ldl see low density lipoprotein cholesterol
Tài liệu Báo cáo khoa học: Affinity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx
... the low density lipoprotein (LDL) receptor pathway A lattice model for LDL binding J Biol Chem 266, 19296– 19302 Hwang J & Menon KM (1983) Characterization of low density and high density lipoprotein ... of [125I]TC-PCSK9 (see below) TLDLR possesses distinct binding domains for apoB-100 (the main apolipoprotein in LDL) and PCSK9 In agreement with previous studies showing that LDL can inhibit the ... levels of plasma LDL cholesterol, whereas loss-of-function mutations are associated with low levels of plasma LDL cholesterol [1,8–12] Further data supporting the importance of PCSK9 in cholesterol...
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Tài liệu Báo cáo khoa học: Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages docx
... values compared to the native LDL (P > 0.05) Total cholesterol Native LDL LDL plus EDTA Methylglyoxal -LDL Glycolaldehyde -LDL Glucose -LDL Glucose -LDL + Cu2+ Free cholesterol Cholesteryl ester ... from cholesterol and cholesteryl ester accumulation by macrophage cells present in the artery wall [3] Lowdensity lipoproteins (LDLs) are the likely source of this lipid, with unregulated LDL ... using LDL- free medium following exposure of HMDMs to labeled glycolaldehyde- and methylglyoxal-modified LDL, and control LDL, for 96 h The use of LDL- free medium during the chase period allows...
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Báo cáo khoa học: Protective effect of dietary curcumin and capsaicin on induced oxidation of low-density lipoprotein, iron-induced hepatotoxicity and carrageenan-induced inflammation in experimental rats ppt
... Inhibition of oxidation of human low- density lipoprotein by phenolic substances in red wine Lancet 341, 544–547 Miyagi Y, Miwa K & Inoue H (1997) Inhibition of lowdensity lipoprotein oxidation by flavonoids ... 57 of low- density lipoprotein Am J Clin Nutr 53, 314S– 321S Jialal I & Grundy SM (1992) Effect of dietary supplementation with alpha-tocopherol on the oxidative modification of low- density lipoprotein ... A relatively large amount of cholesterol in LDL fraction is atherogenic, whereas that in the high -density lipoprotein fraction appears protective [3] Oxidation of LDL has been suggested to play...
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Báo cáo khoa học: Protective effects of endomorphins, endogenous opioid peptides in the brain, on human low density lipoprotein oxidation pdf
... lipid peroxidation and antioxidants in oxidative modification of LDL Free Radic Biol Med 13, 341–390 Steinberg D (1997) Low density lipoprotein oxidation and its pathological significance J Biol ... acid-induced protein damage FEBS Lett 532, 80–84 49 Noguchi N & Niki E (1994) Apolipoprotein B protein oxidation in low- density lipoproteins Methods Enzymol 233, 490–494 FEBS Journal 273 (2006) 1275–1284 ... activity follows the sequence EM1 > GSH > EM2 in conjugated diene formation Moreover, TBARS formation is also used to detect lipid peroxidation products in LDL oxidation It is clearly seen by comparison...
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Báo cáo khoa học: Anti- and pro-oxidant effects of quercetin in copper-induced low density lipoprotein oxidation Quercetin as an effective antioxidant against pro-oxidant effects of urate potx
... Flavonoids and urate in copper-induced low- density lipoprotein oxidation (Eur J Biochem 271) 1999 pro-oxidant effects of urate in copper-induced low- density lipoprotein oxidation Eur J Biochem 269, ... low- density lipoprotein Free Rad Res 30, 1–9 Berliner, J.A., Territo, M.C., Sevanian, A., Ramin, S., Kim, J.A., Bamshad, B., Esterson, M & Fogelman, A.M (1990) Minimally modified low density lipoproteins ... by isolated human low density lipoprotein undergoing oxidation Free Radic Biol Med 25, 519–528 Lynch, S.M & Frei, B (1995) Reduction of copper not iron, by human low density lipoprotein J Biol...
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Báo cáo Y học: Structural and compositional changes in very low density lipoprotein triacylglycerols during basal lipolysis potx
... lipoprotein particles displacing especially apolipoprotein A-I [28] Apolipoprotein B or lipids were not displaced from low density lipoprotein (LDL) particles indicating that neither should there ... of rat hepatic very low density lipoproteins in the endoplasmic reticulum J Biol Chem 268, 3555–3562 Goldberg, I.J (1996) Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism ... U.J.F., Tsukamoto, K., Glick, J.M & Rader, D.J (2000) Hepatic apolipoprotein E expression promotes very low density lipoprotein- apolipoprotein B production in vivo in mice J Lipid Res 41, 1673–1679...
