genetics of ischemic stroke emphasis on candidate gene association studies
Advances in the Treatment of Ischemic Stroke Edited by Maurizio Balestrino docx
... reduction of metabolic rate, promotion of energy recovery after ischemia, inhibition of glutamate release, inhibition of cell death pathways, inhibition of free radical formation, inhibition of inflammation, ... inflammation, preservation of the BBB, stimulation of neurotrophin expression, and numerous effects on molecular responses to ischemia (e.g., inhibition of AMPK and MAPK activation, inhibition of SMAC/Diablo, ... with reductions in zinc ion release/translocation, generation of ROS, and activation of microglia Maier et al (2002) reported that intra -ischemic hypothermia (33°C/2h) reduced production of the superoxide...
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Báo cáo hóa học: " The effects of hypertonic fluid administration on the gene expression of inflammatory mediators in circulating leucocytes in patients with septic shock: a preliminary study" pptx
... magnitude of plasma volume expansion, dilution of hemoglobin (Hb) concentration was assessed hour after the fluid administration Laboratory protocol One milliliter of blood was added to ml of M guanidine ... Haren has no conflicts of interest to disclose Dr Pickkers has no conflicts of interest to disclose Mr Cursons has no conflicts of interest to disclose Prof Sleigh has no conflicts of interest ... limitations Septic shock patients are not a homogenous population, and the expression of inflammatory mediators is highly variable and not only dependent on the source of sepsis but also on the genetic...
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ADVANCES IN THE TREATMENT OF ISCHEMIC STROKE pptx
... reduction of metabolic rate, promotion of energy recovery after ischemia, inhibition of glutamate release, inhibition of cell death pathways, inhibition of free radical formation, inhibition of inflammation, ... inflammation, preservation of the BBB, stimulation of neurotrophin expression, and numerous effects on molecular responses to ischemia (e.g., inhibition of AMPK and MAPK activation, inhibition of SMAC/Diablo, ... with reductions in zinc ion release/translocation, generation of ROS, and activation of microglia Maier et al (2002) reported that intra -ischemic hypothermia (33°C/2h) reduced production of the superoxide...
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ADVANCES IN THE PRECLINICAL STUDY OF ISCHEMIC STROKE pdf
... antiproliferative effect Inhibiton of VEGF Inhibiton of laser-induced choroidal neovascularization Inhibition of COX-2 expression and adhesion of monocytes Inhibition of superoxide anion-mediated impairment ... neuronal apoptosis in the SHRSP/Izm rats Ischemic Neurodegeneration in Stroke- Prone Spontaneously Hypertensive Rats and Its Prevention with Antioxidants Such as Polyphenols 2.3 Gene expression of ... Inhibition of VEGF-induced angiogenesis Protection against peroxynitrite-mediated endothelial cell death Attenuation of TNF alpha-induced activation; inhibition of NF-kappaB Inhibition of MCP-1...
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Báo cáo khoa học: " Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical and histopathological findings" docx
... lesions were confirmed by histopathologic examinations In conclusion, we have developed a canine model of ischemic stroke that has a resemblance to real stroke patients However, additional studies ... model of ischemic stroke 375 had a relatively small lesion on the occipital lobe related to vision and the cerebrum Even though ID had the second largest lesion, the reduced level of consciousness ... Neurobehavioral score Motor function day week weeks month months Consciousness day week weeks month months Head turning day week weeks month months Identification (ID) number 1 1 2 1 1 1 2 1 2...
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Báo cáo khoa học: "Bench-to-bedside review: Genetics and proteomics: deciphering gene association studies in critical illness" pps
... the impact of population stratification on genetic association studies Nat Genet 2004, 36:388-393 39 Cardon LR, Palmer LJ: Population stratification and spurious allelic association Lancet 2003, ... three genes of interest on chromosome 2q The associations between these three genes and chronic obstructive pulmonary disease were tested using family based design, and the association with one of ... In contrast to linkage analysis, association studies detect association between genetic variants and disease across individuals in large populations Most association studies are population based,...
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Báo cáo y học: "Use of a multi-virus array for the study of human viral and retroviral pathogens: gene expression studies and ChIP-chip analysis" pot
... However, many of the applications we envision will require determination of RNA expression levels To demonstrate this capability, we focused on the expression of HHV-6B, HIV-1, and KSHV genes from ... citation purposes) Retrovirology 2004, http://www.retrovirology.com/content/1/1/10 Figure of Analysis viral gene expression Analysis of viral gene expression (A) HHV-6B gene expression Only the ... particular spot corresponding to that amplicon We obtained amplicons for 254 genes in the first generation of the chip and 264 in the second generation, with failed amplifications giving either no...
