growth hormone insulin like growth factor i

... Ljunghall S: Circulating levels of insulin- like growth factor- I and -II, and IGF- binding protein-3 in inflammation and after parathyroid hormone infusion Bone Miner 1994, 24:25-31 33 De Benedetti F, ... Alonzi T, Moretta A, Lazzaro D, Costa P, Poli V, Martini A, Ciliberto G, Fattori E: Interleukin causes growth impairment in transgenic mice through a decrease in insulinlike growth factor- I A ... generalized osteoporosis Ann Rheum Dis, in press 28 Heemskerk VH, Daemen MA, Buurman WA: Insulin- like growth factor- 1 (IGF-1) and growth hormone (GH) in immunity and inflammation Cytokine Growth Factor...

Ngày tải lên: 09/08/2014, 01:21

... both in nutrient availability and in cytokine activation are implicated Circulating levels of IGF -I and of the insulin- like growth factor binding protein -I (IGFBP -I) are exquisitely sensitive ... good quality clinical trial data, clinicians may need to turn to basic science investigations to aid decision-making The mechanism by which outcome in critically ill patients might be influenced ... Borkmann M, Tan K, Caterson ID, McWilliam DB: Relationship of somatomedin C /insulin- like growth factor I levels to conventional nutritional indices in critically ill patients Crit Care Med 1987, 15:732-736...

Ngày tải lên: 13/08/2014, 08:20

... Silkmoth IGF -like peptide N Okamoto et al Members of the insulin- like peptide (ILP) family are present in a wide variety of metazoans In vertebrates, insulin and insulin- like growth factors (IGFs) ... putative 20 amino acid signal peptide and a 68 amino acid peptide belonging to the insulin family (Fig 3C) If the signal peptide is eliminated and disulfide bridges are formed as in other insulin ... This article describes the purification and characterization of this peptide, and shows that 8K-BLP is more like IGFs than like insulin 1222 Fig Fluctuation of 8K-BLP in Bombyx hemolymph during...

Ngày tải lên: 18/02/2014, 13:20

... Journal compilation ª 2006 FEBS 3713 Insulin- like growth factor signaling A Fanzani et al A B Fig Neu2 expression is strictly dependent on insulin- like growth factor (IGF-1) signaling (A) C2BP5 ... of insulin- like growth factor I Mol Cell Biol 19, 3115– 3124 James PL, Stewart CE & Rotwein P (1996) Insulin- like growth factor binding protein-5 modulates muscle differentiation through an insulin- like ... Fanzani et al Insulin- like growth factor signaling A B C D E Fig Neu2-induced differentiation is blocked by PI3 kinase and mammalian target of rapamycin (mTOR) inhibitors, and Neu2 overexpression...

Ngày tải lên: 19/02/2014, 06:20

... Jones JI & Clemmons DR (1995) Insulin- like growth factors and their binding proteins: biological actions Endocrinol Rev 16, 3–34 Rechler MM (1993) Insulin- like growth factor binding proteins Vitam ... (N-(R)(2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-l3-(2¢-naphthyl)alaninyl-l-alanine 2-aminoethyl amide; TAPI-1) did not affect the processing A commercially available proteinase inhibitor mixture containing AEBSF, aprotinin and some other inhibitors inhibited ... insulin- binding activity and IGF ⁄ insulin- dependent growth- stimulating activity but acquires high cell adhesion activity by proteolytic cleavage It seems conceivable that matriptase regulates tumor growth...

Ngày tải lên: 19/02/2014, 07:20

... T, Popowiicz GM, Siwanowicz I, Huber R & Holak TA (2006) Structural basis for the inhibition of insulin- like growth factors by insulin- like growth factorbinding proteins Proc Natl Acad Sci USA ... metalloproteinase-7 degrades all insulin- like growth factor binding proteins and facilitates insulin- like growth factor bioavailability Biochem Biophys Res Commun 333, 1011–1016 41 Binoux M, Lalou ... LJ, Skinner CD & Koski KG (2005) Insulin- like growth factor II and binding proteins 15 16 17 18 19 20 21 22 and from second trimester human amniotic fluid are associated with infant birth weight...

Ngày tải lên: 07/03/2014, 00:20

... 0 Time (s) Fig BIAcore analysis of IGF-II and IGF-II analogue binding to highanity recombinant IGF1R Binding of IGF-II (A), des-(1±6)-IGF-II (B) and Arg6-IGF-II (C) to rhIGF1R measured by BIAcore ... Insulin- like growth factor (IGF) -I binding to IGF-binding proteins and IGF receptors is modi®ed by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF-II ... Ling, N & Rosenfeld, R.G (1991) [Leu27] insulin- like growth factor II is highly selective for the type-II IGF receptor in binding, cross-linking and thymidine incorporation experiments Endocrinology...

