... studied out-of-hospital cardiacarrestsurvivors who were successfully resuscitated in out-of-hospital settings and consecutively admitted to intensive care units from the beginning of January 2008 ... whether NDEs occur before, during, or after the period of cardiacarrest [3] During cardiac arrest, the petCO2 falls to very low levels, reflecting the very low cardiac output achieved with cardiopulmonary ... equilibrium should be adopted in resuscitation guidelines Key messages • The incidence of NDEs in out-of-hospital cardiacarrestsurvivors is 21.2% • NDE occur more often in patients with higher petCO2...
... function incardiacarrestsurvivors Resuscitation 2009, 80:1223-1228 doi: 10.1186/1757-7241-18-29 Cite this article as: Heradstveit et al., Capillary leakage in post -cardiac arrestsurvivors during ... of intravascular COP is one important factor in determining fluid flux across the capillary membrane The decline in COP in plasma was probably due to hemodilution, which is also reflected in ... function over time in patients after cardiacarrest [35] The clinical implication of the present study is that post -cardiac arrest patients can be liberally infused with crystalloids during the first...
... years) in the cardiacarrest group, 28 patients were resuscitated using CPR, whereas the remaining 22 patients only underwent cardioversion Incardiacarrest patients, three subgroups were defined ... myocardial infarction; CA, cardiac arrest; NS, not significant; T3, tri-iodothyronine; T4, thyroxine; TSH, thyroid-stimulating hormone Table LVEF, TFTs, troponin and CK-MB levels in the cardiacarrest ... arrest patients died within the first months, only one patient died in the AMI group Of the cardiacarrest patients who died, 11 had an intervention lasting longer than 10 min, eight had an intervention...
... hypothermia during advanced life support: a preliminary study in out-of-hospital cardiacarrest Crit Care 2008, 12:R31 Froehler MT, Geocadin RG: Hypothermia for neuroprotection after cardiac arrest: ... myocardial infarction Int J Cardiol 2008 [Epub ahead of print] Hypothermia After CardiacArrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiacarrest N ... Therapeutic hypothermia after cardiacarrest – the implementation of the ILCOR guidelines in clinical routine is possible! [Letter.] Crit Care 2006, 10:425 Nolan JP, Deakin CD, Soar J, Böttiger BW,...
... found to occur, the staff involved will be given extra training in the trial procedures Blinding Because of the nature of the interventions, paramedics cannot be blinded, and will be aware of ... Resuscitation Councils SG is a Principal Research Fellow at the Warwick Clinical Trials Unit specialising in clinical trials and statistical methods in medical research Competing interests The authors declare ... efficiency of the trial, recruitment will be predominantly concentrated in urban areas Individual patients will be eligible if: they are incardiacarrestin the out-of-hospital environment on arrival...
... 60-90 minutes, requiring an additional cooling method to maintain mild hypothermia [40,41,58] Combination of cold intravenous fluids with cool-packs or cooling pads in the out-of-hospital setting ... hypothermia was induced with an i.v infusion of 30 ml/ kg 4° cold saline In another swine study, surface cooling to 34°C during the first 30 minutes of prolonged resuscitation increased rate of ... supply during use, which makes them unsuitable for use in the out-of-hospital setting Easy to use non-invasive cooling methods for induction of mild hypothermia in the out-of-hospital setting include...
... to be cautious before jumping to conclusions affecting our clinical practice One concern raised in the current reviews [5,6] is the lack of on-going hospital cooling in patients brought to hospital ... not make sense anymore to limit cooling to VF cardiac arrests only [1,2,8] We cool the brain because it suffers from a combination of anoxic and re-perfusion injury, not because of a specific heart ... to treat unconscious survivors of OHCA actively in the ICU, TH should be part of standard care Whether you should move the cooling into ambulances or the homes of cardiacarrest victims is another...
... [35] during sepsis or septic shock, indicating a potential role of infection and inflammation in the release of S-100 protein Due to the high infection rate in patients receiving MTH in our study, ... active warming was applied before induction of MTH Hypothermia was induced via infusion of one to two litres of cold (about 6°C) saline in combination with body surface cooling using bags filled ... baseline Discussion In the present study the administration of MTH did not significantly influence serum levels of S-100 protein in patients surviving non-traumatic out-of-hospital cardiac arrest...
... registry of in- hospital cardiac arrests that collects data according to standardized Utstein definitions.6,11-15 Cardiacarrest is defined as cessation of cardiac mechanical activity as determined by ... Recurrent arrests occurred 12,603 Patients had an initial arrest 3291 Had an arrestin the emergency room, the operating room, or a procedure area 9312 Had an arrestin an intensive care unit or in ... guidelines for reviewing, reporting, and conducting research on in- hospital resuscitation: the in- hospital ‘Utstein style.’ Circulation 1997; 95:2213-39 12 Cummins RO, Sanders A, Mancini E, Hazinski...
... to increase the use of induced hypothermia for cardiacarrestsurvivors We hypothesize that two main factors contribute to the poor implementation of induced hypothermia in hospitals: existing ... AHA guideline on therapeutic hypothermia will result in an increase in post -cardiac arrest patients receiving appropriate therapeutic hypothermia Methods/design The setting Figure Chain of survival ... out-of-hospital cardiacarrest The hospitals in this project include the 33 southern Ontario hospitals already participating in the University of Toronto regional coordinating centre site of the Dainty...