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Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients potx
... the involvement of genetic components in the pathogenesis of ischemic stroke [31] Ischemic stroke shares many common risk factors with other vascular disease, such as hypertension, diabetes, hyperlipidemia ... interaction of the HO-1 genotype and above risk factors on ischemic stroke Methods Participants A total of 183 consecutively hospitalized first-ever ischemic stroke (IS) inpatients and 164 non -stroke ... In summary of our findings, the protective effect of HO-1 genotype on ischemic stroke depended on the presence of lipid conditions, that is, the levels of HDL-C, it may explain the controversial...
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Parkinson’s disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons ppsx
... SNpc neurons, expression of genes within this neuronal population seems to be a suitable criterion for narrowing down the number of genes to be further analyzed for identification of PD genes to ... 610297 for PARK1-13 Of 199 genes, the cytogenetic locations of 20 overlapped with that of PARK loci, which were labeled PD candidate genes One of these genes, UCHL1, is a known PD gene, and were within ... identification of genes, which may be the risk factors or responsible for the onset or progression of the disease Recently, we identified the expression pattern of the genes within two major nuclei of...
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báo cáo khoa học:" Health-Related Quality of Life after Ischemic Stroke: The Impact of Pharmaceutical Interventions on Drug Therapy (Pharmaceutical Care Concept)" docx
... substantial contributions to conception and design, acquisition of data, analysis and interpretation of data RR, and JMK have made substantial contributions to conception and design All authors have ... Quality of life among stroke survivors evaluated year after stroke: Experience of a stroke unit Stroke 2000, 31:2995-3000 de Haan R: Measuring quality of life after stroke using the SF-36 Stroke ... education and care of patients after ischemic stroke by dedi- Hohmann et al Health and Quality of Life Outcomes 2010, 8:59 http://www.hqlo.com/content/8/1/59 Page of cated pharmacists based on a concept...
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Báo cáo y học: " Effect of erythropoietin on level of circulating endothelial progenitor cells and outcome in patients after acute ischemic stroke" ppsx
... experimental studies [36] including the enhancement of mobilization of EPCs to circulation, attenuation of inflammatory response and cellular apoptosis, and reduction in oxidative stress [24,37-40], only ... observational studies [19,20,41] are too inconsistent to reach a significant conclusion In the current study, we found an association between EPO therapy and reduction of the incidence of 90-day ... based on our recent report [24] Definition and exclusion criteria Stroke was defined as sudden onset of loss of global or focal cerebral function persisting for more than 24 h Patients of any...
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Báo cáo y học: "Effect of erythropoietin therapy on clinical outcome in patients after acute ischemic stroke: a debatable issue" doc
... Niaosong District, Kaohsiung City, 833, Taiwan 2Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, ... C; EPO Stroke Trial Group: Recombinant human erythropoietin in the treatment of acute ischemic stroke Stroke 2009, 40:e647-656 Minnerup J, Wersching H, Schäbitz W: Erythropoietin for stroke treatment: ... Chang WN: Effect of erythropoietin on level of circulating endothelial progenitor cells and outcome in patients after acute ischemic stroke Crit Care 2011, 15:R40 Tseng MY, Hutchinson PJ, Richards...
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Báo cáo y học: "Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome"
... prevention of stroke in patients with ischemic stroke or transient ischemic attack A statement for healthcare professionals from the American Heart Association/ America Stroke Association Council in Stroke ... prevention of stroke in patients with ischemic stroke or transient ischemic attack and with antiphospholipid antibodies (aPL), antiplatelet therapy is reasonable for cases of cryptogenic ischemic stroke ... Methods We focused on the secondary prevention of stroke with APS, and compared single antiplatelet therapy and a combination of antiplatelet and anticoagulation therapy in ischemic stroke patients...
