function of glial cells
Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
Ngày tải lên :
14/02/2014, 18:20
... recruitment of
MOF to recently transcribed regions, especially at the
3¢ ends of genes where H3-K36me3 is enriched [128].
In mammalian cells MOF also exists as part of a sepa-
rate MOF–MSLv1 complex ... posi-
tions of regulatory elements required for
function in either T cells or mast cells.
Shown below are the positions that nucleo-
somes and GATA-2 occupy in unstimulated
T cells and mast cells [85].
Active ... cells
depletion of MOF, but not Tip60, results in reduced
global levels of AcH4-K16 and defective DNA damage
response [131]. In mouse embryos, MOF is essential
for AcH4-K16, and loss of MOF results...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
Ngày tải lên :
14/02/2014, 18:20
... absence of B lymphocytes
and plasma cells and very low levels of immunoglobu-
lins of all classes. Humoral immune responses are
essentially nonexistent. T cells are not affected, but
myeloid cells ... family of cytoplasmic
enzymes that are important for several aspects of leu-
kocyte biology. Both loss- and gain -of -function muta-
tions in humans have been instrumental in our
understanding of their ... total
protein level, of BTK–SYK was less than that of ITK–
SYK in 293T relative to COS7 cells. 293T cells express
endogenous SYK, but we do not know whether this
kinase influences the behavior of the fusion...
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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
Ngày tải lên :
14/02/2014, 18:20
... the inhibition of CYP activity observed in the
absence of changes in protein expression in rabbit he-
patocytes [22]. ROS indirectly reduced the activity of
selected isoforms of CYP by inducing ... recognition of pathogen invasion and a facili-
tation of the body’s subsequent immune responses [27].
The stimulation of these receptors activates inflamma-
tory responses characterized by the release of ... drug-metabolizing dysfunction during sepsis T H. Kim et al.
2312 FEBS Journal 278 (2011) 2307–2317 ª 2011 The Authors Journal compilation ª 2011 FEBS
Role of Kupffer cells in pathogenesis of sepsis-induced
drug...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
Ngày tải lên :
14/02/2014, 19:20
... full-length
v-KIND; DKIND1, deletion of KIND1;
DKIND2, deletion of KIND2; DKIND1 + 2,
deletion of both KIND1 and KIND2; DRasN,
deletion of RasN; DGEF, deletion of
RasGEF; KIND1, KIND1 domain; KIND2,
KIND2 ... pull-
down assay of combinations of EGFP-fused KIND1
or KIND2 of v-KIND with GST-fused CD2-1-6-1 or
CD2-1-6-2 of MAP2. We successfully detected a pull
down for the combination of EGFP-KIND2 and
GST-CD2-1-6-2, ...
α
-MAP2
kDa
50
37
25
CBB
A
B
Fig. 2. Of all members of the KIND family
of proteins, only KIND2 binds to MAP2.
Pull-down assay (PD) of the endogenous
MAP2 from cerebellar lysates of P21 mice
(A, left) and...
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Tài liệu The Electrical Properties of Cancer Cells pptx
Ngày tải lên :
14/02/2014, 22:20
... cells to well differentiated cells. Some
cancers are almost completely composed of undifferentiated cells that are
biochemically similar to embryonic cells because of increased expression of ... properties of cancer cells part 1
• Some of the characteristic features of cancerous cells that affect their electrical
activity are:
1. Cancer cells are less efficient in their production of cellular ... by Brewer to raise the cell pH of cancer cells up to
a range of 8.0. Brewer thought that raising the pH of cancer cells this high would
kill cancer cells. Use of cesium in cancer has met with...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
Ngày tải lên :
16/02/2014, 09:20
... stimulation of ERK1 ⁄ 2 and
Pak1 pathways, gefitinib might lead to inhibition of
invasiveness of human cancer cells through the inhibi-
tion of ERK1 ⁄ 2 and Pak1. The use of gefitinib in cells
with ... phos-
phorylation state of their proteins, thereby changing
the amount and localization of Bcl-2 family members.
However, each type of cancer has its own way of
disrupting the balance of the networks of signaling
cascades ... inhibition of Bax phosphorylation.
Regulation of Bax also occurs by mechanisms other
than phosphorylation. Gefitinib inhibits growth of
human gallbladder adenocarcinoma cells (HAG-1) by
arresting the cells...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
Ngày tải lên :
16/02/2014, 15:20
... GIF
expression in response to these different types of brain
injury was often observed in glial cells accumulating at
the degenerating area, where the glial scar was begin-
ning to form. Intriguingly, ... regulating synaptic levels of zinc, as
the GIF-deficient mice had a reduced content of Zn(II)
within a number of brain regions [28].
