largeregions exploring the roles of nesting and subsidiarity
Tài liệu Gravitational Physics: Exploring the Structure of Space and Time pdf
... system the precession of the orbit of Mercury and the bending of light by the Sun Over the ensuing decades theoretical analyses deepened the understanding of the theory and exhibited the richness and ... of matter • The development of string theory and the quantum theory of geometry as promising candidates for the union of quantum mechanics and general relativity • The first descriptions of the ... from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine The members of the committee responsible for the report were chosen for their...
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Gravitational Physics Exploring the Structure of Space and Time docx
... system the precession of the orbit of Mercury and the bending of light by the Sun Over the ensuing decades theoretical analyses deepened the understanding of the theory and exhibited the richness and ... of matter • The development of string theory and the quantum theory of geometry as promising candidates for the union of quantum mechanics and general relativity • The first descriptions of the ... from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine The members of the committee responsible for the report were chosen for their...
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Báo cáo y học: "Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes." potx
... important to note that the fate and the final number of copies of each bystander gene can be, and often is, different from that of the target gene, and that the fates of different bystander genes in ... for one part of the HCNE array to break off from one copy of the GRB, as long as the equivalent part of the array is still in cis to the other copy of the target gene (for an example and detailed ... WGD and subsequent processes on the structure of GRBs: correct estimation of the extent of the GRB and distinguishing between the target gene(s) and the bystander genes in a GRB With regard to the...
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The roles of rac1 and syncollin in regulated exocytosis insulin secreting INS 1 cells as a model
... hyperglycemia Study of the exocytosis using the insulin secretion model will benefit to the understanding of both the fundamental mechanism of regulated exocytosis and the pathogenesis of diabetes development ... features allowing them to be sorted at the level of the TGN For proinsulin, it has been shown that residues 16 (Leu) and 17 (Glu) of the A-chain and 13 (Glu) and 17 (Leu) of the B-chain serve ... Several regions, including the position of cysteins that form the disulfide bond, the N- and C-terminal regions of A chain and the hydrophobic residues at the C-terminal of B chain, are highly conserved...
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Effects of apolipoprotein e on n methyl d aspartate receptor signalling the roles of ageing and chicken extract
... the first lane and the size of the rectangular box is standardized for the rest of the lanes Lane profiles were plotted and a straight horizontal line was drawn defining the x-axis (the background) ... exclude the unusually bright staining (artefacts) at the periphery of the sections The total area of staining over the threshold within the ROIs was computed by the software and this total area of ... around the band of interest in the first lane such that the box is wide enough to cover the largest band and but will not overlap with a band in the next lane This lane is selected as the first...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits to the chicken AP-2 The role of AP-2a was further studied in zebrafish ... tumorigenesis and genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene ... because of the severe skeletal defects in growth and the development of face and limbs [17–19] Donner et al tried to link the expression of AP-2a in these tissues to upstream signaling pathways They...
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Tài liệu Báo cáo khoa học: Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I pdf
... ATnI130)252, and ATnI232)292 did not migrate into the gels, while free ATnI-52K and ATnI1)128 exhibited a band near the origin and at the middle of the gel, respectively The bands corresponding to the ... PAGE Lanes a and d, in the absence of both TnC and Ca2+; lanes b and e, in the presence of TnC and the absence of Ca2+; lanes c and f, in the presence of both TnC and Ca2+ Ac, actin; Tm, tropomyosin; ... actin and TnC in the absence and presence, respectively, of Ca2+ These phenomena should directly reflect the mechanism of Ca2+ switching involving the alternative binding of the C-terminal region of...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... s, and indicate re-oxidation of the flavin and the formation of the hydride-Meisenheimer complex of TNT (C) As for panel B except the spectral changes are recorded over an extended time period and ... proximity of the N5 atom A putative flipping motion of the progesterone molecule along an axis parallel to the FMN plane aligns the C1-C2 with the 4666 plane of the isoalloxazine ring and in close ... confirming that the mutation of Tyr186 to Phe186 does not grossly perturb the overall framework of the enzyme or the active site The active sites of the enzymes are shown in stick format with the sigmaA...
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Tài liệu Báo cáo khoa học: "Exploring the Use of Linguistic Features in Domain and Genre Classification" potx
... grave for the LPE experiments because of the ceiling effect and the small size of the complete data set, therefore, we did not rerun the corresponding experiments Furthermore, the number of codebook ... feature selection and evaluation and give a brief description of the algorithms used We then report on the results of the two suites of experiments 5.1 Feature S e l e c t i o n The set of all potential ... text The frequencies were standardised using z-scores, so that the resulting random variables have a mean of and a variance of The z-scores were rounded Proceedings of EACL '99 down to the next...
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Báo cáo khoa học: Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis pptx
... Schematic representation of the roles of the FadD proteins encoded by the DIM + PGL locus in the biosynthesis of DIMs and related compounds in Mycobacterium tuberculosis The role of the activation enzymes ... promote the transfer of the p-HB moiety onto PKS15 ⁄ [16,18] To examine the involvement of FadD29 in the biosynthesis of DIMs and PGLs, we took advantage of the existence in the laboratory of an ... the activation of the various intermediates in DIM and PGL biosynthesis has not been analyzed This study was undertaken to dissect the roles of FadD22, FadD26 and FadD29 in the biosynthesis of...
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The Economics of Small Business Finance: The Roles of Private Equity and Debt Markets in the Financial Growth Cycle potx
... businesses and academics in the nature and behavior of the financial At the core of this issue are questions about the type of financing need and receive at various stages of their growth, the nature of ... implications among these alternative of small business finance is a growing of small business finance For example, the impact of the U.S of the early 1990s and the effect of the consolidation of the banking ... credit, and other sources of funds These data allow for tests of research regarding the cost and availability of different types of external finance and how the cost and availability vary with the...
