function of glial cells in brain

... shown that interactions between KCs and endotoxin comprise the initiating event lead- ing to hepatotoxicity in liver injury, including endotox- emia and ischemia ⁄ reperfusion injury [14]. In our studies, ... signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. Drug Metab Dispos 36, 95–101. 10 Ghose R, Guo T & Haque N (2009) Regulation of gene expression of hepatic ... factor-a and interleukin-6 were decreased by depletion of KCs. Our findings suggest that ablation of KCs protects against hepatic drug-metabolizing dysfunction by modulation of the in ammatory...

Ngày tải lên: 14/02/2014, 18:20

... to comment on the the function of clue words within analysis. The theory of clue interpretation gives insight into a known construction within sample dialogues; examining the computational ... Complexity analysis of this algorithm indicates that it works in linear time (i.e. it takes a linear factor of the number of nodes of the tree to locate all propositions in tile representation). ... existing forms and possible categories. 258 A COMFUTATIONAL THEORY OF THE FUNCTION OF CLUE WORDS IN ARGUMENT UNDERSTANDING Robin Cohen Department of Computer Science University of Toronto...

Ngày tải lên: 08/03/2014, 18:20

Ngày tải lên: 14/03/2014, 23:20

Ngày tải lên: 19/06/2014, 10:20

Ngày tải lên: 20/06/2014, 01:20

Ngày tải lên: 28/06/2014, 15:20

... suggesting that this MT isoform has different and distinct functions within the brain. Furthermore, the discovery and continued investigation of this brain- spe- cific MT isoform has led to intense interest ... remained elevated for almost a month [19,20]. The increase in GIF expression in response to these different types of brain injury was often observed in glial cells accumulating at the degenerating ... properties. In this review, we examine the recent developments regarding the function of neuronal growth-inhibi- tory factor within the brain, particularly in response to brain injury or during neurodegenerative...

Ngày tải lên: 16/02/2014, 15:20

Ngày tải lên: 16/03/2014, 13:20

Ngày tải lên: 29/03/2014, 22:21

Ngày tải lên: 19/06/2014, 22:20

Ngày tải lên: 19/06/2014, 22:20

... CD34+ cells in circulation during dieting program was 69% ± 50%. In conclusion, the weight loss program analyzed in our study resulted in the improvement of the number of CD34+ cells in circulation ... positive cells was per- formed by adopting the gating strategy defined by the International Society of Haematotherapy and Graft Engineering (ISHAGE) guidelines [27]. The method of the selection of ... breakfast consisted of coffee/tea with no sugar or one fruit serving, while lunch and dinner each consisted of 3.5 oz lean protein, a vegetable serving, bread serving, and a fruit serving. The pro- gram...

Ngày tải lên: 25/10/2012, 10:51

... signaling. This finding corroborates the interaction observed between various intracellular signaling pathways and apoptosis induced by 1mM concentration of ethanol in HepG2 cells [19]. Int. ... . Interestingly, HMGN3 has been found to be associated with resistance against anticancer drugs including vinblastine, topotecan, paclitaxel and doxorubincin in human hepatocellular carcinoma ... (including Kupffer cells) [41, 42], and ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut mucosa to endotoxins [43, 44]. These...

Ngày tải lên: 31/10/2012, 15:28

... expression of claudin-1 in the cytoplasm, with some nuclear expression of claudin-1. B) Treatment of these cells with PKA inhibitor results in nuclear translocation of claudin-1 in as little as 15 minutes, ... is involved in claudin-1 expression and localization. Indeed, a study shows that increasing β-catenin in- creases the expression of claudin-1 in colorectal cancer cells, and that claudin-1 ... lo- calization of claudin-1. Nuclear claudin-1 does not increase melanoma cell motility. We have previously shown that increasing the levels of CLDN-1 increases the invasion of melanoma cells (4)....

Ngày tải lên: 03/11/2012, 11:17

... family of cyto- plasmic tyrosine kinases. In 1993, loss -of -function mutations in the BTK gene were reported as the cause of X-linked agammaglobulinemia. Of all the existing 90 tyrosine kinases in ... pro- tein kinase B (PKB)]. In AKT, a cysteine substitution of the corresponding R25 in the pleckstrin homology (PH) domain also results in loss of function [16,17], thereby demonstrating related functions ... locations of the missense mutation in the BTK PH domain; arginine 28 is in dark blue, encircled in red. Bottom left: SH2 domain. Right: kinase domain. The mutated residues are indicated in yellow,...

Ngày tải lên: 14/02/2014, 18:20

... full-length v-KIND; DKIND1, deletion of KIND1; DKIND2, deletion of KIND2; DKIND1 + 2, deletion of both KIND1 and KIND2; DRasN, deletion of RasN; DGEF, deletion of RasGEF; KIND1, KIND1 domain; KIND2, KIND2 ... the v-KIND-MAP2 interaction within cells. The MAP2-binding core module of v-KIND is involved in targeting to neuronal dendrites and dendrite growth We next investigated the MAP2 binding core of v-KIND ... stain) EGFP EGFP-KIND2-1 EGFP-KIND2-2 EGFP-KIND2-3 EGFP-KIND2-4 EGFP-KIND2-5 EGFP-KIND2 EGFP-KIND1 KIND2-1 487 KIND2-2 521 KIND2-3 555 KIND2-5 589 KIND2-4 488 456 620 KIND2 v-KIND + + + – – Interaction EGFP EGFP- KIND2-1 Input IB:...

Ngày tải lên: 14/02/2014, 19:20

... long-chain saturated fatty acids (SFAs) led to increased expression of proin- flammatory cytokines, inhibition of insulin signaling, induction of endoplasmic reticulum (ER) stress, and promotion of ... carcinoma cells were grown in DMEM containing 10% heat-inactivated fetal bovine serum, 2 mm glutamine, 100 UÆmL )1 penicillin, and 100 ngÆmL )1 streptomycin, at 37 °C in air with 5% CO 2 . Cells ... in two phases according to the intensity and the duration of the stress. An initial adaptive response culminates in the temporary inhibition of protein synthesis, providing cells with the opportunity to...

Ngày tải lên: 14/02/2014, 22:20

... CIP1 is involved in gefitinib-induced growth inhibition in HNSCC [58]. Another group of cell-cycle regulatory molecules – those of the INK4 family – has also been implicated in gefitinib-induced inhibition ... for the induction of Bim in gefitinib-triggered apoptosis of NSCLC cells. Bax Bax is a 21-kDa multi-BH domain pro-apoptotic pro- tein and acts downstream of BH3-only proteins. The induction of Bax ... are down-regulated by gefitinib or erlotinib in intestinal epithelial cells [53]. Furthermore, the expression of cIAP-1 and of X-linked IAP is reduced by AG1478 in squamous cell carcinoma cell lines NA and...

Ngày tải lên: 16/02/2014, 09:20