liver tumor initiating cells cancer stem cells past studies current status and future perspectives
Báo cáo y học: "Chemotherapy in advanced bladder cancer: current status and future" pdf
... Increased signaling through VEGFR and FGFR characterizes many TCC tumors and increased tumor vascularization Angiogenesis is a very important step to tumor growth, invasion and metastasis Therefore, ... muscle invasive bladder cancer? Oncol Rev 2011 doi:10.1186/1756-8722-4-35 Cite this article as: Ismaili et al.: Chemotherapy in advanced bladder cancer: current status and future Journal of Hematology ... A comparison of cisplatin and the combination of cisplatin and cyclophosphamide in advanced urothelial cancer A National Bladder Cancer Collaborative Group A Study Cancer 1983, 52(5):767-72 Harke...
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báo cáo khoa học: " MicroRNAs involved in neoplastic transformation of liver cancer stem cells" pot
... demonstrating the existence of SP cells in both fetal liver cells and in primary rodent HCC cancer cells induced by chemical carcinogens Since the HCC cancer cells and fetal liver cells used in our study ... phenotype of liver cancer stem cells, as distinguished from normal hepatic stem cells and from oncogene and tumor suppressor gene mutations The gene and protein networks directly targeted and affected ... that many cancers may harbor a small population of cancer stem cells (CSCs) These cells not only exhibit stem cell characteristics, but also, importantly, are tumor- initiating cells and are responsible...
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báo cáo hóa học:" Ovarian cancer: emerging concept on cancer stem cells" docx
... normal stem cells and cancer stem cells, there are mechanistic differences in some cancers Interestingly, the mechanistic differences in selfrenewal between normal stem cells and cancer stem cells ... multi-potential stem cells, tissue-specific stem cells, progenitor cells, mature cells, and cancer cells described the direct isolation of populations containing cancer stem cells in various ... cancer stem cells Self-renewal and differentiation potentials are the features of stem cells Origin of cancer stem cells Self-renewal and differentiation potentials are the features of stem cells...
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báo cáo hóa học:" MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells" ppt
... CD44, CD24, ESA and ALDH1 in different cancers [1] Few of these markers were used for the confirmation of an MUC4 enriched cancer stem cell population Stem cells and cancer stem cells are known ... and the cancer stem cell population in MUC4 overexpressed ovarian cancer cells Further, we have analyzed cancer stem cell and self-renewal specific markers in the isolated populations These studies ... overexpressed ovarian cancer cells induce the aggressiveness of the cancer cells and enrich the cancer stem cell population It also showed that MUC4 is expressed in the ovarian cancer stem cell population...
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Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps
... overexpression P63+ basal /stem cells were transformed into AR+ or ARcancer cells but rarely into ChgA+ neuroendocrine cancer cells Conventional human prostate cancer cells include malignant cells of luminal, ... signalling may promote primary prostatic cancer stem cells [20] However, the tumorigenic activation of basal/ stem cells and their progression toward a metastatic status under the influence of Hh signalling ... P63 + cancer cells in the metastatic loci and generation of prostate-like glandular structures Our data support the prostate cancer stem cell characteristics observed in previous studies and, ...
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Báo cáo y học: "Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study" pptx
... AK1C3 [19] and CD44 [20] have been proposed to be the markers of cancer stem cells Their expression in tumor cells could correlate with their aggressive biological behavior, drug resistance and poor ... SCLC comparisons and thus specific to LCNEC Interestingly, AK1C1, AK1C3, AL1A1, and CD44 have been reported to be biomarkers of cancer stem cells (see Discussion) In Table BASP and SEGN are significantly ... expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells Mol Cancer 2007, 6:75 19 Pfeiffer MJ, Smit FP, Sedelaar JP, Schalken JA: Steroidogenic enzymes and stem cell markers...
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báo cáo khoa học: " Microarray-based analysis of microRNA expression in breast cancer stem cells" doc
... right, tumors developed from × 105 and × 106 MCF-7 cells and from × 103 and × 104 BCSCs 24-well plates on top of irradiated NIH/3T3 feeder cells At day 3, the number of adherent cells increased, and ... extensive roles and is expressed in embryonic stem cells [29], neuronal cells [30] and several tumor tissues [31,32] Previous studies have demonstrated that as an oncogene, miR-21 targets the tumor suppressor ... human embryonic stem cells and other stem cells, indicating that these miRNAs may play a constitutive role in maintaining the biological characteristics of stem cells [40,41] Future work should...
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báo cáo khoa học: "Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/b-catenin pathway" potx
... tumorigenic, stem- like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic Cancer Res 2005, 65:6207-6219 Wang J, Guo LP, Chen LZ, Zeng YX, Lu SH: Identification of cancer stem ... of 6, and of inoculations of the same number of the non-SP cells grew tumors, and of 6, and of inoculations of the same number of MCF-7 cells grew tumors The tumors derived from non-SP cells ... selfrenewal of SP cells, and the DDP only inhibits non-SP cells (differentiated cells) leading to the survival of cancerstem like cells (SP cells) [28], which is also consistent with other studies related...
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Báo cáo y học: "Tumor-infiltrating effector cells of α-galactosylceramide-induced antitumor immunity in metastatic liver tumor" pdf
... of liver metastatic models of colon cancer cells Balb/C mice were inoculated with tumor cells to determine the optimal conditions for mimicking liver metastasis of colorectal cancer in humans Liver ... of tumor- infiltrating cells (I) Flow cytometry analysis of tumor- infiltrating cells (I) Leukocytes were isolated from liver parenchyma or metastatic liver tumors as described in the Materials and ... secretion by tumor- infiltrating cells IFN-γ secretion by tumor- infiltrating cells TILs purified from α-GalCer-treated and Vehicle-treated mice were cultured with × 104 target cells for 24 h and supernatants...