ROS scavenging ability of GIF
The coordination of redox-active metal ... important insights into the functional roles
of this protein in the brain, and in particular its ability
to inhibit neurite outgrowth (as described above).
The functional role of GIF synthesis and secretion
in...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
Ngày tải lên :
17/02/2014, 19:20
... Professor of Ecology in the School of Biological and
Chemical Sciences at Queen Mary, University of London.
D
AVID G. RAFFAELLI is Professor of Environmental Science at the University of
York.
R
ONNI ... roles of different kinds of organisms in the flux
and storage of elements in ecosystems. The total biomass per unit area, W,is
simply the sum ofthe body mass of all individuals. For organisms ofsimilar ... Structure and Function of Aquatic Ecosystems
Ecologists have long struggled to predict features of ecological systems, such as
the numbers and diversity of organisms. The wide range of body sizes...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
Ngày tải lên :
18/02/2014, 16:20
... of support, needed for the hinging of the C-ter-
minal part of helix III. This relative rigidity of resi-
due 50 is also relevant to biological function, and has
been long recognized as one of ... Lorentzian function
to the specific spectral density of each experimental
point. Therefore, according to the RSDM analysis
[21], most of the
15
N–
1
H vectors of the TTF-1 HD
core move at the rate of ... values of J(0) and
J(x
N
), an indication of slow local motion consistent
with the presence of a hydrogen bond network that
restricts the excursion of the Glu50 backbone. Other
relevant details of...
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Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modifications ppt
Ngày tải lên :
18/02/2014, 17:20
... the
nuclei of a neuron subpopulation, with no binding to
the nuclei of glial cells. This result suggests that neu-
rons display selective GlcNAc-binding proteins, an
intriguing result in the light of ... clear demonstrations of the
utility of linear ligation assembly, a convergent chemo-
selective approach can offer the key advantages of
more ready and flexible modification of a well-defined
protein ... for the origin of
such complex biological functions [4], which may arise
from a comparatively restricted genetic code [5–7]. As
a consequence of the lack of direct genetic control of
their biosynthesis,...
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Tài liệu Báo cáo khoa học: Bioimaging of the unbalanced expression of microRNA9 and microRNA9* during the neuronal differentiation of P19 cells doc
Ngày tải lên :
18/02/2014, 17:20
... of the primers. Bold font
represents the sequence of mature miR9*
and italic fonts the sequence of mature
miR9. (C) RT-PCR analysis of pri-miR9s dur-
ing the neuronal differentiation of P19 cells
treated ... Department of Nuclear Medicine, Seoul National University College of Medicine, Korea
3 Laboratory of Molecular Imaging and Therapy of Cancer Research Institute, Seoul National University College of Medicine, ... level of mature miR9 than of
mature miR9*.
In vivo visualization of unbalanced expressions of
mature miR9 and miR9* during neurogenesis
To monitor in vivo the endogenously unequal expres-
sion of...
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Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc
Ngày tải lên :
19/02/2014, 06:20
... resting CHO cells
more weakly than Noxo1c (Fig. 3). We also attempted
but failed to assess the intracellular localization of
Noxo1b after treatment of the cells with PMA, as the
cells became ... localization of Noxo1b
and Noxo1c in CHO cells. (A) Intracellular
localization of Noxo1b (upper panels) and
Noxo1c (lower panels) in quiescent CHO
cells. In merged images (right panels), local-
ization of ... membrane localization of Noxo1 cor-
related well with that of the superoxide-producing
activity of Nox1 (Fig. 4C), a weaker activity of
Noxo1c to support Nox1 activity in unstimulated cells
(Fig. 3)...
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Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx
Ngày tải lên :
19/02/2014, 12:20
... form of cyprosin was processed
in different isoforms by the excision of the prosegment and
of most of the PSI [21]. Conversely to what has been found
in vivo [31], heavy and light chains of the ... development [22]. In the case of
phytepsin, gene expression was upregulated in developing
tracheary elements and sieve cells of barley roots. However,
the specific function of the enzyme in these tissues ... total or partial removal of the internal
Fig. 1. Plant aspartic proteinase precursors. Comparison of the amino
acid sequences of representative members of the A1 family of plant
aspartic proteinases....
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
Ngày tải lên :
19/02/2014, 12:20
... selective inhibition of nAChR subpop-
ulations. Among the a-conotoxins, MII has found the
widest application in the characterization of a range of
native nAChRs (Table 1). Because of its relatively ... formation of
MII-sensitive receptors was strongly dependent on expres-
sion of the b2 subunit [72,73] but more surprisingly, also on
expression of b3 subunits [74] (see also Characterization of
nAChR ... and
physiological function( s). Compared to the muscle
nAChR, relatively little is known about the function and
composition of the neuronal nAChRs. This objective has
been greatly hampered by a lack of selective...
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