gram negative bacteria possess sequences which resemble the shared epitope but only proteus infect rheumatoid arthritis patients
Báo cáo y học: "Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis" pptx
... Gregersen PK, Silver J, Winchester RJ: The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis Arthritis Rheum 1987, 30:1205-1213 ... substitutions and risk for development of rheumatoid arthritis Arthritis Rheum 1990, 33:939-941 23 Gorman JD, Criswell LA: The shared epitope and severity of rheumatoid arthritis Rheum Dis Clin North Am ... families, all from the French Caucasian population They proposed that the risk for developing RA depends on whether the RAA sequence occupies positions 72–74 and, if this is the case, on the amino acids...
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Báo cáo y học: "Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-a inhibitor" ppsx
... important RA response measures, which further contributes to the validity of the findings Furthermore, the ACR response rates derived in the current study for patients with no prior exposure ... “sequential therapy” or “therapy interchange,” and rheumatoid arthritis. ” Brand names of biologics were also used for each of the drugs cited above The search was restricted to the English language ... included The sensitivity of the results to this parameter was assessed in the analyses Some studies reported outcomes of multiple switches for the same group of patients, so the same group of patients...
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Báo cáo y học: "Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-a inhibitor" pps
... in six of these eight patients either the anti-dsDNA ELISA or the antinucleosome ELISA also revealed positive test results, none of these sera were positive in the Farr or CLIF assay The Farr ... another test reported a negative test result (Table 2) The Anti-dsDNA-NcX ELISA Biesen et al Arthritis Research & Therapy 2011, 13:R26 http:/ /arthritis- research.com/content/13/1/R26 showed the ... assays other than the Anti-dsDNA-NcX ELISA Surprisingly, and in conflict with current clinical practice, there were some sera that were found to be positive in the CLIF assay but negative in another...
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Chapter 140. Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria (Part 1) pptx
... less common Invasive infection typically occurs in patients with a history of cardiac valvular disease, often in the setting of a recent dental procedure Sixty percent of these patients have been ... in patients with underlying valvular heart disease or with prosthetic valves This organism most frequently affects the aortic valve Many patients have signs and symptoms of long-standing infection ... has been isolated from patients with brain abscess, meningitis, endophthalmitis, parotitis, osteomyelitis, urinary tract infection, pneumonia, and empyema, among other infections Cardiobacterium...
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Chapter 140. Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria (Part 2) ppsx
... prosthetic-valve endocarditis requires weeks of therapy The cure rates for HACEK prosthetic-valve endocarditis appear to be high Unlike prosthetic-valve endocarditis caused by other gram- negative ... added, but its value has not been proven The organism is usually pansensitive, but high-level penicillin resistance has been reported Eikenella corrodens Ampicilli n (2 g q4h) Ceftriaxone (2 The ... kingae Ceftriaxo Fluoroquinolonesb The ne (2 g/d) or prevalence ampicillin (3 g β-lactamase- q6h) producing strains of is increasing Efficacy for invasive infections is best demonstrated for...
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Chapter 140. Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria (Part 3) pot
... by a rim of erythema with central necrosis and ulceration) resembling the lesions seen in Pseudomonas aeruginosa infection Aeromonas causes nosocomial infections related to catheters, surgical ... well, usually as part of a polymicrobial infection C canimorsus and C cynodegmi are endogenous to the canine mouth (Chap e14) Patients infected with these species frequently have a history of ... neutropenic patients with hematologic malignancy, and probably play a role in localized juvenile periodontitis in the immunocompetent host These species have been isolated from many other sites...
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Chapter 140. Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria (Part 4) docx
... with infection in the presence of medical devices, including intravascular catheter– related infections, prosthetic-joint and prosthetic-valve infections, and peritonitis caused by dialysis catheters ... most commonly in immunocompromised hosts Ochrobactrum anthropi causes infections related to central venous catheters in compromised hosts; other invasive infections have been described Other organisms ... putrefaciens The reader is advised to consult subspecialty texts and references for further guidance on these organisms Further Readings Brouqui P, Raoult D: Endocarditis due to rare and fastidious bacteria...
