... susceptibility to seizures The causative role of cytokines in epileptogenesis remains to be elucidated Cytokines may contribute initially to incite seizuresin the developing brain after being induced ... elevated inpatientswith infection and/or systemic inflammatory response syndrome, than in healthy control individuals [19,21] HMGB1 is involved in various diseases without obvious infections; ... inpatients without a family history of febrileseizures than inpatientswith family history These findings may reflect compensatory activation of anti-inflammatory or anti-convulsive mechanisms,...
... impaired in group that comprised patientswith systolic dysfunction Also, the peak VO2 was significantly decreased in group patientswith systolic dysfunction, in comparison with that inpatients without ... that aortic distensibility is not impaired inpatientswith different forms of Chagas' disease, even in those with heart failure Our results observed inpatients without CHF coincide with those ... arterial distensibility Data obtained in experimental studies support this issue by demonstrating that acute infection by trypanosoma cruzi causes inflammatory lesions in large arteries, affecting...
... The wrist patients have a modest decrease in health-focused quality of life within physical domain and scores in accordance with controls within http://www.hqlo.com/content/6/1/90 mental domain ... of giving informed consent, and patients not capable of speaking Norwegian Data was collected over two years During this period, 324 wrist fracture patients and 456 hip fracture patientswith ... of the patientswith a wrist fracture and 307 of those with a hip fracture were examined at the Osteoporosis Centre Sixtyeight wrist and 210 hip fracture patients were excluded (21 wrist patients...
... glycoprotein of high molecular weight which is used in the clinic as a marker of tumor burden There is indeed a strong correlation between rising and falling levels of serum CA125 with progression ... cells were pre-incubated for h with various fluids (10% v/v) obtained from women with advanced ovarian cancer and treated with increasing concentrations of TRAIL for 48 h or with cisplatin or paclitaxel ... OVC346 Consistent with our previous findings in CaOV3 cell line [10], we found that both OVC346 and OVC509 ascites induced Akt activation in primary tumor samples as determined by increased Akt...
... minute (cpm) obtained in cultures with antigen to mean cpm obtained in cultures incubated in the absence of antigen An SI ≥3.0 and a ∆cpm >1,000 (mean cpm obtained in cultures with antigen minus ... it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex J Clin Invest 1992, 90:1061-1066 Hassfeld W, Steiner G, Studnicka-Benke A, Skriner K, Graninger ... for this antigen The data obtained suggest that hnRNP-A2 may constitute an important T cell autoantigen inpatientswith SLE, indicating a potential role for it in the pathogenesis of this disorder...
... fluid neutrophil apoptosis was significantly lower inpatientswith RA than inpatientswith non-RA persistent synovitis (P = 0.0004) or inpatientswith resolving synovitis (P = 0.002) Results ... apoptosis inpatientswith very early inflammatory arthritis (a) Synovial fluid neutrophil apoptosis at clinical arthritis presentation inpatientswith very early inflammatory arthritis divided ... al.: Blockade of interleukin trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo Nat Med...
... regression model This finding isin line with a previous study on major infections in SLE patientsin the Hopkins Lupus Cohort [32] Renal insufficiency is a possible risk factor for infections However, ... admission was required Furthermore, the high incidence of Herpes zoster infection, occurring at least one time in 14% of the patients, isin line with other studies inpatientswith SLE [1,31] With ... one infectious episode since lupus diagnosis in 50% of patientswith SLE, and this high infection rate is confirmed by other studies reporting infectious complications in up to 45% of SLE patients...
... verified using the best available methods, including verifying the clinical attendance records and with direct telecommunication with the patient or their family Statistical Analysis Disease-free interval ... (n = 70) patients, respectively The histological types of 98.5% of the patients were non-keratinising or undifferentiated carcinoma (WHO type II or III) The distribution of patients within the ... hazards regression models risk subset included the patientswith 0-2 independent prognostic factors (score 0-2), the intermediate-risk subset included the patientswith 3-4 independent prognostic...
... overexpressed in inflamed synovial tissue, in particular in the lining layer and in sublining cells [9], and it is elevated in draining lymph from affected joints [10] Furthermore, IL-1β is localized ... IL-1α In murine collagen-induced arthritis [6] and antigen-induced arthritis [7,8], inflammation and cartilage degradation were inhibited by blocking IL-1β but not IL-1α In RA patients, IL-1β is ... processing for paraffin embedding Tissue sections (7 μm) were stained with haematoxylin/eosin or safranin O/fast green Histopathological changes in the knee joints were scored in the patella/ femur...
... of RA disease is change in body composition, with reduced fat free mass (FFM), of which muscle mass is the largest component [13,14] The decline in FFM is, in RA, often associated with increased ... gastric ulcer or intestinal surgery, known eating disorder or steroid injections within weeks The patient characteristics are shown in Table Consequently, the patients had a fairly low disease activity ... DR, Morris CJ: Presence of foam cells containing oxidised low density lipoprotein in the synovial membrane from patientswith rheumatoid arthritis Ann Rheum Dis 1993, 52:677-680 56 Nordin Fredrikson...
