... that the prevalence of diagnosed COPD, the number of deaths, and the associated health costs will increase during the next decade In addition to the social strain, COPD also influences thepatients' ... status in this group ofpatients is relevant for the treatment of COPD, and for the care and rehabilitation ofpatients To this end, the aim ofthe present study was to explore the determinants of ... the members ofthe staff at the learning and coping centre at Haugesund Hospital for assisting the recruitment of COPD patients References 10 11 Competing interests The authors declare that they...
... of PFS times with origin at month in groups ofpatientswith and without 5% decline in VC at month Solid line with closed circle: No decline in VC at month 3; broken line with plus: a ≥ decline ... ofthe PFS times with origin at month for patientswith and without 5% decline of VC at month 3, added the result of log-rank test, is shown in Figure There was no significant difference inthe ... reviewed the efficacy of pirfenidone inthe phase III trial in an exploratory manner using a 5% change in VC as indices, evaluated the coincidence ofthe ratings based on 5% change in VC between...
... including stress urinary incontinence (SUI), urge incontinence, mixed incontinence, neurogenic incontinence, functional incontinence or overflow incontinence [8] This study is restricted to patients ... items), there are subscales for the domains of physical well-being, social well-being, emotional well-being and functional well-being Incontinence Quality of Life Instrument (I-QOL) The Incontinence ... characteristics Within the study time frame of one year a number of 67 patients met inclusion criteria and were therefore eligible for participation inthe study All of them (100%) signed informed consent Of...
... linear regression analysis where the instrument of interest is the dependent and the anchors the independent variable Using the equation one can estimate the minimal important difference ofthe ... manuscript MF participated inthe design ofthe study, collection ofthe data and revised the manuscript SB revised the manuscript HJS participated inthe design ofthe study, performed the statistical ... 0.5.[23] Using the regression equation and the minimal important difference ofthe anchors (0.5 points for the CRQ[15] and points for the FT[23]) we estimated the minimal important difference of the...
... highlighted by the results ofthe VAS rating and the absence of dropouts associated to intolerance to treatment The increase inthe motor FIM™ and the decrease on the VAS for the pain might be due ... encountered by their relatives in reaching the hospital Stability inthepatients performance prior to the start ofthe rehabilitative treatment, supported by the nonstatistical difference of scores ... implementation of different protocols according to the severity ofthe impairment should also be considered The results obtained in terms of recovery in functionality and the restriction of participation,...
... Monitoring and investigation ofthe patients, study coordination MR: Monitoring and investigation ofthe patients, study coordination JS: Investigator, writing ofthe manuscript JB: Idea, writing of ... ofpatients may, rather, need continuous anti-TNF therapy Another finding is that even though there were relapses eventually, in many patientsthe low disease activity at discontinuation of therapy ... duration of response to the initial treatment Ofthe 42 patients, 10 had to be retreated within 12 weeks after discontinuation of infliximab infusions, 37 within 24 weeks, and 38 within 36 weeks...
... if they deemed it necessary for their patients After enrollment, however, specific clinical interventions were not mandated other than the initiation of RLAT at the beginning ofthe study; therefore, ... RLAT inthe injection log within 28 days prior to the visit Because RLAT steady -state plasma concentrations are maintained at a minimum of weeks after the last injection [14], the 28-day interval ... lack of adherence to previous therapy (48.1%) RLAT was initiated at a dose of 25 mg in 75% ofpatients and at either 37.5 mg (13%) or 50 mg (11%) inthe remaining patients Health status The mean...
... especially FMD, together withthe circulating endothelial cell markers, soluble TM and vWFAg, reflecting thestateof activation/ damage ofthe endothelium Finally, we investigated the relationship ... therapy of CS and methotrexate, while seven patients received CS therapy alone The protocol was in full compliance withthe Good Clinical Practices, the Declaration of Helsinki, and the guidelines of ... line(upper layer ofthe adventitia) inthe far (deeper) artery wall All measurements were performed at the end ofthe heart cycle, when the transducerwas inthe mediolateral direction [31] Offline...
... role inthe pathogenesis of COPD [5] and given the increased expression of IL-17 in certain autoimmune diseases [10], this further raises the possibility of its involvement inthe pathogenesis of ... as the number of positive cells/mm The number of cells was corrected for the total number of cells by counting the number of nuclei inthe submucosa The positive staining area of IL-17F in airway ... process in COPD may resemble that in other disorders where Tc17 cells are active These findings contribute to the growing body of information that supports the importance of investigating the role of...
