hallmark of both normal aging and heart failure
Báo cáo Y học: DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I and DNA gyrase docx
... respond to the presence of IPTG, and such clones were indeed found at a frequency of 22% of the second cross over event Southern blot analysis and DNA sequencing of one of these clones in the ... of gyrase activity and gyrase expression for supercoiling are negative (i.e the activity and expression of DNA gyrase is inhibited not stimulated by higher levels of supercoiling) and those of ... regulation of cell function both comprehensively and fairly quantitatively Yet it is of crucial importance to evaluate how much of a given regulation is effected at the level of gene expression and...
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Báo cáo khoa học: " Differential protection by wildtype vs. organelle-specific Bcl-2 suggests a combined requirement of both the ER and mitochondria in ceramide-mediated caspase-independent programmed cell death" docx
... metabolism, Nox1, CYLD, Bmf, and cathepsin and calpain proteases as candidate mediators of ciPCD [2,8-10] However, and despite these advances, a coherent picture of the molecular steps in ciPCD ... that excess formation of ROS triggers ciPCD by activation of the DNA repair enzyme PARP, followed by intracellular depletion of NAD+ and ATP, nuclear translocation of AIF and finally, death [14] ... insertion sequence of the ER-specific isoform of rat hepatic cytochrome b5, directing Bcl-2 to the cytosolic face of the ER In addition, Zhu and coworkers constructed a gene encoding a form of Bcl-2 that...
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báo cáo khoa học: " DNA ligase 1 deficient plants display severe growth defects and delayed repair of both DNA single and double strand breaks" potx
... levels of gamma-radiation [25] or UVC [27] Further analysis investigated the repair kinetics of single and double strand DNA breaks induced in wild type and silenced lines Of the different forms of ... atlig1-RNAiA and 0.35 ± 0.14 mm for atlig1- RNAiB line The final size of mature Arabidopsis leaves is a function of both cell division and cell expansion [16] Therefore, further investigation of the ... [4] Eukaryotes have evolved multiple DNA ligase isoforms, with both specific and overlapping roles in the replication and repair of the nuclear and organellar genomes DNA ligase (LIG1) is present...
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Báo cáo y học: "Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block"
... received during diastole Since both, a reduced myocardial perfusion reserve and diastolic heart failure, are an integral part of systolic heart failure any abnormal shortening of diastolic time, particularly ... corresponding heart rate of each exercise stage and regression analysis was performed An inverse, nonlinear relation between heart rate and LV diastolic time was found in either normal subjects and both ... Isaka N, Nobori T, Ito M Impact of heart rate on mechanical asynchrony and left ventricular contractility in patients with heart failure and normal QRS duration Eur J Heart Fail 2007; 9:637-43 Chattopadhyay...
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báo cáo hóa học:" Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure" pot
... for acute exacerbation of chronic heart failure: a randomized controlled trial Jama 2002, 287:1541-7 Petersen JW, Felker GM: Inotropes in the management of acute heart failure Crit Care Med 2008, ... circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure J Am Coll Cardiol 1998, ... Anti-inflammatory and anti-apoptotic effects of levosimendan in decompensated heart failure: a novel mechanism of drug-induced improvement in contractile performance of the failing heart Curr Med...
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Báo cáo hóa học: "Hybrid approach of ventricular assist device and autologous bone marrow stem cells implantation in end-stage ischemic heart failure enhances myocardial reperfusion" doc
... Collection and assembly of data AK Data analysis and interpretation, collection and assembly of data CP Conception and design, data analysis and interpretation SW Conception and design, data analysis and ... a reduced number of functionally competent cells [17] Therefore, formation of myocytes and coronary vasculature cannot counteract the chronic loss of functional cells and Page of vascular structures ... analysis and interpretation, manuscript writing PA Conception and design, data analysis and interpretation, manuscript writing HA Data analysis and interpretation GK Collection and assembly of data...
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Báo cáo sinh học: "Increase of plasma IL-9 and decrease of plasma IL-5, IL-7, and IFN-g in patients with chronic heart failure" potx
... increase of IL-9 and decrease of IL-5, IL-7, and IFN-g plasma levels, in both ICM and NIDCM CHF patients vs controls and the inverse correlation of IL-5 and IL-9 plasma levels with duration of disease ... renin, galectin-3 [16-18], some of which are also important tools in the diagnosis and pathogenesis of heart failure, in the identification of subjects at risk of heart failure, risk stratification, ... Unit of the Catholic University of Sacred Heart of Rome out of 210 patients admitted to the unit during the same period Baseline patient demographic variables, heart failure classification and...