... 53:1725 Guglina ME: [Intravenous jet administration of nitroglycerin in cardiogenic shock] Klin Med (Mosk) 1990, 68:56-58 Guglina ME: High-dose nitroglycerin in cardiogenic shock Klin Med [Mosk] 1997, ... patient, as well as the times of infusions, are listed in Table BP became obtainable or increased in 20 of 22 patients immediately after intravenous NTG was administered In the end, 13 patients survived ... had clinical shock syndrome In another study evaluating incremental doses of intravenous NTG in patients with left ventricular failure the maximal hemodynamic benefit, in terms of decrease in wedge...
... reperfusion following ischemia include the production of stress-related proteins, such as heat shock proteins These proteins, in turn, are believed to influence other gene products Elevations in heat shock ... heat shock protein-70 in the hippocampus are blunted by hypothermia [17] Additionally, arachidonic acid products may be involved in an inflammatory cascade, affecting cell survival In gerbils, hypothermia ... are included here to give a perspective on relative discharge statistics following cardiacarrest from other series Hypothermia begun hours after the initial insult is not likely to affect the initial...
... hypothesis maintaining that the initial PetCO2 should be higher in an asphyxial arrest model than in a VF/pulseless ventricular tachycardia (VT) cardiacarrest model In the asphyxial cardiacarrest ... resuscitation intervention There is growing evidence that indicates positive pressure ventilation may be postponed for several minutes in instances of arrythmic arrest whereas it might be life-saving in instances ... PetCO2 in asphyxial cardiacarrest are significantly higher than in VF/VT cardiacarrestIn asphyxial arrest there is also no significant difference in inital values of the PetCO2 in patients with...
... protein originating in glial cells, in contrast with NSE, which is of neuronal origin S100 B has been shown to be a good predictor of neurological recovery in patients surviving cardiacarrest ... sampling does not need to be made at a defined time point greatly increases the clinical applicability of using NSE levels as a marker of prognosis after cardiac arrest, because this step can be included ... as early as 24 hours after a cardiacarrestin a cohort of 407 normothermic patients, most of whom were survivors of an out-of-hospital cardiacarrest Using a predefined cutoff value of 33 ng/...
... resuscitation from cardiacarrest Crit Care Med 2006, 34:1935-1940 Laver SR, Padkin A, Atalla A, Nolan JP: Therapeutic hypothermia after cardiac arrest: a survey of practice in intensive care units in the ... United Kingdom Anaesthesia 2006, 61:873-877 Sander M, von Heymann C, Spies C: Implementing the International Liaison Committee on Resuscitation guidelines on hypothermia after cardiacarrest The...
... epinephrine in VF cardiacarrest [30] These seemingly contradictory findings may be explained by the fact that many of the studies not take into account a subgroup analysis such as the distinction ... beneficial incardiacarrest by improving cardiac and brain blood flow during CPR [16-18] Epineprhine increases CPP via systemic arteriolar vasoconstriction, which maintains peripheral vascular ... effect of the combination of the two drugs in comparison to epinephrine alone in the first minute of CPR with an increase of CPP This increase was further attenuated in the second minute when diastolic...
... reduced insurvivors of cardiacarrest treated with therapeutic hypothermia • Another issue with impact on ICU LOS and time on ventilator might be systemic inflammation after cardiacarrest Both infectious ... implementation of the ILCOR guidelines in clinical routine is possible! Crit Care 2006, 10:425 Collins TJ, Samworth PJ: Therapeutic hypothermia following cardiac arrest: a review of the evidence ... outcome after severe brain injury Crit Care Med 2001, 29:178-186 Tiainen M, Roine RO, Pettila V, Takkunen O: Serum neuron-specific enolase and S-100B protein incardiacarrest patients treated...
... course interval listed in Table 4, the following four studies investigated the clinical usefulness in predicting neurological outcome after CPR not in accordance with time course interval Reisinger ... aggravation of brain injury, while brain imaging, physical examination, and electrophysiology all focus on the consequences of brain injury NSE is a protein located in nerve cells and detectable in body ... C: Increased serum levels of the S-100 protein are associated with hypoxic brain damage after cardiacarrest Stroke 1998, 29:473-477 Reisinger J, Hollinger K, Lang W, Steiner C, Winter T, Zeindlhofer...
... failure could be induced by cardiacarrestin a mouse model [18] This finding is in line with our data suggesting an association between hypoxia and the development of AKI after cardiacarrest Furthermore, ... every point of assessment ΔCrea24: change in serum creatinine in the first 24 hours; ΔCrea72: change in serum creatinine in the first 72 hours; CPC: Cerebral Performance Category; ICU = intensive ... regression model including gender, age, APACHE II-score at admission, urine output in the first 24 hours and change in serum creatinine in the first 24 hours (ΔCrea24) as independent factors In this model,...
... imaging (MRI), is useful in assessing the extent of structural brain injury Yet, evaluating hypoxic ischemic brain injury with CT or conventional MRI often underestimates the actual extent of injury ... brain damage by means of measuring the apparent diffusion coefficient (ADC) [9-12] The patterns and extent of brain injury seen in DWI are associated with clinical outcomes in neonates with perinatal ... whole brain or regional brain as a significant prognostic tool for predicting poor outcome in comatose survivors after cardiacarrest [20,21] Therefore, the purpose of our study was to examine whether...