10 of 18 Table Effects of IQ-143 on diverse enzymes of oxidative phosphorylation and energy and nucleotide metabolism of S aureus USA300 and S epidermidis RP62A Concentration of IQ-143 ... administration of IQ-143: the nicotinamide-adenine dinucleotides NAD+, NADH and NADP show substantial decreases of between 10 and 30% and between 30 and 50% dependent on the applied concentration of the ... substrates and IQ-143 at concentrations of μM, 10 μM, and 100 μM as described by Unger and Frank [34] As shown here (and in Figure S3), only very high doses of IQ-143 reduced the activity of the...
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Báo cáo y học: "he effects of chemotherapeutics on cellular metabolism and consequent immune recognition" doc
... Distribution and Level of Fas in L1210/0 and L1210/DDP Cells Distribution and Level of Fas in L1210/0 and L1210/DDP Cells Expression of cell-surface Fas, leftmost panels, and intracellular Fas, ... recognition and destruction of allogeneic tumor cells likely results from increased expression of MHC antigens on the tumor cell surface, processing and presentation of tumor antigens, and expression of ... to Fas/FasL and oncolytic agents has been reported by our group and others [1,8,10,22] While much of our work has involved Fas and FasL, other members of "death inducing" receptor-ligand pairs...
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Báo cáo y học: "Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection" potx
... design of the study and revised the manuscript LC conceived of the study and participated in its design and coordination, aided with statistics and revised the manuscript All authors read and approved ... Effect of TNF-α inhibition by etanercept on proteoglycan metabolism in the presence of conditioned serum In another series of three experiments comparing the effect of conditioned serum and unconditioned ... coupling of the captured antibodies to the microspheres and preparation of detection antibodies were performed as described previously [34,35] For determination of cytokine profiles in SF, aliquots of...
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Báo cáo y học: "Response to: Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection – authors’ reply" ppt
... The Netherlands Published: 17 December 2010 References Moser C: Response to: Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and ... DBF, Dhert WJA, Creemers LB: Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection ... Rutgers M, et al.: Response to: Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection...
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Báo cáo y học: "Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insig" ppt
... Sokoloff L, Wolfe F: Development of criteria for the classification and reporting of osteoarthritis Classification of osteoarthritis of the knee Diagnostic and Therapeutic Criteria Committee of ... telopeptide of type I collagen; SE, standard error of the mean; s, serum; u, urine knee pain irrespective of grade The presence of pain did not influence the ratio of sC2C/sCPII nor that of uCTXII/sCPII ... without knee pain consisted of 22 (female/male ratio: 13/9) with a K/L grade of and (female/male ratio: 7/1) with a K/L grade of (Table and 4) Eight (female/male ratio: 6/2) of the 16 patients Patients...
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Báo cáo y học: " Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway" pot
... of the tested candidate genes are associated with both allergy and vitamin D metabolites Statistical significance, however, was weak, and varied even with different analysis strategies and software ... quartile of outlier of 25-OH-D3 serum levels in 872 participants of the German Asthma Family Study with white skin colour Median,by monthandexamination Median, quartile and outlier of 25-OH-D3 serum ... assays of 25-OH-D3, 807 1,25- OH2-D3 and 903 total IgE Clinical details of the families are given in table Mean 25-OH-D3 level in children was 68 nmol/l (s.d 38 nmol/ l) 50% of values fell below and...
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Báo cáo khoa học: "Influence of insulin on glucose metabolism and energy expenditure in septic patients" ppsx
... steps and 1, and between step and baseline for each individual, and we tested the differences in these calculated values between the groups Results All patients and volunteers remained stable and ... yielded a wide range of values (50–200% of the estimated value, calculated on the basis of age, sex, height and weight) [33] In the present study the baseline EE of the volunteers and septic patients ... large volumes of fluids and/ or vasoactive drug treatment, and no change of body temperature (± 1°C) The main reasons for excluding a patient from the study were haemodynamic instability and changes...
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Báo cáo y học: "The terrestrial evolution of metabolism and life – by the numbers" doc
... capture and expenditure of chemical energy in the covalent bonds of biomass is the phenomenon of metabolism The expenditure of that energy powers changes in the size, organization, and activity of ... allometric scaling of metabolism if its essentials are known [5] As handled, Kleiber's Law also has no variable for the availability of energy, or for the efficiency of its capture and expenditure, ... battery W, and the sources of chemical energy available to it, measured against loss to heat ME is therefore a ratio of amperes of anabolism to amperes of catabolism The recharge rate of the organic...
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Báo cáo y học: "Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients" potx
... Barnett AH, Kumar S: Resistin and type diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated ... mellitus, and severity of disease using the APACHE II score [18] at admittance ICU treatment such as volume therapy, vasopressor infusions, demand of ventilation and ventilation hours, antibiotic and ... length of stay at the ICU was 8.5 days (range to 137 days) and medium length of stay in hospital was 27 days (range to 151 days) Identifying novel biomarkers for linking these states of acute and...
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