function of glial cells

Ngày tải lên: 28/06/2014, 15:20

Ngày tải lên: 07/03/2014, 21:20

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Ngày tải lên: 19/06/2014, 22:20

Ngày tải lên: 03/01/2014, 19:44

... recruitment of MOF to recently transcribed regions, especially at the 3¢ ends of genes where H3-K36me3 is enriched [128]. In mammalian cells MOF also exists as part of a sepa- rate MOF–MSLv1 complex ... posi- tions of regulatory elements required for function in either T cells or mast cells. Shown below are the positions that nucleo- somes and GATA-2 occupy in unstimulated T cells and mast cells [85]. Active ... cells depletion of MOF, but not Tip60, results in reduced global levels of AcH4-K16 and defective DNA damage response [131]. In mouse embryos, MOF is essential for AcH4-K16, and loss of MOF results...

Ngày tải lên: 14/02/2014, 18:20

... absence of B lymphocytes and plasma cells and very low levels of immunoglobu- lins of all classes. Humoral immune responses are essentially nonexistent. T cells are not affected, but myeloid cells ... family of cytoplasmic enzymes that are important for several aspects of leu- kocyte biology. Both loss- and gain -of -function muta- tions in humans have been instrumental in our understanding of their ... total protein level, of BTK–SYK was less than that of ITK– SYK in 293T relative to COS7 cells. 293T cells express endogenous SYK, but we do not know whether this kinase influences the behavior of the fusion...

Ngày tải lên: 14/02/2014, 18:20

... the inhibition of CYP activity observed in the absence of changes in protein expression in rabbit he- patocytes [22]. ROS indirectly reduced the activity of selected isoforms of CYP by inducing ... recognition of pathogen invasion and a facili- tation of the body’s subsequent immune responses [27]. The stimulation of these receptors activates inflamma- tory responses characterized by the release of ... drug-metabolizing dysfunction during sepsis T H. Kim et al. 2312 FEBS Journal 278 (2011) 2307–2317 ª 2011 The Authors Journal compilation ª 2011 FEBS Role of Kupffer cells in pathogenesis of sepsis-induced drug...

Ngày tải lên: 14/02/2014, 18:20

... full-length v-KIND; DKIND1, deletion of KIND1; DKIND2, deletion of KIND2; DKIND1 + 2, deletion of both KIND1 and KIND2; DRasN, deletion of RasN; DGEF, deletion of RasGEF; KIND1, KIND1 domain; KIND2, KIND2 ... pull- down assay of combinations of EGFP-fused KIND1 or KIND2 of v-KIND with GST-fused CD2-1-6-1 or CD2-1-6-2 of MAP2. We successfully detected a pull down for the combination of EGFP-KIND2 and GST-CD2-1-6-2, ... α -MAP2 kDa 50 37 25 CBB A B Fig. 2. Of all members of the KIND family of proteins, only KIND2 binds to MAP2. Pull-down assay (PD) of the endogenous MAP2 from cerebellar lysates of P21 mice (A, left) and...

Ngày tải lên: 14/02/2014, 19:20

... cells to well differentiated cells. Some cancers are almost completely composed of undifferentiated cells that are biochemically similar to embryonic cells because of increased expression of ... properties of cancer cells part 1 • Some of the characteristic features of cancerous cells that affect their electrical activity are: 1. Cancer cells are less efficient in their production of cellular ... by Brewer to raise the cell pH of cancer cells up to a range of 8.0. Brewer thought that raising the pH of cancer cells this high would kill cancer cells. Use of cesium in cancer has met with...

Ngày tải lên: 14/02/2014, 22:20

... stimulation of ERK1 ⁄ 2 and Pak1 pathways, gefitinib might lead to inhibition of invasiveness of human cancer cells through the inhibi- tion of ERK1 ⁄ 2 and Pak1. The use of gefitinib in cells with ... phos- phorylation state of their proteins, thereby changing the amount and localization of Bcl-2 family members. However, each type of cancer has its own way of disrupting the balance of the networks of signaling cascades ... inhibition of Bax phosphorylation. Regulation of Bax also occurs by mechanisms other than phosphorylation. Gefitinib inhibits growth of human gallbladder adenocarcinoma cells (HAG-1) by arresting the cells...