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Tài liệu Insight into Alternative Approaches for Control of Avian Influenza in Poultry, with Emphasis on Highly Pathogenic H5N1 doc
... expression of the transgene from generation to generation require extensive studies Regulatory approval, mass production, costs and marketing of commercial AIV resistant pedigree lines, consumer ... subtypes including HPAIV H5N1 [241–244] Additional genetic candidates that contribute to inhibition of AIV replication could be useful in creation of genetically modified chickens such as cyclophilin ... [4] Constant genetic and antigenic variation of AIV is an intriguing feature for continuous evolution of the virus in nature [5] Gradual antigenic changes due to acquisition of point mutations...
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Tài liệu Overview on Poultry Sector and HPAI Situation for Indonesia with Special Emphasis on the Island of Java - Background Paper doc
... of the NAQS contribution to the HPAI campaign should be conducted as soon as possible to ensure that this contribution is optimised o Vaccination of kampong chickens, magnitude and duration of ... and one or two contributing components Non-vertical integration (D-Type) has only one primary component and only one or two contributing components 10 Africa/Indonesia Team Working Paper Table ... millionston/year 1.2 million ton/year 1.6 million ton/year NA NA 120 ton/years 120 tons/years NA NA Charoen Phokphand 337,44 millions DOC 58,150 millions/years Japfa Comfeed All others NA Wonokoyo...
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Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression docx
... expression of a protein(s) required for induction of the Timp-1 gene Time course of TSA action upon PMA- and TGF-b1-induced Timp-1 expression The time course of induction of Timp-1 gene expression ... effect on basal expression of Timp-1, only on induced gene expression In conclusion, this is to our knowledge, the only described instance of HDAC inhibitors having opposite effects on the same gene, ... modification of histones, via acetylation, methylation and phosphorylation [15–18] Acetylation by histone acetyltransferases (HATs) occurs on specific lysine residues on the N-terminal tails of histone...
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A REVIEW OF MILK PRODUCTION IN INDIA WITH PARTICULAR EMPHASIS ON SMALL-SCALE PRODUCERS pdf
... combination of production (physical data) and accounting (economic data) TIPI-CAL also consists of both a structure of costs of production and a simulation component (without optimisation) The ... the inclusion of these farm types provides a valuable picture of the effects of economies of scale and location on Haryana dairy farm types Explanations of variables; year and sources of data: ... International Farm Comparison Network (IFCN) and utilises the concept of typical farms Farm types are determined on the basis of the knowledge of regional dairy experts One farm ‘type’ of each region...
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Báo cáo khoa học: Effect of ecdysone receptor gene switch ligands on endogenous gene expression in 293 cells docx
... the effect of dimethylsulfoxide itself on the expression of genes in 293 cells The expressions of a total of 43 genes were modulated with P £ 0.01 with a two-fold change in expression Among the ... Optimization of a-acylaminoketone ecdysone agonists for control of gene expression Bioorg Med Chem Lett 13, 1883–1886 Tice CM, Michelotti EL & Hormann RE (2004) Ketone ligands for ecdysterone receptors ... showed a total of 566 up-regulated genes and 398 down-regulated genes (Fig 8A) Among these, only 38 genes showed P £ 0.01 and two-fold or greater induction (Table 1) Only three of these genes showed...
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Báo cáo sinh học: "Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pot
... Love BB, Gordon DL, Marsh EE: Classification of subtype of acute ischemic stroke Definitions for use in a multicenter clinical trial Toast Trial of org 10172 in acute stroke treatment Stroke 1993, ... approaches for ischemic stroke This and future studies could contribute to better molecular characterization of the deleterious consequences of thrombolytic therapy, and lead to the development of effective ... neurons from NMDA-induced neuronal Rodríguez-González et al Journal of Translational Medicine 2011, 9:58 http://www.translational-medicine.com/content/9/1/58 Page of Figure Significant correlations...
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Báo cáo sinh học: "Combination of cyclosporine and erythropoietin improves brain infarct size and neurological function in rats after ischemic stroke" potx
... reaction, and ROS generation [16,23,30,31] Additionally, inflammatory components of the ischemic cascades further perpetuate cellular apoptosis and necrosis in ischemic region [15,16,22,23,30-33] One ... 4B) On the other hand, the protein expression of NOX-2 did not differ among the groups (Figure 4C) In contrast, the protein expression of endothelial NOS (eNOS), in index of anti-inflammation, ... expression of Bax (Figure Yuen et al Journal of Translational Medicine 2011, 9:141 http://www.translational-medicine.com/content/9/1/141 Page of 14 Figure Ratios of infarct area to total coronal...
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