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báo cáo hóa học:" Increase of plasma IL-9 and decrease of plasma IL-5, IL-7, and IFN-g in patients with chronic heart failure" pptx
... increase of IL-9 and decrease of IL-5, IL-7, and IFN-g plasma levels, in both ICM and NIDCM CHF patients vs controls and the inverse correlation of IL-5 and IL-9 plasma levels with duration of disease ... renin, galectin-3 [16-18], some of which are also important tools in the diagnosis and pathogenesis of heart failure, in the identification of subjects at risk of heart failure, risk stratification, ... Unit of the Catholic University of Sacred Heart of Rome out of 210 patients admitted to the unit during the same period Baseline patient demographic variables, heart failure classification and...
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báo cáo hóa học: " Differential aspects of stroke and congestive heart failure in quality of life reduction: a case series with three comparison groups" pot
... Freemantle N, Cleland JGF: The impact of heart failure on health-related quality of life data acquired in the baseline phase of the CARE-HF study European Journal of Heart Failure 2005, 7:243-251 ... heart failure and caregivers) Proportion (%) of abnormal responses in EQ-5D domains of mobility, pain, self-care, anxiety/depression and usual activities between patients with stroke, congestive heart ... Pinto et al.: Differential aspects of stroke and congestive heart failure in quality of life reduction: a case series with three comparison groups Health and Quality of Life Outcomes 2011 9:65 Submit...
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Sudden Death in Patients with Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both pdf
... Flores is director of the Center for the Advancement of Underserved Children and a professor of pediatrics, epidemiology, and health policy at the Medical College of Wisconsin and the Children’s ... Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both On page 2581, lines and 10 in the Results section of the Abstract should have stated that ``83 percent of all patients ... of the graft with maintenance of normal immune function in other respects — will eventually open the door to normal lives and life spans for all transplant recipients Dr Hunt is a professor of...
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báo cáo khoa học: "Patient Care Teams in treatment of diabetes and chronic heart failure in primary care: an observational networks study" pptx
... size of networks, network centralization of medical treatment and advice, degree centrality of health professionals and patients, and in overlap of medical and advice networks Centrality of the ... http://www.implementationscience.com/content/6/1/66 Page of Table Mean and standard deviation of network parameters, and differences between chronic conditions Total Standard deviation Diabetes Chronic heart failure Significance of difference ... delivery and outcomes Size and diversity are the number of involved health professionals and different disciplines A high number of involved health professionals could hinder coordination of care...
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ABC of heart failure History and epidemiology - part 1 potx
... mild heart failure and include patients treated with diuretics who not have heart failure Incidence of heart failure The Framingham data show an age adjusted annual incidence of heart failure of ... studies of the epidemiology of heart failure and left ventricular dysfunction have been conducted, including a study of the incidence of heart failure in one west London district (Hillingdon heart failure ... the Framingham heart study, coronary heart disease accounted for only 46% of cases of heart failure in men and 27% of chronic heart failure cases in women Coronary artery disease and hypertension...
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ABC of heart failure History and epidemiology - part 3 doc
... management of patients with chronic heart failure Although it is clear that some drugs improve symptoms, others offer both symptomatic and prognostic benefits, and the management of heart failure ... with heart failure Lancet 1997;349:747-52 x Remme WJ The treatment of heart failure The Task Force of the Working Group on Heart Failure of the European Society of Cardiology Eur Heart J 1997;18:736-53 ... course of alcoholic cardiomyopathy Ann Intern Med 1974;80:293-7 x The Task Force of the Working Group on Heart Failure of the European Society of Cardiology Guidelines on the treatment of heart failure...
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ABC of heart failure History and epidemiology - part 4 ppt
... cases of acute heart failure Second line drug treatment Chronic heart failure Chronic heart failure can be “compensated” or “decompensated.” In compensated heart failure, symptoms are stable, and ... management of heart failure With improved survival and reduced admission rates (achieved by effective treatment) and a reduction in numbers of hospital beds, the community management of heart failure ... demonstrable abnormality of cardiac function on objective testing A study from Finland reported that only 32% of patients suspected of having heart failure by primary care doctors had definite heart failure...