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Báo cáo khoa học: Binding areas of urokinase-type plasminogen activator– plasminogen activator inhibitor-1 complex for endocytosis receptors of the low-density lipoprotein receptor family, determined by site-directed mutagenesis doc
... to the endocytosis receptors alpha2-macroglobulin receptor low- density lipoprotein receptor-related protein and very -low- density lipoprotein receptor involves basic residues in the inhibitor ... Specicity of serine proteinase serpin complex binding to very -low- density lipoprotein receptor and alpha2macroglobulin receptor low- density- lipoprotein- receptor-related protein Eur J Biochem 248, ... 10 Li Y, Knisely JM, Lu W, McCormick LM, Wang J, Henkin J, Schwartz AL & Bu G (2002) Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell...
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Báo cáo Y học: Anti- and pro-oxidant effects of urate in copper-induced low-density lipoprotein oxidation pdf
... trigger for low density lipoprotein oxidation Biochim Biophys Acta 1347, 191198 39 Rice-Evans, C., Leake, D., Bruckdorfer, R & Diplock, A.T (1996) Practical approaches to low density lipoprotein ... by isolated human low density lipoprotein undergoing oxidation Free Radic Biol Med 25, 519528 47 Lynch, S.M & Frei, B (1995) Reduction of copper not iron, by human low density lipoprotein J Biol ... native LDL (see below) Finally Bagnati et al [23] reported that 10 lM urate introduced in the LDL solutions 30 after Cu2+ clearly stimulated the peroxidation only for Cu2+ to LDL ratios lower than...
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Báo cáo y học: "Autoantibodies to low-density-lipoprotein-receptor-related protein 2 (LRP2) in systemic autoimmune diseases" pps
... CD69-homologous amino acid sequence and one of the LDLR domains, which were thought to bind various ligands such as apolipoprotein Eβ very -low- density lipoproteins, lactoferrin, and aprotinin [17] ... with low density lipoprotein receptor-related protein in systemic autoimmune diseases J Immunol 2001, 166:1360-1369 Hussain MM: Structural, biochemical and signaling properties of the low- density ... expressed as a maltose-binding protein (MBP) fusion protein EGF, epidermal growth factor; LDL, low- density lipoprotein without anti-LRP2 autoAbs P values of less than 0.05 were considered to be...
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Báo cáo y học: " Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low-density lipoprotein and exhibit decreased activity of the lipoprotein-associated phospholipase A2" pot
... high -density lipoprotein- cholesterol and autoantibody titers against oxidized low- density lipoprotein Correlation lipoprotein- cholesterol and autoantibody titers against oxidized low- density lipoprotein ... levels of high -density lipoprotein (HDL) -cholesterol and autoantibody titers against (a) oxidized low- density lipoprotein in the propagation phase (oxLDLP) and (b) oxidized low- density lipoprotein ... oxidized low- density lipoprotein Three types of mildly oxLDL were prepared and used as antigens: oxLDLL at the end of the lag phase, oxLDLP at the end of the propagation phase and oxLDLD at the...
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Báo cáo y học: "Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces leukocyte adhesion within the intestinal microcirculation in experimental endotoxemia in rats" potx
... oxidized low- density lipoprotein receptor-1 Proc Natl Acad Sci USA 2000, 97:360-364 Oka K, Sawamura T, Kikuta K, Itokawa S, Kume N, Kita T, Masaki T: Lectinlike oxidized low- density lipoprotein ... functional capillary density; FITC: fluorescein isothiocyanate; HR: heart rate; IgG: immunoglobulin G; IL: interleukin; IVM: intravital fluorescence microscopy; LDL: low- density lipoprotein; LOX-1: ... LOX-1 The exposure of LDL to oxidative stress generates OxLDL The expression of the OxLDL receptor LOX-1 is upregulated by the increased occurrence of OxLDL Interestingly, the OxLDL-induced upregulation...
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Functional role of low density lipoprotein receptor related protein 5 and 6 in alzheimers disease
... immunoprecipitation LCM control L-cell conditioned medium LDL low density lipoprotein LOAD late-onset Alzheimer's disease LRP low density lipoprotein receptor-related protein L-Wnt-3a cells L-cells ... dynamics in AD 13 1.4 ApoE receptors 14 1.4.1 Low density lipoprotein receptor family 14 1.4.2 Low density lipoprotein- related protein and 16 1.4.3 Dysregulated Wnt ... through its receptors 14 ApoE receptors include the core members from LDL receptor family such as low density lipoprotein (LDL) receptor-related protein (LRP) 1, apoE receptor (apoER2) as well...
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Pathways driven sparse regression identifies pathways and genes associated with high density lipoprotein cholesterol in two asian cohorts
... high -density lipoprotein cholesterol (HDLC) levels in two separate cohorts of Asian adults HDLC refers to the cholesterol carried by small lipoprotein molecules, so called high density lipoproteins ... simulations, and apply it to a study searching for pathways and genes associated with high -density lipoprotein cholesterol in two separate East Asian cohorts we describe a sparse regression method ... pathways used in our application study looking at pathways and genes associated with high -density lipoprotein cholesterol levels in two Asian GWAS cohorts where l (lw0) and a(0ƒaƒ1) are parameters...
