innate and acquired immunity and epithelial cell function in chronic rhinosinusitis
Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
... diseases including T1D [6] T1 D is a chronic autoimmune disease that results in the destruction of the insulin-producing beta (b) cells of pancreatic islets of Langerhans, resulting in insulin deficiency ... cells in vitro, and this increased T reg cell function, in contrast to controls, restrains the expansion and effector functions of CD4+ Teff cells more efficiently in vivo [9] Interestingly, T1 D ... to an increase in the cellular frequency of FOXP3+ T cells, originating from nTreg cells and de novo induced Treg cells [91] Clinical trials are currently underway to assess the effects and benefits...
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Báo cáo y học: "Hypoxia, hypoxia inducible factor and myeloid cell function" pdf
... recruitment, bacterial killing and persistent myeloid cell- mediated inflammation PHD, prolyl hydroxylase domain-containing enzyme; FIH, factor inhibiting HIF; IKKB, IκB kinase beta; SLC11a1, phagocyte-specific ... however, in part depend on the dominant HIF subunit specific to the cell type and on the physiological or disease conditions in which that cell is functioning Novel hypoxia inducible factor targets in ... response to inflammatory stimuli that would precede the role of hepcidin in maintaining the iron sequestration by macrophages, again demonstrating a dual regulation by NF-κB and HIF inflammatory...
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Báo cáo y học: "Thymic function and T cell parameters in a natural human experimental model of seasonal infectious diseases and nutritional burden" potx
... starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice J Clin Invest 1999, 104:1051-1059 16 Casanueva FF, Dieguez C: Neuroendocrine regulation and actions of leptin Front ... atrophy[17] In humans, postmortem studies show thymic involution in the severely malnourished[18] Furthermore, cytokines including IL-7 and IL-2 which are important for thymic and T cell development ... high infection and harvest/low infection seasonal cycles of weight lost and gain observed for the past decades [25] Growth was also reported to deteriorate in infants during the hungry/high infection...
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Antigen specific effector CD8 t cells regulate allergic responses via IFN y and dendritic cell function
... link between the innate and adaptive immunity DCs are located within and below the airway epithelium, forming an extensive network and capturing antigens via the dendrites protruding between epithelial ... al., 1998) Epithelial cells and asthma symptoms Other than affecting DC functions to modulate asthma, epithelial cells are involved in asthma pathogenesis in many other ways Epithelial cells have ... their role in maintaining an intact lining of the airways, it is not difficult to imagine that disruption of epithelial cell functions might be the first step towards the onset of AHR (Qin et al.,...
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
... ANT1-silencing induces glioblastoma cell death A Fig Analysis of ANT1 and ANT2 expression in nontransfected ADF cells and in ANT1- and ANT2-silenced ADF cells (A) Number of ANT1 and ANT2 transcripts in ... reduction in cell viability induced by ANT1 siRNA requires protein synthesis ANT1-silencing induces ADF cell apoptosis and a non-apoptotic cell death modality similar to paraptosis To gain more insight ... siRNA + puromycin Fig Effect of ANT1 and ANT2-silencing on ADF cells (A) Cell growth curves analyzed by crystal violet assay in nontransfected ADF cells, and in Scramble- and ANT1 siRNA and ANT2 siRNA...
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Báo cáo khoa học: Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours pot
... the other hand, at least in endothelial cells, protein kinase A is involved in HIF-1a phosphorylation under intermittent hypoxia but not under chronic hypoxia, and protein kinase A inhibition ... Hippel–Lindau tumour suppressor protein acts as the substrate recognition protein of the E3 ubiquitin ligase complex [43], and induces the ubiquitination of HIF-1a on its N-terminal and C-terminal ... control mice Interestingly, no increase in lung micrometastasis was observed in mice exposed to chronic hypoxia [15], suggesting again that intermittent hypoxia has different effects from chronic...