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Báo cáo y học: " Multiple myeloma presenting with high-output heart failure and improving with anti-angiogenesis therapy: two case reports and a review of the literature" pdf
... of 9.1 g/dl, a platelet count of 105,00 per microliter, a blood urea nitrogen of 13 mg/dl, a creatinine of 1.0 mg/dl, an albumin of 3.9 g/dl, and a calcium of 9.2 mg/dl His ECG demonstrated normal ... for a hemoglobin of 9.1 g/dl, a platelet count of 10,000 per microliter, a blood urea nitrogen of 55 mg/dl, a creatinine of 1.0 mg/ dl, an albumin of 3.6 g/dl, and a calcium of 13 mg/dl The ECG ... traditional heart failure therapies such as beta blockers, ACE inhibitors and diuretics are not useful and may be detrimental As with other causes of high-output failure such as profound anemia,...
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Báo cáo y học: "Direct comparison of serial B-type natriuretic peptide and NT-proBNP levels for prediction of short- and long-term outcome in acute decompensated heart failure" ppt
... acquisition of data, analysis and interpretation of data, and drafting of the manuscript TB contributed to the acquisition of data, the conception and design of the study, and critical revision of the ... al: Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology Eur Heart J 2005, 26:384-416 ... Evaluation and Management of Heart Failure) : developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart...
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Báo cáo y học: "Combination of lung ultrasound (a comet-tail sign) and N-terminal pro-brain natriuretic peptide in differentiating acute heart failure from chronic obstructive pulmonary disease and asthma as cause of acute dyspnea in prehospital emergency
... diagnosis of acute heart failure: the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Acute Heart Failure Score Am Heart J 2006, 151:48-54 19 Hanley JA, McNeil BJ: A method of comparing ... NPV and 100% PPV for differentiating heart failure as the cause of acute dyspnea compared to pulmonary causes in the prehospital setting • Both ultrasound examinations and NT-pro-BNP point -of- care ... heart failure: state of the rat Prehosp Emerg Care 2003, 7:13-23 Remes J, Miettinen H, Reunanen A, Pyörälä K: Validity of clinical diagnosis of heart failure in primary health care Eur Heart J...
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Assessment and quantification of foetal electrocardiography and heart rate variability of normal foetuses from early to late gestational periods 5
... KA Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UKheart) Circulation ... value of heart rate variability in chronic congestive heart failure (Veterans Affairs' Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure) Am J Cardiol 2002; 90(1): 24-8 40 Bland ... G, Potratz J, Wiegand UK, Brandes A, Kluge N, Katus HA Circadian profile of cardiac autonomic nervous modulation in healthy subjects: differing effects of aging and gender on heart rate variability...
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Assessment and quantification of foetal electrocardiography and heart rate variability of normal foetuses from early to late gestational periods 4
... standard deviation of the differences (indicated by the spreading out of Comparison of novel versus commercial HRV softwares 188 Table 11-2: Bland-Altman analysis (mean difference) of time- and ... Comparison of novel versus commercial HRV softwares 181 Figure 11-3: A screen on Nevrokard HRV software showing the HRV power spectrum and calculated VLF, LF and HF power in absolute and normalized ... difference and the mean, and whether the assumption of constant standard deviation of the differences is satisfied When the data points on the Bland-Altman plot spread out as the magnitude of measurements...
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Assessment and quantification of foetal electrocardiography and heart rate variability of normal foetuses from early to late gestational periods 3
... both the normal and ectopic beats and thus gave an accurate measure of the true fHR The case history highlights the usefulness of non-invasive fECG in the determination of foetal heart rate and ... bpm Mean foetal heart rate mNN msec Mean of all NN intervals SDNN msec Standard deviation of all NN intervals rMSSD msec The square root of the mean of the sum of the squares of differences between ... spectra Heart rate variability of healthy foetuses 153 CHAPTER 10 HEART RATE VARIABILITY OF HEALTHY FOETUSES Heart rate variability of healthy foetuses 154 Introduction Evaluation of foetal heart...
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