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Báo cáo y học: "Dextran sulfate sodium and 2,4,6-trinitrobenzene sulfonic acid induce lipid peroxidation by the proliferation of intestinal gram-negative bacteria in mice" doc
... mice These gram- negative bacteria, Proteus mirabilis, E coli and K pneumoniae, produces endotoxin, which activates TLR-4-linked NF-kB Treatment with DSS or TNBS increased the number of gram- negative ... knockout C3H/HeJ mice was prepared according to the above protocols These mice were anesthetized with ether and then sacrificed on the rd and 7th day after the administration of TNBS and DSS, respectively ... thought that the disease might be attributed to complex mucosal immune responses to resident enteric bacteria[ 30,31] The innate immune system recognizes the presence of specific bacterial antigens...
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Báo cáo y học: "Aerosolized colistin for the treatment of nosocomial pneumonia due to multidrug-resistant Gram-negative bacteria in patients without cystic fibrosis" ppt
... susceptibility of the pathogen(s) to commonly tested antimicrobial agents, as well as the outcome of the infection and of the patient R56 The mean age of the patients was 59.6 years and most of them were ... rates among Gramnegative bacteria, especially in the ICU setting, and the absence of new and effective alternative therapeutic options [16-18] The idea of using colistin or polymyxin B (which belongs ... receive the intravenous therapy after the end of aerosolized therapy (for 32 days) The pneumonia was observed to respond to treatment in seven out of eight patients who received supplemental therapy...
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Báo cáo y học: "Aerosolized colistin for the treatment of nosocomial pneumonia due to multidrug-resistant Gram-negative bacteria in patients without cystic fibrosi" pdf
... the ‘therapy of no choice’, in particular where resistance to carbapenems (the therapy of choice) and other classes of antimicrobials is identified It has become evident over the years that the ... agents and the development of novel antibiotics, the prevention of multidrugresistant Gram- negative pneumonia in hospitals is of great importance Strategies include elevation of the head of the bed, ... attained in four of the five patients for whom follow-up cultures were available (in 50% of the patients who received nebulized colistin) Microbiological outcomes for the remaining three patients are...
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Inactivation of gram negative bacteria by low pressure RF remote plasma excited in n2 o2 mixture and SF6 gases
... the field of bacteria disinfection Acknowledgment The authors would like to thank the Director General of AECS, the Head of the Physics Department, the Head of the Chemistry Department, and the ... eliminate all the different kinds of microorganisms except E coli O157, which was decreased only to 2×102 CFU/ml According to these results, the best conditions were 4.5 cm distance from the source, ... Figure shows the effect of SF6 plasma on all the previously mentioned microorganisms, using 96-well plates Total inactivation of all the tested bacteria was seen only minutes after the application...
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Báo cáo y học: "Vacuum-assisted closure device in intensive care unit patients and dissemination of Gram-negative bacteria" pptx
... http://ccforum.com/content/14/2/413 In the report of Papanikolaou and colleagues, we understand that patients developed fistulas before VAC applications and not as a result of their use In cases like these, the optimal ... treatment might be firstly the surgical treatment of the fistula, followed by VAC therapy Indeed, VAC devices can be used to prevent intestinal fistula formation [2], but to the best of our knowledge, ... experience [1], the presence of bacterial colonization was routinely monitored by serial control of the peritoneal fluid drained, and we did not find any microbiological complication The complication...
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Summary MULTIDRUG RESISTANT GRAM NEGATIVE ORGANISMS EPIDEMIOLOGY AND OUTCOMES IN THE ICU
... Multidrug-resistant Gram- negative Infection Gram- negative clinical isolates Nosocomial Gram- negative infection Nosocomial susceptible Gram- negative bacilli infection Nosocomial multidrug-resistant Gram negative ... Amongst the patients with SIRS, 183(7.7%) patients acquired nosocomial multidrug-resistant Gram- negative bacilli infection in the hospital and of these, 76(41.5%) were acquired in the ICU viii The ... appropriate antibiotic therapy Multidrug-resistant Gram- negative bacilli infection Multidrug-resistant Gram- negative 47 47 iv 48 50 53 54 54 bacilli bacteremia Multidrug-resistant Gram- negative bacilli...