Ngày tải lên: 16/02/2014, 09:20

... GIF expression in response to these different types of brain injury was often observed in glial cells accumulating at the degenerating area, where the glial scar was begin- ning to form. Intriguingly, ... regulating synaptic levels of zinc, as the GIF-deficient mice had a reduced content of Zn(II) within a number of brain regions [28]. ROS scavenging ability of GIF The coordination of redox-active metal ... important insights into the functional roles of this protein in the brain, and in particular its ability to inhibit neurite outgrowth (as described above). The functional role of GIF synthesis and secretion in...

Ngày tải lên: 16/02/2014, 15:20

... Professor of Ecology in the School of Biological and Chemical Sciences at Queen Mary, University of London. D AVID G. RAFFAELLI is Professor of Environmental Science at the University of York. R ONNI ... roles of different kinds of organisms in the flux and storage of elements in ecosystems. The total biomass per unit area, W,is simply the sum ofthe body mass of all individuals. For organisms ofsimilar ... Structure and Function of Aquatic Ecosystems Ecologists have long struggled to predict features of ecological systems, such as the numbers and diversity of organisms. The wide range of body sizes...

Ngày tải lên: 17/02/2014, 19:20

... of support, needed for the hinging of the C-ter- minal part of helix III. This relative rigidity of resi- due 50 is also relevant to biological function, and has been long recognized as one of ... Lorentzian function to the specific spectral density of each experimental point. Therefore, according to the RSDM analysis [21], most of the 15 N– 1 H vectors of the TTF-1 HD core move at the rate of ... values of J(0) and J(x N ), an indication of slow local motion consistent with the presence of a hydrogen bond network that restricts the excursion of the Glu50 backbone. Other relevant details of...

Ngày tải lên: 18/02/2014, 16:20

... the nuclei of a neuron subpopulation, with no binding to the nuclei of glial cells. This result suggests that neu- rons display selective GlcNAc-binding proteins, an intriguing result in the light of ... clear demonstrations of the utility of linear ligation assembly, a convergent chemo- selective approach can offer the key advantages of more ready and flexible modification of a well-defined protein ... for the origin of such complex biological functions [4], which may arise from a comparatively restricted genetic code [5–7]. As a consequence of the lack of direct genetic control of their biosynthesis,...

Ngày tải lên: 18/02/2014, 17:20

... of the primers. Bold font represents the sequence of mature miR9* and italic fonts the sequence of mature miR9. (C) RT-PCR analysis of pri-miR9s dur- ing the neuronal differentiation of P19 cells treated ... Department of Nuclear Medicine, Seoul National University College of Medicine, Korea 3 Laboratory of Molecular Imaging and Therapy of Cancer Research Institute, Seoul National University College of Medicine, ... level of mature miR9 than of mature miR9*. In vivo visualization of unbalanced expressions of mature miR9 and miR9* during neurogenesis To monitor in vivo the endogenously unequal expres- sion of...

Ngày tải lên: 18/02/2014, 17:20

... resting CHO cells more weakly than Noxo1c (Fig. 3). We also attempted but failed to assess the intracellular localization of Noxo1b after treatment of the cells with PMA, as the cells became ... localization of Noxo1b and Noxo1c in CHO cells. (A) Intracellular localization of Noxo1b (upper panels) and Noxo1c (lower panels) in quiescent CHO cells. In merged images (right panels), local- ization of ... membrane localization of Noxo1 cor- related well with that of the superoxide-producing activity of Nox1 (Fig. 4C), a weaker activity of Noxo1c to support Nox1 activity in unstimulated cells (Fig. 3)...

Ngày tải lên: 19/02/2014, 06:20

... form of cyprosin was processed in different isoforms by the excision of the prosegment and of most of the PSI [21]. Conversely to what has been found in vivo [31], heavy and light chains of the ... development [22]. In the case of phytepsin, gene expression was upregulated in developing tracheary elements and sieve cells of barley roots. However, the specific function of the enzyme in these tissues ... total or partial removal of the internal Fig. 1. Plant aspartic proteinase precursors. Comparison of the amino acid sequences of representative members of the A1 family of plant aspartic proteinases....

Ngày tải lên: 19/02/2014, 12:20

... selective inhibition of nAChR subpop- ulations. Among the a-conotoxins, MII has found the widest application in the characterization of a range of native nAChRs (Table 1). Because of its relatively ... formation of MII-sensitive receptors was strongly dependent on expres- sion of the b2 subunit [72,73] but more surprisingly, also on expression of b3 subunits [74] (see also Characterization of nAChR ... and physiological function( s). Compared to the muscle nAChR, relatively little is known about the function and composition of the neuronal nAChRs. This objective has been greatly hampered by a lack of selective...

Ngày tải lên: 19/02/2014, 12:20