transforming growth factor β in tissue fibrosis

Ngày tải lên: 12/08/2014, 14:20

... Serum concentrations of transforming growth factor- beta1 and ferritin. Results: High concentrations of transforming growth factor- beta1 were noticed in patients suffering from both fatty liver and ... be assessing liver fibrosis in FL patients during a long period of time by using non invasive tools such as fibrosis mark- ers or elastograghy. Conclusion Similar levels of TFβ1 and ferritin in fatty ... TGF -β1 and ferritinFigure 2 Association between serum TGF -β1 and ferritin. TGF -β1 , transforming growth factor- beta1. 100 200 300 400 500 600 700 200 180 160 140 120 100 80 60 40 20 Ferritin ng/mL TGF-ò1...

Ngày tải lên: 18/06/2014, 15:20

... of various transforming growth factor (TGF)-beta signaling molecules in cartilageStaining of various transforming growth factor (TGF)-beta signaling molecules in cartilage. Paraffin sections ... Boumediene K: Mediation of interleukin-1beta- induced transforming growth factor beta1 expression by acti- vator protein 4 transcription factor in primary cultures of bovine articular chondrocytes: ... synthesis, increasing matrix metalloproteinase expression [5], and stimulating nitric oxide production [6]. Transforming growth factor (TGF)-beta is an important ana- bolic factor in OA. It is...

Ngày tải lên: 09/08/2014, 07:20

... catabolic cyto- kines [1]. The aim of this commentary is to place in context a recent article in this journal of anabolic growth factor, trans- forming growth factor- β (TGF -β) signaling in articular ... morphogens and growth factors and catabolic cytokines is at the crux of the problem of osteoarthritis. One such signal is transforming growth factor- β (TGF -β) . The impaired TGF -β signaling has been ... cartilage in aging mice [2]. This commentary will discuss TGF -β signaling and osteoarthritis in an experimental investigation in the mouse. It is important to bear in mind that results obtained in mice...

Ngày tải lên: 09/08/2014, 07:20

... activate TGF -β 1 , a ratio of levels of TGF -β 1 in freshly col- lected blood and after 90 minutes of clotting at 37°C was determined. The degranulation of platelets during clotting results in release ... Mann-Whitney U test. IMT, intima-media thickness; LDL, low-density lipoprotein; SLICC, Systemic Lupus International Collaborating Clinics; TGF, transforming growth factor. Arthritis Research ... latent TGF -β 1 in an in vitro assay that utilizes the physiological activation of latent TGF -β 1 that occurs nor- mally during blood clotting. The activation of TGF -β 1 during clotting is complex,...

Ngày tải lên: 09/08/2014, 08:22

Ngày tải lên: 09/08/2014, 10:20

Ngày tải lên: 09/08/2014, 10:22

Ngày tải lên: 10/08/2014, 05:21

Ngày tải lên: 11/08/2014, 08:21

Ngày tải lên: 11/08/2014, 08:22

Ngày tải lên: 12/08/2014, 11:22

Ngày tải lên: 12/08/2014, 15:23

... 509 The bFGF binding requires speciđc motifs on highly sulfated HS chains. Sodium chlorate, in inducing structural alteration of HS chains, prevents the bFGF binding. Our results indicate that ... type and activating growth factor [50]. In NIH 3T3 đbroblasts, FiRE w as shown to be selectively induced by bFGF whereas in keratinocytes, FiRE was not induced by this growth factor. Whether ... M.A., Hartmann, D.J. & Benhamed, M. (1992) Transforming growth factor b1 inhibits gonadotropin action i n cultured porcine Sertoli cells. Endocrinol. 130, 831±836. 40. Ackland, J.F., Schwartz,...

Ngày tải lên: 21/02/2014, 03:20

... 2009) doi:10.1111/j.1742-4658.2009.07031.x The integrated roles of small GTPases in executing the transforming growth factor b (TGFb) signaling pathway have attracted increasing atten- tion in recent years. In this review, ... disintegrin and metalloprotein- ase) facilitated signaling by inducing the accumulation of TbRII in early endosomal vesicles and counteract- ing the internalization of TbRII into a caveolin1-posi- tive ... containing Eps15 homology (EH) domains. POB1 interacts directly with the EH-containing proteins epsin and eps15, which have been reported to be involved in the regulation of EGF and transferin...