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Báo cáo khoa học: Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a hemeregulated phosphodiesterase from Escherichia coli pptx
... influences the rate of auto-oxidation and the redox potential of the heme iron, but, surprisingly, they had less effect on the characteristics of O2 and CO binding Finally, we discuss the roles of these ... the polarity of the heme distal side, the direction of the heme-bound O2 molecule, and the redox potential of the heme iron [5] The reason why the auto-oxidation rate of the Leu99 and Leu115 mutants ... accompany the redox change Specifically, there is a switch in the heme axial ligand and changes in the flexibility of the FG loop (residues 86–96) in the protein when the redox state of the heme...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
... HD These processes may not be independent of each other Detailed descriptions of these processes are beyond the scope of this review In the present review, we specifically focus on the role of ... (45 kDa) and the activated caspase-1 (20 kDa) are shown by the arrows on the left The bar diagram (right panel) shows the average (n = 3) of integrated optical density (IOD) of the bands obtained ... elegans model of HD [45] The increased functional role of NMDAR in HD and the involvement of HIP-1 in NMDAR-mediated phosphorylation of Htt [18] further indicate the possible participation of HIP-1...
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Báo cáo khoa học: cGMP and glutathione-conjugate transport in human erythrocytes The roles of the multidrug resistance-associated proteins, MRP1, MRP4 and MRP5 pot
... Uptake of [3H]cGMP in the absence of ATP but in the presence of the nonhydrolysable ATP analogue, ATP-c-S, was less than 5% of the uptake in the presence of ATP The amount of [3H]cGMP taken up by these ... compared using an F-test on the ratio of the variance associated with the reduction in degrees of freedom to the variance of the fit with the smaller number of degrees of freedom [33], VR ¼ ðSSE2 ... to the protein concentration of the membrane vesicles, and all data were corrected for the amount of radiolabelled substrate bound to the filter in the absence of vesicle protein The substrate and...
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Báo cáo khoa học: Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake potx
... the roles of PrRP in the control of stress responses may depend upon the nature of stressful stimuli used Stressful stimuli affect food intake and increase energy expenditure On the other hand, ... in the brainstem and hypothalamus, and induce neuroendocrine and behavioral responses Food intake also activates the brainstem and hypothalamus, resulting in the termination of meals and the ... Y Takayanagi and T Onaka PrRP and RFRPs in metabolism and stress Table Summary of mammalian RFamide peptides and their receptors The effects of administration of RFamide peptides upon...
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Báo cáo khoa học: Tracking interactions that stabilize the dimer structure of starch phosphorylase from Corynebacterium callunae Roles of Arg234 and Arg242 revealed by sequence analysis and site-directed mutagenesis doc
... elements of rmGP [4] and EcMalP [3] onto the linear sequence of StP and thus measures the extent of conservation of the respective ÔsitesÕ in StP As in other GPs, the catalytic site and the PLP ... selected and the inserts sequenced The bottom of the figure (B) indicates the positions of BamHI and HindIII fragments, relative to the entire StP structural gene they represent prototypes of regulated ... responsible for the observed tetramer : dimer ratio of % 0.2 in Histagged StP, and likewise the Arg fi Ala mutants thereof The results suggest that if the occurrence of tetrameric and dimeric forms of His-tagged...
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Báo cáo sinh học: " Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse" pdf
... Since the latter Abs are a fraction of the Figure Composition of MAPs Composition of MAPs The amino acid (aa) composition of the scaffolds of G39d and G40d is shown in single letter code The triple ... of Health The help of Marion Sacks in the preparation of the manuscript and of Soheila Nikpour in the preparation of the figures is gratefully acknowledged References Determination of M2e-specific ... airways [24-26] The reason for this appears to be the lower rate of transudation of serum IgG through the pseudostratified columnar epithelium of upper airways than the thinner epithelium of respiratory...
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báo cáo hóa học: " Exploring the validity of estimating EQ-5D and SF-6D utility values from the health assessment questionnaire in patients with inflammatory arthritis" potx
... participated in the design of the study and performed the statistical analysis and interpretation of data, and drafted the manuscript; ML participated in the design of the study and the statistical ... completed and returned all the baseline questionnaires and were included in this analysis; 224 (85%) of the STIVEA cohort, 453 (97%) of the BROSG cohort, and 795 (92%) of the BSRBR patients There ... imputation of utility values, rather than a single imputation as performed here Furthermore, the ability to predict the SF-6D and EQ5D from the HAQ is complicated by the weighting of items in the EQ-5D...
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báo cáo hóa học: " Struggles, strengths, and strategies: an ethnographic study exploring the experiences of adolescents living with an ostomy" doc
... ambivalence then relief surrounding disclosure, participants used this process of truth-telling to ultimately determine the extent and value of their friendship with the recipient of the information They ... analysis of similarity and difference within transcript codes, (iii) organization of codes in the development of categorization schemes, and (iv) solidification of themes through review of codes ... Whether to Tell Others About the Ostomy Participants described a personal struggle over disclosing the ostomy to others They appeared to experience shame and embarrassment about the ostomy and, ...
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báo cáo hóa học:" Unsaturated phosphatidylcholines lining on the surface of cartilage and its possible physiological roles" potx
... analysis The total amount of PC was then worked out by adding the amounts of individual PC species together In our study the total amount of PC species was < 20 µg The relative percentages of each of ... ~60 % of all PC species in the lung regions of the body The present results offer further support to the Page of (page number not for citation purposes) Journal of Orthopaedic Surgery and Research ... experiment, the collection, analysis and interpretation of data, the drafting the manuscript and acquisition of funding RWC contributes to the analysis and interpretation of data, drafting the manuscript...
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