malignant and benign are commonly found in the cranial base
Báo cáo khoa học: Acute intermittent porphyria – impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein properties pdf
... blue and green, respectively; the positions of the mutated amino acids are indicated in red; and the position of the last amino acid before the frameshift is shown in black The interacting partners ... partners of the mutated residues are shown in yellow and the dipyrromethane (DPM) cofactor is shown in the ball and stick representation Magenta indicates the beginning and the end of the region ... (Fig 4B) The same pair is also found in the E coli enzyme Both residues are conserved in all sequences with no exception The interaction fixes the C-terminal domain to the interdomain hinge whose...
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Báo cáo y học: "Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort" pdf
... with UA, and controls The chi-square test was also used to compare the proportion of anti-CCP between RA patients and UA patients and, within the RA group, to compare the proportion of RF and anti-CCP ... on the early pathogenic role of B lymphocytes in RA and suggests that targeting these cells might be a useful therapeutic strategy in early RA Competing interests The authors declare that they ... IgG in 55% of the patients, and elevated levels of immunoglobulin FLCs in 22% (compared with 0% in healthy donors, according to previous studies [9,23]) During follow-up, it will be interesting...
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Báo cáo khoa học: " Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit"
... introduced the potential for bias in the results and is a limitation of the study Medical errors are among the leading causes of death in the United States In its highly publicised report, the Institute ... occurred during the CPOE prescribing period The patient outcome scores are given in Tables and Most of the errors were minor in outcome, although two non-intercepted errors with CPOE led to an increased ... amphotericin was intended The doses of these two products are not interchangeable and the high dose prescribed would have been nephrotoxic In the third case, vancomycin was prescribed g intravenously...
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A study on cultural obstacles to the teaching and learning of speaking skills in the classroom of grade 10 at nguyen tat thanh high school
... main intentions are being realized” (Martin Bygate, 1987) and then adjust their speech based on reaction from listeners The words are being spoken as they are being decided and as they are being ... of other factors involved in speaking 1.3 Cultural factors in the teaching and learning of speaking skills in classrooms 1.3.1 What cultural factors influence on the teaching and the learning ... behavior shared with others The concept include a group’s way of thinking, feeling, and acting, and fixed patterns for doing certain things According to Thompson (1990:132), the pattern meaning embodied...
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Tài liệu Material Usage and Condition of Existing Bridges in the U.S pptx
... perform the required inspections Each state then collects the inspection reports for all bridges in the state and submits them annually to the FHWA, where they are entered into the National Bridge Inventory ... creating and maintaining the NBI is to monitor the condition of bridges carrying public highways Therefore, for funding and reporting purposes, the FHWA considers only structures meeting the following ... using reinforced and/ or prestressed concrete superstructures In Hawaii, during the same period, the share is 100% In Maryland, only 11.3% of the bridge deck area was supported on reinforced and/ or...
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Tài liệu CONSUMER PREFERENCE AND CONSUMPTION OF ORGANIC PRODUCTS IN THE EASTERN CAPE PROVINCE OF SOUTH AFRICA docx
... marked increases in the future demand of all organic products This augurs well for the growth of the organic industry in the Eastern Cape and in South Africa in general The findings of this study are ... that there will be a marked increase in demand for fresh vegetables, fresh fruits meat and meat products and milk and milk products in the Transkei According to GROLINK (2006) the growth in the ... maintain its identity in the face of others, and therefore creates a feeling of "belonging" (Buruiana 2003) 17 10 Factors affecting the consumer awareness of organic products The results of the...
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Tài liệu Temi di discussione: Are there asymmetries in the response of bank interest rates to monetary shocks? pdf
... of the lending rate to a tight and an easy monetary policy is 14 basis points in the first period and basis points in the second In the case of deposits the difference is -12 basis points in the ... lending rates in the case of monetary tightening In the second period, the only asymmetry is detected in the response of the lending rate to a deviation in the long run relationship between the interest ... tB In this AVECM, the three cointegrating vectors are normalized on rates iD, iL and iB The constant terms µD and µL are the intermediation margins; µB is the mark-up between iB and iM; βD and...