Ngày tải lên: 08/03/2014, 22:20

... (Fig S1A) so we cannot rule out the possibility of the inhibition of other lipid or pro- Fig IGF-1 induced activation of mTOR signaling is prevented by PI3K inhibitor wortmannin and mTOR inhibitor ... muscle is the insulin like growth factor- 1 (IGF-1) ⁄ insulin- dependent pathway [5,6] Stimulation of muscle cells with growth factors such as IGF-1 leads to the activation of phosphoinositide 3-kinase ... that this step is likely critical for mTOR activation by dissociating the interaction between GAP activity of the TSC1 ⁄ TSC2 complex and Rheb Results and Discussion IGF-1-induced activation of...

Ngày tải lên: 15/03/2014, 11:20

... Hafezian, G Rahimi-Mianji (2010) Association of single nucleotide polymorphisms in IGF -I, IGF-II and IGFBP-II with production traits in breeder hens of Mazandaran native fowls breeding station ... tìm thấy kiểu gen GG, AG cu i AA quần thể nghiên cứu 39 Đa dạng di truyền gen Insulin- like growth factor binding protein gà đa dạng di truyền gen Insulin- like growth factor binding protein gà Bảng ... gi i hạn kiểm tra đánh giá gel agarose nhuộm v i ethium bromide Nồng độ thông số trình chạy i n di thể bảng 37 Đa dạng di truyền gen Insulin- like growth factor binding protein gà đa dạng di...

Ngày tải lên: 24/03/2014, 23:21

... 465-472 Ninh NX, Thissen JP, Collette et al 1996 Zinc supplementation increases growth and circulating insulin- like growth factor I (IGF -I) in Vietnamese growth- retarded children Am J Clin Nutr ... (1998) Continuous administration of growth hormone (GH) does not prevent the decrease of IGF -I gene expressionin zinc-deprived rats despite normalization of liver GH binding Growth Horm & IGF Res ... Serum insulin- like growth factor I/ IGF -I concentrations in Vietnamese pre-school children The study was carried out in 642 pre-school children in order to determine the reference values of serum IGF -I, ...

Ngày tải lên: 25/03/2014, 03:22

... Abbreviations (IGF): Insulin- like Growth Factor; (IGF1R): Insulin- like Growth Factor- 1 receptor; (IGFBP-3): Insulin- like Growth Factor Binding Protein-3; (IGFBP-4): Insulin- like Growth Factor Binding; ... Formelli F: Relationships between plasma insulin- like growth factor- I and insulin- like growth factor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide Clin Cancer ... Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I: IGFBP-4 is an inhibitor of canonical Wnt signaling required...

Ngày tải lên: 18/06/2014, 15:20

... PL, Nanni P, Picci P, Scotlandi K: Inhibition of insulin- like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing’s sarcoma cells Clin Cancer ... Scotlandi K, Benini S, Nanni P, Lollini PL, Nicoletti G, Landuzzi L, Serra M, Manara MC, Picci P, Baldini N: Blockage of insulin- like growth factor- I receptor inhibits the growth of Ewing’s sarcoma in ... National Osteosarcoma Etiology Study Group: Analysis of genes critical for growth regulation identifies Insulin- like Growth Factor Receptor variations with possible functional significance as risk...

Ngày tải lên: 18/06/2014, 16:20

... (Calbiochem-Novabiochem, San Diego, CA) needed for ANT inhibition, the efficiency of Atr was first examined in its classical role, i. e for its ability to inhibit oxidative phosphorylation For analysis, increasing ... deserves particular mention is that IGF-II treatment improved significantly lipid metabolism, diminishing cholesterol and triglycerides and increasing free fatty acids circulating levels [6] Since fatty ... physiological conditions Atr competes with ADP in ANT blocking mitochondrial respiration Full inhibition of the oxygen consumption induced by addition of ADP was obtained in liver mitochondria...

Ngày tải lên: 18/06/2014, 22:20

... diameter; IGF -I, Insulin- like growth factor- I; IGF -I zSDS, SDS of IGF -I levels according to age; IGFBP-1, IGF-binding protein-1; IGFBP-3, IGFbinding protein-3; IGF -I/ IGFBP-3, IGF -I/ IGFBP-3 ratio Table ... mass); IR: (insulin resistance); HS: (hepatic steatosis); GH: (growth hormone) ; IGF -I: (insulin- like growth factor- 1); IGFBP: (IGF binding protein); BMI: (body mass index); HOMA: (homeostasis model ... SDS of IGF -I levels according to age; IGFBP-1, IGF-binding protein-1; IGFBP-3, IGF-binding protein-3; IGF -I/ IGFBP-3, IGF -I/ IGFBP-3 ratio Savastano et al Journal of Translational Medicine 2011,...

