role of glial cells in cerebral ischemia

... shown that interactions between KCs and endotoxin comprise the initiating event lead- ing to hepatotoxicity in liver injury, including endotox- emia and ischemia ⁄ reperfusion injury [14]. In our studies, ... signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. Drug Metab Dispos 36, 95–101. 10 Ghose R, Guo T & Haque N (2009) Regulation of gene expression of hepatic ... USA). Binding of all of the anti- bodies was detected using an ECL detection system (iNtRON Biotechnology, Seoul, Korea) in accordance with the manu- facturer’s instructions. The intensity of the...

Ngày tải lên: 14/02/2014, 18:20

Ngày tải lên: 20/06/2014, 01:20

... signaling. This finding corroborates the interaction observed between various intracellular signaling pathways and apoptosis induced by 1mM concentration of ethanol in HepG2 cells [19]. Int. ... . Interestingly, HMGN3 has been found to be associated with resistance against anticancer drugs including vinblastine, topotecan, paclitaxel and doxorubincin in human hepatocellular carcinoma ... (including Kupffer cells) [41, 42], and ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut mucosa to endotoxins [43, 44]. These...

Ngày tải lên: 31/10/2012, 15:28

Ngày tải lên: 16/03/2014, 18:20

Ngày tải lên: 08/10/2013, 15:56

... China Statistics Yearbook, China Financial Yearbook and People’s Bank of China Statistics Quarterly bulletin. B. Development of direct financing and indirect financing markets providing financing ... in exploring on-line banking business as well as in promoting non-bank financial institutions. Efforts should be made in upgrading financial operations and financial services, and in conducting ... The role of FDI in institution building Over the past 20 years, foreign financial institutions, mainly foreign banks have played an important role in the opening up of Chinese financial industry....

Ngày tải lên: 18/10/2013, 07:15

... renewed interest in examining the indications for BCG vaccination in the United States included consideration of the wide range of vaccine efficacies deter- mined by clinical trials and estimated in ... should continue to be included in ongoing testing programs if their skin-test results are <5 mm induration. Those vaccinees who have positive tuberculin skin-test reactions (≥5 mm of induration) ... preventing pulmonary TB in adoles- cents and adults. These studies also were not useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered 6...

Ngày tải lên: 15/02/2014, 13:20

... would involve the following determinations: in terms of producing information about possible invest- ments and allocating capital, the financial (a) developing and analyzing measures of the ... REPORT 2013 1 GLOBAL FINANCIAL DEVELOPMENT REPORT 2013 Rethinking the Role of the State in Finance Washington, D.C. GLOBAL FINANCIAL DEVELOPMENT REPORT 2013 BENCHMARKING FINANCIAL SYSTEMS AROUND ... respondents seeing potential benefits in more stringent supervision of new finan- cial instruments in light of the crisis. A majority also see a scope for a more active role of the state in promoting technological...

Ngày tải lên: 16/02/2014, 10:20

... “Small Business Lending and the Changing Structure of the Banking Industry,” Journal of Banking and Finance, August. Sullivan, Richard J. 2000. “How Has the Adoption of Internet Banking Affected Performance ... larger banks in making small business loans. Loan officers at small banks can take into account a wide variety of factors in reviewing applications for small business loans, including the character of ... understanding issues facing community banks. I. THE CURRENT ROLE OF COMMUNITY BANKS The banking system in the United States has always been unique in the sense of containing large numbers of small...

Ngày tải lên: 16/02/2014, 11:20

... dis- charge can contain a wide range of contaminants and originate from a myriad of sources. Some of the biggest generators of toxic industrial waste include mining, pulp mills, tanneries, sugar ... from mining operations can contain silt and rock particles and sur- factants. Depending on the type of ore deposit being mined, tailings can also contain heavy metals like copper, lead, zinc, ... examples of persistent environmental damage caused by the discharge of toxic mine waste. In Papua New Guinea for ex- ample, companies discharge millions of tons of contaminated mine waste into...