... file) Insulin resistance was evaluated from fasting glucose and insulin using the Homeostasis Model Assessment of Insulin Resistance (HOMA IR) [30] and the Quantitative Insulin Sensitivity Check Index ... insulin resistance and chronic kidney disease in nondiabetic patients, independent of other risk factors [64] Insulin resistance has also been described inpatientswith RA and may associate with ... dysfunction inpatientswith RA In this study, we focus on the potential association of UA with renal dysfunction inpatientswith RA and investigate whether such an association is independent...
... preservation [1-3] Recently, sitagliptin, the first DPP-4 inhibitor launched on the market, has been approved for use in combination with insulin Sitagliptin combined with insulin significantly reduces blood ... dosage of insulin units may be a solution to this problem; however, in practice, this can cause an increased risk of hypoglycemia and weight gain Incretin-based drugs (GLP-1 receptor agonists and ... b-cells However, whether this is the case in humans has not been investigated The possibility of using GLP-1 analogues inpatientswith type diabetes is now emerging [6] As in the animal model [5],...
... diagnosis of ARDS The most important finding in the present study was that the marked elevation of ELF KL-6 within days after the diagnosis appeared to correlate with poor prognosis in ARDS patients ... serum between the patientswith primary and secondary ARDS or between the patientswith and without preexisting ILD Interestingly, we found no significant difference in each comparison These data ... DW, Martin TR, Wiener-Kronish JP: Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia J Clin Invest 1999, 104:743-750 10 Bitterman PB: Pathogenesis of fibrosis in acute lung injury...
... mortality in ALI patients ventilated with lung-protective ventilation during this stage of disease In addition, if prospectively validated, these findings may help identify patients who are failing ... Other studies, including the Kings County Lung Injury Project and the ARDSNet trial of steroids for persistent ARDS, reported surprisingly low mortality rates inpatients requiring prolonged ventilation ... cumulative risk of complications associated with mechanical ventilation, including ventilator- associated pneumonia and sepsis, increases with each ventilator day, we were surprised to find that...
... levels are increased in scleroderma patientswith pulmonary hypertension and GDF-15 protein was predominantly located in monocytes infiltrating the lung tissue [18] In the present study we investigated ... physiology Intense signal for GDF 15 is noted in cells lining vascular channels Inset shows prominent luminal staining of GDF-15 in endothelial cells (arrowhead) Note lower signal for GDF-15 in the ... different cytokines and signaling pathways interact with each other, it is difficult to define the precise role of a single cytokine in such a complex milieu Key players in vascular remodeling of PAH...
... because dynamic hyperinflation is the main cause of shortness of breath inpatientswith COPD However, breathlessness during exercise is measured in most studies to evaluate this relationship Purpose ... clinical dyspnea is also unknown There are also important considerations in the clinical practice setting A common misunderstanding is that hypoxemia is causing dyspnea, and proper oxygen administration ... EELV is maintained at a level above the statically determined relaxation volume of the respiratory system In flow-limited patients, the mechanical time-constant for lung emptying is increased in...
... and increased risk of emergency department visits and hospitalizations for asthma [29,30] These findings are also in line with previous studies linking lower SES (assessed using arealevel and individual-level ... even with the inclusion of all covariates These findings are consistent with previous studies finding significant associations between lower childhood SES and worse asthma morbidity, including increased ... whom 1739 patients (91%) were screened for inclusion in the study (the remaining 165 patients had insufficient medical information with which to conduct pre-screening) A total of 885 patients...
... especially in seropositive disease In established RA, insulin resistance (IR) is increased and associated with CVD We investigated factors associated with IR in an inception cohort of patientswith ... arthritis, Insulin Resistance factor, Early inflammatory Introduction Cardiovascular disease (CVD) remains the leading cause of death inpatientswith inflammatory polyarthritis (IP) and is particularly ... associated with seropositive disease [1-4] Insulin resistance (IR) is known to be increased inpatientswith established RA [5,6] and has been shown to be a risk factor for both clinical CVD...
... system during the early development of PLE, rather than a causal factor However, reports of opportunistic infections inpatientswith PLE are rare [5,10] This finding isin agreement with our ... albumin, × 50 ml 20%/day), a single immunglobulin infusion (Sandoglobin®), C1-esterase-inhibitor (Berinert®) and prednisolon (3 × mg/day per orally; during the early phase, in addition, 10–20 mg intravenously) ... 7, and was increased at this time Protein levels were below the normal range at PLE onset; α1-globulin, α2-globulin and β-globulin were elevated in most patients, whereas γ-globulin was below...