Ngày tải lên: 18/06/2014, 22:20

... paracrine growth factor displaying activities in a variety of neuropathologies [24, 25] IGF -I is cleaved within the brain to release an N-terminal tripeptide [26] GPE, like IGF -I, is neuroprotective ... administering both IGF -I and LPS i. c.v [11], i. c.v IGF -I has anti-depression like activity, but not anti-sickness activity against i. p administered LPS 11 IGF -I does not affect preexisting LPS-induced ... Central administration of insulin- like growth factor- I decreases depressive -like behavior and brain cytokine expression in mice J Neuroinflammation 2011, 8:12 Yirmiya R, Pollak Y, Barak O, Avitsur...

Ngày tải lên: 19/06/2014, 22:20

... (Calbiochem-Novabiochem, San Diego, CA) needed for ANT inhibition, the efficiency of Atr was first examined in its classical role, i. e for its ability to inhibit oxidative phosphorylation For analysis, increasing ... deserves particular mention is that IGF-II treatment improved significantly lipid metabolism, diminishing cholesterol and triglycerides and increasing free fatty acids circulating levels [6] Since fatty ... physiological conditions Atr competes with ADP in ANT blocking mitochondrial respiration Full inhibition of the oxygen consumption induced by addition of ADP was obtained in liver mitochondria...

Ngày tải lên: 20/06/2014, 04:20

... diameter; IGF -I, Insulin- like growth factor- I; IGF -I zSDS, SDS of IGF -I levels according to age; IGFBP-1, IGF-binding protein-1; IGFBP-3, IGFbinding protein-3; IGF -I/ IGFBP-3, IGF -I/ IGFBP-3 ratio Table ... mass); IR: (insulin resistance); HS: (hepatic steatosis); GH: (growth hormone) ; IGF -I: (insulin- like growth factor- 1); IGFBP: (IGF binding protein); BMI: (body mass index); HOMA: (homeostasis model ... SDS of IGF -I levels according to age; IGFBP-1, IGF-binding protein-1; IGFBP-3, IGF-binding protein-3; IGF -I/ IGFBP-3, IGF -I/ IGFBP-3 ratio Savastano et al Journal of Translational Medicine 2011,...

Ngày tải lên: 20/06/2014, 04:20

... Insulin- like Growth Factor IGF1R IGF-1 Receptor IGFBP Insulin- Like Growth Factor Binding Protein kDa kilo Dalton LB M i trường Luria-Bertani MCS Multiple Cloning Site PBST Phosphate Buffered Saline ... cạnh hIGF-1 giúp cân chu trình chuyển hoá protein, lipid, carbohydrate nhiều lo i hormone hợp chất sinh học khác Sự thiếu hụt hIGF-1 trẻ gây bệnh IGFD (Insulin- like growth factor deficiency) ... tăng trƣởng hIGF-1 (human Insulin- like growth factor 1) 1.1.1 Gi i thiệu Trong trình tăng trưởng phát triển thể từ giai đoạn thai nhi đến lúc trưởng thành chịu chi ph i nhiều lo i hormone khác...

Ngày tải lên: 25/07/2014, 08:29

... exciting possibility that the screen might have identified a fly IGFBP Indeed, Imp-L2 had previously been shown to bind human IGF -I, IGF-II and insulin in vitro with high affinity [1], but its binding ... evolutionarily conserved function of the Drosophila insulin receptor and insulin- like peptides in growth control Curr Biol 2001, 11:213-221 Mohan S, Baylink DJ: IGF-binding proteins are multifunctional ... of Imp-L2 (Drosophila), Insulin- related peptide binding protein (IBP; S frugiperda), ZIG-4 (C elegans) and IGFBP-rP1 (human) were aligned using ClustalW2 [18] Residues identical or similar in...

Ngày tải lên: 06/08/2014, 18:21

... proteins (IGFBPs), in insulin- like of NBI-31772, a small-molecule inhibitor of the binding of priActivitygrowth rabbit chondrocytes lin -like growth factor (IGF)-1 to IGF-binding proteins (IGFBPs), ... Changes in the local regulation of insulin- like growth factors I and II and insulin- like growth factor- binding proteins in osteoarthritis of the canine stifle joint secondary to cruciate ligament ... 39:968-978 Morales TI: The insulin- like growth factor binding proteins in uncultured human cartilage Increases in insulin- like growth factor binding protein during osteoarthritis Arthritis Rheum 2002,...

Ngày tải lên: 09/08/2014, 01:23