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Báo cáo hóa học: " Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats" pptx
... 15 μm in diameter) in BIA was substantially lower in group than in groups and on IHC staining (Figure 9A-D) All of these findings indicate an ADMSC-induced enhancement in neurogenesis and vasculogenesis ... in brain infarct area and differentiation into endothelial -cell phenotype The IHF imaging (A) (400×) results showing double stains of CM-Dil and DAPI-positive cells (white arrows) in the brain ... inhibitor (PAI)-1 in BIA, indexes of inflammation, were significantly elevated in group compared with groups and 3, and significantly lower in group than in group These findings indicate that ADMSC...
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Báo cáo y học: "The relationship between predicted peptide–MHC β class II affinity and T-cell activation in a HLA-DRβ1*0401 transgenic mouse model" pptx
... specific amino acid side-chains within a bound peptide contribute to DR4 binding affinity, depending on their location within the binding groove [11–13] Models such as these have defined a number ... predicting peptide–MHC affinity This model defines the relative affinity of an amino acid for a specific DR4 binding pocket The sum of all amino acid contributions from each of the nine DR4 binding ... cells (antigenpresenting cells [APCs]) and specific peptide antigen (10 µg/ml) These T -cell lines were maintained by repeated alternating cycles of weekly restimulation with IL-2 or peptide and...
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Báo cáo y học: "Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis" docx
... cultured in hypoxia showed increased secretion of another gelatinase, MMP-9 [15] Hypoxia upregulated MMP-2 and MMP-9 activity in a variety of adenocarcinoma cell lines and increased their invasiveness ... synovial lining, resulting in destructive changes to the joints and soft tissues, most commonly in the hand and wrist Approximately 50% of patients with RA have tendon involvement, and tenosynovial ... (CytoSelect Cell Migration assay; Cell Biolabs Inc., San Diego, CA, USA), and then inverted and photographed Inserts were subsequently placed in extraction solution (CytoSelect Cell Migration assay; Cell...
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Báo cáo y học: "DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Faslpr/lpr mice in vivo" potx
... replaced with random nucleotide triplets Similarly, ODNs INH-44, INH-46, and INH-48 are linear derivatives of INH-18 lacking CCT, GGG, or both triplets INH-4 and INH13 are palindromic or linear analogues ... fluorescence-activated cell sorting staining The ratio between the CD21intCD23+ follicular B cells and CD21highCD23low/- marginal zone B cells was approximately 8:1 to 15:1 in control strains and in young ... phosphate-buffered saline stimulation (Figure 2) Similar findings were obtained in human primary B cells/B -cell lines In contrast to resting B cells, when 'professional antigen-presenting cells' (for example,...
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Báo cáo y học: " Over-expression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium" pdf
... of injection, the hearts were harvested, washed in PBS, and fixed in 10% formalin overnight at 4°C Paraffin embedded tissues were cut into 5-μm sections and stained by Masson’s Trichrome staining ... in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells Int J Mol Me 2002, 10:433-440 Zeng B, Ren X, Lin G, Zhu C, Chen H, Yin J, Jiang H, Yang B, Ding D: Paracrine ... myocardial infarction in situ and in the perfused heart in vitro Tissue Cell 1997, 29:733-743 Fishbein MC, Maclean D, Maroko PR: Experimental myocardial infarction in the rat: qualitative and quantitative...
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Báo cáo y học: "The association between microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: a cross-sectional study" pdf
... endothelial-dependent function in healthy individuals have reported mixed findings, with some reporting an association between microvascular and macrovascular endothelial-dependent function [22,23] and others ... UK) according to previously established guidelines [41] Following ten minutes of rest, endothelium-independent responses were examined by administration of a 500-μg sublingual glyceryl trinitrate ... the study and helped with data analysis and drafting the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests...
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Báo cáo khoa học: "N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown" pps
... decrease in lactate signal intensities in liver tissue, and an increase in four patients in the cardiac index The increase in cardiac index after NAC administration has already been shown in clinical ... shown to increase the cardiac index and oxygen delivery in fulminant hepatic failure and in septic shock [4,6,10] Devlin and colleagues showed in a recent study that the indocyanine green elimination ... An in vitro study has shown that cell dysfunction leads to the inhibition of pyruvate dehydrogenase within minutes, thus leading to a pyruvate and lactate accumulation in the cell [14] Accordingly,...
