... epidermalgrowth factor: expressionand site-directed mutagenesis ofepidermalgrowthfactor gene Biochemistry 27 , 728 9– 729 5 52 Engler, D.A., Montelione, G.T & Niyogi, S.K (1990) Human epidermalgrowth ... in responseto curdlan Therefore, it was then studied whether inhibition of tyrosine kinase-mediated phosphorylation resulted also in a reduction ofexpressionof the three genes studied here As ... contains an ORF, from nucleotides 100–1 02to nucleotides 22 42 22 44(stop); the Ó FEBS 20 04 Activation of sponge cells by (1fi3)-b-D-glucan (Eur J Biochem 27 1) 1 929 Fig The Suberites domuncula potential...
... FEBS 20 02 Ligand specificities of ErbB-1/ErbB-4 chimeras (Eur J Biochem 26 9) 23 25 contain N-terminal portions of the extracellular region of ErbB-1 ( )24 to 479, )24 to 311, and )24 to 163) and ... of the receptor [19 ,22 ] The b sheet of EGF may bind to domain I of ErbB-1, and the other surface of the ligand binds to domain III of the receptor Recently, Gly441 of the ErbB-1 domain III was ... 40-kDa epidermalgrowth factor/ transforming growthfactor a-binding domain produced by limited proteolysis of the extracellular domain of the epidermalgrowthfactorreceptor J Biol Chem 26 8, 1976–1981...
... Christofori G (20 08) Modulation of endocrine pancreas development but not FEBS Journal 27 6 (20 09) 523 9– 525 1 ª 20 09 The Authors Journal compilation ª 20 09 FEBS T Nagashima et al 24 25 26 27 28 29 ... BW, Harris PL, Haserlat SM, Supko JG, Haluska FG et al (20 04) Activating 525 0 15 16 17 18 19 20 21 22 23 mutations in the epidermalgrowthfactorreceptor underlying responsiveness of non-small-cell ... EGF-inducible, as was observed for ERRFI1 expression, this was not the case Rather, we found that MIG6 expression was static and correlated with basal phosphorylation levels of EGFR and SHC, and was negatively...
... to hyperplasia of the synovial lining, where synovial cells display increased expressionof the EGF receptor ErbB -2 (also known as c-neu or HER2 ) [7,13,14] and amplify IL-1-mediated release of ... Scranton V, Cheng HC: Roles of transforming growth factor- α andepidermalgrowthfactor in chick limb development Dev Biol 1998, 20 2:43-55 Bernier SM, Goltzman D: Regulation ofexpressionof the ... maintained in the presence of tumor necrosis factor Cell viability is and/ or epidermalgrowthfactor (EGF) alpha (TNF-α) and/ or epidermalgrowthfactor (EGF) Subconfluent monolayers of chondrocytes were...
... 22 36 -22 50 del E746-A750 del 5'-TCCCAGAAGGTGAGAAAGTTAAAATTCCCGTCGCTATCAAG-3' 41 mer 22 37 -22 54 del E746-T751 del 5'-(T )20 AGTTAAAATTCCCGTCGCTATCAAGG-3' 46 mer 22 40 -22 57 del L747-S7 52 del 5'-(T )23 AGTTAAAATTCCCGTCGCTATCAAGGAAT-3 ... Case(s) with EGFR mutation(s) L747-S7 52 del L858R -21 6 G/T 22 35 -22 49 del E746-A750 del 22 36 -22 50 del 22 40 -22 57 del 25 73 T>G Adenocarcinoma (n = 26 ) 3 Bronchioloalveolar carcinoma (n = 6) 0 Squamous ... of Figure Detection of wild-type and mutant EGFR by primer extension analysis NSCLC DNA samples of wild-type EGFR and ones containing the following mutations: -21 6 G/T, 22 35 -22 49 del, 22 36 -22 50...
... treatment of HER2 overexpressing metastatic breast cancer J Clin Oncol 20 02, 20 :719- 726 Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ: Mechanisms of disease: understanding resistance to HER2 -targeted ... and 60 mg/m2, respectively) was started as first-line metastatic therapy in February 20 02for four months The chemotherapy regimen was then changed to 40 mg/m2 vinorelbine plus 600 mg/m2 gemcitabine ... human breast cancer xenografts on therapy with humanized monoclonal antibody to HER- 2receptorand DNA-reactive drugs Oncogene 1998, 17 :22 35 -22 49 Falkson G, Gelman RS, Pandya KJ, et al: Eastern...
... Dimerization of EGFR 14 1.1.7 EGFR and lipid raft 16 1.1.8 EGFR and the cytoskeleton 22 1 .2 Other members of ErbB family 25 1 .2. 1 ErbB2 25 1 .2. 2 ErbB3 ... binds to receptors, receptors are able to form a 2: 2 back-toback dimer with ligands embedded in each of their ligand-binding pocket formed by domain L1 and L2 (Ferguson 20 08) This leads to the allosteric ... al 20 10) However, inherent and acquired resistance is still a threat and this emphasizes the need for new drugs andtherapy development 1 .2. 2 ErbB3 In contrast to ErbB2, ErbB3 has the ligand-binding...