Ngày tải lên: 07/03/2014, 01:20

... the binding of TN. The plasminogen-like growth factors HGF and MSP are very similar to Plg in their domain structure and each of them contains four kringle domains. Prothrombin has two kringle domains ... part in angiogenesis. HGF is a 90-kDa glycoprotein composed of a 60-kDa a chain and a 30-kDa b chain covalently linked by a disulphide bond. The a chain contains an N-terminal heparin-binding ... M. (1998) The plasminogen binding site of the C-type lectin tetranectin is located in the carbohydrate recognition domain, and binding is sensitive to both calcium and lysine. J. Biol. Chem....

Ngày tải lên: 17/03/2014, 03:20

... the cytokines involved in the induction of FXR1 remain un- characterized. The regulation by the anti -in ammatory cytokine transforming growth factor- b1 (TGF-b1) of the proinflammatory cytokine TNF-a ... interleukin; LPS, lipopolysaccharide; MAPK, mitogen-activated protein kinase; Q-PCR, quantitative PCR; RFP, red fluorescent protein; siRNA, small interfering RNA; TGF-b1, transforming growth factor- b1; ... example, in the stabilization of chemokine mRNA. TGF-b1 opposes LPS-induced chemokine stabilization by inhibiting p38 MAPK [33]. To determine whether this signalling pathway was involved in FXR1 induction,...

Ngày tải lên: 22/03/2014, 21:21

... IFN, interferon; IL, interleukin; SBE, Smad-binding element; SeP, selenoprotein P; TGF, transforming growth factor; TGIF, 5 0 -TG-3 0 - interacting factor; TbR, TGF-b receptor; PAI-1, plasminogen ... binding element (SBE) in the JunB promoter that acts as a transforming growth factor- beta, activin, and bone morphogenetic protein- inducible enhancer. J. Biol. Chem. 273, 21145–21152. 17. Vindevoghel, ... m M NaP i ,4mM spermidine, and 3 mg poly(dI : dC). Where indicated, 5 pmol unlabelled probe was included in the binding reaction. Binding was performed for 15 min, at this point 1 mL anti-(Smad-2-,...

Ngày tải lên: 31/03/2014, 23:20

... gel. 13. Incubate gel in Coomassie stain for 15 min at room temperature with shaking. 14. Incubate gel in destain solution changing the solution every 10 min until back- ground staining is removed and ... Three activator protein-1-binding sites bound by the Fra-2-JunD complex cooperate for the regu- lation of murine laminin _3A (lama3A) promoter activity by transforming growth factor- `. J. Biol. ... Smad4/DPC4 and Smad3 mediate transforming growth factor- ` (TGF-`) signaling through direct binding to a novel TGF-`-responsive element in the human plasminogen acitvator inhibi- tor-1 promoter. J....

Ngày tải lên: 11/04/2014, 07:14

... important pathogenic factor in the disease [9-12]. The detection of TGF -β1 and fibrosis in vessels bearing Aβ deposits in human brains [6], together with the β amyloidogenic role of TGF -β1 in mouse models, ... TGF -β1 , transforming growth factor β1 , TZD, thiazolidinedione. Competing interests Gary Landreth received a honorarium for a talk given to Takeda North America in 2003, and received funding from ... JRF/ cAβ40/10 and JRF/cAβ42/26, which specifically recognize the carboxyl-terminals of mouse Aβ40 and Aβ42, respec- tively and JRF/rAβ1-15/2, which binds to the N-terminus of murine Aβ. Applications...

Ngày tải lên: 19/06/2014, 22:20

... hyyoun@snu.ac.kr In vitro and in vivo gene therapy with CMV vector-mediated presumed dog β -nerve growth factor in pyridoxine-induced neuropathy dogs Jin-Young Chung 1 , Jung-Hoon Choi 2 , Il-Seob Shin 1 , ... and gene therapy using recombinant pdβ-NGF plasmid in the dog model, having pyridoxine-induced peripheral neuropathy. Materials and Methods Cloning of the presumed dog β- NGF Genomic DNA was ... presumed dog β -nerve growth factor (pd β -NGF) was generated and cloned and its expression was confirmed in CHO cells. The recombinant pd β -NGF protein reacted with a human β -NGF antibody...

Ngày tải lên: 07/08/2014, 23:22