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Báo cáo y học: "B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgRIIb, which are modulated by anti-tumor necrosis factor therapy" potx
... cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgRIIb, which are modulated by anti-tumor necrosis factor therapy Arthritis Research & Therapy ... contributions DC participated in the design of the study, carried out the acquisition and analysis of data, and drafted the manuscript OA participated in B-cell Catalán et al Arthritis Research & Therapy ... mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCPnegative patients and for monitoring infliximab therapy Arthritis Res Ther 2008, 10:R142 Page 11 of 11 doi:10.1186/ar2985...
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báo cáo hóa học: " The health-related quality of life in rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis: a comparison with a selected sample of healthy people" potx
... difference scores (the s-score or normal score) were also calculated by subtracting the mean scores of the patients from the mean scores of the general population, followed by the division of these deviations ... questionnaire to maximise the response rate The patients were instructed to complete all the questionnaires at home and to return them in a prepaid envelope To increase the response rate the nonresponders ... respect to the general population The age and sex distributions of the patients with RA and PsA and those with AS are significantly different (p < 0.001) Slightly more than one quarter of the patients...
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Báo cáo y học: "The value of sensitive imaging modalities in rheumatoid arthritis pdf
... has yet to be standardised, and the quality of the examination is highly dependent upon the skill of the operator and the use of optimal equipment Furthermore, there are potential problems with ... However, the image quality, and therefore interpretation, will depend on a number of technical factors including the magnet strength, the use of dedicated coils and the choice of MRI sequences ... Pease C, Green MJ, Veale DJ, Isaacs JD, Emery P: The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis Arthritis Rheum 2000, 43: 2762-2770 Grassi W, Filippucci...
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Báo cáo y học: "Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction" potx
... intensity The CT value of the βactin message was used as an internal standard When the target messages were detected in both the control samples and the OA or RA samples by RT-PCR, the ratio for the ... not uniformly decreased in the knee synovium of OA or RA patients, even though the patients were significantly older than the control donors Hence, it is unclear whether the different expression ... simultaneously for the messages of both target gene and β-actin gene in the same sample tube when the intensity of the reporter fluorescent signal reached 10 times the standard deviation of the baseline...
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Báo cáo y học: "Association between the TNFRII 196R allele and diagnosis of rheumatoid arthritis" potx
... sequence referred to as the shared epitope [8] The predictive value of the shared epitope alleles for diagnosis of RA was studied in a cohort of 680 patients with early unclassified arthritis and was ... differentiate rheumatoid arthritis from undifferentiated polyarthritis in patients with early arthritis J Rheumatol 2002, 29:2074-2076 Gregersen PK, Silver J, Winchester RJ: The shared epitope hypothesis ... 0.012), their combination did not improve upon the diagnostic accuracy of the TNFRII 196R allele alone R1060 Arthritis Research & Therapy Vol No Goëb et al We also tested the hypothesis that there...
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Báo cáo y học: "DAS28 best reflects the physician''''s clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment" potx
... variable Not only the discriminant scores, but also the coefficients of this discriminant function were quite similar to the coefficients of the DAS28, indicating the robustness of the scores and ... were performed for the other variables The AUC of the differences between weeks 0–22, weeks 6–22 and weeks 14–22 of the other variables were all less than 0.700 (data not shown) These analyses indicate ... built the final model to discriminate the rheumatologist's decision, which was only slightly better than the DAS28 We think that the small gain in discriminative properties in comparison with the...
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Báo cáo y học: "Reshaping Cinderella’s slipper: the shared epitope hypothesis" docx
... Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis Arthritis Res Ther 2006, 8:R79 Gregersen P, Silver J, Winchester R: The shared epitope hypothesis: An approach ... supports the shared epitope hypothesis of rheumatoid arthritis susceptibility Arthritis Rheum 2005, 52:1063-1068 Gorman JD, David-Vaudey E, Pai M, Lum RF, Criswell LA: Particular HLA-DRB1 shared epitope ... Yakima Indians Further evidence for the "shared epitope" hypothesis Arthritis Rheum 1991, 34:43-47 Winchester R: The molecular basis of susceptibility to rheumatoid arthritis Adv Immunol 1994, 56:389-466...
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