... Streuli CH (20 02) Activation of BAD by therapeutic inhibition ofepidermalgrowthfactorreceptorand transactivation by insulin-like growthfactorreceptor J Biol Chem 27 7, 27 643 27 650 10 Janmaat ... JF & Arteaga CL (20 01) Epidermalgrowthfactorreceptor (HER1 ) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2 ⁄ neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo Cancer ... Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer Cancer Lett 191, 22 9 23 7 57 Takeuchi K, Motoda Y & Ito F (20 06) Role of transcription factor activator protein...
... HP & Dittmann K (20 08) Activation of protein kinase Ce stimulates DNA-repair via epidermalgrowthfactor 3 42 124 125 126 127 128 129 130 receptor nuclear accumulation Radiother Oncol 86, 383–390 ... EGFR( 622 -660) and its interaction with Ca2+ ⁄ calmodulin Biochemistry 45, 127 04– 127 14 59 Yamane K, Toyoshima C & Nishimura S (19 92) Ligand-induced functions of the epidermalgrowthfactorreceptor ... transactivation ofepidermalgrowthfactorreceptor mediated by PKC FEBS Lett 517, 20 6 21 0 Li H, Ruano MJ & Villalobo A (20 04) Endogenous calmodulin interacts with the epidermalgrowthfactorreceptor in...
... is localized to the cytoplasmic surface of early endosomes J Biol Chem 27 2, 20 538 20 544 27 Ebner, R & Derynck, R (1991) Epidermalgrowthfactorand transforming growth factor- alpha: differential ... PDGF receptorand members of the src family of tyrosine kinases Cell 62, 481–4 92 Dahl, M.E., Arai, K.I & Watanabe, S (20 00) Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common ... in rat fibroblasts J Cell Sci 109, 20 05 20 12 Steen, H., Kuster, B., Fernandez, M., Pandey, A & Mann, M (20 02) Tyrosine phosphorylation mapping of the epidermalgrowthfactorreceptor signaling...
... 22 23 24 25 26 27 28 29 Suh HS, Choi S, Khattar P, Choi N, Lee SC: Histone deacetylase inhibitors suppress the expressionof inflammatory and innate immune response genes in human microglia and ... production of PGE2 and PGD2 in LPS-activated microglia (Fig 1C) To investigate whether the enhancement of PGE2 was due to an increase in the expressionof other prostaglandin synthases, we investigated ... synthesis of PGE2 and PGD2 was also strongly enhanced (Fig 4C) We further investigated whether NVP-BEZ235 increases COX -2 and mPGES-1, as well as prostaglandin synthesis, in absence of LPS As shown...
... kinases: association with epidermalgrowthfactor receptor/ transforming growthfactor alpha expression in head and neck squamous carcinoma and inhibition by anti -epidermal growthfactorreceptor ... targets for radiation therapy: bringing preclinical data into clinical trials Clin Cancer Res 20 03, 9:3518-3 520 Sartor C: Mechanisms of Disease: radiosensitization by epidermalgrowthfactorreceptor ... on survival and pattern of relapse in patients with Page of (page number not for citation purposes) Radiation Oncology 20 06, 1:11 21 22 23 24 25 26 27 28 29 30 31 32 33 advanced head and neck carcinoma...
... caspase-7, and caspase-9, as a result, inhibits apoptosis [19 -21 ] Survivin can also bind the effector cell death proteases caspases-3 and -7 and inhibit caspase activity and cell death Furthermore, ... significance was noted and whether the Bcl-xL gene is Figure The effect of oxymatrine on release of mitochondrial cytochrome c and activation of caspase-3 The effect of oxymatrine on release of mitochondrial ... Oxymatrine releasing cytochrome c and activated caspase-3 Oxymatrine treatment led to a dose-dependent release of cytochrome c and activation of caspase-3 (Figure 5) A remarkable increase of cytochrome...
... cell hyperplasia with mucus accumulation in the 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 airways of patients who died of severe asthma attack Chest 19 92, 1101:916– 921 Burgel P-R, ... Amishima M, Munakata M , Nasuhara Y, Sato A, Takahashi T, Homma Y, Kawakami Y: Expressionofepidermalgrowthfactorandepidermalgrowthfactorreceptor immunoreactivity in the asthmatic human airway ... of EGF receptorexpressionto goblet cell hyperplasia in nasal polyps J Allergy Clin Immunol 20 00, 106:705–7 12 Boucher RC, Knowles MR, Yankaskas JR: Cystic fibrosis.7 In: Textbook of Respiratory...