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cancer stem cells theories and practice_part1 pps
... Stem Cells to Overcome Drug Resistance 401 Miaorong She and Xilin Chen Chapter 21 Cancer Stem Cells and Chemoresistance Suebwong Chuthapisith Chapter 22 Cancer Stem Cells in Drug Resistance and ... with CD44+ tumor cells have the worse outcome, and for glioblastoma (brain cancer) and colon cancer patients, CD133+ cells are the culprit, although not all CD133+ cells are tumor cells and some ... Cruz and Isidro Sanchez-Garcia Part Stem Cells in Specific Tumors 61 Chapter Breast Cancer Stem Cells 63 Marco A Velasco-Velázquez, Xuanmao Jiao and Richard G Pestell Chapter Glioma Stem Cells: ...
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cancer stem cells theories and practice_part2 pdf
... normal stem cells to cancer stem cells Adult normal stem cells represent one purported origin of cancer stem cells What causes the transformation from normal stem cells to cancer stem cells? ... Visvader, J.; Weissman, I.L & Wahl, G.M (2006) Cancer stem cells perspectives on current status and future directions: AACR Workshop on cancer stem cells Cancer Research, Vol.66, No.19, (October 2006), ... www.adultpdf.com 64 Cancer Stem Cells Theories and Practice studies suggest that the ability of a tumor to proliferate and propagate relies on a small population of stem- like cells, called cancer stem cells...
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cancer stem cells theories and practice_part3 pot
... [62] Murine and human hematopoietic stem cells [63-64], murine neural stem cells [65], normal and malignant human mammary stem cells [66], and normal and malignant human colorectal stem cells [62,67] ... factors For instance, Wnt ligands are produced and released from both stem cells and niche cells, BMP and Shh are released from niche cells and epithelial cells respectively, and Notch signaling is ... www.adultpdf.com 80 Cancer Stem Cells Theories and Practice Discovery of neural and glioma stem cells The discovery of adult neural stem cells paved the way for the glioma stem cell field Until...
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cancer stem cells theories and practice_part4 ppsx
... www.adultpdf.com Cancer Stem Cells in Lung Cancer: Distinct Differences between Small Cell and Non-Small Cell Lung Carcinomas 133 [90] Li, L., Neaves, W.B (2006) Normal stem cells and cancer stem cells: ... chemiluminescence system (ECL, Amersham) This is trial version www.adultpdf.com 124 Cancer Stem Cells Theories and Practice This is trial version www.adultpdf.com Cancer Stem Cells in Lung Cancer: Distinct ... 126 Cancer Stem Cells Theories and Practice Table Cancer stem cell markers in small cell lung carcinoma amd non-small cell lung carcinoma This is trial version www.adultpdf.com Cancer Stem Cells...
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cancer stem cells theories and practice_part9 docx
... review this issue with depth Stem cells and cancer stem cell theory Stem Cells In order to understand cancer stem cells a brief description of normal adult stem cells and the environment in which ... metastasis, and immunosurveillance avoidance in tumors This is trial version www.adultpdf.com Cancer Stem Cells as a New Opportunity for Therapeutic Intervention 381 Cancer Stem Cells Cancer Stem Cells ... trastuzumab-resistant tumour -initiating breast cancer stem cells Breast Cancer Res Treat, in press This is trial version www.adultpdf.com 378 Cancer Stem Cells Theories and Practice Vazquez-Martin, A., Oliveras-Ferraros,...
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Báo cáo y học: "Liposarcoma cells with aldefluor and CD133 activity have a cancer stem cell potential" pot
... marker for human hematopoietic stem and progenitor cells Blood 1997, 90:5002-5012 22 Wu Y, Wu PY: CD133 as a marker for cancer stem cells: progresses and concerns Stem Cells Dev 2009, 18:1127-1134 ... cancer stem and progenitor cells Stem Cells Dev 2009, 18:17-25 Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, et al: ALDH1 is a marker of normal and malignant human mammary stem ... colon -cancer -initiating cells Nature 2007, 445:111-115 27 Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, et al: Distinct populations of cancer stem cells determine tumor growth and metastatic...
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Báo cáo y học: "Population genetics of cancer cell clones: possible implications of cancer stem cells" pptx
... MF, Weisman IL: Stem cells, cancer and cancer stem cells Nature 2001, 414:105-111 15 Shipitsin M, Polyak K: The cancer stem cell hypothesis: in search of definitions, markers, and relevance Lab ... Vormoor J: Understanding the cancer stem cell Br J Cancer 2010, 103:439-445 11 Lindeman GJ, Visrader JE: Insights into the cell of origin in breast cancer and breast cancer stem cells Asia Pac J ... of stem cells is calculated by assuming one stem cell per 57 000 non -stem cells [28] A greater proportion of stem cells would result in a less dramatic difference Naugler Theoretical Biology and...
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Báo cáo y học: " Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions" pps
... of tumor cells [3] that are defined by the expression of CD34+CD38- surface antigens and have been termed leukemic stem cells Similar tumor- initiating cells have also been found in 'solid' cancers, ... primitive cancer cells PTL induces apoptosis in primitive cancer cells Percent viability of prostate cancer cells and cells from a patient with BPH treated with increasing concentrations of PTL Cells ... signature Stem cells Stem cells (c) Committed basal Committed basal Stem Committed cells basal (d) Malignancy signature Tumour Birnie et al R83.3 Gleason included Benign Figure Distinctive stem cell and...
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