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Tài liệu Báo cáo khoa học: Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle doc
... the SH2 domain binds to pYi on the C-terminal tail, and the Src homology (SH3) domain binds to the linker between the SH2 and kinase domains at the back of the small lobe, preventing the formation ... responses in (C) and the QSS curves (black and blue) are shown in the plane of si and s1 k1 = 0.03 s)1 For all plots shown in (A–D), the remaining parameters are given in the legend to Fig 2C states Interestingly, ... Arrows in (B) show the time point of step changes in [RPTP] The corresponding [RPTP] values, 117.5, 126.5 and 135.5 nM, are indicated by dashed lines 1–3 in (A) and shown by upper line in (B) The...
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Tài liệu Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model doc
... ‘diffuse’ into the myofibrils, is also evident in the Fabry mice (Fig 7A) The VT1 binding in the Fabry mouse lung (Fig 7C) was increased in the bronchiolar epithelium Staining of bronchiolar epithelial ... [11], and in the heart, possibly due to the association of Gb3 synthesis with the microvasculature GSL synthesis in man and mouse are distinct, particularly in the kidney, where Gb3 can be found in ... g, i–l) ·16 * ¼ central veins, p ¼ portal veins Inserts in (a) and (b) show Kupffer cell staining, and in (d) portal vein endothelial VT1 cell staining Most VT1 staining is lost after CsA treatment...
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Tài liệu Báo cáo khoa học: Changes in rat liver mitochondria with aging Lon protease-like activity and N e-carboxymethyllysine accumulation in the matrix doc
... a decrease in the amount of this protein in the matrix We have not detected any significant modification in the amount of this protein in the matrix We can conclude that the decrease in this enzymatic ... oxygen consumed per minute and per mg protein The rate of oxygen consumption in state and in state 4, respiratory control ratio (RCR) of oxygen consumptions in states and and the ADP/O ratio were ... with aging (Eur J Biochem 270) 2299 Western blotting of modified proteins Fig Determination of CML-protein content in liver mitochondrial matrix with aging The CML content in the matrix proteins...
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Tài liệu Báo cáo khoa học: Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain ppt
... involvement of ADH1 and ADH4 in ethanol oxidation in brain tissue Regarding retinoid metabolism in the adult brain, enzymes other than ADH4 must be active, because in vivo and in vitro data indicate ... expression of ADH3 in most of the analyzed areas in the brain, with highest expression levels in hippocampus, cerebellum and particularly in human brain, in the red nucleus Using the same methodology, ... expression was found in Purkinje cells and white matter of the cerebellum, and in hippocamus and cortex Both ADH classes were also shown to be present in the choroid plexus These data are in contradiction...
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Tài liệu Báo cáo khoa học: Moult cycle-related changes in biological activity of moult-inhibiting hormone (MIH) and crustacean hyperglycaemic hormone (CHH) in the crab, Carcinus maenas From target to transcript ppt
... of MIH and CHH in the sinus gland during the moult cycle As individual SG from single crabs always contained almost identical profiles and quantities of peptides (preliminary experiments using pairs ... that MIH and CHH transcription and translation are somewhat invariant during the moult cycle, certainly there are no overt differences in mRNA levels in the XO or stored peptide contents of the SG ... variations in binding kinetics, as YO membranes from C4 animals were always run in parallel, to compare other experiments, and similar increases in Bmax for CHH were not seen during postmoult The significance...
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Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf
... underlined and indicated above the sequence (") The two catalytic residues identified in the P fluorescens endogalactanase [11] are indicated above the alignment (^) and are in white against a ... and containing the galA gene and approximately 700 bp 3¢-flanking region, in pIM4700 (containing the pkiA promoter) A niger The sugar composition of the arabinogalactans from potato, onion and soy ... proteins The three arabinogalactans were incubated with GALA for 15 min, 30 min, h and 20 h to determine the substrate specificity of the enzyme The degradation of the polymer Ó FEBS 2002 and subsequent...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... Numbers in vertical framed arrows indicate the position of the introns The boxes indicate amino-acid substitutions skipping of three successive exons during the course of the processing of the primary ... components e and d seem to be in common with the A variant Therefore, band b represents the only component specific to the M variant The intensities of the bands in the MF pattern indicate that variant ... both the protein and genomic level The complete amino-acid sequence of the M variant has been determined Starting from genomic DNA, we amplified, by PCR, the coding regions (exons) and their intron...
