... that the variants undergo very fast optical (and thus structural)changes within the dead time ofthe stopped-flowapparatus. In the case ofthe K13N mutant, this hypo-thesis finds support from the ... Thus, the binding of sulfate to the acid-dena-tured protein promotes the route towards the nativeconformation. (b) The mutated residues K13, K88,and T89, all located in segments ofthe polypeptidecontaining ... expressionsystemA version ofthe horse cytochrome c synthetic gene wasdesigned on the basis ofthe sequence of a previously repor-ted cytochrome c synthetic gene [35], and its synthesis wasaccomplished...
... 17 ofthe Act concerning the conditions of Accession ofthe Czech Republic, the Republic of Estonia, the Republic of Cyprus, the Republic of Latvia, the Republic of Lithuania, the Republic of ... established, the President, the Vice-President and the other members of the Executive Board shall be appointed by common accord ofthe governments ofthe Member States at the level of Heads of State ... III(4) ofthe Treaty of Amsterdam. 1345.2. The General Council shall comprise the President and Vice-President ofthe ECB and the Governors ofthe nationalcentral banks. The other members of the...
... irrespective ofthe amount ofthe loan. However, the larger the loan, the larger the amount ofthe repayment installment, and a large installment may strain the repayment capacity ofthe borrower ... b) There has, therefore, to be a linkage between the amount ofthe loan and the tenure ofthe loan. It is, therefore, suggested that for loans not exceeding Rs. 15,000, the tenure ofthe loan ... and the cost of funds to the MFI. While this, too, suffers from the drawbacks of an interest cap, it is fairer to the MFI since it is not exposed to the risk of volatility of cost of funds....
... high: the number of consultations per capita is higher in Japanthan in any other OECD country [9], and the rates of hospital utilization are high as well. These trends havemade the shortage of ... predictinglong-term trends in the supply of and demand for medi-cal practitioners in the debate over the medical studentquota.Our hypothesis is that the proposed additionalincrease in the medical student ... a serious doctor surplus in the future, especially because the population of Japan is decreasing. The purpose of this research is to project the future growth ofthe Japanese medical doctor workforce...
... and 42 (8%) of unknown gender.It was the mother who answered the questionnaire in89.5% ofthe sample, it was the father in 4.57% of the sample, and it was someone else in 6.28% ofthe sample.Distribution ... 254 parent s of chil-dren aged 2-18 years. It was the mother who answered the questionnaire in 92.52% ofthe sample, and it was the father in 7.48% ofthe sample. No parent in the patientgroup ... properties of the Hungarian version ofthe PedsQL™ 4.0 Generic CoreScale and the PedsQL™ 3.0 Cardiac Module. The findings generally support the feasibility, reliabilityand validity ofthe Hungarian...
... Magnitudes in the correlations of all DQOL domains with the physical relevant domains of the D-39S (diabetes control and energy/mobility) wereslightly larger than with other domains ofthe D-39S(social ... discriminant validity of the DQOL against the D-39S and the RAND-12. In general,domain scores ofthe DQOL were moderately correlatedwith the D-39S (except sexual functioning) and the RAND-12 PHC ... correlation coeffi-cients ofthe satisfaction domain ofthe DQOL with diabe-tes control and energy/mobility ofthe D-39S were all0.57, which were larger than with the other D-39 domains(0.30...
... toxicity of chemotherapy or the isolation to which the individual is subjected [9,15]. The analysis ofthe correlation between the scores the chil-dren/adolescents obtained and those obtained by the guardians ... hospitals ofthe city. A total of 190 families of Bra-zilian children between the ages of 2 and 18 years, of bothgenders, with malignant neoplasm in various phases of treatment or control ofthe ... self-administered mode of administration needs further investigation. Finally,there was no report by the patients or guardians of anylack of comprehension regarding the questions. The lack of validation...
... Comparisons to the mean scores of the other subscales within the present study to those of the previous PedsQL™ school study [3], the mean scoreson the social functioning scale of both healthy childrenand ... parent proxy-report ofthe Korean version of PedsQL™4.0 Generic Core Scales for school population healthresearch in Korea. However, the utilization ofthe Koreanversion ofthe PedsQL™ 4.0 Generic ... study aimed to assess the psychometric properties ofthe Korean translation ofthe PedsQL™ 4.0 Generic Core Scales.Methods: Following the guidelines for linguistic validation, the original US English...
... well as the proportions of respondentsreporting impairment in the 5 EQ domains. The magni-tude and significance ofthe ORs for the EQ-5D domains,as well as the sign and significance ofthe regression ... applicability. The primary goal of our study was to assess the applicabil-ity, internal consistency, and construct validity ofthe Ital-ian version ofthe EQ-5D in a random sample of the citizens of Bologna ... set-tings, it lacks of empirical evaluations in Italy. The lack of information on the construct validity and reliability of the instrument as well as the absence of utilities estimated in the Italian...
... demonstrate the feasibility of the Japanese version ofthe PedsQL 3.0 Cancer Module.Discussion The present study demonstrated t he reliability, validity,and feasibility ofthe Japanese version ofthe ... validation ofthe Japanese ver-sion has not been conducted. The aim of this study was to demonstrate the reliabil-ity, validity, and feasibility ofthe Japanese version of the PedsQL 3.0 Cancer ... low in the validation study ofthe Chi-nese version [17]. The German and the Brazil ian ver-sions ofthe PedsQL Cancer Module did not report the analysis for separate age groups. However, the...
... target, further confirmed the role of LHBs in the HBV attachment [23]. Recently, the attachment site of LHBs was functionally narrowed down to the amino acids 21–47 of preS1 by employing synthetic ... translocation ofthe internally sequence of PreS1 domain onto the viral surface [62, 63]. This supports the hypothesis that the low pH in the endosome may induce the conformation change of HBV surface ... a result ofthe variation of loading, because the expression ofthe thimet oligopeptidase gene in the same condition did not show any difference (Figure 2C). The over-expression ofthe SPIK...