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Cellular gene expression profiles of human macrophages exposed to chlamydia pneumoniae and treated with low density lipoprotein
... sphere The major types of lipoproteins includes chylomicrons, very low density lipoproteins (VLDL), low density lipoproteins (LDL) , lipoprotein Lp(a) and high density lipoproteins (HDL) Chylomicrons ... Chlamydia pneumoniae, and low density lipoprotein Introduction The second model consists of human macrophage U937 cell line and low density lipoprotein, after addition of low density lipoprotein The model ... oxidation (Kuo C.C., et al 1993.) Following an elevation in plasma low density lipoprotein (LDL) cholesterol levels will result in the penetration of low density lipoprotein into the arterial wall...
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Báo cáo khoa học: Plasmodium falciparum merozoite surface protein 1 Glycosylation and localization to low-density, detergent-resistant membranes in the parasitized erythrocyte pdf
... the environment of ordered lipids [29] and accumulate in the low density, detergent-resistant membranes recovered after equilibrium density centrifugation of Triton X-100 lysates of mammalian ... vesicles with the target cell membrane [39] The low Mr C-terminal MSP-1 fragments, like the endogenous GPI-linked CD59, are selectively enriched in low density, detergent-resistant membranes of the ... However, following SDS/ PAGE separation of MSP-1 fragments, the labelled GPI anchors appear dissociated from the 19-kDa fragment carrying the C-terminal epitope (compare Figs and 3) The lower Mr...
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Introducing Low-Density Parity-Check Codes doc
... 3.7: The evolution of probability density functions with iteration number in density evolution See Example 3.5 z = f (x, y) the density of z can be found as follows: f (z)dz = f (x, y)dxdy ∆Dz ... very well with a much reduced complexity Introducing Low- Density Parity-Check Codes, Sarah Johnson ACoRN Spring School version 1.1 1.3 Low- density parity-check (LDPC) codes As their name suggests, ... Topic 1: Low- Density Parity-Check Codes 1.1 Introduction Low- density parity-check (LDPC) codes are forward error-correction codes,...
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Báo cáo Y học: Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins doc
... Northoff, H (1993) Prevention of endotoxin-induced monokine release by human low- and high -density lipoproteins and by apolipoprotein A-I Infect Immun 61, 5140–5146 Yu B., Hailman, E & Wright, S.D ... recombinant form) compensates the phosphate charges to an only very low degree, the zeta potential remains lower than )40 mV, which seems to be connected with the observation that albumin does not ... Distribution and kinetics of lipoproteinbound endotoxin Infect Immun 69, 2821–2828 Casas, A.T., Hubsch, A.P., Rogers, B.C & Doran, J.E (1995) Reconstituted high -density lipoprotein reduces LPS-stimulated...
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Báo cáo khoa học: Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes Formation of modified and oxidized particles pot
... of LDL )1 LDL (density 1.019–1.063 gÆmL ) was prepared from plasma of fasted, healthy volunteers by density gradient ultracentrifugation as described previously [21] After isolation, LDL was dialysed ... bars, mg LDL proteinÆmL)1 with 100 mM GA; horizontal striped bars, mg LDL proteinÆmL)1 with 10 mM GA; dark stippled bars, mg LDL proteinÆmL)1 with mM GA; light stippled bars, 0.4 mg LDL proteinÆmL)1 ... analogous LDL incubations Native LDL and AcLDL were also examined but these data are not shown for reasons of clarity; the values obtained for these materials were within the expected range (see above)...
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báo cáo hóa học:" Low-density nanoporous iron foams synthesized by sol-gel autocombustion" pot
... loose and very low in density Conclusion A convenient sol-gel autocombustion method was employed in the synthesis of iron foams Moreover, the iron foams are characterized by very low density and ... 4a,b, it can be seen clearly that the volume of the synthesized sample expanded about ten times larger than that of the corresponding gel This volume expansion reveals the very low density and porous ... Porous nanostructured materials possess many good properties including high surface area, ultralow density, and high strength-to-weight ratio So they are attractive materials for use in a number...
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Báo cáo y học: "Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis" ppsx
... Metrology Index; HDL-C, high -density lipoprotein cholesterol; IMT, intima-media thickness; LDL- C, low- density lipoprotein cholesterol; OR, odds ratio; oxLDL, oxidized low- density lipoprotein; piHDL, proinflammatory ... apoB-rich low- density lipoproteins (LDLs) and very -low- density lipoproteins (VLDLs) by the actions of cholesterol ester transfer protein (CETP) Conversely, phospholipids are transferred from LDLs/VLDLs ... [5-7] The following lipids are rich in apoB: low- density lipoproteins (LDLs), very -low- density lipoproteins (VLDLs) (which are also rich in triglycerides), and intermediate -density lipoproteins...
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