... marker ofdisease severity, was the key covariate The impact of baseline FEV on the dose response inthe absence of any model-based interpretation is shown in figure The figure shows the individual ... largely independent ofdisease severity Finally, it is instructive to place the findings of this analysis inthe context ofthe GOLD classification of COPD severity [19] For this purpose, patients ... 6), the similar outcomes from the two analyses reinforce the overall conclusions while providing further insights into the impact of patient characteristics on dose response The key finding of the...
... and planning ofthe meta analysis and in writing and editing the manuscript; PW and MW were involved inthe writing and editing ofthe manuscript and responsible for the searches ofthe databases ... proportion of subjects achieving a clinically significant improvement in health status (4-point or more decrease from baseline inthe total score for the SGRQ; 10-point or greater increase in total ... relevant, including standard deviations (SD) Results Study characteristics Table summarises the nine studies included inthe metaanalysis, together withthe main eligibility criteria The study...
... contains the cough event Cough is indicated by a single solid line at the end ofthe breath that contains the cough Note the change inthe posture from supine to upright to supine immediately following ... abnormalities ofthe upper respiratory tract, and/or (2) if patients were using prescribed or over the counter anti-tussive medications within 24-hours ofthe start ofthe study The protocol was ... during the adjudication process if there was uncertainty with respect to the occurrence of a cough Scoring the video in duplicate was an arduous task which likely increased the possibility of...
... this distinction undermines the clinical utility of either surrogate of high V/Q All clinical estimates ofthe gas exchange function ofthe injured lungs are subject to major simplifying assumptions, ... emerging need for a new or expanded definition of ARDS as the definition includes a heterogeneous population, thus creating noise and hampering therapeutic advances inthe field In addition to the ... of their disease and the utility of findings restricted to patients without hemodynamic and respiratory instability or high levels of FiO2 would be questionable Even withthe limitations of both...
... patients is the decrease inthe excretion of erythropoietin (EPO) inthe kidneys The invention of recombinant human erythropoietin (Rhu EPO) has opened a turning-point inthe treatment of anemia ... and TSAT inthe subjects of study 3.2.1 The features of serum EPO inthe subjects of study Table 3.5 The comparision ofthe average of EPO levels inthe subjects of study The subjects of study ... iron status ofpatients without iron supplementation through serum ferritin and TSAT inpatients after the first months of chronic hemodialysis Structure ofthe thesis: The thesis includes 121...
... solvation, owing to increased water-binding capacity This may allow the protein to remain in a hydrated state, preventing the binding of inorganic cations inthe high-salt solution, and also preventing ... between the two enzymes can be seen inthe manner of Fig Comparison ofthe binding modes ofthe ligands The structures of B subtilis GGT and B anthracis CapD (Protein Data Bank ID: 3G9K) are shown in ... ofthe ligands Moreover, in GGT the a-carboxyl group ofthe glutamate protrudes into the groove, whereas in CapD the corresponding c-carboxyl group ofthe dipeptide analog is skewed towards the...
... According to the preoperative planning the maxilla was placed inthe new advanced position and then fixed with microplates (figure 4) placement is ineffective for bone mass maintenance inthe long ... a method of Le Fort I osteotomy in combination with simultanously bone grafting inthe anterior and posterior maxilla and placement of endosseous implants for treatment ofpatientswith atrophied ... relationship amongst others due to the cleft palate Minor degree maxillary alveolar atrophy was found inthe anterior maxilla because ofthe still remaining teeth there The first step of our treatment...
... elevated inthe bronchoalveolar lavage fluid ofpatientswith CF Matrix metalloproteinases, implicated in remodeling of inflamed areas ofthe lung, are found in excess inthe lungs ofpatientswith ... diphtheria toxin Exotoxin A catalyzes the transfer ofthe ADP-ribosyl moiety of nicotinamide adenine dinucleotide onto elongation factor 2, which then is inactive in protein synthesis Exotoxin ... surface binding of bacteria is not quantitatively important inthe establishment of infection, it may be important for the initiation of an exuberant inflammatory response [33] The binding of pilin...
... peptide sequence The M13 binding results in shortening ofthe linker, bringing CFP within FRET distance of YFP and changing the emission wavelength from cyan to yellow The Ca2+ binding affinity was ... permutation is the repositioning ofthe N and C-termini ofthe protein to different regions ofthe sequence, connecting the original termini with a flexible peptide linker to pro‐ duce a continuous, ... barrel (step 3) The posi‐ StateoftheArtin Biosensors - General Aspects tioning of side chains surrounding the chromophore is crucial for stabilizing the intermediates inthe process of chromophore...