Ngày tải lên: 17/02/2014, 10:20

... 3T3-L1 cells were cultured in DMEM containing 10% fetal bovine serum. OP9 cells were grown in aMEM containing 20% fetal bovine serum. C2C12 cells were maintained in DMEM containing 10% fetal bovine ... or without hematoxylin staining. In hypoxia experiments, 3T3-L1 cells were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati, OH, USA) constantly maintained at 1% O 2 . Culture medium ... post-transfection by maintaining the cells in culture medium containing 2% horse serum. Cells were fixed on day 4 of differentiation and stained with hematoxylin and eosin. One of two independent experiments...

Ngày tải lên: 18/02/2014, 08:20

... calcium-independent phospholipase A 2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting cera- mide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase. ... leading to the accumulation of sphingomyelin [27]. Because one of the pathways for ceramide recycling is the sphingomyelin pathway, it is conceivable that in addition to the accumulation of Fig. ... protein contain- ing motifs consistent with a role in the intracellular transport of cholesterol to post-lysosomal destinations. Cells from NPC subjects show a decrease in acid sphingomyelinase activity,...

Ngày tải lên: 18/02/2014, 14:20

... role in skin wound healing. After a skin injury, PPARb expression is rap- idly elevated in the epidermis at the wound edges; dele- tion of a single PPARb allele results in delayed wound healing ... cultured human keratinocytes [14]. In this study, we examined the interaction between CerK and PPARb, and its role in regulating keratino- cyte survival. We report that in a mouse keratinocyte cell line upregulation ... containing putative CERK-PPRE was analyzed by PCR. In the ChIP DNA obtained with the anti-PPARb IgG, the amount of DNA containing putative CERK-PPRE was significantly greater in the chromatin of cells...

Ngày tải lên: 18/02/2014, 18:20

... detected at the dimer interface of the models or in the surroundings of the hinge loop residues. Likewise, the models of nonex- changing and exchanging HHP-RNase were prepared start- ing from 1Z7X. ... strong, neutralizing action of the cytosolic RNase inhibitor (cRI), a 50-kDa protein containing 16 leu- cine-rich repeat motifs [7,8]. In fact, onconase from Rana pipiens eggs [9], and seminal RNase ... detected at the dimer interface of the models or in the surroundings of the mutated residues. The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure...

Ngày tải lên: 19/02/2014, 06:20

... substrate binding process. This provides strong evidence that N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1 ... that N-linked oligosaccharide side-chains are important for the GABA transport activity. 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the terminal ... transporter in HeLa cells was abolished by tunicamycin, a potent inhibitor of N-glycosylation [18]. We found that inhibi- tion of N-glycosylation processing by dMM did not G. Cai et al. Role of N-glycosylation...

Ngày tải lên: 19/02/2014, 17:20

... questions in pointing out the value of applying a CN methodology to cross- linguistic study. In explaining the representation issues for French, we will first, briefly provide background in current ... hension of French, will form the basis of the discussion. 4.1 Word Boundaries in On-Line Comprehension of French Because of the parallel activation of all meanings of each recognized word in ... and in what contexts these morphemes are affected. The study includes off-line picture naming which forces use of articles in all of the above contexts, as well as on-line production of these...

Ngày tải lên: 21/02/2014, 20:20

... Ph.D. Associate Professor Department of Political Science University of Oklahoma Norman, OK Stanton A. Glantz, Ph.D. Professor of Medicine Department of Medicine Division of Cardiology University of California, ... consequences of smoking are rarely depicted in movies. 4. Cross-sectional studies show that, among adolescents, exposure to smoking in movies is associated with initiation of smoking, independent of ... needed on the role exposure to smoking in movies plays in adolescents’ smoking beyond the initiation phase. 6. Experimental studies show that images of cigarette smoking in film can in uence adolescent...

Ngày tải lên: 06/03/2014, 01:20

Ngày tải lên: 06/03/2014, 08:20

Ngày tải lên: 06/03/2014, 10:20