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Báo cáo y học: "The effect of open lung ventilation on right ventricular and left ventricular function in lung-lavaged pigs" pps
... approved by the institutional animal investigation committee, and the care and handling of the animals were in accordance with the European Community guidelines In 10 pigs weighing 32 ± 1.3 kg, ... considered in each animal during each ventilation strategy as the slope of RV stroke work and REDV obtained with and without inflation of the balloon on the Foley catheter in the inferior caval vein ... manuscript, JJMT helped in the statistical analysis and revising the manuscript BL and AJJCB helped in the design of the study and revising the manuscript FC and AP participated in the design of the...
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Báo cáo y học: "Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats" pot
... markers, including AT activity, fibrin/fibrinogen degradation products (FDP), and fibrinogen levels and red blood cell (RBC), white blood cell (WBC), and the platelet counts, were measured in the ... syndecans in tissue injury and inflammation Mol Cells 2007, 24:153-166 Alexopoulou AN, Multhaupt HA, Couchman JR: Syndecans in wound healing, inflammation and vascular biology Int J Biochem Cell Biol ... proteins as HSPGs and has been found to bind and regulate most of the key mediators of tissue injury and inflammation Thus, HS is thought to coordinate the host response to infectious tissue injury...
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Báo cáo y học: " Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection" docx
... scattering Cells staining negative for CD3 and positive for CD(16+56) were considered as natural-killer (NK) cells Cells staining positive for both CD3 and CD(16+56) were considered NKT cells ... CD8-lymphocytes and the rate of apoptosis of CD8-lymphocytes decrease; in primary bacteremia the rate of apoptosis of NKT cells increase; and in VAP/HAP the rate of apoptosis of NKT cells and of NK cells increase ... comprising history, thorough physical examination, blood cell counts, blood biochemistry, blood gas, blood culturing from peripheral and central lines, urine cultures, chest x-ray, and chest and...
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Báo cáo khoa học: In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis pot
... control and in chronic vitamin A-deficiency Liver differential display analysis was performed in control and chronic vitamin A-deficient rats (50 days) Several bands were differentially expressed in chronic ... was detected in liver and lung indicating that the amount of p53 protein was significantly increased in the liver and lung from vitamin A-deficient rats that in controls c-Jun protein was significantly ... mgÆkg)1 body weight, intraperitoneally) Blood was collected from the aorta in heparinized syringes and then liver and lung samples were taken and processed immediately Retinol and retinyl palmitate...
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báo cáo khoa học:" Predictors of health status do not change over three-year periods and exacerbation makes difference in Chronic Obstructive Pulmonary Disease" ppsx
... breathing room air Body weight and height were measured Body mass index [BMI = weight in kg/(height in m)2] was calculated Smoking history was obtained by patient interview using standardized instruments ... follow-up This finding reinforces the impact of exacerbation in clinical outcomes; exacerbations of COPD indicate clinical instability and progression of the disease and are associated with increased ... classes, since 51 were in class 1, 23 in class 2, 14 in class and patients in class (p
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Báo cáo y học: " A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease" pot
... exacerbations with the medical notes relating to clinic attendances in the intervening year to increase accuracy As part of their routine clinical care at clinic visits during the year patients had been ... transfer During follow up, decline in fat free mass was independently associated with more marked gas trapping, a higher FFM at baseline and use of maintenance oral corticosteroids, whereas FFM increased ... marked in those with reduced fat free mass and declined further over the course of a year The only parameter predicting decline in QMVC during follow up was QMVC at baseline Of note the mean decline...
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Báo cáo y học: " Health-related quality of life and long-term prognosis in chronic hypercapnic respiratory failure: a prospective survival analysis" docx
... to increased mortality Accordingly, in COPD mortality was high and HRQL low In this respect there was as link between HRQL and mortality in all diseases associated with CHRF and HMV although in ... contained in the SRI Of course, HRQL can be no more than one factor in the multivariate panel determining the clinical state and prognosis of patients with CHRF Conclusion In summary, our findings ... prognostic factor in COPD [5] In line with this, the present investigation showed a tendency towards an association between the SRI subdomain "physical functioning" and mortality in COPD (KaplanMeier;...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25