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Tài liệu A Comparison of Conventional and Organic Milk Production Systems in the U.S. potx
... ownership costs include the annualized cost of maintaining the capital investment (economic depreciation and interest) in the dairy operation, and costs for non-real estate property taxes and insurance ... management, sourcing new and different inputs, and initiation of the certification process, among others, are required during transition For example, the pasture and cropland providing feed for organic ... operating and capital ownership costs ranged from $6.67 in the Northeast to $7.81 in the West The higher price premiums paid to Northeast producers in 2005 covered these added costs, but not in the...
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Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... W8 and E9 together and separately; G13, N18, M22 and D23 together and separately; and N29 and D30 together, replacing these residues by the corresponding ones in a We also mutated KES to QDR, and ... respectively In the present study, the catalytic domains are indicated by capital letters (A and B) and the C-terminal peptides by lower case letters (a and b), so that the wild-type enzymes are abbreviated ... mutations in the t peptides are indicated For each mutant, the cellular and secreted activities are shown by bars to the left and the right AChE and BChE activities were determined by the Ellman...
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Báo cáo khoa học: The signature amidase from Sulfolobus solfataricus belongs to the CX3C subgroup of enzymes cleaving both amides and nitriles Ser195 and Cys145 are predicted to be the active site nucleophiles pot
... than the SsAH-WT (Table 1) The behaviour of this mutant can be rationally explained on the basis of the homology model, as the increased occupancy deriving from the arginine side chain in position ... thiomidate and acyl-enzyme intermediates, and tetrahedral ( 109.5°) water-bonded intermediate In contrast, serine and thiol protease and amidase are confined to interacting with planar substrates and ... plasmids carrying the mutant genes, in order to screen for nitrile, amide and ester hydrolysis Each colony was grown in a 50-mL flask containing 20 mL LB medium containing 50 lgÆmL)1 ampicillin and 34...
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Báo cáo khoa học: Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell receptor f chain by the protein tyrosine kinase Lck potx
... of the six ITAM tyrosines in TCRf and simulated trypsin digest of His-cTCRf The ITAM tyrosines have been named according to the ITAM they are in and their position within each ITAM (towards the ... electrostatic interactions in SH2 domain recognition: salt dependence of tyrosyl-phosphorylated peptide binding to the tandem SH2 domain of the Syk kinase and the single SH2 domain of the Src kinase ... tyrosine 1N to be the first phosphorylated Differences arising in the order of phosphorylation of the subsequent tyrosines in the whole cTCRf chain in vitro, relative to the single-tyrosine-containing...
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Báo cáo khoa học: "COMMON TOPICS AND COHERENT SITUATIONS: INTERPRETING ELLIPSIS IN THE CONTEXT OF DISCOURSE INFERENCE" ppt
... elliptical and event referential forms as to whether they leave behind an empty constituent in the syntax and whether they are anaphoric in the semantics Empty constituents in the syntax are not in themselves ... constituent in the syntax, and (2) whether the form is anaphoric in the semantics In subsequent sections, we show how the distinct mechanisms for recovering these types of missing information interact ... way of their corresponding node(s) in the syntax; the operations performed on these representations are dictated by the nature of the constraints imposed The two types of inference are distinguished...
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Báo cáo khoa học: Mutagenesis of hydrogenase accessory genes of Synechocystis sp. PCC 6803 Additional homologues of hypA and hypB are not active in hydrogenase maturation ppt
... recombination and an inserted Gmr cassette pGEM-T vector with the hypD gene and an inserted Spr cassette in the Eco91I site pGEM-T vector with the hypE gene and an inserted Kmr cassette in the ... vector inserted in the SalI ⁄ NdeI site pDH1 vector containing SalI ⁄ NdeI hypC gene of the phypC vector inserted in the SalI ⁄ NdeI site pDH1 vector containing SalI ⁄ NdeI hypD gene of the phypD ... vector inserted in the SalI ⁄ NdeI site pDH1 vector containing SalI ⁄ NdeI hypE gene of the phypE vector inserted in the SalI ⁄ NdeI site pDH1 vector containing SalI ⁄ NdeI hypF gene of the phypF...
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